Isolation and characterization of polyphenols from Euphorbia heterophylla L. (Euphorbiaceae) leaves

Detalhes bibliográficos
Autor(a) principal: Tostes, João Batista de Freitas
Data de Publicação: 2019
Outros Autores: Silva, Antonio Jorge Ribeiro da, Kuster, Ricardo Machado
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/32583
Resumo: Fundação Oswaldo Cruz. Instituto de Tecnologia em Fármacos. Rio de Janeiro, RJ, Brasil.
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spelling Tostes, João Batista de FreitasSilva, Antonio Jorge Ribeiro daKuster, Ricardo Machado2019-04-18T13:29:00Z2019-04-18T13:29:00Z2019TOSTES, João Batista de Freitas; SILVA, Antonio Jorge Ribeiro da; KUSTER, Ricardo Machado. Isolation and characterization of polyphenols from Euphorbia heterophylla L. (Euphorbiaceae) leaves. Revista Fitos,Rio de Janeiro, v. 13, n. 1, p. 49-60, abr. 2019.https://www.arca.fiocruz.br/handle/icict/3258310.17648/2446-4775.2019.6962466-4775Fundação Oswaldo Cruz. Farmanguinhos. Núcleo de Gestão em Biodiversidade e Saúde.Isolation and characterization of polyphenols from Euphorbia heterophylla L. (Euphorbiaceae) leavesinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto de Tecnologia em Fármacos. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Pesquisa de Produtos Naturais Walter B. Mors. Rio de Janeiro, RJ, Brasil.Universidade Federal do Espírito Santo. Departamento de Química. Espírito Santo, ES, Brasil.Many of Euphorbiaceae species are recognized as traditional medicinal plants and the oils and latex of many species have also economic importance. In fact, Euphorbia heterophylla L., belonging to this family and popularly known in Brazil as “leiteira”, “flor-de-poetas” and wild poinsettia, has been used traditionally in Africa and India to treat many kinds of health disorders. However, the chemical composition of this species has been little studied so far. In the present investigation, the flavonoids quercitrin (quercetin 3-O-α-L-rhamnopyranoside), hyperin (quercetin 3-O-β-D-galactopyranoside), isoquercitrin (quercetin 3-O-β-D-glucopyranoside) and isoquercitrin 6”-malonate (quercetin 3-O-β-D-(6”-malonate)-glucopyranoside) were isolated from an ethyl acetate partition of aqueous ketone extract from E. heterophylla leaves. The dehydroellagitannins geraniin and phyllantusiin D as well as 1,2,3,4,6- penta-O-galloyl- β-D-glucopyranoside, caffeic acid  and the coumarin aesculetin (6,7-dihydroxycoumarin) were also isolated. All the compounds were characterized by spectroscopic methods such as 1H and 13C-NMR, COSY, HETCOR, APT and by comparison with literature data. The presence of these substances of relevant bioactivity is reported for the first time in E. heterophylla through our study supporting in this way the medicinal use of this specie.EuphorbiaceaeEuphorbia heterophylla L.PolyphenolsFlavonoid GlycosidesDehydroellagitanninsAesculetininfo:eu-repo/semantics/openAccessengreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txttext/plain1748https://www.arca.fiocruz.br/bitstream/icict/32583/1/license.txt8a4605be74aa9ea9d79846c1fba20a33MD51ORIGINALjoao_batista_freitas_et_all.pdfapplication/pdf323020https://www.arca.fiocruz.br/bitstream/icict/32583/2/joao_batista_freitas_et_all.pdfba36445a720c539332a2eb4cf92d276dMD52TEXTjoao_batista_freitas_et_all.pdf.txtjoao_batista_freitas_et_all.pdf.txtExtracted texttext/plain36779https://www.arca.fiocruz.br/bitstream/icict/32583/3/joao_batista_freitas_et_all.pdf.txtaf1998f8755d24f7926f424c03d7df49MD53icict/325832020-03-25 23:03:29.253oai:www.arca.fiocruz.br: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Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352020-03-26T02:03:29Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Isolation and characterization of polyphenols from Euphorbia heterophylla L. (Euphorbiaceae) leaves
title Isolation and characterization of polyphenols from Euphorbia heterophylla L. (Euphorbiaceae) leaves
spellingShingle Isolation and characterization of polyphenols from Euphorbia heterophylla L. (Euphorbiaceae) leaves
Tostes, João Batista de Freitas
Euphorbiaceae
Euphorbia heterophylla L.
Polyphenols
Flavonoid Glycosides
Dehydroellagitannins
Aesculetin
title_short Isolation and characterization of polyphenols from Euphorbia heterophylla L. (Euphorbiaceae) leaves
title_full Isolation and characterization of polyphenols from Euphorbia heterophylla L. (Euphorbiaceae) leaves
title_fullStr Isolation and characterization of polyphenols from Euphorbia heterophylla L. (Euphorbiaceae) leaves
title_full_unstemmed Isolation and characterization of polyphenols from Euphorbia heterophylla L. (Euphorbiaceae) leaves
title_sort Isolation and characterization of polyphenols from Euphorbia heterophylla L. (Euphorbiaceae) leaves
author Tostes, João Batista de Freitas
author_facet Tostes, João Batista de Freitas
Silva, Antonio Jorge Ribeiro da
Kuster, Ricardo Machado
author_role author
author2 Silva, Antonio Jorge Ribeiro da
Kuster, Ricardo Machado
author2_role author
author
dc.contributor.author.fl_str_mv Tostes, João Batista de Freitas
Silva, Antonio Jorge Ribeiro da
Kuster, Ricardo Machado
dc.subject.en.none.fl_str_mv Euphorbiaceae
Euphorbia heterophylla L.
Polyphenols
Flavonoid Glycosides
Dehydroellagitannins
Aesculetin
topic Euphorbiaceae
Euphorbia heterophylla L.
Polyphenols
Flavonoid Glycosides
Dehydroellagitannins
Aesculetin
description Fundação Oswaldo Cruz. Instituto de Tecnologia em Fármacos. Rio de Janeiro, RJ, Brasil.
publishDate 2019
dc.date.accessioned.fl_str_mv 2019-04-18T13:29:00Z
dc.date.available.fl_str_mv 2019-04-18T13:29:00Z
dc.date.issued.fl_str_mv 2019
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv TOSTES, João Batista de Freitas; SILVA, Antonio Jorge Ribeiro da; KUSTER, Ricardo Machado. Isolation and characterization of polyphenols from Euphorbia heterophylla L. (Euphorbiaceae) leaves. Revista Fitos,Rio de Janeiro, v. 13, n. 1, p. 49-60, abr. 2019.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/32583
dc.identifier.doi.pt_BR.fl_str_mv 10.17648/2446-4775.2019.696
dc.identifier.eissn.pt_BR.fl_str_mv 2466-4775
identifier_str_mv TOSTES, João Batista de Freitas; SILVA, Antonio Jorge Ribeiro da; KUSTER, Ricardo Machado. Isolation and characterization of polyphenols from Euphorbia heterophylla L. (Euphorbiaceae) leaves. Revista Fitos,Rio de Janeiro, v. 13, n. 1, p. 49-60, abr. 2019.
10.17648/2446-4775.2019.696
2466-4775
url https://www.arca.fiocruz.br/handle/icict/32583
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Fundação Oswaldo Cruz. Farmanguinhos. Núcleo de Gestão em Biodiversidade e Saúde.
publisher.none.fl_str_mv Fundação Oswaldo Cruz. Farmanguinhos. Núcleo de Gestão em Biodiversidade e Saúde.
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
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