Myelin breakdown favours Mycobacterium leprae survival in Schwann cells

Detalhes bibliográficos
Autor(a) principal: Mietto, Bruno Siqueira
Data de Publicação: 2020
Outros Autores: Souza, Beatriz Junqueira de, Rosa, Patricia Sammarco, Pessolani, Maria Cristina Vidal, Lara, Flavio Alves, Sarno, Euzenir Nunes
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/40997
Resumo: Acesso aberto em 26/04/2020 - https://onlinelibrary.wiley.com/doi/full/10.1111/cmi.13128
id CRUZ_63c17062ff795306d74a556beda42bec
oai_identifier_str oai:www.arca.fiocruz.br:icict/40997
network_acronym_str CRUZ
network_name_str Repositório Institucional da FIOCRUZ (ARCA)
repository_id_str 2135
spelling Mietto, Bruno SiqueiraSouza, Beatriz Junqueira deRosa, Patricia SammarcoPessolani, Maria Cristina VidalLara, Flavio AlvesSarno, Euzenir Nunes2020-04-27T18:42:59Z2020-04-27T18:42:59Z2020MIETTO, Bruno Siqueira et al. Myelin breakdown favours Mycobacterium leprae survival in Schwann cells. Cellular Microbiology, v. 22,p. 1-8, 2020.1462-5814https://www.arca.fiocruz.br/handle/icict/4099710.1111/cmi.131281462-5822Acesso aberto em 26/04/2020 - https://onlinelibrary.wiley.com/doi/full/10.1111/cmi.13128Universidade Federal de Juiz de Fora. Instituto de Ciências Biológicas. Juiz de Fora, MG, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil.Instituto Lauro de Souza Lima. São Paulo, SP, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil.Leprosy neuropathy is a chronic degenerative infectious disorder of the peripheral nerve caused by the intracellular obligate pathogen Mycobacterium leprae (M. leprae). Among all nonneuronal cells that constitute the nerve, Schwann cells are remarkable in supporting M. leprae persistence intracellularly. Notably, the success of leprosy infection has been attributed to its ability in inducing the demyelination phenotype after contacting myelinated fibres. However, the exact role M. leprae plays during the ongoing process of myelin breakdown is entirely unknown. Here, we provided evidence showing an unexpected predilection of leprosy pathogen for degenerating myelin ovoids inside Schwann cells. In addition, M. leprae infection accelerated the rate of myelin breakdown and clearance leading to increased formation of lipid droplets, by modulating a set of regulatory genes involved in myelin maintenance, autophagy, and lipid storage. Remarkably, the blockage of myelin breakdown significantly reduced M. leprae content, demonstrating a new unpredictable role of myelin dismantling favouring M. leprae physiology. Collectively, our study provides novel evidence that may explain the demyelination phenotype as an evolutionarily conserved mechanism used by leprosy pathogen to persist longer in the peripheral nerve.engWiley 12 MonthsProcessos de doençasInfecçãoMetabolismoInteração microbiano-célulaMicobactériasDisease processesInfectionMetabolismMicrobial–cell interactionMycobacteriaMyelin breakdown favours Mycobacterium leprae survival in Schwann cellsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/40997/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALEuzenirSarno_FlavioLara_etal_IOC_2020.pdfEuzenirSarno_FlavioLara_etal_IOC_2020.pdfapplication/pdf1872768https://www.arca.fiocruz.br/bitstream/icict/40997/2/EuzenirSarno_FlavioLara_etal_IOC_2020.pdf02b9a69565b672c930fab5865065c3a3MD52TEXTEuzenirSarno_FlavioLara_etal_IOC_2020.pdf.txtEuzenirSarno_FlavioLara_etal_IOC_2020.pdf.txtExtracted texttext/plain35781https://www.arca.fiocruz.br/bitstream/icict/40997/3/EuzenirSarno_FlavioLara_etal_IOC_2020.pdf.txtf2cc6e105830890f6f9d1cc8a53d9fc7MD53icict/409972020-04-30 14:40:12.425oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352020-04-30T17:40:12Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Myelin breakdown favours Mycobacterium leprae survival in Schwann cells
title Myelin breakdown favours Mycobacterium leprae survival in Schwann cells
spellingShingle Myelin breakdown favours Mycobacterium leprae survival in Schwann cells
Mietto, Bruno Siqueira
Processos de doenças
Infecção
Metabolismo
Interação microbiano-célula
Micobactérias
Disease processes
Infection
Metabolism
Microbial–cell interaction
Mycobacteria
title_short Myelin breakdown favours Mycobacterium leprae survival in Schwann cells
title_full Myelin breakdown favours Mycobacterium leprae survival in Schwann cells
title_fullStr Myelin breakdown favours Mycobacterium leprae survival in Schwann cells
title_full_unstemmed Myelin breakdown favours Mycobacterium leprae survival in Schwann cells
title_sort Myelin breakdown favours Mycobacterium leprae survival in Schwann cells
author Mietto, Bruno Siqueira
author_facet Mietto, Bruno Siqueira
Souza, Beatriz Junqueira de
Rosa, Patricia Sammarco
Pessolani, Maria Cristina Vidal
Lara, Flavio Alves
Sarno, Euzenir Nunes
author_role author
author2 Souza, Beatriz Junqueira de
Rosa, Patricia Sammarco
Pessolani, Maria Cristina Vidal
Lara, Flavio Alves
Sarno, Euzenir Nunes
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Mietto, Bruno Siqueira
Souza, Beatriz Junqueira de
Rosa, Patricia Sammarco
Pessolani, Maria Cristina Vidal
Lara, Flavio Alves
Sarno, Euzenir Nunes
dc.subject.other.pt_BR.fl_str_mv Processos de doenças
Infecção
Metabolismo
Interação microbiano-célula
Micobactérias
topic Processos de doenças
Infecção
Metabolismo
Interação microbiano-célula
Micobactérias
Disease processes
Infection
Metabolism
Microbial–cell interaction
Mycobacteria
dc.subject.en.pt_BR.fl_str_mv Disease processes
Infection
Metabolism
Microbial–cell interaction
Mycobacteria
description Acesso aberto em 26/04/2020 - https://onlinelibrary.wiley.com/doi/full/10.1111/cmi.13128
publishDate 2020
dc.date.accessioned.fl_str_mv 2020-04-27T18:42:59Z
dc.date.available.fl_str_mv 2020-04-27T18:42:59Z
dc.date.issued.fl_str_mv 2020
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv MIETTO, Bruno Siqueira et al. Myelin breakdown favours Mycobacterium leprae survival in Schwann cells. Cellular Microbiology, v. 22,p. 1-8, 2020.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/40997
dc.identifier.issn.pt_BR.fl_str_mv 1462-5814
dc.identifier.doi.none.fl_str_mv 10.1111/cmi.13128
dc.identifier.eissn.none.fl_str_mv 1462-5822
identifier_str_mv MIETTO, Bruno Siqueira et al. Myelin breakdown favours Mycobacterium leprae survival in Schwann cells. Cellular Microbiology, v. 22,p. 1-8, 2020.
1462-5814
10.1111/cmi.13128
1462-5822
url https://www.arca.fiocruz.br/handle/icict/40997
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Wiley 12 Months
publisher.none.fl_str_mv Wiley 12 Months
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/40997/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/40997/2/EuzenirSarno_FlavioLara_etal_IOC_2020.pdf
https://www.arca.fiocruz.br/bitstream/icict/40997/3/EuzenirSarno_FlavioLara_etal_IOC_2020.pdf.txt
bitstream.checksum.fl_str_mv 5a560609d32a3863062d77ff32785d58
02b9a69565b672c930fab5865065c3a3
f2cc6e105830890f6f9d1cc8a53d9fc7
bitstream.checksumAlgorithm.fl_str_mv MD5
MD5
MD5
repository.name.fl_str_mv Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)
repository.mail.fl_str_mv repositorio.arca@fiocruz.br
_version_ 1798324999687241728

Registros relacionados