On the presence of hepatic stellate cells in portal spaces

Detalhes bibliográficos
Autor(a) principal: Fonseca, Yannick de Oliveira
Data de Publicação: 2011
Outros Autores: Lima, Camila Bião, Santos, Elisângela Trindade, Andrade, Zilton de Araújo
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/2818
Resumo: Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
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spelling Fonseca, Yannick de OliveiraLima, Camila BiãoSantos, Elisângela TrindadeAndrade, Zilton de Araújo2011-08-30T13:45:19Z2011-08-30T13:45:19Z2011FONSECA, Y. de O. et al. On the presence of hepatic stellate cells in portal spaces. Memórias do Instituto Oswaldo Cruz, v. 100, n. 3, p. 289-291, 2005.0074-0276https://www.arca.fiocruz.br/handle/icict/2818engEspaço ExtracelularHepatócitosCirrose HepáticaSistema PortaHistocitoquímicaAnimaisCamundongosRatos WistarHepatic stelate cellsPortal fibrosisPortal myofibroblastsEspaço ExtracelularHepatócitosCirrose HepáticaSistema PortaOn the presence of hepatic stellate cells in portal spacesinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilPrevious studies in mice with hypervitaminosis A have demonstrated that fat-storing cells (hepatic stellate cells- HSCs) participate in schistosomal granuloma fibrogenesis. The origin of such cells in portal areas, away from the Disse spaces, was herein investigated. HSCs were identified in frozen sections of the liver by means of Sudan III staining. They appeared as red-stained cells disposed along the sinusoids of normal mice, but were never found within portal spaces. However, in the chronically inflamed portal spaces of Capillaria hepatica-infected mice, Sudan III-positive cells were frequently present among leukocytes and fibroblast-like cells. Thus, there are no resident HSCs in portal spaces, but their presence there in chronic inflammatory processes indicates that they are able to migrate from peri-sinusoidal areas in order to reach the portal areasinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALFonseca YO On the presence of hepatic....pdfFonseca YO On the presence of hepatic....pdfapplication/pdf10644797https://www.arca.fiocruz.br/bitstream/icict/2818/1/Fonseca%20YO%20On%20the%20presence%20of%20hepatic....pdf129edf3728a4cbe88d954020fc261bb3MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81648https://www.arca.fiocruz.br/bitstream/icict/2818/2/license.txte095249ac7cacefbfe39684dfe45e706MD52TEXTFonseca YO On the presence of hepatic....pdf.txtFonseca YO On the presence of hepatic....pdf.txtExtracted texttext/plain9337https://www.arca.fiocruz.br/bitstream/icict/2818/5/Fonseca%20YO%20On%20the%20presence%20of%20hepatic....pdf.txt375984ca7157397ec0d7c756dbb55ebeMD55THUMBNAILFonseca YO On the presence of hepatic....pdf.jpgFonseca YO On the presence of hepatic....pdf.jpgGenerated Thumbnailimage/jpeg2277https://www.arca.fiocruz.br/bitstream/icict/2818/4/Fonseca%20YO%20On%20the%20presence%20of%20hepatic....pdf.jpgb9c5550a2bec0dfda46e4f5df3275159MD54icict/28182023-03-15 14:32:56.077oai:www.arca.fiocruz.br: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Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:32:56Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv On the presence of hepatic stellate cells in portal spaces
title On the presence of hepatic stellate cells in portal spaces
spellingShingle On the presence of hepatic stellate cells in portal spaces
Fonseca, Yannick de Oliveira
Espaço Extracelular
Hepatócitos
Cirrose Hepática
Sistema Porta
Histocitoquímica
Animais
Camundongos
Ratos Wistar
Hepatic stelate cells
Portal fibrosis
Portal myofibroblasts
Espaço Extracelular
Hepatócitos
Cirrose Hepática
Sistema Porta
title_short On the presence of hepatic stellate cells in portal spaces
title_full On the presence of hepatic stellate cells in portal spaces
title_fullStr On the presence of hepatic stellate cells in portal spaces
title_full_unstemmed On the presence of hepatic stellate cells in portal spaces
title_sort On the presence of hepatic stellate cells in portal spaces
author Fonseca, Yannick de Oliveira
author_facet Fonseca, Yannick de Oliveira
Lima, Camila Bião
Santos, Elisângela Trindade
Andrade, Zilton de Araújo
author_role author
author2 Lima, Camila Bião
Santos, Elisângela Trindade
Andrade, Zilton de Araújo
author2_role author
author
author
dc.contributor.author.fl_str_mv Fonseca, Yannick de Oliveira
Lima, Camila Bião
Santos, Elisângela Trindade
Andrade, Zilton de Araújo
dc.subject.other.pt_BR.fl_str_mv Espaço Extracelular
Hepatócitos
Cirrose Hepática
Sistema Porta
Histocitoquímica
Animais
Camundongos
Ratos Wistar
topic Espaço Extracelular
Hepatócitos
Cirrose Hepática
Sistema Porta
Histocitoquímica
Animais
Camundongos
Ratos Wistar
Hepatic stelate cells
Portal fibrosis
Portal myofibroblasts
Espaço Extracelular
Hepatócitos
Cirrose Hepática
Sistema Porta
dc.subject.en.pt_BR.fl_str_mv Hepatic stelate cells
Portal fibrosis
Portal myofibroblasts
dc.subject.decs.pt_BR.fl_str_mv Espaço Extracelular
Hepatócitos
Cirrose Hepática
Sistema Porta
description Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
publishDate 2011
dc.date.accessioned.fl_str_mv 2011-08-30T13:45:19Z
dc.date.available.fl_str_mv 2011-08-30T13:45:19Z
dc.date.issued.fl_str_mv 2011
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv FONSECA, Y. de O. et al. On the presence of hepatic stellate cells in portal spaces. Memórias do Instituto Oswaldo Cruz, v. 100, n. 3, p. 289-291, 2005.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/2818
dc.identifier.issn.none.fl_str_mv 0074-0276
identifier_str_mv FONSECA, Y. de O. et al. On the presence of hepatic stellate cells in portal spaces. Memórias do Instituto Oswaldo Cruz, v. 100, n. 3, p. 289-291, 2005.
0074-0276
url https://www.arca.fiocruz.br/handle/icict/2818
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
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reponame_str Repositório Institucional da FIOCRUZ (ARCA)
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