Is endothelial microvascular function equally impaired among patients with chronic Chagas and ischemic cardiomyopathy?

Detalhes bibliográficos
Autor(a) principal: Borges, Juliana Pereira
Data de Publicação: 2018
Outros Autores: Mendes, Fernanda de Souza Nogueira Sardinha, Lopes, Gabriella de Oliveira, Sousa, Andréa Silvestre de, Mediano, Mauro Felippe Felix, Tibiriçá, Eduardo
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/33949
Resumo: 2020-07-10
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spelling Borges, Juliana PereiraMendes, Fernanda de Souza Nogueira SardinhaLopes, Gabriella de OliveiraSousa, Andréa Silvestre deMediano, Mauro Felippe FelixTibiriçá, Eduardo2019-07-10T14:41:14Z2019-07-10T14:41:14Z2018BORGES, Juliana Pereira et al. Is endothelial microvascular function equally impaired among patientswith chronic Chagas and ischemic cardiomyopathy? International Journal of Cardiology, v. 265, p. 35-37, 2018.0167-5273https://www.arca.fiocruz.br/handle/icict/3394910.1016/j.ijcard.2018.04.133engElsevierIs endothelial microvascular function equally impaired among patients with chronic Chagas and ischemic cardiomyopathy?info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article2020-07-10State University of Rio de Janeiro. Laboratory of Physical Activity and Health Promotion. Rio de Janeiro, RJ, Brazil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil / Ministry of Health. National Institute of Cardiology. Rio de Janeiro, RJ, Brazil .Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.Ministry of Health. National Institute of Cardiology. Rio de Janeiro, RJ, Brazil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Investigação Cardiovascular. Rio de Janeiro, RJ, Brasil.Background: Chronic Chagas cardiomyopathy (CCC) and cardiomyopathies due to other etiologies involve differences in pathophysiological pathways that are still unclear. Systemic microvascular abnormalities are associatedwith the pathogenesis of ischemic heart disease. However, systemic microvascular endothelial function in CCCremains to be elucidated. Thus, we compared the microvascular endothelial function of patients presentingwith CCC to those with ischemic cardiomyopathy disease. Methods: Microvascular reactivity was assessed in 21 patients with cardiomyopathy secondary to Chagas disease, 21 patients with cardiomyopathy secondary to ischemic disease and 21 healthy controls. Microvascular bloodflow was assessed in the skin of the forearm using laser speckle contrast imaging coupled with iontophoresisof acetylcholine (ACh). Results: Peak increase in forearm bloodflow with ACh iontophoresis in relation to baseline was greater in healthy controls than in patients with heart disease (controls: 162.7 ± 58.4%vs. ischemic heart disease: 74.1± 48.3% andChagas: 85.1 ± 68.1%; pb0.0001). Patients with Chagas and ischemic cardiomyopathy presented similar ACh-induced changes from baseline in skin bloodflow (p = 0.55).Conclusion:Endothelial microvascular function was equally impaired among patients with CCC and ischemic cardiomyopathy.Chagas heart diseaseIschemic heart diseaseCoronary artery diseaseEndothelial functionCutaneous vascular conductanceMicrovascular flowmetryinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83104https://www.arca.fiocruz.br/bitstream/icict/33949/1/license.txt79178e5f2a0eb066867a274556814938MD51ORIGINALve_Borges_Juliana_etal_INI_2018.pdfve_Borges_Juliana_etal_INI_2018.pdfapplication/pdf368744https://www.arca.fiocruz.br/bitstream/icict/33949/2/ve_Borges_Juliana_etal_INI_2018.pdfcebba818dace8cf329293f50c5976742MD52TEXTve_Borges_Juliana_etal_INI_2018.pdf.txtve_Borges_Juliana_etal_INI_2018.pdf.txtExtracted 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dc.title.pt_BR.fl_str_mv Is endothelial microvascular function equally impaired among patients with chronic Chagas and ischemic cardiomyopathy?
title Is endothelial microvascular function equally impaired among patients with chronic Chagas and ischemic cardiomyopathy?
spellingShingle Is endothelial microvascular function equally impaired among patients with chronic Chagas and ischemic cardiomyopathy?
Borges, Juliana Pereira
Chagas heart disease
Ischemic heart disease
Coronary artery disease
Endothelial function
Cutaneous vascular conductance
Microvascular flowmetry
title_short Is endothelial microvascular function equally impaired among patients with chronic Chagas and ischemic cardiomyopathy?
title_full Is endothelial microvascular function equally impaired among patients with chronic Chagas and ischemic cardiomyopathy?
title_fullStr Is endothelial microvascular function equally impaired among patients with chronic Chagas and ischemic cardiomyopathy?
title_full_unstemmed Is endothelial microvascular function equally impaired among patients with chronic Chagas and ischemic cardiomyopathy?
title_sort Is endothelial microvascular function equally impaired among patients with chronic Chagas and ischemic cardiomyopathy?
author Borges, Juliana Pereira
author_facet Borges, Juliana Pereira
Mendes, Fernanda de Souza Nogueira Sardinha
Lopes, Gabriella de Oliveira
Sousa, Andréa Silvestre de
Mediano, Mauro Felippe Felix
Tibiriçá, Eduardo
author_role author
author2 Mendes, Fernanda de Souza Nogueira Sardinha
Lopes, Gabriella de Oliveira
Sousa, Andréa Silvestre de
Mediano, Mauro Felippe Felix
Tibiriçá, Eduardo
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Borges, Juliana Pereira
Mendes, Fernanda de Souza Nogueira Sardinha
Lopes, Gabriella de Oliveira
Sousa, Andréa Silvestre de
Mediano, Mauro Felippe Felix
Tibiriçá, Eduardo
dc.subject.en.pt_BR.fl_str_mv Chagas heart disease
Ischemic heart disease
Coronary artery disease
Endothelial function
Cutaneous vascular conductance
Microvascular flowmetry
topic Chagas heart disease
Ischemic heart disease
Coronary artery disease
Endothelial function
Cutaneous vascular conductance
Microvascular flowmetry
description 2020-07-10
publishDate 2018
dc.date.issued.fl_str_mv 2018
dc.date.accessioned.fl_str_mv 2019-07-10T14:41:14Z
dc.date.available.fl_str_mv 2019-07-10T14:41:14Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv BORGES, Juliana Pereira et al. Is endothelial microvascular function equally impaired among patientswith chronic Chagas and ischemic cardiomyopathy? International Journal of Cardiology, v. 265, p. 35-37, 2018.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/33949
dc.identifier.issn.pt_BR.fl_str_mv 0167-5273
dc.identifier.doi.none.fl_str_mv 10.1016/j.ijcard.2018.04.133
identifier_str_mv BORGES, Juliana Pereira et al. Is endothelial microvascular function equally impaired among patientswith chronic Chagas and ischemic cardiomyopathy? International Journal of Cardiology, v. 265, p. 35-37, 2018.
0167-5273
10.1016/j.ijcard.2018.04.133
url https://www.arca.fiocruz.br/handle/icict/33949
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
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reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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