Epidemiological-clinical profile and mortality in patients coinfected with Trypanosoma cruzi/HIV: experience from a Brazilian reference center

Detalhes bibliográficos
Autor(a) principal: Hasslocher-Moreno, Alejandro Marcel
Data de Publicação: 2022
Outros Autores: Sousa, Andrea Silvestre de, Xavier, Sergio Salles, Mendes, Fernanda de Souza Nogueira Sardinha, Nunes, Estevão Portela, Grinsztejn, Beatriz, Mediano, Mauro Felippe Felix
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
DOI: 10.1590/0037-8682-0240-2022
Texto Completo: https://www.arca.fiocruz.br/handle/icict/55452
Resumo: Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.
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spelling Hasslocher-Moreno, Alejandro MarcelSousa, Andrea Silvestre deXavier, Sergio SallesMendes, Fernanda de Souza Nogueira SardinhaNunes, Estevão PortelaGrinsztejn, BeatrizMediano, Mauro Felippe Felix2022-11-04T11:48:21Z2022-11-04T11:48:21Z2022HASSLOCHER-MORENO, Alejandro Marcel et al. Epidemiological-clinical profile and mortality in patients coinfected with Trypanosoma cruzi/HIV: experience from a Brazilian reference center. Revista da Sociedade Brasileira de Medicina Tropical, v. 55, p. 1-8, 2022.1678-9849https://www.arca.fiocruz.br/handle/icict/5545210.1590/0037-8682-0240-2022engSociedade Brasileira de Medicina Tropical - SBMTEpidemiological-clinical profile and mortality in patients coinfected with Trypanosoma cruzi/HIV: experience from a Brazilian reference centerinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil / Universidade Federal do Rio de Janeiro. Faculdade de Medicina. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em DST/AIDS. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em DST/AIDS. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.Background: The recent urbanization of Chagas disease (CD) has contributed to a greater risk of coexistence with human immunodeficiency virus (HIV) and AIDS. Methods: This retrospective observational study included patients who were followed at INI-Fiocruz between July 1986 and October 2021. All patients underwent an assessment protocol that included sociodemographic profile, epidemiological history, and clinical evaluation. Descriptive data analyses included reports of the medians and frequencies of variables of interest. Differences in medians between groups were tested using the Mann-Whitney U test. Differences in frequency were tested using Fisher's exact test. Results: Among 2201 patients, 11 (0.5%) were identified with Trypanosoma cruzi/HIV coinfection. Of these, 63.6% were women with a median age of 51.0 years old. Two patients had the indeterminate form of CD, six had the cardiac form, two had the digestive form and one had the cardio-digestive form. Half of the patients were undergoing antiretroviral treatment at the time of coinfection diagnosis with a median CD4+ count of 350 cells/μL and a viral load of 1500 copies/μL. Four patients underwent a xenodiagnosis test at coinfection diagnosis, which all yielded positive results; two of them presented high parasitemia under the risk of reactivation. Prophylaxis for CD reactivation was administered to four patients; two with ketoconazole and two with benznidazole. Six patients died after a median follow-up of 22.5 months, with AIDS being the most common cause of death. Only one case of reactivation was observed. Conclusions: Early diagnosis and prompt treatment of CD reactivation dramatically reduced mortality. Identification of Trypanosoma cruzi/HIV co-infection is crucial to planning a close follow-up of coinfected patients.Chagas diseaseTrypanosoma cruziHIVAIDSCoinfectionMortalityinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALEpidemiological-clinical profile and mortality in patients coinfected with Trypanosoma cruziHIV. Experience from a Brazilian reference center.pdfEpidemiological-clinical profile and mortality in patients coinfected with Trypanosoma cruziHIV. 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dc.title.en_US.fl_str_mv Epidemiological-clinical profile and mortality in patients coinfected with Trypanosoma cruzi/HIV: experience from a Brazilian reference center
title Epidemiological-clinical profile and mortality in patients coinfected with Trypanosoma cruzi/HIV: experience from a Brazilian reference center
spellingShingle Epidemiological-clinical profile and mortality in patients coinfected with Trypanosoma cruzi/HIV: experience from a Brazilian reference center
Hasslocher-Moreno, Alejandro Marcel
Chagas disease
Trypanosoma cruzi
HIV
AIDS
Coinfection
Mortality
title_short Epidemiological-clinical profile and mortality in patients coinfected with Trypanosoma cruzi/HIV: experience from a Brazilian reference center
title_full Epidemiological-clinical profile and mortality in patients coinfected with Trypanosoma cruzi/HIV: experience from a Brazilian reference center
title_fullStr Epidemiological-clinical profile and mortality in patients coinfected with Trypanosoma cruzi/HIV: experience from a Brazilian reference center
title_full_unstemmed Epidemiological-clinical profile and mortality in patients coinfected with Trypanosoma cruzi/HIV: experience from a Brazilian reference center
title_sort Epidemiological-clinical profile and mortality in patients coinfected with Trypanosoma cruzi/HIV: experience from a Brazilian reference center
author Hasslocher-Moreno, Alejandro Marcel
author_facet Hasslocher-Moreno, Alejandro Marcel
Sousa, Andrea Silvestre de
Xavier, Sergio Salles
Mendes, Fernanda de Souza Nogueira Sardinha
Nunes, Estevão Portela
Grinsztejn, Beatriz
Mediano, Mauro Felippe Felix
author_role author
author2 Sousa, Andrea Silvestre de
Xavier, Sergio Salles
Mendes, Fernanda de Souza Nogueira Sardinha
Nunes, Estevão Portela
Grinsztejn, Beatriz
Mediano, Mauro Felippe Felix
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Hasslocher-Moreno, Alejandro Marcel
Sousa, Andrea Silvestre de
Xavier, Sergio Salles
Mendes, Fernanda de Souza Nogueira Sardinha
Nunes, Estevão Portela
Grinsztejn, Beatriz
Mediano, Mauro Felippe Felix
dc.subject.en.en_US.fl_str_mv Chagas disease
Trypanosoma cruzi
HIV
AIDS
Coinfection
Mortality
topic Chagas disease
Trypanosoma cruzi
HIV
AIDS
Coinfection
Mortality
description Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.
publishDate 2022
dc.date.accessioned.fl_str_mv 2022-11-04T11:48:21Z
dc.date.available.fl_str_mv 2022-11-04T11:48:21Z
dc.date.issued.fl_str_mv 2022
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv HASSLOCHER-MORENO, Alejandro Marcel et al. Epidemiological-clinical profile and mortality in patients coinfected with Trypanosoma cruzi/HIV: experience from a Brazilian reference center. Revista da Sociedade Brasileira de Medicina Tropical, v. 55, p. 1-8, 2022.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/55452
dc.identifier.issn.en_US.fl_str_mv 1678-9849
dc.identifier.doi.none.fl_str_mv 10.1590/0037-8682-0240-2022
identifier_str_mv HASSLOCHER-MORENO, Alejandro Marcel et al. Epidemiological-clinical profile and mortality in patients coinfected with Trypanosoma cruzi/HIV: experience from a Brazilian reference center. Revista da Sociedade Brasileira de Medicina Tropical, v. 55, p. 1-8, 2022.
1678-9849
10.1590/0037-8682-0240-2022
url https://www.arca.fiocruz.br/handle/icict/55452
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Sociedade Brasileira de Medicina Tropical - SBMT
publisher.none.fl_str_mv Sociedade Brasileira de Medicina Tropical - SBMT
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/55452/3/Epidemiological-clinical%20profile%20and%20mortality%20in%20patients%20coinfected%20with%20Trypanosoma%20cruziHIV.%20Experience%20from%20a%20Brazilian%20reference%20center.pdf
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