Is endothelial microvascular function equally impaired among patients with chronic Chagas and ischemic cardiomyopathy?
Autor(a) principal: | |
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Data de Publicação: | 2018 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
DOI: | 10.1016/j.ijcard.2018.04.133 |
Texto Completo: | https://www.arca.fiocruz.br/handle/icict/33949 |
Resumo: | 2020-07-10 |
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Borges, Juliana PereiraMendes, Fernanda de Souza Nogueira SardinhaLopes, Gabriella de OliveiraSousa, Andréa Silvestre deMediano, Mauro Felippe FelixTibiriçá, Eduardo2019-07-10T14:41:14Z2019-07-10T14:41:14Z2018BORGES, Juliana Pereira et al. Is endothelial microvascular function equally impaired among patientswith chronic Chagas and ischemic cardiomyopathy? International Journal of Cardiology, v. 265, p. 35-37, 2018.0167-5273https://www.arca.fiocruz.br/handle/icict/3394910.1016/j.ijcard.2018.04.133engElsevierIs endothelial microvascular function equally impaired among patients with chronic Chagas and ischemic cardiomyopathy?info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article2020-07-10State University of Rio de Janeiro. Laboratory of Physical Activity and Health Promotion. Rio de Janeiro, RJ, Brazil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil / Ministry of Health. National Institute of Cardiology. Rio de Janeiro, RJ, Brazil .Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.Ministry of Health. National Institute of Cardiology. Rio de Janeiro, RJ, Brazil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Investigação Cardiovascular. Rio de Janeiro, RJ, Brasil.Background: Chronic Chagas cardiomyopathy (CCC) and cardiomyopathies due to other etiologies involve differences in pathophysiological pathways that are still unclear. Systemic microvascular abnormalities are associatedwith the pathogenesis of ischemic heart disease. However, systemic microvascular endothelial function in CCCremains to be elucidated. Thus, we compared the microvascular endothelial function of patients presentingwith CCC to those with ischemic cardiomyopathy disease. Methods: Microvascular reactivity was assessed in 21 patients with cardiomyopathy secondary to Chagas disease, 21 patients with cardiomyopathy secondary to ischemic disease and 21 healthy controls. Microvascular bloodflow was assessed in the skin of the forearm using laser speckle contrast imaging coupled with iontophoresisof acetylcholine (ACh). Results: Peak increase in forearm bloodflow with ACh iontophoresis in relation to baseline was greater in healthy controls than in patients with heart disease (controls: 162.7 ± 58.4%vs. ischemic heart disease: 74.1± 48.3% andChagas: 85.1 ± 68.1%; pb0.0001). Patients with Chagas and ischemic cardiomyopathy presented similar ACh-induced changes from baseline in skin bloodflow (p = 0.55).Conclusion:Endothelial microvascular function was equally impaired among patients with CCC and ischemic cardiomyopathy.Chagas heart diseaseIschemic heart diseaseCoronary artery diseaseEndothelial functionCutaneous vascular conductanceMicrovascular flowmetryinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83104https://www.arca.fiocruz.br/bitstream/icict/33949/1/license.txt79178e5f2a0eb066867a274556814938MD51ORIGINALve_Borges_Juliana_etal_INI_2018.pdfve_Borges_Juliana_etal_INI_2018.pdfapplication/pdf368744https://www.arca.fiocruz.br/bitstream/icict/33949/2/ve_Borges_Juliana_etal_INI_2018.pdfcebba818dace8cf329293f50c5976742MD52TEXTve_Borges_Juliana_etal_INI_2018.pdf.txtve_Borges_Juliana_etal_INI_2018.pdf.txtExtracted 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dc.title.pt_BR.fl_str_mv |
Is endothelial microvascular function equally impaired among patients with chronic Chagas and ischemic cardiomyopathy? |
title |
Is endothelial microvascular function equally impaired among patients with chronic Chagas and ischemic cardiomyopathy? |
spellingShingle |
Is endothelial microvascular function equally impaired among patients with chronic Chagas and ischemic cardiomyopathy? Borges, Juliana Pereira Chagas heart disease Ischemic heart disease Coronary artery disease Endothelial function Cutaneous vascular conductance Microvascular flowmetry |
title_short |
Is endothelial microvascular function equally impaired among patients with chronic Chagas and ischemic cardiomyopathy? |
title_full |
Is endothelial microvascular function equally impaired among patients with chronic Chagas and ischemic cardiomyopathy? |
title_fullStr |
Is endothelial microvascular function equally impaired among patients with chronic Chagas and ischemic cardiomyopathy? |
title_full_unstemmed |
Is endothelial microvascular function equally impaired among patients with chronic Chagas and ischemic cardiomyopathy? |
title_sort |
Is endothelial microvascular function equally impaired among patients with chronic Chagas and ischemic cardiomyopathy? |
author |
Borges, Juliana Pereira |
author_facet |
Borges, Juliana Pereira Mendes, Fernanda de Souza Nogueira Sardinha Lopes, Gabriella de Oliveira Sousa, Andréa Silvestre de Mediano, Mauro Felippe Felix Tibiriçá, Eduardo |
author_role |
author |
author2 |
Mendes, Fernanda de Souza Nogueira Sardinha Lopes, Gabriella de Oliveira Sousa, Andréa Silvestre de Mediano, Mauro Felippe Felix Tibiriçá, Eduardo |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Borges, Juliana Pereira Mendes, Fernanda de Souza Nogueira Sardinha Lopes, Gabriella de Oliveira Sousa, Andréa Silvestre de Mediano, Mauro Felippe Felix Tibiriçá, Eduardo |
dc.subject.en.pt_BR.fl_str_mv |
Chagas heart disease Ischemic heart disease Coronary artery disease Endothelial function Cutaneous vascular conductance Microvascular flowmetry |
topic |
Chagas heart disease Ischemic heart disease Coronary artery disease Endothelial function Cutaneous vascular conductance Microvascular flowmetry |
description |
2020-07-10 |
publishDate |
2018 |
dc.date.issued.fl_str_mv |
2018 |
dc.date.accessioned.fl_str_mv |
2019-07-10T14:41:14Z |
dc.date.available.fl_str_mv |
2019-07-10T14:41:14Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
BORGES, Juliana Pereira et al. Is endothelial microvascular function equally impaired among patientswith chronic Chagas and ischemic cardiomyopathy? International Journal of Cardiology, v. 265, p. 35-37, 2018. |
dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/33949 |
dc.identifier.issn.pt_BR.fl_str_mv |
0167-5273 |
dc.identifier.doi.none.fl_str_mv |
10.1016/j.ijcard.2018.04.133 |
identifier_str_mv |
BORGES, Juliana Pereira et al. Is endothelial microvascular function equally impaired among patientswith chronic Chagas and ischemic cardiomyopathy? International Journal of Cardiology, v. 265, p. 35-37, 2018. 0167-5273 10.1016/j.ijcard.2018.04.133 |
url |
https://www.arca.fiocruz.br/handle/icict/33949 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.publisher.none.fl_str_mv |
Elsevier |
publisher.none.fl_str_mv |
Elsevier |
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reponame:Repositório Institucional da FIOCRUZ (ARCA) instname:Fundação Oswaldo Cruz (FIOCRUZ) instacron:FIOCRUZ |
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Fundação Oswaldo Cruz (FIOCRUZ) |
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FIOCRUZ |
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FIOCRUZ |
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