Evaluation of SPf66 malaria vaccine efficacy in Brazil

Detalhes bibliográficos
Autor(a) principal: Urdaneta, Margarita
Data de Publicação: 1998
Outros Autores: Prata, Aluizio, Struchiner, Claudio J., Tosta, C. Eduardo, Tauil, Pedro, Boulos, Marcos
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/29464
Resumo: Fundação Oswaldo Cruz. Escola Nacional de Saúde Pública Sergio Arouca. Rio de Janeiro, RJ, Brasil.
id CRUZ_641dd9ecb0b04d92eef197b90cb41756
oai_identifier_str oai:www.arca.fiocruz.br:icict/29464
network_acronym_str CRUZ
network_name_str Repositório Institucional da FIOCRUZ (ARCA)
repository_id_str 2135
spelling Urdaneta, MargaritaPrata, AluizioStruchiner, Claudio J.Tosta, C. EduardoTauil, PedroBoulos, Marcos2018-10-09T14:55:45Z2018-10-09T14:55:45Z1998URDANETA, Margarita et al. Evaluation of SPf66 malaria vaccine efficacy in Brazil. American Journal of Tropical Medicine and Hygiene, v. 58, n. 3, p. 378-385, 1998.0002-9637https://www.arca.fiocruz.br/handle/icict/2946410.4269/ajtmh.1998.58.3780002-9637engAmerican Society of Tropical Medicine and HygieneAméricasBrasilAssistência à SaúdePaíses em DesenvolvimentoDoençaAssistência AmbulatorialImunizaçãoAmérica LatinaMaláriaOrganização e AdministraçãoDoenças ParasitáriasAtenção Primária à SaúdeAvaliação de Programas e Projetos de SaúdeProjetos de PesquisaRelatório de PesquisaAmérica do SulVacinaçãoAmericasBrazilClinical ResearchDelivery of Health CareDeveloping CountriesDiseasesHealth ServicesImmunizationLatin AmericaMalaria-prevention and controlOrganization and AdministrationParasitic DiseasesPrimary Health CareProgram EvaluationResearch MethodologyResearch ReportSouth AmericaVaccination and VaccinesAmericasBrazilDelivery of Health CareDeveloping CountriesDiseaseImmunizationLatin AmericaMalariaOrganization and AdministrationParasitic DiseasesPrimary Health CareProgram EvaluationResearch ReportSouth AmericaVaccinationEvaluation of SPf66 malaria vaccine efficacy in Brazilinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Escola Nacional de Saúde Pública Sergio Arouca. Rio de Janeiro, RJ, Brasil.Faculdade de Medicina do Triangulo Mineiro. Uberaba, MG, Brasil.Universidade de Brasília. Departamento de Saúde Coletiva. Núcleo de Medicina Tropical e Nutrição. Laboratório de Malária. Brasília, DF, Brasil.Universidade de São Paulo. Faculdade de Medicina. Departamento de Doenças Infecciosas e Parasitarias. São Paulo, SP, Brasil.Universidade de Brasília. Brasília, DF, Brasil.Universidade de São Paulo. Faculdade de Medicina. São Paulo, SP, Brasil.This paper reports the efficacy results of the randomized, placebo-controlled, field trial of SPf66 malaria vaccine in Costa Marques, Rondonia, Brazil. This region is characterized by the seasonal distribution of Plasmodium falciparum and P. vivax infections, and the recent occupation by migrants from nonendemic areas. A total of 800 individuals of both sexes, ranging in age from seven to 60 years, were included in the study. Of the initial cohort, 572 participants completed the vaccination schedule. Clinical and parasitologic evaluations were obtained by active and passive searches on a periodic basis. The overall protective efficacy against P. falciparum infections was -1.6% (-32.9% to 22.4%), and 14.1% (-17.0% to 36.9%) for the first episode. The overall protective efficacy for P. vivax infections was -19.7% (-44.8% to 1.03%), and -10.8% (-41.1% to 12.8%) for the first episode. No statistical evidence of an overall significant protective effect of SPf66 malaria vaccine against P. falciparum and P. vivax malaria was obtained in this trial.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/29464/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALEvaluationSPf66Malaria.pdfEvaluationSPf66Malaria.pdfapplication/pdf68422https://www.arca.fiocruz.br/bitstream/icict/29464/2/EvaluationSPf66Malaria.pdf9517de6876cb9e1b24f41c0c228f0b3cMD52TEXTEvaluationSPf66Malaria.pdf.txtEvaluationSPf66Malaria.pdf.txtExtracted texttext/plain43014https://www.arca.fiocruz.br/bitstream/icict/29464/3/EvaluationSPf66Malaria.pdf.txt7197eb46d8388b9c28de2d67330f8966MD53icict/294642023-01-12 15:19:48.601oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-01-12T18:19:48Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Evaluation of SPf66 malaria vaccine efficacy in Brazil
title Evaluation of SPf66 malaria vaccine efficacy in Brazil
spellingShingle Evaluation of SPf66 malaria vaccine efficacy in Brazil
Urdaneta, Margarita
Américas
Brasil
Assistência à Saúde
Países em Desenvolvimento
Doença
Assistência Ambulatorial
Imunização
América Latina
Malária
Organização e Administração
Doenças Parasitárias
Atenção Primária à Saúde
Avaliação de Programas e Projetos de Saúde
Projetos de Pesquisa
Relatório de Pesquisa
América do Sul
Vacinação
Americas
Brazil
Clinical Research
Delivery of Health Care
Developing Countries
Diseases
Health Services
Immunization
Latin America
Malaria-prevention and control
Organization and Administration
Parasitic Diseases
Primary Health Care
Program Evaluation
Research Methodology
Research Report
South America
Vaccination and Vaccines
Americas
Brazil
Delivery of Health Care
Developing Countries
Disease
Immunization
Latin America
Malaria
Organization and Administration
Parasitic Diseases
Primary Health Care
Program Evaluation
Research Report
South America
Vaccination
title_short Evaluation of SPf66 malaria vaccine efficacy in Brazil
title_full Evaluation of SPf66 malaria vaccine efficacy in Brazil
title_fullStr Evaluation of SPf66 malaria vaccine efficacy in Brazil
title_full_unstemmed Evaluation of SPf66 malaria vaccine efficacy in Brazil
title_sort Evaluation of SPf66 malaria vaccine efficacy in Brazil
author Urdaneta, Margarita
author_facet Urdaneta, Margarita
Prata, Aluizio
Struchiner, Claudio J.
Tosta, C. Eduardo
Tauil, Pedro
Boulos, Marcos
author_role author
author2 Prata, Aluizio
Struchiner, Claudio J.
Tosta, C. Eduardo
Tauil, Pedro
Boulos, Marcos
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Urdaneta, Margarita
Prata, Aluizio
Struchiner, Claudio J.
Tosta, C. Eduardo
Tauil, Pedro
Boulos, Marcos
dc.subject.other.pt_BR.fl_str_mv Américas
Brasil
Assistência à Saúde
Países em Desenvolvimento
Doença
Assistência Ambulatorial
Imunização
América Latina
Malária
Organização e Administração
Doenças Parasitárias
Atenção Primária à Saúde
Avaliação de Programas e Projetos de Saúde
Projetos de Pesquisa
Relatório de Pesquisa
América do Sul
Vacinação
topic Américas
Brasil
Assistência à Saúde
Países em Desenvolvimento
Doença
Assistência Ambulatorial
Imunização
América Latina
Malária
Organização e Administração
Doenças Parasitárias
Atenção Primária à Saúde
Avaliação de Programas e Projetos de Saúde
Projetos de Pesquisa
Relatório de Pesquisa
América do Sul
Vacinação
Americas
Brazil
Clinical Research
Delivery of Health Care
Developing Countries
Diseases
Health Services
Immunization
Latin America
Malaria-prevention and control
Organization and Administration
Parasitic Diseases
Primary Health Care
Program Evaluation
Research Methodology
Research Report
South America
Vaccination and Vaccines
Americas
Brazil
Delivery of Health Care
Developing Countries
Disease
Immunization
Latin America
Malaria
Organization and Administration
Parasitic Diseases
Primary Health Care
Program Evaluation
Research Report
South America
Vaccination
dc.subject.en.pt_BR.fl_str_mv Americas
Brazil
Clinical Research
Delivery of Health Care
Developing Countries
Diseases
Health Services
Immunization
Latin America
Malaria-prevention and control
Organization and Administration
Parasitic Diseases
Primary Health Care
Program Evaluation
Research Methodology
Research Report
South America
Vaccination and Vaccines
dc.subject.decs.pt_BR.fl_str_mv Americas
Brazil
Delivery of Health Care
Developing Countries
Disease
Immunization
Latin America
Malaria
Organization and Administration
Parasitic Diseases
Primary Health Care
Program Evaluation
Research Report
South America
Vaccination
description Fundação Oswaldo Cruz. Escola Nacional de Saúde Pública Sergio Arouca. Rio de Janeiro, RJ, Brasil.
publishDate 1998
dc.date.issued.fl_str_mv 1998
dc.date.accessioned.fl_str_mv 2018-10-09T14:55:45Z
dc.date.available.fl_str_mv 2018-10-09T14:55:45Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv URDANETA, Margarita et al. Evaluation of SPf66 malaria vaccine efficacy in Brazil. American Journal of Tropical Medicine and Hygiene, v. 58, n. 3, p. 378-385, 1998.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/29464
dc.identifier.issn.pt_BR.fl_str_mv 0002-9637
dc.identifier.doi.pt_BR.fl_str_mv 10.4269/ajtmh.1998.58.378
dc.identifier.eissn.none.fl_str_mv 0002-9637
identifier_str_mv URDANETA, Margarita et al. Evaluation of SPf66 malaria vaccine efficacy in Brazil. American Journal of Tropical Medicine and Hygiene, v. 58, n. 3, p. 378-385, 1998.
0002-9637
10.4269/ajtmh.1998.58.378
url https://www.arca.fiocruz.br/handle/icict/29464
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv American Society of Tropical Medicine and Hygiene
publisher.none.fl_str_mv American Society of Tropical Medicine and Hygiene
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/29464/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/29464/2/EvaluationSPf66Malaria.pdf
https://www.arca.fiocruz.br/bitstream/icict/29464/3/EvaluationSPf66Malaria.pdf.txt
bitstream.checksum.fl_str_mv 5a560609d32a3863062d77ff32785d58
9517de6876cb9e1b24f41c0c228f0b3c
7197eb46d8388b9c28de2d67330f8966
bitstream.checksumAlgorithm.fl_str_mv MD5
MD5
MD5
repository.name.fl_str_mv Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)
repository.mail.fl_str_mv repositorio.arca@fiocruz.br
_version_ 1813009179267301376

Registros relacionados