A New Source of (R)-Limonene and Rotundifolone from Leaves of Lippia pedunculosa (Verbenaceae) and their Trypanocidal Properties

Detalhes bibliográficos
Autor(a) principal: Menezes, Leociley Rocha Alencar
Data de Publicação: 2014
Outros Autores: Santos, Nilmara Nunes, Meira, Cássio Santana, Santos, Jamyle Andrade Ferreira dos, Guimarães, Elisalva Teixeira, Soares, Milena Botelho Pereira, Nepel, Angelita, Barison, Andersson, Costa, Emmanoel Vilaça
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/20671
Resumo: FAPITEC/SE (Editais No 07/2009 and 10/2009), FAPESB, CNPq, FINEP, UFPR and CAPES
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spelling Menezes, Leociley Rocha AlencarSantos, Nilmara NunesMeira, Cássio SantanaSantos, Jamyle Andrade Ferreira dosGuimarães, Elisalva TeixeiraSoares, Milena Botelho PereiraNepel, AngelitaBarison, AnderssonCosta, Emmanoel Vilaça2017-08-17T17:17:45Z2017-08-17T17:17:45Z2014MENEZES, R. L. A. et al. A New Source of (R)-Limonene and Rotundifolone from Leaves of Lippia pedunculosa (Verbenaceae) and their Trypanocidal Properties. Natural Product Communications, v. 9, n. 6, p. 737-739, 2014.1934-578Xhttps://www.arca.fiocruz.br/handle/icict/20671FAPITEC/SE (Editais No 07/2009 and 10/2009), FAPESB, CNPq, FINEP, UFPR and CAPESUniversidade Federal de Sergipe. Departamento de Química. São Cristóvão, SE, BrasilUniversidade Federal de Sergipe. Departamento de Química. São Cristóvão, SE, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Universidade do Estado da Bahia. Departamento de Ciências da Vida. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Universidade do Estado da Bahia. Departamento de Ciências da Vida. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Hospital São Rafael. Centro de Biotecnologia e Terapia Celular. Salvador, BA, BrasilUniversidade Federal do Paraná. Departamento de Química. Curitiba, PR, BrasilUniversidade Federal do Paraná. Departamento de Química. Curitiba, PR, BrasilUniversidade Federal de Sergipe. Departamento de Química. Itabaiana, SE, BrasilInvestigation by GC-FID and GC-MS of the essential oil (LPOE) from the leaves of Lippia pedunculosa revealed, as the major compounds, the monoterpenes rotundifolone (71.7%) and (R)-limonene (21.8%). These two compounds and the minor constituent piperitenone (1.2%) were also isolated from the leaves and identified by spectrometric analysis. LPOE and isolated compounds were evaluated for their trypanocidal activity against epimastigote and trypomastigote forms of Trypanosoma cruzi. Significant results with IC50 values lower than 34.0 g.mL-1 were observed against these forms of T. cruzi for LPOE and isolated compounds. Rotundifolone was the most active compound with an IC50 lower than 10.0 g.mL-1 for both forms of T. cruzi. The effects of LPOE and isolated compounds were also evaluated in cultures of macrophages infected with T. cruzi. Treatment with (R)-limonene and rotundifolone caused a moderate reduction in the percentage of macrophages infected by T. cruzi and in the number of intracellular parasites at concentrations non-toxic to macrophages.engNatural Product IncorporationLippia pedunculosaÓleo essencialAtividade tripanocidaMonoterpenosLimonenoRotundifoliaLippia pedunculosaEssential oilTrypanocidal activityMonoterpenesLimoneneRotundifoloneA New Source of (R)-Limonene and Rotundifolone from Leaves of Lippia pedunculosa (Verbenaceae) and their Trypanocidal Propertiesinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/20671/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALMenezes L A new source....pdfMenezes L A new 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dc.title.pt_BR.fl_str_mv A New Source of (R)-Limonene and Rotundifolone from Leaves of Lippia pedunculosa (Verbenaceae) and their Trypanocidal Properties
title A New Source of (R)-Limonene and Rotundifolone from Leaves of Lippia pedunculosa (Verbenaceae) and their Trypanocidal Properties
spellingShingle A New Source of (R)-Limonene and Rotundifolone from Leaves of Lippia pedunculosa (Verbenaceae) and their Trypanocidal Properties
Menezes, Leociley Rocha Alencar
Lippia pedunculosa
Óleo essencial
Atividade tripanocida
Monoterpenos
Limoneno
Rotundifolia
Lippia pedunculosa
Essential oil
Trypanocidal activity
Monoterpenes
Limonene
Rotundifolone
title_short A New Source of (R)-Limonene and Rotundifolone from Leaves of Lippia pedunculosa (Verbenaceae) and their Trypanocidal Properties
title_full A New Source of (R)-Limonene and Rotundifolone from Leaves of Lippia pedunculosa (Verbenaceae) and their Trypanocidal Properties
title_fullStr A New Source of (R)-Limonene and Rotundifolone from Leaves of Lippia pedunculosa (Verbenaceae) and their Trypanocidal Properties
title_full_unstemmed A New Source of (R)-Limonene and Rotundifolone from Leaves of Lippia pedunculosa (Verbenaceae) and their Trypanocidal Properties
title_sort A New Source of (R)-Limonene and Rotundifolone from Leaves of Lippia pedunculosa (Verbenaceae) and their Trypanocidal Properties
author Menezes, Leociley Rocha Alencar
author_facet Menezes, Leociley Rocha Alencar
Santos, Nilmara Nunes
Meira, Cássio Santana
Santos, Jamyle Andrade Ferreira dos
Guimarães, Elisalva Teixeira
Soares, Milena Botelho Pereira
Nepel, Angelita
Barison, Andersson
Costa, Emmanoel Vilaça
author_role author
author2 Santos, Nilmara Nunes
Meira, Cássio Santana
Santos, Jamyle Andrade Ferreira dos
Guimarães, Elisalva Teixeira
Soares, Milena Botelho Pereira
Nepel, Angelita
Barison, Andersson
Costa, Emmanoel Vilaça
author2_role author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Menezes, Leociley Rocha Alencar
Santos, Nilmara Nunes
Meira, Cássio Santana
Santos, Jamyle Andrade Ferreira dos
Guimarães, Elisalva Teixeira
Soares, Milena Botelho Pereira
Nepel, Angelita
Barison, Andersson
Costa, Emmanoel Vilaça
dc.subject.other.pt_BR.fl_str_mv Lippia pedunculosa
Óleo essencial
Atividade tripanocida
Monoterpenos
Limoneno
Rotundifolia
topic Lippia pedunculosa
Óleo essencial
Atividade tripanocida
Monoterpenos
Limoneno
Rotundifolia
Lippia pedunculosa
Essential oil
Trypanocidal activity
Monoterpenes
Limonene
Rotundifolone
dc.subject.en.pt_BR.fl_str_mv Lippia pedunculosa
Essential oil
Trypanocidal activity
Monoterpenes
Limonene
Rotundifolone
description FAPITEC/SE (Editais No 07/2009 and 10/2009), FAPESB, CNPq, FINEP, UFPR and CAPES
publishDate 2014
dc.date.issued.fl_str_mv 2014
dc.date.accessioned.fl_str_mv 2017-08-17T17:17:45Z
dc.date.available.fl_str_mv 2017-08-17T17:17:45Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv MENEZES, R. L. A. et al. A New Source of (R)-Limonene and Rotundifolone from Leaves of Lippia pedunculosa (Verbenaceae) and their Trypanocidal Properties. Natural Product Communications, v. 9, n. 6, p. 737-739, 2014.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/20671
dc.identifier.issn.pt_BR.fl_str_mv 1934-578X
identifier_str_mv MENEZES, R. L. A. et al. A New Source of (R)-Limonene and Rotundifolone from Leaves of Lippia pedunculosa (Verbenaceae) and their Trypanocidal Properties. Natural Product Communications, v. 9, n. 6, p. 737-739, 2014.
1934-578X
url https://www.arca.fiocruz.br/handle/icict/20671
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Natural Product Incorporation
publisher.none.fl_str_mv Natural Product Incorporation
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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