Toxoplasmose congênita

Detalhes bibliográficos
Autor(a) principal: Cardoso, Rita Alves de Almeida
Data de Publicação: 1956
Outros Autores: Guimarães, Felippe Nery, Garcia, Aparecida Pinto
Tipo de documento: Artigo
Idioma: por
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/53363
Resumo: Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil.
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spelling Cardoso, Rita Alves de AlmeidaGuimarães, Felippe NeryGarcia, Aparecida Pinto2022-06-17T19:17:19Z2022-06-17T19:17:19Z1956CARDOSO, Rita Alves de Almeida; GUIMARÃES, Felippe Nery; GARCIA, Aparecida Pinto. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 54, n. 3, p. 1 - 22, 1956.0074-0206https://www.arca.fiocruz.br/handle/icict/5336310.1590/S0074-027619560003000081678-8060porFundação Oswaldo Cruz. Instituto Oswaldo Cruz.Toxoplasmose congênitaDescoberta da ParasitaIdentidade das espécies de ToxoplasmaCaracteres biológicosTaxoplasmose humanaToxoplasmose congênitainfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Fernandes Figueira. Rio de Janeiro, RJ, Brasil.e had the opportunity to study 6 cases of the congenital form of toxoplasmosis, found in a series of 1200 necropsies of fetuses and newborn babies, realized at 3 different hospitals in Rio de Janeiro, Brazil. Among the 6 cases, 4 were premature babies liveborn at the 6th-8th gestational month and 2 were stillborn (1 premature and 1 at term). In all those cases, the diagnosis was based in the detection of the parasite in tissues and in one case it was even isolated the Toxoplasma from the necrotic material found in the cranial cavity. This strain of Toxoplasma, pathogenic to pigeons, to guinea pigs and to mice, is preserved by successive transfers in mice. Some facts observed in those cases present an interest not only strictly anatomic but also have certain value for the better acknowlegment of the disease. First, we want to call the attention to the presence of a sudden high fever, during or just before pregnancy in the 4 cases in which the maternal anamnesis was perfectly studied; this fever that was preceded by a normal beginning of pregnancy, had relatively rapid remission, but in 2 cases was immediately followed by uterine bleeding and premature delivery, although the puerperium had been apparently normal. It is known that are normal the subsequent children of the mothers that delivered a baby with toxoplasmosis and that several women have normal babies before the toxoplasmotic one. We believe that the fever observed in our cases could be indicative of the beginning of maternal infection and those are the reasons why we emphasize the need of careful anamnesis, specially in the cases actually diagnosed as inapparent infection. Another fact to notice is that in 5 of our cases the event premature delivery happened always between the 6th and the 8th months of pregnancy, and the only term fetus was delivered in advanced stage of maceration. The above mentioned facts could agree with the opinion of FRENKEL (1949), when he declared that "primary infection of the pregnant mother appears more likely to be the commoner mode of fetal toxoplasmic infection", but they would disagree with WEINMAN (1952) who believes that the transmission of Toxoplasma to the fetus is more frequent through a pregnant woman with chronic disease and who says "that infection contracted during pregnancy may and probably does happen from time to time"...Still in connection with the transmission of toxoplasmosis, we want to note the verification of inflammatory lesions in the placental villi and in the umbilical cord in 3 of the 4 cases in which such organs were examined at the microscope. In the case n. 1, we found several pseudocysts of Toxoplasma in the placenta, and the fibroblasts of Wharton's jelly were particularly rich in isolated forms and in colonies of Toxoplasma; the easy multiplication of the parasite in that tissue calls the attention and even suggests its utilisation for Toxoplasma's cultivation. The confirmation of Toxoplasma in human placenta was made only recently by CRISTEN et al. (1951) and by NEGHME et al. (1952), in Chile; it is not frequent in the literature, what gives some value to our present verification. Another observation was that provided by the case n. 6. This baby, a premature one of the 6th month, was 14 days old and-died with signs of respiratory disease, the causa mortis have been pneumonia. At the necropsy, we found no gross change that suggested toxoplasmosis, except the presence of some small necrotic focuses in the cerebral nervous substance around the ventricles. As a matter of fact, there was no enlargement of spleen or liver and neither leptomeningitis nor hydrocephalus. Such focuses were attributed to possible anoxia and in fact they are extremely similar to anoxial softenings, even when they are examined at the microscope; its structure composed of a central necrotic zone, surrounded by proliferated neuroglia and by a variable deposit of calcium salts, closely simulated the anoxial softenings, when the microscopical examination is based in the common histological preparations (hematoxilin-eosin, etc.). But when we examine preparations by the Giemsa or by the periodic acid-Schiff methods, we will note the presence of Toxoplasma, with its typical aspect or a little changed by degeneration. When we describe this observation, we wish to evidence the need of the search of Toxoplasma and closed parasites, in the cases of supposed pure anoxial softenings of nervous substance, in children. The frequency with which the congenital toxoplasmosis was anatomically verified should be emphasized, although the disease had not been clinically suspected, and it should be borne in mind that the second case of toxoplasmosis reported in the world was observed in Brazil by MAGARINOS TORRES; this case was the first to be described of the generalized congenital form of the infection, i. e. with myocardial lesions and parasites in skeletal muscles and skin.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; 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dc.title.pt_BR.fl_str_mv Toxoplasmose congênita
title Toxoplasmose congênita
spellingShingle Toxoplasmose congênita
Cardoso, Rita Alves de Almeida
Toxoplasmose congênita
Descoberta da Parasita
Identidade das espécies de Toxoplasma
Caracteres biológicos
Taxoplasmose humana
title_short Toxoplasmose congênita
title_full Toxoplasmose congênita
title_fullStr Toxoplasmose congênita
title_full_unstemmed Toxoplasmose congênita
title_sort Toxoplasmose congênita
author Cardoso, Rita Alves de Almeida
author_facet Cardoso, Rita Alves de Almeida
Guimarães, Felippe Nery
Garcia, Aparecida Pinto
author_role author
author2 Guimarães, Felippe Nery
Garcia, Aparecida Pinto
author2_role author
author
dc.contributor.author.fl_str_mv Cardoso, Rita Alves de Almeida
Guimarães, Felippe Nery
Garcia, Aparecida Pinto
dc.subject.other.pt_BR.fl_str_mv Toxoplasmose congênita
Descoberta da Parasita
Identidade das espécies de Toxoplasma
Caracteres biológicos
Taxoplasmose humana
topic Toxoplasmose congênita
Descoberta da Parasita
Identidade das espécies de Toxoplasma
Caracteres biológicos
Taxoplasmose humana
description Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil.
publishDate 1956
dc.date.issued.fl_str_mv 1956
dc.date.accessioned.fl_str_mv 2022-06-17T19:17:19Z
dc.date.available.fl_str_mv 2022-06-17T19:17:19Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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dc.identifier.citation.fl_str_mv CARDOSO, Rita Alves de Almeida; GUIMARÃES, Felippe Nery; GARCIA, Aparecida Pinto. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 54, n. 3, p. 1 - 22, 1956.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/53363
dc.identifier.issn.pt_BR.fl_str_mv 0074-0206
dc.identifier.doi.none.fl_str_mv 10.1590/S0074-02761956000300008
dc.identifier.eissn.none.fl_str_mv 1678-8060
identifier_str_mv CARDOSO, Rita Alves de Almeida; GUIMARÃES, Felippe Nery; GARCIA, Aparecida Pinto. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 54, n. 3, p. 1 - 22, 1956.
0074-0206
10.1590/S0074-02761956000300008
1678-8060
url https://www.arca.fiocruz.br/handle/icict/53363
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dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
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dc.publisher.none.fl_str_mv Fundação Oswaldo Cruz. Instituto Oswaldo Cruz.
publisher.none.fl_str_mv Fundação Oswaldo Cruz. Instituto Oswaldo Cruz.
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
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