Epigenetic inactivation of the p53-induced long noncoding RNA TP53 target 1 in human cancer

Detalhes bibliográficos
Autor(a) principal: Diaz-Lagares, Angel
Data de Publicação: 2016
Outros Autores: Crujeiras, Ana B, Lopez-Serra, Paula, Soler, Marta, Setien, Fernando, Goyal, Ashish, Sandoval, Juan, Hashimoto, Yutaka, Cardús, Anna Martinez, Gomez, Antonio, Heyn, Holger, Moutinho, Catia, Espada, Jesús, Vidal, August, Paúles, Maria, Galán, Maica, Sala, Núria, Akiyama, Yoshimitsu, Martínez-Iniesta, María, Vallve, Maria de Lourdes Farre, Villanueva, Alberto, Gross, Matthias, Diederichs, Sven, Guil, Sonia, Esteller, Manel
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/18161
Resumo: Maria de Lourdes Farré Vallve - Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Patologia Experimental. Salvador, BA, Brasil. aCancer Epigenetics and Biology Program (PEBC), Bellvitge Biomedical Research Institute (IDIBELL), L’Hospitalet de Llobregat, 08908 Barcelona, Catalonia, Spain; bCentro de Investigación Biomédica en Red (CIBER) Fisiopatología de la Obesidad y Nutrición (CIBERobn), Instituto Salud Carlos III, 28029 Madrid, Spain; cEndocrine Division, Complejo Hospitalario Universitario de Santiago, 15706 Santiago de Compostela, Spain; dDivision of RNA Biology and Cancer (B150), German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany; eInstitute of Pathology, University Hospital Heidelberg, 69120 Heidelberg, Germany; fExperimental Dermatology and Skin Biology Group, Ramón y Cajal Institute for Biomedical Research (IRYCIS), Ramón y Cajal University Hospital, 28034 Madrid, Spain; gBionanotechnology Laboratory, Bernardo O’Higgins University, Santiago 8370854, Chile; hPathology Department, Hospital Universitari de Bellvitge, IDIBELL, L’Hospitalet de Llobregat, 08907 Barcelona, Catalonia, Spain; iDepartment of Medical Oncology, Catalan Institute of Oncology (ICO), IDIBELL, L’Hospitalet de Llobregat, 08908 Barcelona, Catalonia, Spain; jUnit of Nutrition and Cancer, Cancer Epidemiology Research Program, ICO, IDIBELL, 08908 Barcelona, Catalonia, Spain; kDepartment of Molecular Oncology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, 113-8510 Tokyo, Japan; lProgram Against Cancer Therapeutic Resistance (ProCURE), ICO, IDIBELL, L’Hospitalet del Llobregat, 08908 Barcelona, Catalonia, Spain; mLaboratory of Experimental Pathology (LAPEX), Gonçalo Moniz Research Center, Oswaldo Cruz Foundation (CPQGM/ FIOCRUZ) and National Institute of Science and Technology of Tropical Diseases (INCT/DT), 40296710 Salvador, Bahia, Brazil; nDivision of Cancer Research, Department of Thoracic Surgery, Medical Center–University of Freiburg, 79106 Freiburg, Germany; oFaculty of Medicine, University of Freiburg, 79106 Freiburg, Germany; pGerman Cancer Consortium (DKTK), 79106 Freiburg, Germany; qDepartament de Ciències Fisiològiques II, Escola de Medicina, Universitat de Barcelona, 08907 Barcelona, Catalonia, Spain; and rInstitució Catalana de Recerca i Estudis Avançats (ICREA), 08010 Barcelona, Catalonia, Spain
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spelling Diaz-Lagares, AngelCrujeiras, Ana BLopez-Serra, PaulaSoler, MartaSetien, FernandoGoyal, AshishSandoval, JuanHashimoto, YutakaCardús, Anna MartinezGomez, AntonioHeyn, HolgerMoutinho, CatiaEspada, JesúsVidal, AugustPaúles, MariaGalán, MaicaSala, NúriaAkiyama, YoshimitsuMartínez-Iniesta, MaríaVallve, Maria de Lourdes FarreVillanueva, AlbertoGross, MatthiasDiederichs, SvenGuil, SoniaEsteller, Manel2017-03-24T13:57:19Z2017-03-24T13:57:19Z2016DIAZ-LAGARES, A. et al. Epigenetic inactivation of the p53-induced long noncoding RNA TP53 target 1 in human cancer. Proceedings of the National Academy of Sciences, E7535–E7544, 2016.1091-6490https://www.arca.fiocruz.br/handle/icict/1816110.1073/pnas.1608585113Maria de Lourdes Farré Vallve - Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Patologia Experimental. Salvador, BA, Brasil. aCancer Epigenetics and Biology Program (PEBC), Bellvitge Biomedical Research Institute (IDIBELL), L’Hospitalet de Llobregat, 08908 Barcelona, Catalonia, Spain; bCentro de Investigación Biomédica en Red (CIBER) Fisiopatología de la Obesidad y Nutrición (CIBERobn), Instituto Salud Carlos III, 28029 Madrid, Spain; cEndocrine Division, Complejo Hospitalario Universitario de Santiago, 15706 Santiago de Compostela, Spain; dDivision of RNA Biology and Cancer (B150), German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany; eInstitute of Pathology, University Hospital Heidelberg, 69120 Heidelberg, Germany; fExperimental Dermatology and Skin Biology Group, Ramón y Cajal Institute for Biomedical Research (IRYCIS), Ramón y Cajal University Hospital, 28034 Madrid, Spain; gBionanotechnology Laboratory, Bernardo O’Higgins University, Santiago 8370854, Chile; hPathology Department, Hospital Universitari de Bellvitge, IDIBELL, L’Hospitalet de Llobregat, 08907 Barcelona, Catalonia, Spain; iDepartment of Medical Oncology, Catalan Institute of Oncology (ICO), IDIBELL, L’Hospitalet de Llobregat, 08908 Barcelona, Catalonia, Spain; jUnit of Nutrition and Cancer, Cancer Epidemiology Research Program, ICO, IDIBELL, 08908 Barcelona, Catalonia, Spain; kDepartment of Molecular Oncology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, 113-8510 Tokyo, Japan; lProgram Against Cancer Therapeutic Resistance (ProCURE), ICO, IDIBELL, L’Hospitalet del Llobregat, 08908 Barcelona, Catalonia, Spain; mLaboratory of Experimental Pathology (LAPEX), Gonçalo Moniz Research Center, Oswaldo Cruz Foundation (CPQGM/ FIOCRUZ) and National Institute of Science and Technology of Tropical Diseases (INCT/DT), 40296710 Salvador, Bahia, Brazil; nDivision of Cancer Research, Department of Thoracic Surgery, Medical Center–University of Freiburg, 79106 Freiburg, Germany; oFaculty of Medicine, University of Freiburg, 79106 Freiburg, Germany; pGerman Cancer Consortium (DKTK), 79106 Freiburg, Germany; qDepartament de Ciències Fisiològiques II, Escola de Medicina, Universitat de Barcelona, 08907 Barcelona, Catalonia, Spain; and rInstitució Catalana de Recerca i Estudis Avançats (ICREA), 08010 Barcelona, Catalonia, SpainBellvitge Biomedical Research Institute (IDIBELL). L’Hospitalet de Llobregat. Cancer Epigenetics and Biology Program (PEBC). Barcelona, Catalonia, SpainBellvitge Biomedical Research Institute (IDIBELL). L’Hospitalet de Llobregat. Cancer Epigenetics and Biology Program (PEBC). Barcelona, Catalonia, Spain / Instituto Salud Carlos III. Centro de Investigación Biomédica en Red (CIBER) Fisiopatología de la Obesidad y Nutrición (CIBERobn). Madrid, Spain / Complejo Hospitalario Universitario de Santiago. Endocrine Division. Santiago de Compostela, SpainBellvitge Biomedical Research Institute (IDIBELL). L’Hospitalet de Llobregat. Cancer Epigenetics and Biology Program (PEBC). Barcelona, Catalonia, Spain. Múltipla - ver em NotasLong noncoding RNAs (lncRNAs) are important regulators of cellular homeostasis. However, their contribution to the cancer phenotype still needs to be established. Herein, we have identified a p53-induced lncRNA, TP53TG1, that undergoes cancer-specific promoter hypermethylation-associated silencing. In vitro and in vivo assays identify a tumor-suppressor activity for TP53TG1 and a role in the p53 response to DNA damage. Importantly, we show that TP53TG1 binds to the multifaceted DNA/RNA binding protein YBX1 to prevent its nuclear localization and thus the YBX1-mediated activation of oncogenes. TP53TG1 epigenetic inactivation in cancer cells releases the transcriptional repression of YBX1-targeted growth-promoting genes and creates a chemoresistant tumor. TP53TG1 hypermethylation in primary tumors is shown to be associated with poor outcome. The epigenetic loss of TP53TG1 therefore represents an altered event in an lncRNA that is linked to classical tumoral pathways, such as p53 signaling, but is also connected to regulatory networks of the cancer cell.engNational Academy of SciencesMetilação do DNARNAEpigenéticaCancerDNA methylationLong noncoding RNAEpigeneticsCancerEpigenetic inactivation of the p53-induced long noncoding RNA TP53 target 1 in human cancerinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/18161/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALLagares AD Epigenetic inactivation....pdfLagares AD Epigenetic 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dc.title.pt_BR.fl_str_mv Epigenetic inactivation of the p53-induced long noncoding RNA TP53 target 1 in human cancer
title Epigenetic inactivation of the p53-induced long noncoding RNA TP53 target 1 in human cancer
spellingShingle Epigenetic inactivation of the p53-induced long noncoding RNA TP53 target 1 in human cancer
Diaz-Lagares, Angel
Metilação do DNA
RNA
Epigenética
Cancer
DNA methylation
Long noncoding RNA
Epigenetics
Cancer
title_short Epigenetic inactivation of the p53-induced long noncoding RNA TP53 target 1 in human cancer
title_full Epigenetic inactivation of the p53-induced long noncoding RNA TP53 target 1 in human cancer
title_fullStr Epigenetic inactivation of the p53-induced long noncoding RNA TP53 target 1 in human cancer
title_full_unstemmed Epigenetic inactivation of the p53-induced long noncoding RNA TP53 target 1 in human cancer
title_sort Epigenetic inactivation of the p53-induced long noncoding RNA TP53 target 1 in human cancer
author Diaz-Lagares, Angel
author_facet Diaz-Lagares, Angel
Crujeiras, Ana B
Lopez-Serra, Paula
Soler, Marta
Setien, Fernando
Goyal, Ashish
Sandoval, Juan
Hashimoto, Yutaka
Cardús, Anna Martinez
Gomez, Antonio
Heyn, Holger
Moutinho, Catia
Espada, Jesús
Vidal, August
Paúles, Maria
Galán, Maica
Sala, Núria
Akiyama, Yoshimitsu
Martínez-Iniesta, María
Vallve, Maria de Lourdes Farre
Villanueva, Alberto
Gross, Matthias
Diederichs, Sven
Guil, Sonia
Esteller, Manel
author_role author
author2 Crujeiras, Ana B
Lopez-Serra, Paula
Soler, Marta
Setien, Fernando
Goyal, Ashish
Sandoval, Juan
Hashimoto, Yutaka
Cardús, Anna Martinez
Gomez, Antonio
Heyn, Holger
Moutinho, Catia
Espada, Jesús
Vidal, August
Paúles, Maria
Galán, Maica
Sala, Núria
Akiyama, Yoshimitsu
Martínez-Iniesta, María
Vallve, Maria de Lourdes Farre
Villanueva, Alberto
Gross, Matthias
Diederichs, Sven
Guil, Sonia
Esteller, Manel
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Diaz-Lagares, Angel
Crujeiras, Ana B
Lopez-Serra, Paula
Soler, Marta
Setien, Fernando
Goyal, Ashish
Sandoval, Juan
Hashimoto, Yutaka
Cardús, Anna Martinez
Gomez, Antonio
Heyn, Holger
Moutinho, Catia
Espada, Jesús
Vidal, August
Paúles, Maria
Galán, Maica
Sala, Núria
Akiyama, Yoshimitsu
Martínez-Iniesta, María
Vallve, Maria de Lourdes Farre
Villanueva, Alberto
Gross, Matthias
Diederichs, Sven
Guil, Sonia
Esteller, Manel
dc.subject.other.pt_BR.fl_str_mv Metilação do DNA
RNA
Epigenética
Cancer
topic Metilação do DNA
RNA
Epigenética
Cancer
DNA methylation
Long noncoding RNA
Epigenetics
Cancer
dc.subject.en.pt_BR.fl_str_mv DNA methylation
Long noncoding RNA
Epigenetics
Cancer
description Maria de Lourdes Farré Vallve - Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Patologia Experimental. Salvador, BA, Brasil. aCancer Epigenetics and Biology Program (PEBC), Bellvitge Biomedical Research Institute (IDIBELL), L’Hospitalet de Llobregat, 08908 Barcelona, Catalonia, Spain; bCentro de Investigación Biomédica en Red (CIBER) Fisiopatología de la Obesidad y Nutrición (CIBERobn), Instituto Salud Carlos III, 28029 Madrid, Spain; cEndocrine Division, Complejo Hospitalario Universitario de Santiago, 15706 Santiago de Compostela, Spain; dDivision of RNA Biology and Cancer (B150), German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany; eInstitute of Pathology, University Hospital Heidelberg, 69120 Heidelberg, Germany; fExperimental Dermatology and Skin Biology Group, Ramón y Cajal Institute for Biomedical Research (IRYCIS), Ramón y Cajal University Hospital, 28034 Madrid, Spain; gBionanotechnology Laboratory, Bernardo O’Higgins University, Santiago 8370854, Chile; hPathology Department, Hospital Universitari de Bellvitge, IDIBELL, L’Hospitalet de Llobregat, 08907 Barcelona, Catalonia, Spain; iDepartment of Medical Oncology, Catalan Institute of Oncology (ICO), IDIBELL, L’Hospitalet de Llobregat, 08908 Barcelona, Catalonia, Spain; jUnit of Nutrition and Cancer, Cancer Epidemiology Research Program, ICO, IDIBELL, 08908 Barcelona, Catalonia, Spain; kDepartment of Molecular Oncology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, 113-8510 Tokyo, Japan; lProgram Against Cancer Therapeutic Resistance (ProCURE), ICO, IDIBELL, L’Hospitalet del Llobregat, 08908 Barcelona, Catalonia, Spain; mLaboratory of Experimental Pathology (LAPEX), Gonçalo Moniz Research Center, Oswaldo Cruz Foundation (CPQGM/ FIOCRUZ) and National Institute of Science and Technology of Tropical Diseases (INCT/DT), 40296710 Salvador, Bahia, Brazil; nDivision of Cancer Research, Department of Thoracic Surgery, Medical Center–University of Freiburg, 79106 Freiburg, Germany; oFaculty of Medicine, University of Freiburg, 79106 Freiburg, Germany; pGerman Cancer Consortium (DKTK), 79106 Freiburg, Germany; qDepartament de Ciències Fisiològiques II, Escola de Medicina, Universitat de Barcelona, 08907 Barcelona, Catalonia, Spain; and rInstitució Catalana de Recerca i Estudis Avançats (ICREA), 08010 Barcelona, Catalonia, Spain
publishDate 2016
dc.date.issued.fl_str_mv 2016
dc.date.accessioned.fl_str_mv 2017-03-24T13:57:19Z
dc.date.available.fl_str_mv 2017-03-24T13:57:19Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv DIAZ-LAGARES, A. et al. Epigenetic inactivation of the p53-induced long noncoding RNA TP53 target 1 in human cancer. Proceedings of the National Academy of Sciences, E7535–E7544, 2016.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/18161
dc.identifier.issn.pt_BR.fl_str_mv 1091-6490
dc.identifier.doi.none.fl_str_mv 10.1073/pnas.1608585113
identifier_str_mv DIAZ-LAGARES, A. et al. Epigenetic inactivation of the p53-induced long noncoding RNA TP53 target 1 in human cancer. Proceedings of the National Academy of Sciences, E7535–E7544, 2016.
1091-6490
10.1073/pnas.1608585113
url https://www.arca.fiocruz.br/handle/icict/18161
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv National Academy of Sciences
publisher.none.fl_str_mv National Academy of Sciences
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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https://www.arca.fiocruz.br/bitstream/icict/18161/2/Lagares%20AD%20Epigenetic%20inactivation....pdf
https://www.arca.fiocruz.br/bitstream/icict/18161/3/Lagares%20AD%20Epigenetic%20inactivation....pdf.txt
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bitstream.checksumAlgorithm.fl_str_mv MD5
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MD5
repository.name.fl_str_mv Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)
repository.mail.fl_str_mv repositorio.arca@fiocruz.br
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