TNF alpha inhibits apoptotic cell clearance in the lung, exacerbating acute inflammation
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2009 |
| Outros Autores: | , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/9470 |
Resumo: | Department of Pediatrics. Program in Cell Biology. Denver, Colorado / Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil. |
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Borges, Valeria de MatosVandivier, R. WilliamMcPhillips, Kathleen A.Kench, Jennifer A.Morimoto, KonosukeGroshong, Steve D.Richens, Tiffany R.Graham, Brian B.Muldrow, Alaina M.Van Heule, LeaHenson, Peter M.Janssen, William J.2015-02-10T13:26:54Z2015-02-10T13:26:54Z2009BORGES, V. M. et al. TNF alpha inhibits apoptotic cell clearance in the lung, exacerbating acute inflammation. American Journal Physiology Lung Cell Molecular Physiology, v. 297, n. 4, p. 586-595, 2009.1522-1504https://www.arca.fiocruz.br/handle/icict/947010.1152/ajplung.90569.2008engAmerican Physiological SocietyTNF alpha inhibits apoptotic cell clearance in the lung, exacerbating acute inflammationinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleDepartment of Pediatrics. Program in Cell Biology. Denver, Colorado / Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil.National Jewish Health. Department of Medicine. Denver, Colorado, USA.Department of Pediatrics. Program in Cell Biology. Denver, Colorado, USA.Department of Pediatrics. Program in Cell Biology. Denver, Colorado, USA.University of Colorado Health Sciences Center. Division of Pulmonary Sciences and Critical Care Medicine. Department of Medicine. Denver, Colorado, USA / Institute of Tropical Medicine. Nagasaki University. Department of Clinical Medicine. Nagasaki, Japan.National Jewish Health. Department of Medicine. Denver, Colorado, USA.University of Colorado Health Sciences Center. Division of Pulmonary Sciences and Critical Care Medicine. Department of Medicine. Denver, Colorado, USA.University of Colorado Health Sciences Center. Division of Pulmonary Sciences and Critical Care Medicine. Department of Medicine. Denver, Colorado, USA.National Jewish Health. Department of Medicine. Denver, Colorado, USA.National Jewish Health. Department of Medicine. Denver, Colorado, USA.Department of Pediatrics. Program in Cell Biology. Denver, Colorado, USA.National Jewish Health. Department of Medicine. Denver, Colorado, USA / University of Colorado Health Sciences Center. Division of Pulmonary Sciences and Critical Care Medicine. Department of Medicine. Denver, Colorado, USA.Efficient removal of apoptotic cells is essential for resolution of inflammation. Failure to clear dying cells can exacerbate lung injury and lead to persistent inflammation and autoimmunity. Here we show that TNFalpha blocks apoptotic cell clearance by alveolar macrophages and leads to proinflammatory responses in the lung. Compared with mice treated with intratracheal TNFalpha or exogenous apoptotic cells, mice treated with the combination of TNFalpha plus apoptotic cells demonstrated reduced apoptotic cell clearance from the lungs and increased recruitment of inflammatory leukocytes to the air spaces. Treatment with intratracheal TNFalpha had no effect on the removal of exogenous apoptotic cells from the lungs of TNFalpha receptor-1 (p55) and -2 (p75) double mutant mice and no effect on leukocyte recruitment. Bronchoalveolar lavage from mice treated with TNFalpha plus apoptotic cells contained increased levels of proinflammatory cytokines IL-6, KC, and MCP-1, but exhibited no change in levels of anti-inflammatory cytokines IL-10 and TGF-beta. Administration of TNFalpha plus apoptotic cells during LPS-induced lung injury augmented neutrophil accumulation and proinflammatory cytokine production. These findings suggest that the presence of TNFalpha in the lung can alter the response of phagocytes to apoptotic cells leading to inflammatory cell recruitment and proinflammatory mediator production.ApoptosisPhagocytosisApoptose/efeitos de drogasPulmão/patologiaPneumonia/etiologiaFator de Necrose Tumoral alfa/farmacologiaAnimaisEnsaio de Imunoadsorção EnzimáticaFemininoCitometria de FluxoInflamação/etiologiaInterleucina-10/metabolismoLeucócitos/metabolismoLipopolissacarídeos/farmacologiaPulmão/efeitos de drogasMacrófagos Alveolares/citologiaCamundongosCamundongos Endogâmicos BALB CNeutrófilos/metabolismoFagocitosePneumonia/fisiopatologiaReceptores Tipo I de Fatores de Necrose Tumoral/fisiologiainfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-81914https://www.arca.fiocruz.br/bitstream/icict/9470/1/license.txt7d48279ffeed55da8dfe2f8e81f3b81fMD51ORIGINALBorges VM TNFa inhibits...pdfBorges VM TNFa inhibits...pdfapplication/pdf1659310https://www.arca.fiocruz.br/bitstream/icict/9470/2/Borges%20VM%20TNFa%20inhibits...pdf7a5cf45cfd5c24fbebef00744b571b27MD52TEXTBorges VM TNFa inhibits...pdf.txtBorges VM TNFa inhibits...pdf.txtExtracted texttext/plain43340https://www.arca.fiocruz.br/bitstream/icict/9470/3/Borges%20VM%20TNFa%20inhibits...pdf.txt69fabaf85d4ad020706955c31d8bf029MD53icict/94702023-03-15 14:33:04.571oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:33:04Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false |
| dc.title.pt_BR.fl_str_mv |
TNF alpha inhibits apoptotic cell clearance in the lung, exacerbating acute inflammation |
| title |
TNF alpha inhibits apoptotic cell clearance in the lung, exacerbating acute inflammation |
| spellingShingle |
TNF alpha inhibits apoptotic cell clearance in the lung, exacerbating acute inflammation Borges, Valeria de Matos Apoptosis Phagocytosis Apoptose/efeitos de drogas Pulmão/patologia Pneumonia/etiologia Fator de Necrose Tumoral alfa/farmacologia Animais Ensaio de Imunoadsorção Enzimática Feminino Citometria de Fluxo Inflamação/etiologia Interleucina-10/metabolismo Leucócitos/metabolismo Lipopolissacarídeos/farmacologia Pulmão/efeitos de drogas Macrófagos Alveolares/citologia Camundongos Camundongos Endogâmicos BALB C Neutrófilos/metabolismo Fagocitose Pneumonia/fisiopatologia Receptores Tipo I de Fatores de Necrose Tumoral/fisiologia |
| title_short |
TNF alpha inhibits apoptotic cell clearance in the lung, exacerbating acute inflammation |
| title_full |
TNF alpha inhibits apoptotic cell clearance in the lung, exacerbating acute inflammation |
| title_fullStr |
TNF alpha inhibits apoptotic cell clearance in the lung, exacerbating acute inflammation |
| title_full_unstemmed |
TNF alpha inhibits apoptotic cell clearance in the lung, exacerbating acute inflammation |
| title_sort |
TNF alpha inhibits apoptotic cell clearance in the lung, exacerbating acute inflammation |
| author |
Borges, Valeria de Matos |
| author_facet |
Borges, Valeria de Matos Vandivier, R. William McPhillips, Kathleen A. Kench, Jennifer A. Morimoto, Konosuke Groshong, Steve D. Richens, Tiffany R. Graham, Brian B. Muldrow, Alaina M. Van Heule, Lea Henson, Peter M. Janssen, William J. |
| author_role |
author |
| author2 |
Vandivier, R. William McPhillips, Kathleen A. Kench, Jennifer A. Morimoto, Konosuke Groshong, Steve D. Richens, Tiffany R. Graham, Brian B. Muldrow, Alaina M. Van Heule, Lea Henson, Peter M. Janssen, William J. |
| author2_role |
author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Borges, Valeria de Matos Vandivier, R. William McPhillips, Kathleen A. Kench, Jennifer A. Morimoto, Konosuke Groshong, Steve D. Richens, Tiffany R. Graham, Brian B. Muldrow, Alaina M. Van Heule, Lea Henson, Peter M. Janssen, William J. |
| dc.subject.en.pt_BR.fl_str_mv |
Apoptosis Phagocytosis |
| topic |
Apoptosis Phagocytosis Apoptose/efeitos de drogas Pulmão/patologia Pneumonia/etiologia Fator de Necrose Tumoral alfa/farmacologia Animais Ensaio de Imunoadsorção Enzimática Feminino Citometria de Fluxo Inflamação/etiologia Interleucina-10/metabolismo Leucócitos/metabolismo Lipopolissacarídeos/farmacologia Pulmão/efeitos de drogas Macrófagos Alveolares/citologia Camundongos Camundongos Endogâmicos BALB C Neutrófilos/metabolismo Fagocitose Pneumonia/fisiopatologia Receptores Tipo I de Fatores de Necrose Tumoral/fisiologia |
| dc.subject.decs.pt_BR.fl_str_mv |
Apoptose/efeitos de drogas Pulmão/patologia Pneumonia/etiologia Fator de Necrose Tumoral alfa/farmacologia Animais Ensaio de Imunoadsorção Enzimática Feminino Citometria de Fluxo Inflamação/etiologia Interleucina-10/metabolismo Leucócitos/metabolismo Lipopolissacarídeos/farmacologia Pulmão/efeitos de drogas Macrófagos Alveolares/citologia Camundongos Camundongos Endogâmicos BALB C Neutrófilos/metabolismo Fagocitose Pneumonia/fisiopatologia Receptores Tipo I de Fatores de Necrose Tumoral/fisiologia |
| description |
Department of Pediatrics. Program in Cell Biology. Denver, Colorado / Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil. |
| publishDate |
2009 |
| dc.date.issued.fl_str_mv |
2009 |
| dc.date.accessioned.fl_str_mv |
2015-02-10T13:26:54Z |
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2015-02-10T13:26:54Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
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BORGES, V. M. et al. TNF alpha inhibits apoptotic cell clearance in the lung, exacerbating acute inflammation. American Journal Physiology Lung Cell Molecular Physiology, v. 297, n. 4, p. 586-595, 2009. |
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https://www.arca.fiocruz.br/handle/icict/9470 |
| dc.identifier.issn.none.fl_str_mv |
1522-1504 |
| dc.identifier.doi.none.fl_str_mv |
10.1152/ajplung.90569.2008 |
| identifier_str_mv |
BORGES, V. M. et al. TNF alpha inhibits apoptotic cell clearance in the lung, exacerbating acute inflammation. American Journal Physiology Lung Cell Molecular Physiology, v. 297, n. 4, p. 586-595, 2009. 1522-1504 10.1152/ajplung.90569.2008 |
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American Physiological Society |
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American Physiological Society |
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