Genetic signatures of gene flow and malaria-driven natural selection in sub-Saharan populations of the "endemic Burkitt Lymphoma belt"
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2019 |
| Outros Autores: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/39721 |
Resumo: | Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brasil / Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Biologia. Belo Horizonte, MG, Brasil /Center for Research on Genomics & Global Health, National Institutes of Health. US Department of Health and Human Services. Bethesda, Maryland, USA. |
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Gouveia, Mateus HenriqueBergen, Andrew W.Borda, VictorNunes, KellyLeal, Thiago P.Ogwang, Martin D.Yeboah, Edward D.Mensah, James E.Kinyera, TobiasOtim, IsaacNabalende, HadijahLegason, Ismail D.Mpoloka, Sununguko WataMokone, Gaonyadiwe GeorgeKerchan, PatrickBhatia, KishorReynolds, Steven J.Birtwum, Richard B.Adjei, Andrew A.Tettey, YaoTay, EvelynHoover, RobertPfeiffer, Ruth M.Biggar, Robert J.Goedert, James J.Prokunina-Olsson, LudmilaDean, MichaelYeager, MeredithCosta, Maria Fernanda Furtado LimaHsing, Ann W.Tishkoff, Sarah A.Chanock, Stephen J.Santos, Eduardo TarazonaMbulaiteye, Sam M.2020-02-04T16:03:51Z2020-02-04T16:03:51Z2019GOUVEIA, Mateus Henrique et al. Genetic signatures of gene flow and malaria-driven natural selection in sub-Saharan populations of the "endemic Burkitt Lymphoma belt". PLoS Genetics, v. 15, n. 3, p. 1-21, 2019.1932-6203https://www.arca.fiocruz.br/handle/icict/3972110.1371/journal.pgen.1008027engPublic Library of ScienceUgandaAfricaGhanaMalariaUgandaAfricaGhanaMalariaGene flowNatural selectionPopulationGeneticsLakesGenetic signatures of gene flow and malaria-driven natural selection in sub-Saharan populations of the "endemic Burkitt Lymphoma belt"info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brasil / Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Biologia. Belo Horizonte, MG, Brasil /Center for Research on Genomics & Global Health, National Institutes of Health. US Department of Health and Human Services. Bethesda, Maryland, USA.Division of Cancer Epidemiology and Genetics. National Cancer Institute. National Institutes of Health. US Department of Health and Human Services. Bethesda, Maryland, USA.Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Biologia. Belo Horizonte, MG, Brasil.Universidade de São Paulo. Instituto de Biociências. Departamento de Genética e Biologia Evolutiva. São Paulo, SP, Brasil.Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Biologia. Belo Horizonte, MG, Brasil / Universidade Federal de Minas Gerais. Departamento de Estatística. Belo Horizonte, MG, Brasil.EMBLEM Study. African Field Epidemiology Network. Kampala, Uganda.University of Ghana Medical School, Accra, Ghana.University of Ghana Medical School, Accra, Ghana.EMBLEM Study. African Field Epidemiology Network. Kampala, Uganda.EMBLEM Study. African Field Epidemiology Network. Kampala, Uganda.EMBLEM Study. African Field Epidemiology Network. Kampala, Uganda.EMBLEM Study. African Field Epidemiology Network. Kampala, Uganda.Department of Biological Sciences. University of Botswana. Gaborone, Botswana.Department of Biomedical Sciences. University of Botswana School of Medicine. Gaborone, Botswana.EMBLEM Study. African Field Epidemiology Network. Kampala, Uganda.Division of Cancer Epidemiology and Genetics. National Cancer Institute. National Institutes of Health. US Department of Health and Human Services. Bethesda, Maryland, USA.Division of Intramural Research. National Institute of Allergy and Infectious Diseases. National Institutes of Health. US Department of Health and Human Services. Bethesda, Maryland, USA.University of Ghana Medical School. Accra, Ghana.University of Ghana Medical School. Accra, Ghana.University of Ghana Medical School. Accra, Ghana.University of Ghana Medical School. Accra, Ghana.Division of Cancer Epidemiology and Genetics. National Cancer Institute. National Institutes of Health. US Department of Health and Human Services. Bethesda, Maryland, USA.Division of Cancer Epidemiology and Genetics. National Cancer Institute. National Institutes of Health. US Department of Health and Human Services. Bethesda, Maryland, USA.Division of Cancer Epidemiology and Genetics. National Cancer Institute. National Institutes of Health. US Department of Health and Human Services. Bethesda, Maryland, USA.Division of Cancer Epidemiology and Genetics. National Cancer Institute. National Institutes of Health. US Department of Health and Human Services. Bethesda, Maryland, USA.Laboratory of Translational Genomics. Division of Cancer Epidemiology and Genetics. National Cancer Institute. National Institutes of Health. USDepartment of Health and Human Services. Bethesda, Maryland, USA.Laboratory of Translational Genomics. Division of Cancer Epidemiology and Genetics. National Cancer Institute. National Institutes of Health. US Department of Health and Human Services. Bethesda, Maryland, USA.Cancer Genomics Research Laboratory. Leidos Biomedical Research. Frederick National Laboratory for Cancer Research. US Department of Health and Human Services. Frederick, Maryland, USA.Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brasil.Stanford Cancer Institute. Stanford University. Stanford, California, USA.Department of Genetics and Biology, University of Pennsylvania, Philadelphia, USA.Division of Cancer Epidemiology and Genetics. National Cancer Institute. National Institutes of Health. US Department of Health and Human Services. Bethesda, Maryland, USA.Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Biologia Geral. Belo Horizonte, MG, Brasil.Division of Cancer Epidemiology and Genetics. National Cancer Institute. National Institutes of Health. US Department of Health and Human Services. Bethesda, Maryland, USA.Populations in sub-Saharan Africa have historically been exposed to intense selection from chronic infection with falciparum malaria. Interestingly, populations with the highest malaria intensity can be identified by the increased occurrence of endemic Burkitt Lymphoma (eBL), a pediatric cancer that affects populations with intense malaria exposure, in the so called “eBL belt” in sub-Saharan Africa. However, the effects of intense malaria exposure and sub-Saharan populations’ genetic histories remain poorly explored. To determine if historical migrations and intense malaria exposure have shaped the genetic composition of the eBL belt populations, we genotyped ~4.3 million SNPs in 1,708 individuals from Ghana and Northern Uganda, located on opposite sides of eBL belt and with ≥ 7 months/year of intense malaria exposure and published evidence of high incidence of BL. Among 35 Ghanaian tribes, we showed a predominantly West-Central African ancestry and genomic footprints of gene flow from Gambian and East African populations. In Uganda, the North West population showed a predominantly Nilotic ancestry, and the North Central population was a mixture of Nilotic and Southern Bantu ancestry, while the Southwest Ugandan population showed a predominant Southern Bantu ancestry. Our results support the hypothesis of diverse ancestral origins of the Ugandan, Kenyan and Tanzanian Great Lakes African populations, reflecting a confluence of Nilotic, Cushitic and Bantu migrations in the last 3000 years. Natural selection analyses suggest, for the first time, a strong positive selection signal in the ATP2B4 gene (rs10900588) in Northern Ugandan populations. These findings provide important baseline genomic data to facilitate disease association studies, including of eBL, in eBL belt populations.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83082https://www.arca.fiocruz.br/bitstream/icict/39721/1/license.txt9193a7c197bc67acd023525e72a03240MD51ORIGINALGenetic signatures of gene flow and malaria-driven.pdfGenetic signatures of gene flow and malaria-driven.pdfapplication/pdf11801795https://www.arca.fiocruz.br/bitstream/icict/39721/2/Genetic%20signatures%20of%20gene%20flow%20and%20malaria-driven.pdffd87b07ab4fac498d62a72df070e920dMD52TEXTGenetic signatures of gene flow and malaria-driven.pdf.txtGenetic signatures of gene flow and malaria-driven.pdf.txtExtracted 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| dc.title.pt_BR.fl_str_mv |
Genetic signatures of gene flow and malaria-driven natural selection in sub-Saharan populations of the "endemic Burkitt Lymphoma belt" |
| title |
Genetic signatures of gene flow and malaria-driven natural selection in sub-Saharan populations of the "endemic Burkitt Lymphoma belt" |
| spellingShingle |
Genetic signatures of gene flow and malaria-driven natural selection in sub-Saharan populations of the "endemic Burkitt Lymphoma belt" Gouveia, Mateus Henrique Uganda Africa Ghana Malaria Uganda Africa Ghana Malaria Gene flow Natural selection Population Genetics Lakes |
| title_short |
Genetic signatures of gene flow and malaria-driven natural selection in sub-Saharan populations of the "endemic Burkitt Lymphoma belt" |
| title_full |
Genetic signatures of gene flow and malaria-driven natural selection in sub-Saharan populations of the "endemic Burkitt Lymphoma belt" |
| title_fullStr |
Genetic signatures of gene flow and malaria-driven natural selection in sub-Saharan populations of the "endemic Burkitt Lymphoma belt" |
| title_full_unstemmed |
Genetic signatures of gene flow and malaria-driven natural selection in sub-Saharan populations of the "endemic Burkitt Lymphoma belt" |
| title_sort |
Genetic signatures of gene flow and malaria-driven natural selection in sub-Saharan populations of the "endemic Burkitt Lymphoma belt" |
| author |
Gouveia, Mateus Henrique |
| author_facet |
Gouveia, Mateus Henrique Bergen, Andrew W. Borda, Victor Nunes, Kelly Leal, Thiago P. Ogwang, Martin D. Yeboah, Edward D. Mensah, James E. Kinyera, Tobias Otim, Isaac Nabalende, Hadijah Legason, Ismail D. Mpoloka, Sununguko Wata Mokone, Gaonyadiwe George Kerchan, Patrick Bhatia, Kishor Reynolds, Steven J. Birtwum, Richard B. Adjei, Andrew A. Tettey, Yao Tay, Evelyn Hoover, Robert Pfeiffer, Ruth M. Biggar, Robert J. Goedert, James J. Prokunina-Olsson, Ludmila Dean, Michael Yeager, Meredith Costa, Maria Fernanda Furtado Lima Hsing, Ann W. Tishkoff, Sarah A. Chanock, Stephen J. Santos, Eduardo Tarazona Mbulaiteye, Sam M. |
| author_role |
author |
| author2 |
Bergen, Andrew W. Borda, Victor Nunes, Kelly Leal, Thiago P. Ogwang, Martin D. Yeboah, Edward D. Mensah, James E. Kinyera, Tobias Otim, Isaac Nabalende, Hadijah Legason, Ismail D. Mpoloka, Sununguko Wata Mokone, Gaonyadiwe George Kerchan, Patrick Bhatia, Kishor Reynolds, Steven J. Birtwum, Richard B. Adjei, Andrew A. Tettey, Yao Tay, Evelyn Hoover, Robert Pfeiffer, Ruth M. Biggar, Robert J. Goedert, James J. Prokunina-Olsson, Ludmila Dean, Michael Yeager, Meredith Costa, Maria Fernanda Furtado Lima Hsing, Ann W. Tishkoff, Sarah A. Chanock, Stephen J. Santos, Eduardo Tarazona Mbulaiteye, Sam M. |
| author2_role |
author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Gouveia, Mateus Henrique Bergen, Andrew W. Borda, Victor Nunes, Kelly Leal, Thiago P. Ogwang, Martin D. Yeboah, Edward D. Mensah, James E. Kinyera, Tobias Otim, Isaac Nabalende, Hadijah Legason, Ismail D. Mpoloka, Sununguko Wata Mokone, Gaonyadiwe George Kerchan, Patrick Bhatia, Kishor Reynolds, Steven J. Birtwum, Richard B. Adjei, Andrew A. Tettey, Yao Tay, Evelyn Hoover, Robert Pfeiffer, Ruth M. Biggar, Robert J. Goedert, James J. Prokunina-Olsson, Ludmila Dean, Michael Yeager, Meredith Costa, Maria Fernanda Furtado Lima Hsing, Ann W. Tishkoff, Sarah A. Chanock, Stephen J. Santos, Eduardo Tarazona Mbulaiteye, Sam M. |
| dc.subject.other.pt_BR.fl_str_mv |
Uganda Africa Ghana Malaria |
| topic |
Uganda Africa Ghana Malaria Uganda Africa Ghana Malaria Gene flow Natural selection Population Genetics Lakes |
| dc.subject.en.pt_BR.fl_str_mv |
Uganda Africa Ghana Malaria Gene flow Natural selection Population Genetics Lakes |
| description |
Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brasil / Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Biologia. Belo Horizonte, MG, Brasil /Center for Research on Genomics & Global Health, National Institutes of Health. US Department of Health and Human Services. Bethesda, Maryland, USA. |
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2019 |
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2019 |
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2020-02-04T16:03:51Z |
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2020-02-04T16:03:51Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
| dc.identifier.citation.fl_str_mv |
GOUVEIA, Mateus Henrique et al. Genetic signatures of gene flow and malaria-driven natural selection in sub-Saharan populations of the "endemic Burkitt Lymphoma belt". PLoS Genetics, v. 15, n. 3, p. 1-21, 2019. |
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https://www.arca.fiocruz.br/handle/icict/39721 |
| dc.identifier.issn.pt_BR.fl_str_mv |
1932-6203 |
| dc.identifier.doi.none.fl_str_mv |
10.1371/journal.pgen.1008027 |
| identifier_str_mv |
GOUVEIA, Mateus Henrique et al. Genetic signatures of gene flow and malaria-driven natural selection in sub-Saharan populations of the "endemic Burkitt Lymphoma belt". PLoS Genetics, v. 15, n. 3, p. 1-21, 2019. 1932-6203 10.1371/journal.pgen.1008027 |
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