The role of ST2 and ST2 genetic variants in schistosomiasis

Detalhes bibliográficos
Autor(a) principal: Long, Xin
Data de Publicação: 2017
Outros Autores: Daya, Michelle, Zhao, Jianping, Rafaels, Nicholas, Liang, Huifang, Potee, Joseph, Campbell, Monica, Zhang, Bixiang, Araujo, Maria Ilma Andrade Santos, Oliveira, Ricardo Riccio, Mathias, Rasika A, Gao, Li, Ruczinski, Ingo, Georas, Steve N, Vercelli, Donata, Beaty, Terri H, Barnes, Kathleen C, Chen, Xiaoping, Chen, Qian
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/25808
Resumo: Oliveira, Ricardo Riccio. Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil. aHepatic Surgery Center, bthe Clinical Study Center of Liver Surgery in Hubei Province, and cthe Division of Gastroenterology and Hepatology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan; dthe Johns Hopkins Asthma and Allergy Center, Johns Hopkins University School of Medicine, and ethe Bloomberg School of Public Health, The Johns Hopkins University, Baltimore; fthe Biomedical Informatics and Personalized Medicine, University of Colorado School of Medicine, Aurora; gthe Arizona Respiratory Center, University of Arizona, Tucson; hthe Department ofMedicine, University of Rochester Medical Center, Rochester; ithe Servico de Imunologia, Hospital Universitario Professor Edgard Santos, and jthe Instituto Goncalo Moniz, Fundacao Oswaldo Cruz - Bahia, Salvador - Xin Long, MD, PhD,a,b,d Michelle Daya, PhD,f Jianping Zhao, MD,a,b Nicholas Rafaels, MS,d Huifang Liang, MD, PhD,a,b Joseph Potee, MS,d Monica Campbell, MS,d Bixiang Zhang, MD,a,b Maria Ilma Araujo, PhD,i Ricardo R. Oliveira, MS, PhD,j Rasika A. Mathias, ScD,d Li Gao, MD, PhD,d Ingo Ruczinski, PhD,e Steve N. Georas, MD,h Donata Vercelli, MD,g Terri H. Beaty, PhD,e Kathleen C. Barnes, PhD,d Xiaoping Chen, MD,a,b and Qian Chen, MD, PhD
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spelling Long, XinDaya, MichelleZhao, JianpingRafaels, NicholasLiang, HuifangPotee, JosephCampbell, MonicaZhang, BixiangAraujo, Maria Ilma Andrade SantosOliveira, Ricardo RiccioMathias, Rasika AGao, LiRuczinski, IngoGeoras, Steve NVercelli, DonataBeaty, Terri HBarnes, Kathleen CChen, XiaopingChen, Qian2018-04-12T14:30:20Z2018-04-12T14:30:20Z2017LONG, X. et al. The role of ST2 and ST2 genetic variants in schistosomiasis. Journal of Allergy and Clinical Immunology, v. 140, p. 1416-1422, 2017.0091-6749https://www.arca.fiocruz.br/handle/icict/2580810.1016/j.jaci.2016.12.969Oliveira, Ricardo Riccio. Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil. aHepatic Surgery Center, bthe Clinical Study Center of Liver Surgery in Hubei Province, and cthe Division of Gastroenterology and Hepatology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan; dthe Johns Hopkins Asthma and Allergy Center, Johns Hopkins University School of Medicine, and ethe Bloomberg School of Public Health, The Johns Hopkins University, Baltimore; fthe Biomedical Informatics and Personalized Medicine, University of Colorado School of Medicine, Aurora; gthe Arizona Respiratory Center, University of Arizona, Tucson; hthe Department ofMedicine, University of Rochester Medical Center, Rochester; ithe Servico de Imunologia, Hospital Universitario Professor Edgard Santos, and jthe Instituto Goncalo Moniz, Fundacao Oswaldo Cruz - Bahia, Salvador - Xin Long, MD, PhD,a,b,d Michelle Daya, PhD,f Jianping Zhao, MD,a,b Nicholas Rafaels, MS,d Huifang Liang, MD, PhD,a,b Joseph Potee, MS,d Monica Campbell, MS,d Bixiang Zhang, MD,a,b Maria Ilma Araujo, PhD,i Ricardo R. Oliveira, MS, PhD,j Rasika A. Mathias, ScD,d Li Gao, MD, PhD,d Ingo Ruczinski, PhD,e Steve N. Georas, MD,h Donata Vercelli, MD,g Terri H. Beaty, PhD,e Kathleen C. Barnes, PhD,d Xiaoping Chen, MD,a,b and Qian Chen, MD, PhDNational Institutes of Health (grant R01HL112088), the Mary Beryl Patch Turnbull Scholar Program, the Major and Special Program of National Science and Technology in Twelfth Five-year Plan of China (grant 2012ZX10002016-004), the National Natural Science Foundation of China (grant 81471612), State Key Project on Infection Disease of China (grants 2012ZX10002016-004 and 2012ZX10002010-001- 004), the Natural Science Foundation of Hubei Province, China (grant 2011BCB035), and the Hepatic Surgery Clinical Study Center of Hubei Province, China (grants 2014BKB089 and 2013BCB026).Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, BrasilMúltipla – ver em NotasChronic schistosomiasis and its severe complication, periportal fibrosis, are characterized by a predominant Th2 response. To date, specific single nucleotide polymorphisms in ST2 have been some of the most consistently associated genetic variants for asthma. Objective: We investigated the role of ST2 (a receptor for the TH2 cytokine IL-33) in chronic and late-stage schistosomiasis caused by Schistosoma japonicum and the potential effect of ST2 genetic variants on stage of disease and ST2 expression. Methods: We recruited 947 adult participants (339 with endstage schistosomiasis and liver cirrhosis, 307 with chronic infections without liver fibrosis, and 301 health controls) from a S japonicum–endemic area (Hubei, China). Six ST2 single nucleotide polymorphisms were genotyped. Serum soluble ST2 (sST2) was measured by ELISA, and ST2 expression in normal liver tissues, Hepatitis B virus–induced fibrotic liver tissues, and S japonicum–induced fibrotic liver tissues was measured by immunohistochemistry. Results:We found sST2 levels were significantly higher in the endstage group (36.04 [95% CI, 33.85-38.37]) compared with chronic cases and controls (22.7 [95% CI, 22.0-23.4], P < 1E-10). In addition, S japonicum–induced fibrotic liver tissues showed increased ST2 staining compared with normal liver tissues (P5.0001). Markers rs12712135, rs1420101, and rs6543119 were strongly associated with sST2 levels (P52E-10, 5E-05, and 6E-05, respectively), and these results were replicated in an independent cohort from Brazil living in a S mansoni endemic region. Conclusions: We demonstrate for the first time that end-stage schistosomiasis is associated with elevated sST2 levels and show that ST2 genetic variants are associated with sST2 levels in patients with schistosomiasis.engElseviersST2ST2Schistosoma japonicumCirrose hepáticasST2ST2Schistosoma japonicumLiver cirrhosis immunohistochemistryThe role of ST2 and ST2 genetic variants in schistosomiasisinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/25808/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALLong X The role of ST2 and ST2 genetic variants....pdfLong X The role of ST2 and ST2 genetic 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dc.title.pt_BR.fl_str_mv The role of ST2 and ST2 genetic variants in schistosomiasis
title The role of ST2 and ST2 genetic variants in schistosomiasis
spellingShingle The role of ST2 and ST2 genetic variants in schistosomiasis
Long, Xin
sST2
ST2
Schistosoma japonicum
Cirrose hepática
sST2
ST2
Schistosoma japonicum
Liver cirrhosis immunohistochemistry
title_short The role of ST2 and ST2 genetic variants in schistosomiasis
title_full The role of ST2 and ST2 genetic variants in schistosomiasis
title_fullStr The role of ST2 and ST2 genetic variants in schistosomiasis
title_full_unstemmed The role of ST2 and ST2 genetic variants in schistosomiasis
title_sort The role of ST2 and ST2 genetic variants in schistosomiasis
author Long, Xin
author_facet Long, Xin
Daya, Michelle
Zhao, Jianping
Rafaels, Nicholas
Liang, Huifang
Potee, Joseph
Campbell, Monica
Zhang, Bixiang
Araujo, Maria Ilma Andrade Santos
Oliveira, Ricardo Riccio
Mathias, Rasika A
Gao, Li
Ruczinski, Ingo
Georas, Steve N
Vercelli, Donata
Beaty, Terri H
Barnes, Kathleen C
Chen, Xiaoping
Chen, Qian
author_role author
author2 Daya, Michelle
Zhao, Jianping
Rafaels, Nicholas
Liang, Huifang
Potee, Joseph
Campbell, Monica
Zhang, Bixiang
Araujo, Maria Ilma Andrade Santos
Oliveira, Ricardo Riccio
Mathias, Rasika A
Gao, Li
Ruczinski, Ingo
Georas, Steve N
Vercelli, Donata
Beaty, Terri H
Barnes, Kathleen C
Chen, Xiaoping
Chen, Qian
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Long, Xin
Daya, Michelle
Zhao, Jianping
Rafaels, Nicholas
Liang, Huifang
Potee, Joseph
Campbell, Monica
Zhang, Bixiang
Araujo, Maria Ilma Andrade Santos
Oliveira, Ricardo Riccio
Mathias, Rasika A
Gao, Li
Ruczinski, Ingo
Georas, Steve N
Vercelli, Donata
Beaty, Terri H
Barnes, Kathleen C
Chen, Xiaoping
Chen, Qian
dc.subject.other.pt_BR.fl_str_mv sST2
ST2
Schistosoma japonicum
Cirrose hepática
topic sST2
ST2
Schistosoma japonicum
Cirrose hepática
sST2
ST2
Schistosoma japonicum
Liver cirrhosis immunohistochemistry
dc.subject.en.pt_BR.fl_str_mv sST2
ST2
Schistosoma japonicum
Liver cirrhosis immunohistochemistry
description Oliveira, Ricardo Riccio. Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil. aHepatic Surgery Center, bthe Clinical Study Center of Liver Surgery in Hubei Province, and cthe Division of Gastroenterology and Hepatology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan; dthe Johns Hopkins Asthma and Allergy Center, Johns Hopkins University School of Medicine, and ethe Bloomberg School of Public Health, The Johns Hopkins University, Baltimore; fthe Biomedical Informatics and Personalized Medicine, University of Colorado School of Medicine, Aurora; gthe Arizona Respiratory Center, University of Arizona, Tucson; hthe Department ofMedicine, University of Rochester Medical Center, Rochester; ithe Servico de Imunologia, Hospital Universitario Professor Edgard Santos, and jthe Instituto Goncalo Moniz, Fundacao Oswaldo Cruz - Bahia, Salvador - Xin Long, MD, PhD,a,b,d Michelle Daya, PhD,f Jianping Zhao, MD,a,b Nicholas Rafaels, MS,d Huifang Liang, MD, PhD,a,b Joseph Potee, MS,d Monica Campbell, MS,d Bixiang Zhang, MD,a,b Maria Ilma Araujo, PhD,i Ricardo R. Oliveira, MS, PhD,j Rasika A. Mathias, ScD,d Li Gao, MD, PhD,d Ingo Ruczinski, PhD,e Steve N. Georas, MD,h Donata Vercelli, MD,g Terri H. Beaty, PhD,e Kathleen C. Barnes, PhD,d Xiaoping Chen, MD,a,b and Qian Chen, MD, PhD
publishDate 2017
dc.date.issued.fl_str_mv 2017
dc.date.accessioned.fl_str_mv 2018-04-12T14:30:20Z
dc.date.available.fl_str_mv 2018-04-12T14:30:20Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
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dc.identifier.citation.fl_str_mv LONG, X. et al. The role of ST2 and ST2 genetic variants in schistosomiasis. Journal of Allergy and Clinical Immunology, v. 140, p. 1416-1422, 2017.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/25808
dc.identifier.issn.pt_BR.fl_str_mv 0091-6749
dc.identifier.doi.none.fl_str_mv 10.1016/j.jaci.2016.12.969
identifier_str_mv LONG, X. et al. The role of ST2 and ST2 genetic variants in schistosomiasis. Journal of Allergy and Clinical Immunology, v. 140, p. 1416-1422, 2017.
0091-6749
10.1016/j.jaci.2016.12.969
url https://www.arca.fiocruz.br/handle/icict/25808
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dc.publisher.none.fl_str_mv Elsevier
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