Epidemiological surveillance of birth defects compatible with thalidomide embryopathy in Brazil

Detalhes bibliográficos
Autor(a) principal: Vianna, Fernanda Sales Luiz
Data de Publicação: 2011
Outros Autores: López-Camelo, Jorge S., Leite, Júlio César Louguercio, Sanseverino, Maria Teresa Vieira, Dutra, Maria da Graça, Castilla, Eduardo E., Faccini, Lavínia Schüler
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/16719
Resumo: Hospital de Clínicas de Porto Alegre. Serviço de Genética Médica. Serviço de Informações Teratógenos.INAGEMP (Instituto Nacional de Gene´ tica Me´dica Populacional). Porto Alegre, RS, Brasil / Universidade Federal do Rio Grande do Sul. Departamento de Genética. INAGEMP. Porto Alegre, RS, Brasil.
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spelling Vianna, Fernanda Sales LuizLópez-Camelo, Jorge S.Leite, Júlio César LouguercioSanseverino, Maria Teresa VieiraDutra, Maria da GraçaCastilla, Eduardo E.Faccini, Lavínia Schüler2017-01-05T10:40:18Z2017-01-05T10:40:18Z2011VIANNA, Fernanda Sales Luiz; et al. Epidemiological Surveillance of Birth Defects Compatible with Thalidomide Embryopathy in Brazil. Plos One, v.6, n.7, e21735, 5p, July 2011.1932-6203https://www.arca.fiocruz.br/handle/icict/1671910.1371/journal.pone.0021735engPublic Library of ScienceVigilância EpidemiológicaDefeitos de nascençaEmbriopatia da talidomidaBrasilEpidemiological SurveillanceBirth DefectsThalidomide EmbryopathyBrazilEpidemiological surveillance of birth defects compatible with thalidomide embryopathy in Brazilinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleHospital de Clínicas de Porto Alegre. Serviço de Genética Médica. Serviço de Informações Teratógenos.INAGEMP (Instituto Nacional de Gene´ tica Me´dica Populacional). Porto Alegre, RS, Brasil / Universidade Federal do Rio Grande do Sul. Departamento de Genética. INAGEMP. Porto Alegre, RS, Brasil.INAGEMP at ECLAMC (Latin-American Collaborative Study of Congenital Malformations) in IMBICE: Instituto Multidisciplinario de Biologia Celular. La Plata, Argentina / INAGEMP at ECLAMC in CEMIC: Centro de Educación Médica e Investigación Clínica, Buenos Aires, Argentina.Hospital de Clínicas de Porto Alegre. Serviço de Genética Médica. Serviço de Informações Teratógenos.INAGEMP (Instituto Nacional de Gene´ tica Me´dica Populacional). Porto Alegre, RS, BrasilHospital de Clínicas de Porto Alegre. Serviço de Genética Médica. Serviço de Informações Teratógenos.INAGEMP (Instituto Nacional de Gene´ tica Me´dica Populacional). Porto Alegre, RS, BrasilINAGEMP at ECLAMC in Laboratório de Epidemiologia de Malformações Congênitas, Instituto Oswaldo Cruz, FIOCRUZ, Rio de Janeiro, RJ, Brasil.INAGEMP at ECLAMC in CEMIC: Centro de Educación Médica e Investigación Clínica. Buenos Aires, Argentina / INAGEMP at ECLAMC in Laborató´ rio de Epidemiologia de Malformações Congênitas. Instituto Oswaldo Cruz. FIOCRUZ. Rio de Janeiro, RJ, Brasil.Hospital de Clínicas de Porto Alegre. Serviço de Genética Médica. Serviço de Informações Teratógenos.INAGEMP (Instituto Nacional de Gene´ tica Me´dica Populacional). Porto Alegre, RS, Brasil / Universidade Federal do Rio Grande do Sul. Departamento de Genética. INAGEMP. Porto Alegre, RS, Brasil.The thalidomide tragedy of the 1960s resulted in thousands of children being born with severe limb reduction defects (LRD), among other malformations. In Brazil, there are still babies born with thalidomide embryopathy (TE) because of leprosy prevalence, availability of thalidomide, and deficiencies in the control of drug dispensation. Our objective was to implement a system of proactive surveillance to identify birth defects compatible with TE. Along one year, newborns with LRD were assessed in the Brazilian hospitals participating in the Latin-American Collaborative Study of Congenital Malformations (ECLAMC). A phenotype of LRD called thalidomide embryopathy phenotype (TEP) was established for surveillance. Children with TEP born between the years 2000-2008 were monitored, and during the 2007-2008 period we clinically investigated in greater detail all cases with TEP (proactive period). The period from 1982 to 1999 was defined as the baseline period for the cumulative sum statistics. The frequency of TEP during the surveillance period, at 3.10/10,000 births (CI 95%: 2.50-3.70), was significantly higher than that observed in the baseline period (1.92/10,000 births; CI 95%: 1.60-2.20), and not uniformly distributed across different Brazilian regions. During the proactive surveillance (2007-2008), two cases of suspected TE were identified, although the two mothers had denied the use of the drug during pregnancy. Our results suggest that TEP has probably increased in recent years, which coincides with the period of greater thalidomide availability. Our proactive surveillance identified two newborns with suspected TE, proving to be a sensitive tool to detect TE. The high frequency of leprosy and the large use of thalidomide reinforce the need for a continuous monitoring of TEP across Brazil.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/16719/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALmariagraça_dutra_etal_IOC_2011.pdfmariagraça_dutra_etal_IOC_2011.pdfapplication/pdf150776https://www.arca.fiocruz.br/bitstream/icict/16719/2/mariagra%c3%a7a_dutra_etal_IOC_2011.pdf99f8b70cd082bb6436f68cc42bc84eacMD52TEXTmariagraça_dutra_etal_IOC_2011.pdf.txtmariagraça_dutra_etal_IOC_2011.pdf.txtExtracted texttext/plain29696https://www.arca.fiocruz.br/bitstream/icict/16719/3/mariagra%c3%a7a_dutra_etal_IOC_2011.pdf.txtd51ac19074f233d4b20783ef5d381a56MD53icict/167192020-07-17 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dc.title.pt_BR.fl_str_mv Epidemiological surveillance of birth defects compatible with thalidomide embryopathy in Brazil
title Epidemiological surveillance of birth defects compatible with thalidomide embryopathy in Brazil
spellingShingle Epidemiological surveillance of birth defects compatible with thalidomide embryopathy in Brazil
Vianna, Fernanda Sales Luiz
Vigilância Epidemiológica
Defeitos de nascença
Embriopatia da talidomida
Brasil
Epidemiological Surveillance
Birth Defects
Thalidomide Embryopathy
Brazil
title_short Epidemiological surveillance of birth defects compatible with thalidomide embryopathy in Brazil
title_full Epidemiological surveillance of birth defects compatible with thalidomide embryopathy in Brazil
title_fullStr Epidemiological surveillance of birth defects compatible with thalidomide embryopathy in Brazil
title_full_unstemmed Epidemiological surveillance of birth defects compatible with thalidomide embryopathy in Brazil
title_sort Epidemiological surveillance of birth defects compatible with thalidomide embryopathy in Brazil
author Vianna, Fernanda Sales Luiz
author_facet Vianna, Fernanda Sales Luiz
López-Camelo, Jorge S.
Leite, Júlio César Louguercio
Sanseverino, Maria Teresa Vieira
Dutra, Maria da Graça
Castilla, Eduardo E.
Faccini, Lavínia Schüler
author_role author
author2 López-Camelo, Jorge S.
Leite, Júlio César Louguercio
Sanseverino, Maria Teresa Vieira
Dutra, Maria da Graça
Castilla, Eduardo E.
Faccini, Lavínia Schüler
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Vianna, Fernanda Sales Luiz
López-Camelo, Jorge S.
Leite, Júlio César Louguercio
Sanseverino, Maria Teresa Vieira
Dutra, Maria da Graça
Castilla, Eduardo E.
Faccini, Lavínia Schüler
dc.subject.other.pt_BR.fl_str_mv Vigilância Epidemiológica
Defeitos de nascença
Embriopatia da talidomida
Brasil
topic Vigilância Epidemiológica
Defeitos de nascença
Embriopatia da talidomida
Brasil
Epidemiological Surveillance
Birth Defects
Thalidomide Embryopathy
Brazil
dc.subject.en.pt_BR.fl_str_mv Epidemiological Surveillance
Birth Defects
Thalidomide Embryopathy
Brazil
description Hospital de Clínicas de Porto Alegre. Serviço de Genética Médica. Serviço de Informações Teratógenos.INAGEMP (Instituto Nacional de Gene´ tica Me´dica Populacional). Porto Alegre, RS, Brasil / Universidade Federal do Rio Grande do Sul. Departamento de Genética. INAGEMP. Porto Alegre, RS, Brasil.
publishDate 2011
dc.date.issued.fl_str_mv 2011
dc.date.accessioned.fl_str_mv 2017-01-05T10:40:18Z
dc.date.available.fl_str_mv 2017-01-05T10:40:18Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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status_str publishedVersion
dc.identifier.citation.fl_str_mv VIANNA, Fernanda Sales Luiz; et al. Epidemiological Surveillance of Birth Defects Compatible with Thalidomide Embryopathy in Brazil. Plos One, v.6, n.7, e21735, 5p, July 2011.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/16719
dc.identifier.issn.pt_BR.fl_str_mv 1932-6203
dc.identifier.doi.none.fl_str_mv 10.1371/journal.pone.0021735
identifier_str_mv VIANNA, Fernanda Sales Luiz; et al. Epidemiological Surveillance of Birth Defects Compatible with Thalidomide Embryopathy in Brazil. Plos One, v.6, n.7, e21735, 5p, July 2011.
1932-6203
10.1371/journal.pone.0021735
url https://www.arca.fiocruz.br/handle/icict/16719
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Public Library of Science
publisher.none.fl_str_mv Public Library of Science
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
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