Safety and effectiveness of HAART in tuberculosis-HIV co-infected patients in Brazil
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2013 |
| Outros Autores: | , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/35691 |
Resumo: | 2020-03-19 |
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Santos, A. P. G. dosPacheco, A. G.Staviack, A.Golub, J. E.Chaisson, R. E.Rolla, V. C.Kritski, A. L.Passos, S. R. L.Mello, F. C. de Queiroz2019-09-19T15:07:14Z2019-09-19T15:07:14Z2013SANTOS, A. P. G. dos et al. Safety and effectiveness of HAART in tuberculosis-HIV coinfected patients in Brazil. International Journal of Tuberculosis and Lung Disease, v. 17, n. 2, p. 192-197, Feb. 2013.1027-3719https://www.arca.fiocruz.br/handle/icict/3569110.5588/ijtld.11.08311815-7920engInternational Union Against Tuberculosis and Lung DiseaseSafety and effectiveness of HAART in tuberculosis-HIV co-infected patients in Brazilinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article2020-03-19Federal University of Rio de Janeiro. Clementino Fraga Filho University Hospital. Institute of Thoracic Diseases. Rio de Janeiro, RJ, Brazil.Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Rio de Janeiro, RJ, Brasil.Federal University of Rio de Janeiro. Clementino Fraga Filho University Hospital. Institute of Thoracic Diseases. Rio de Janeiro, RJ, Brazil.Johns Hopkins University. Baltimore, MD, USA.Johns Hopkins University. Baltimore, MD, USA.Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Rio de Janeiro, RJ, Brasil.Federal University of Rio de Janeiro. Clementino Fraga Filho University Hospital. Institute of Thoracic Diseases. Rio de Janeiro, RJ, Brazil.Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Rio de Janeiro, RJ, Brasil.Federal University of Rio de Janeiro. Clementino Fraga Filho University Hospital. Institute of Thoracic Diseases. Rio de Janeiro, RJ, Brazil.BACKGROUND — Antiretroviral therapy (ART) significantly reduces tuberculosis (TB) incidence among persons with human immunodeficiency virus (HIV), but the safety and effectiveness of concomitant treatment for both diseases remain unclear. OBJECTIVE — To evaluate the impact of ART and anti-tuberculosis treatment on survival and risk of adverse events (AE) among co-infected individuals. METHODS — In a retrospective cohort study, clinical data were collected from 618 TB-HIV patients treated with rifampin, isoniazid and pyrazinamide ± ethambutol between 1 January 1995 and 31 December 2003. Patients were categorized into two groups: highly active ART (HAART) or no ART. Different HAART regimens were evaluated. Bivariate analysis, multivariate logistic regression and survival analysis using Cox proportional hazards regression were used. RESULTS — One-year mortality was lower for patients receiving HAART (adjusted hazard ratio [aHR] 0.17, 95%CI 0.09–0.31) compared to no ART. HAART increased the risk of AE (aHR 2.08, 95%CI 1.29–3.36). The odds of AE when receiving a ritonavir + saquinavir HAART regimen was eight-fold higher compared to no ART (OR 8.31, 95%CI 3.04–22.69), while efavirenz-based HAART was not associated with a significantly increased risk of AE (OR 1.42, 95%CI 0.76–2.65). CONCLUSION — HIV patients with TB have significantly better survival if they receive HAART during anti-tuberculosis treatment. Efavirenz-based HAART is associated with fewer AEs than protease inhibitor-based HAART.TuberculosisAIDSHAARTAdverse eventsSurvivalinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txttext/plain1748https://www.arca.fiocruz.br/bitstream/icict/35691/1/license.txt8a4605be74aa9ea9d79846c1fba20a33MD51ORIGINALva_Santos_A_etal_INI_2013.pdfva_Santos_A_etal_INI_2013.pdfapplication/pdf474369https://www.arca.fiocruz.br/bitstream/icict/35691/2/va_Santos_A_etal_INI_2013.pdf53c353893a35a028fe887c9d5f0b1d3aMD52TEXTva_Santos_A_etal_INI_2013.pdf.txtva_Santos_A_etal_INI_2013.pdf.txtExtracted texttext/plain33125https://www.arca.fiocruz.br/bitstream/icict/35691/3/va_Santos_A_etal_INI_2013.pdf.txt2dffa8dd207ac2798264ed31958b3e3bMD53icict/356912021-03-24 16:32:30.221oai:www.arca.fiocruz.br:icict/35691Tk9URTogUExBQ0UgWU9VUiBPV04gTElDRU5TRSBIRVJFClRoaXMgc2FtcGxlIGxpY2Vuc2UgaXMgcHJvdmlkZWQgZm9yIGluZm9ybWF0aW9uYWwgcHVycG9zZXMgb25seS4KCk5PTi1FWENMVVNJVkUgRElTVFJJQlVUSU9OIExJQ0VOU0UKCkJ5IHNpZ25pbmcgYW5kIHN1Ym1pdHRpbmcgdGhpcyBsaWNlbnNlLCB5b3UgKHRoZSBhdXRob3Iocykgb3IgY29weXJpZ2h0Cm93bmVyKSBncmFudHMgdG8gRFNwYWNlIFVuaXZlcnNpdHkgKERTVSkgdGhlIG5vbi1leGNsdXNpdmUgcmlnaHQgdG8gcmVwcm9kdWNlLAp0cmFuc2xhdGUgKGFzIGRlZmluZWQgYmVsb3cpLCBhbmQvb3IgZGlzdHJpYnV0ZSB5b3VyIHN1Ym1pc3Npb24gKGluY2x1ZGluZwp0aGUgYWJzdHJhY3QpIHdvcmxkd2lkZSBpbiBwcmludCBhbmQgZWxlY3Ryb25pYyBmb3JtYXQgYW5kIGluIGFueSBtZWRpdW0sCmluY2x1ZGluZyBidXQgbm90IGxpbWl0ZWQgdG8gYXVkaW8gb3IgdmlkZW8uCgpZb3UgYWdyZWUgdGhhdCBEU1UgbWF5LCB3aXRob3V0IGNoYW5naW5nIHRoZSBjb250ZW50LCB0cmFuc2xhdGUgdGhlCnN1Ym1pc3Npb24gdG8gYW55IG1lZGl1bSBvciBmb3JtYXQgZm9yIHRoZSBwdXJwb3NlIG9mIHByZXNlcnZhdGlvbi4KCllvdSBhbHNvIGFncmVlIHRoYXQgRFNVIG1heSBrZWVwIG1vcmUgdGhhbiBvbmUgY29weSBvZiB0aGlzIHN1Ym1pc3Npb24gZm9yCnB1cnBvc2VzIG9mIHNlY3VyaXR5LCBiYWNrLXVwIGFuZCBwcmVzZXJ2YXRpb24uCgpZb3UgcmVwcmVzZW50IHRoYXQgdGhlIHN1Ym1pc3Npb24gaXMgeW91ciBvcmlnaW5hbCB3b3JrLCBhbmQgdGhhdCB5b3UgaGF2ZQp0aGUgcmlnaHQgdG8gZ3JhbnQgdGhlIHJpZ2h0cyBjb250YWluZWQgaW4gdGhpcyBsaWNlbnNlLiBZb3UgYWxzbyByZXByZXNlbnQKdGhhdCB5b3VyIHN1Ym1pc3Npb24gZG9lcyBub3QsIHRvIHRoZSBiZXN0IG9mIHlvdXIga25vd2xlZGdlLCBpbmZyaW5nZSB1cG9uCmFueW9uZSdzIGNvcHlyaWdodC4KCklmIHRoZSBzdWJtaXNzaW9uIGNvbnRhaW5zIG1hdGVyaWFsIGZvciB3aGljaCB5b3UgZG8gbm90IGhvbGQgY29weXJpZ2h0LAp5b3UgcmVwcmVzZW50IHRoYXQgeW91IGhhdmUgb2J0YWluZWQgdGhlIHVucmVzdHJpY3RlZCBwZXJtaXNzaW9uIG9mIHRoZQpjb3B5cmlnaHQgb3duZXIgdG8gZ3JhbnQgRFNVIHRoZSByaWdodHMgcmVxdWlyZWQgYnkgdGhpcyBsaWNlbnNlLCBhbmQgdGhhdApzdWNoIHRoaXJkLXBhcnR5IG93bmVkIG1hdGVyaWFsIGlzIGNsZWFybHkgaWRlbnRpZmllZCBhbmQgYWNrbm93bGVkZ2VkCndpdGhpbiB0aGUgdGV4dCBvciBjb250ZW50IG9mIHRoZSBzdWJtaXNzaW9uLgoKSUYgVEhFIFNVQk1JU1NJT04gSVMgQkFTRUQgVVBPTiBXT1JLIFRIQVQgSEFTIEJFRU4gU1BPTlNPUkVEIE9SIFNVUFBPUlRFRApCWSBBTiBBR0VOQ1kgT1IgT1JHQU5JWkFUSU9OIE9USEVSIFRIQU4gRFNVLCBZT1UgUkVQUkVTRU5UIFRIQVQgWU9VIEhBVkUKRlVMRklMTEVEIEFOWSBSSUdIVCBPRiBSRVZJRVcgT1IgT1RIRVIgT0JMSUdBVElPTlMgUkVRVUlSRUQgQlkgU1VDSApDT05UUkFDVCBPUiBBR1JFRU1FTlQuCgpEU1Ugd2lsbCBjbGVhcmx5IGlkZW50aWZ5IHlvdXIgbmFtZShzKSBhcyB0aGUgYXV0aG9yKHMpIG9yIG93bmVyKHMpIG9mIHRoZQpzdWJtaXNzaW9uLCBhbmQgd2lsbCBub3QgbWFrZSBhbnkgYWx0ZXJhdGlvbiwgb3RoZXIgdGhhbiBhcyBhbGxvd2VkIGJ5IHRoaXMKbGljZW5zZSwgdG8geW91ciBzdWJtaXNzaW9uLgo=Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352021-03-24T19:32:30Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false |
| dc.title.pt_BR.fl_str_mv |
Safety and effectiveness of HAART in tuberculosis-HIV co-infected patients in Brazil |
| title |
Safety and effectiveness of HAART in tuberculosis-HIV co-infected patients in Brazil |
| spellingShingle |
Safety and effectiveness of HAART in tuberculosis-HIV co-infected patients in Brazil Santos, A. P. G. dos Tuberculosis AIDS HAART Adverse events Survival |
| title_short |
Safety and effectiveness of HAART in tuberculosis-HIV co-infected patients in Brazil |
| title_full |
Safety and effectiveness of HAART in tuberculosis-HIV co-infected patients in Brazil |
| title_fullStr |
Safety and effectiveness of HAART in tuberculosis-HIV co-infected patients in Brazil |
| title_full_unstemmed |
Safety and effectiveness of HAART in tuberculosis-HIV co-infected patients in Brazil |
| title_sort |
Safety and effectiveness of HAART in tuberculosis-HIV co-infected patients in Brazil |
| author |
Santos, A. P. G. dos |
| author_facet |
Santos, A. P. G. dos Pacheco, A. G. Staviack, A. Golub, J. E. Chaisson, R. E. Rolla, V. C. Kritski, A. L. Passos, S. R. L. Mello, F. C. de Queiroz |
| author_role |
author |
| author2 |
Pacheco, A. G. Staviack, A. Golub, J. E. Chaisson, R. E. Rolla, V. C. Kritski, A. L. Passos, S. R. L. Mello, F. C. de Queiroz |
| author2_role |
author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Santos, A. P. G. dos Pacheco, A. G. Staviack, A. Golub, J. E. Chaisson, R. E. Rolla, V. C. Kritski, A. L. Passos, S. R. L. Mello, F. C. de Queiroz |
| dc.subject.en.pt_BR.fl_str_mv |
Tuberculosis AIDS HAART Adverse events Survival |
| topic |
Tuberculosis AIDS HAART Adverse events Survival |
| description |
2020-03-19 |
| publishDate |
2013 |
| dc.date.issued.fl_str_mv |
2013 |
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2019-09-19T15:07:14Z |
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2019-09-19T15:07:14Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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SANTOS, A. P. G. dos et al. Safety and effectiveness of HAART in tuberculosis-HIV coinfected patients in Brazil. International Journal of Tuberculosis and Lung Disease, v. 17, n. 2, p. 192-197, Feb. 2013. |
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https://www.arca.fiocruz.br/handle/icict/35691 |
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1027-3719 |
| dc.identifier.doi.none.fl_str_mv |
10.5588/ijtld.11.0831 |
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1815-7920 |
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SANTOS, A. P. G. dos et al. Safety and effectiveness of HAART in tuberculosis-HIV coinfected patients in Brazil. International Journal of Tuberculosis and Lung Disease, v. 17, n. 2, p. 192-197, Feb. 2013. 1027-3719 10.5588/ijtld.11.0831 1815-7920 |
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International Union Against Tuberculosis and Lung Disease |
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International Union Against Tuberculosis and Lung Disease |
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