Immune response pattern in recurrent Plasmodium vivax malaria

Detalhes bibliográficos
Autor(a) principal: Chaves, Yury Oliveira
Data de Publicação: 2016
Outros Autores: Costa, Allyson Guimarães da, Pereira, Marcelo Luís Monteiro, Lacerda, Marcus Vinícius Guimarães de, Reis, Jordana Grazziela Alves Coelho dos, Martins Filho, Olindo Assis, Carvalho, Andréa Teixeira de, Malheiro, Adriana, Monteiro, Wuelton Marcelo, Orlandi, Patrícia Puccinelli, Marinho, Claudio Romero Farias, Nogueira, Paulo Afonso
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/20056
Resumo: Fundação Oswaldo Cruz. Instituto Leônidas e Maria Deane. Manaus, AM, Brasil.
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spelling Chaves, Yury OliveiraCosta, Allyson Guimarães daPereira, Marcelo Luís MonteiroLacerda, Marcus Vinícius Guimarães deReis, Jordana Grazziela Alves Coelho dosMartins Filho, Olindo AssisCarvalho, Andréa Teixeira deMalheiro, AdrianaMonteiro, Wuelton MarceloOrlandi, Patrícia PuccinelliMarinho, Claudio Romero FariasNogueira, Paulo Afonso2017-07-12T17:09:39Z2017-07-12T17:09:39Z2016CHAVES, Yury Oliveira et al. Immune response pattern in recurrent Plasmodium vivax malaria. Malaria Journal, v. 15, n. 1, p. 1-13, 2016.1475-2875https://www.arca.fiocruz.br/handle/icict/2005610.1186/s12936-016-1501-5engBioMed CentralMalariaPlasmodium vivaxInterleukin‑10MalariaRecurrenceInterleukin‑10CD4+ T‑cellsCD8+ T‑cellsImmune response pattern in recurrent Plasmodium vivax malariainfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Leônidas e Maria Deane. Manaus, AM, Brasil.Fundação Oswaldo Cruz. Instituto Leônidas e Maria Deane. Manaus, AM, Brasil / Universidade do Estado do Amazonas. Programa de Pós‑Graduação em Medicina Tropical. Manaus, AM, Brasil / Fundação de Medicina Tropical Dr. Heitor Vieira Dourado. Manaus, AM, Brasil.Universidade de São Paulo. Instituto de Ciências Biológicas. Departamento de Parasitologia. São Paulo, SP, Brasil.Fundação Oswaldo Cruz. Instituto Leônidas e Maria Deane. Manaus, AM, Brasil / Universidade do Estado do Amazonas. Programa de Pós‑Graduação em Medicina Tropical. Manaus, AM, Brasil / Fundação de Medicina Tropical Dr. Heitor Vieira Dourado. Manaus, AM, Brasil.Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Grupo Integrado de Pesquisas em Biomarcadores de Diagnóstico e Monitoração. Belo Horizonte, MG, Brasil.Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Grupo Integrado de Pesquisas em Biomarcadores de Diagnóstico e Monitoração. Belo Horizonte, MG, Brasil.Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Grupo Integrado de Pesquisas em Biomarcadores de Diagnóstico e Monitoração. Belo Horizonte, MG, Brasil.Fundação Hospitalar de Hematologia e Hemoterapia do Amazonas. Departamento de Ensino e Pesquisa. Manaus, AM, Brasil / Universidade Federal do Amazonas. Programa de Pós‑Graduação em Imunologia Básica e Aplicada. Manaus, AM, Brasil.Universidade do Estado do Amazonas. Programa de Pós‑Graduação em Medicina Tropical. Manaus, AM, Brasil / Fundação de Medicina Tropical Dr. Heitor Vieira Dourado. Manaus, AM, BrasilFundação Oswaldo Cruz. Instituto Leônidas e Maria Deane. Manaus, AM, Brasil.Universidade de São Paulo. Instituto de Ciências Biológicas. Departamento de Parasitologia. São Paulo, SP, Brasil.Fundação Oswaldo Cruz. Instituto Leônidas e Maria Deane. Manaus, AM, Brasil.Background: Plasmodium vivax is the causative agent of human malaria of large geographic distribution, with 35 million cases annually. In Brazil, it is the most prevalent species, being responsible by around 70% of the malaria cases. Methods: A cross‑sectional study was performed in Manaus (Amazonas, Brazil), including 36 adult patients with primary malaria, 19 with recurrent malaria, and 20 endemic controls. The ex vivo phenotypic features of circulating leukocyte subsets (CD4+ T‑cells, CD8+ T ‑cells, NK, NKT, B, B1 and Treg cells) as well as the plasmatic cytokine profile (IL‑2, IL‑4, IL‑6, IL‑10, TNF and IFN‑γ) were assessed, aiming at establishing patterns of immune response characteristic of primary malaria vs recurrent malaria as compared to endemic controls. Results: The proportion of subjects with high levels of WBC was reduced in malaria patients as compared to the endemic control. Monocytes were diminished particularly in patients with primary malaria. The proportion of sub‑jects with high levels of all lymphocyte subsets was decreased in all malaria groups, regardless their clinical status. Decreased proportion of subjects with high levels of CD4+ and CD8+ T ‑cells was found especially in the group of patients with recurrent malaria. Data analysis indicated significant increase in the proportion of the subjects with high plasmatic cytokine levels in both malaria groups, characterizing a typical cytokine storm. Recurrent malaria patients displayed the highest plasmatic IL‑10 levels, that correlated directly with the CD4+/CD8+ T ‑cells ratio and the number of malaria episodes. Conclusion: The findings confirm that the infection by the P. vivax causes a decrease in peripheral blood lympho cyte subsets, which is intensified in the cases of “recurrent malaria”. The unbalanced CD4+/CD8+ T ‑cells ratio, as well as increased IL‑10 levels were correlated with the number of recurrent malaria episodes. These results suggest that the gradual remodelling of the immune response is dependent on the repeated exposure to the parasite, which involves a strict control of the immune response mediated by the D4+/CD8+ T ‑cell unbalance and exacerbated IL‑10 secretion.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83082https://www.arca.fiocruz.br/bitstream/icict/20056/1/license.txt9193a7c197bc67acd023525e72a03240MD51ORIGINALve_Chaves_ Yury_Immune response.CPqRR_2016.pdfve_Chaves_ Yury_Immune response.CPqRR_2016.pdfapplication/pdf838526https://www.arca.fiocruz.br/bitstream/icict/20056/2/ve_Chaves_%20Yury_Immune%20response.CPqRR_2016.pdfe202fcac30b4f6e353569ee4af3ca6c7MD52TEXTve_Chaves_ Yury_Immune response.CPqRR_2016.pdf.txtve_Chaves_ Yury_Immune response.CPqRR_2016.pdf.txtExtracted 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dc.title.pt_BR.fl_str_mv Immune response pattern in recurrent Plasmodium vivax malaria
title Immune response pattern in recurrent Plasmodium vivax malaria
spellingShingle Immune response pattern in recurrent Plasmodium vivax malaria
Chaves, Yury Oliveira
Malaria
Plasmodium vivax
Interleukin‑10
Malaria
Recurrence
Interleukin‑10
CD4+ T‑cells
CD8+ T‑cells
title_short Immune response pattern in recurrent Plasmodium vivax malaria
title_full Immune response pattern in recurrent Plasmodium vivax malaria
title_fullStr Immune response pattern in recurrent Plasmodium vivax malaria
title_full_unstemmed Immune response pattern in recurrent Plasmodium vivax malaria
title_sort Immune response pattern in recurrent Plasmodium vivax malaria
author Chaves, Yury Oliveira
author_facet Chaves, Yury Oliveira
Costa, Allyson Guimarães da
Pereira, Marcelo Luís Monteiro
Lacerda, Marcus Vinícius Guimarães de
Reis, Jordana Grazziela Alves Coelho dos
Martins Filho, Olindo Assis
Carvalho, Andréa Teixeira de
Malheiro, Adriana
Monteiro, Wuelton Marcelo
Orlandi, Patrícia Puccinelli
Marinho, Claudio Romero Farias
Nogueira, Paulo Afonso
author_role author
author2 Costa, Allyson Guimarães da
Pereira, Marcelo Luís Monteiro
Lacerda, Marcus Vinícius Guimarães de
Reis, Jordana Grazziela Alves Coelho dos
Martins Filho, Olindo Assis
Carvalho, Andréa Teixeira de
Malheiro, Adriana
Monteiro, Wuelton Marcelo
Orlandi, Patrícia Puccinelli
Marinho, Claudio Romero Farias
Nogueira, Paulo Afonso
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Chaves, Yury Oliveira
Costa, Allyson Guimarães da
Pereira, Marcelo Luís Monteiro
Lacerda, Marcus Vinícius Guimarães de
Reis, Jordana Grazziela Alves Coelho dos
Martins Filho, Olindo Assis
Carvalho, Andréa Teixeira de
Malheiro, Adriana
Monteiro, Wuelton Marcelo
Orlandi, Patrícia Puccinelli
Marinho, Claudio Romero Farias
Nogueira, Paulo Afonso
dc.subject.other.pt_BR.fl_str_mv Malaria
Plasmodium vivax
Interleukin‑10
topic Malaria
Plasmodium vivax
Interleukin‑10
Malaria
Recurrence
Interleukin‑10
CD4+ T‑cells
CD8+ T‑cells
dc.subject.en.pt_BR.fl_str_mv Malaria
Recurrence
Interleukin‑10
CD4+ T‑cells
CD8+ T‑cells
description Fundação Oswaldo Cruz. Instituto Leônidas e Maria Deane. Manaus, AM, Brasil.
publishDate 2016
dc.date.issued.fl_str_mv 2016
dc.date.accessioned.fl_str_mv 2017-07-12T17:09:39Z
dc.date.available.fl_str_mv 2017-07-12T17:09:39Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv CHAVES, Yury Oliveira et al. Immune response pattern in recurrent Plasmodium vivax malaria. Malaria Journal, v. 15, n. 1, p. 1-13, 2016.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/20056
dc.identifier.issn.pt_BR.fl_str_mv 1475-2875
dc.identifier.doi.none.fl_str_mv 10.1186/s12936-016-1501-5
identifier_str_mv CHAVES, Yury Oliveira et al. Immune response pattern in recurrent Plasmodium vivax malaria. Malaria Journal, v. 15, n. 1, p. 1-13, 2016.
1475-2875
10.1186/s12936-016-1501-5
url https://www.arca.fiocruz.br/handle/icict/20056
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv BioMed Central
publisher.none.fl_str_mv BioMed Central
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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