Blockade of TLR2 and TLR4 Attenuates Inflammatory Response and Parasite Load in Cutaneous Leishmaniasis
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2021 |
| Outros Autores: | , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/50231 |
Resumo: | National Institutes of Health (AI 136032 to EC). EC and OB are senior researchers at the Brazilian Council for Scientific and Technological Development (Conselho Nacional de Desenvolvimento Cientı́fico e Tecnológico (CNPq). |
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Carneiro, Pedro PauloDórea, Andreza S.Oliveira, Walker N.Guimarães, Luiz HenriqueBrodskyn, Claúdia IdaCarvalho, Edgar Marcelino deBacellar, Olıvia2021-12-09T12:56:28Z2021-12-09T12:56:28Z2021CARNEIRO, Pedro Paulo et al. Blockade of TLR2 and TLR4 Attenuates Inflammatory Response and Parasite Load in Cutaneous Leishmaniasis. Frontiers in Immunology, 2021.1664-3224https://www.arca.fiocruz.br/handle/icict/5023110.3389/fimmu.2021.706510National Institutes of Health (AI 136032 to EC). EC and OB are senior researchers at the Brazilian Council for Scientific and Technological Development (Conselho Nacional de Desenvolvimento Cientı́fico e Tecnológico (CNPq).Universidade Federal da Bahia. Hospital Universitário Prof. Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil.Universidade Federal da Bahia. Hospital Universitário Prof. Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil.Universidade Federal da Bahia. Hospital Universitário Prof. Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil.Universidade Federal do Sul da Bahia. Faculdade de Medicina. Teixeira de Freitas, BA, Brazil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Ministério da Ciência e Tecnologia. Instituto Nacional de Ciência e Tecnologia de Doenças Tropicais. Conselho Nacional de Desenvolvimento Científico e Tecnológico. Salvador, BA, Brasil.Fundação Estatal Saúde da Família. Instituto Gonçalo Moniz. Fundação Oswaldo Cruz. Salvador, BA, Brasil.Universidade Federal da Bahia. Hospital Universitário Prof. Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil / Fundação Estatal Saúde da Família. Instituto Gonçalo Moniz. Fundação Oswaldo Cruz. Salvador, BA, Brasil.Human cutaneous leishmaniasis (CL) caused by Leishmania braziliensis is characterized by a pronounced inflammatory response associated with ulcer development. Monocytes/ macrophages, the main cells harboring parasites, are largely responsible for parasite control. Toll-like receptor (TLR) signaling leads to the transcription of inflammatory mediators, such as IL-1b and TNF during innate immune response. TLR antagonists have been used in the treatment of inflammatory disease. The neutralization of these receptors may attenuate an exacerbated inflammatory response.We evaluated the ability of TLR2 and TLR4 antagonists to modulate host immune response in L. braziliensis-infected monocytes and cells from CL patient skin lesions. Following TLR2 and TLR4 neutralization, decreased numbers of infected cells and internalized parasites were detected in CL patient monocytes. In addition, reductions in oxidative burst, IL-1b, TNF and CXCL9 production were observed. TNF production by cells from CL lesions also decreased after TLR2 and TLR4 neutralization. The attenuation of host inflammatory response after neutralizing these receptors suggests the potential of TLR antagonists as immunomodulators in association with antimonial therapy in human cutaneous leishmaniasisengFrontiers MediaImunidade inataCitocinasLeishmaniose cutâneaLeishmania braziliensisReceptores toll-likeinnate immunityCytokinesCutaneous leishmaniasisLeishmania braziliensisToll-like receptorsBlockade of TLR2 and TLR4 Attenuates Inflammatory Response and Parasite Load in Cutaneous Leishmaniasisinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83097https://www.arca.fiocruz.br/bitstream/icict/50231/1/license.txt36b51ef91c52b5338d9d29ba0cc807bcMD51ORIGINALCarneiro, Pedro Paulo Blockead.pdfCarneiro, Pedro Paulo Blockead.pdfapplication/pdf6383133https://www.arca.fiocruz.br/bitstream/icict/50231/2/Carneiro%2c%20Pedro%20Paulo%20Blockead.pdf46a5d8a4887375af1a4ee1b1d00edbd3MD52icict/502312023-03-15 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| dc.title.pt_BR.fl_str_mv |
Blockade of TLR2 and TLR4 Attenuates Inflammatory Response and Parasite Load in Cutaneous Leishmaniasis |
| title |
Blockade of TLR2 and TLR4 Attenuates Inflammatory Response and Parasite Load in Cutaneous Leishmaniasis |
| spellingShingle |
Blockade of TLR2 and TLR4 Attenuates Inflammatory Response and Parasite Load in Cutaneous Leishmaniasis Carneiro, Pedro Paulo Imunidade inata Citocinas Leishmaniose cutânea Leishmania braziliensis Receptores toll-like innate immunity Cytokines Cutaneous leishmaniasis Leishmania braziliensis Toll-like receptors |
| title_short |
Blockade of TLR2 and TLR4 Attenuates Inflammatory Response and Parasite Load in Cutaneous Leishmaniasis |
| title_full |
Blockade of TLR2 and TLR4 Attenuates Inflammatory Response and Parasite Load in Cutaneous Leishmaniasis |
| title_fullStr |
Blockade of TLR2 and TLR4 Attenuates Inflammatory Response and Parasite Load in Cutaneous Leishmaniasis |
| title_full_unstemmed |
Blockade of TLR2 and TLR4 Attenuates Inflammatory Response and Parasite Load in Cutaneous Leishmaniasis |
| title_sort |
Blockade of TLR2 and TLR4 Attenuates Inflammatory Response and Parasite Load in Cutaneous Leishmaniasis |
| author |
Carneiro, Pedro Paulo |
| author_facet |
Carneiro, Pedro Paulo Dórea, Andreza S. Oliveira, Walker N. Guimarães, Luiz Henrique Brodskyn, Claúdia Ida Carvalho, Edgar Marcelino de Bacellar, Olıvia |
| author_role |
author |
| author2 |
Dórea, Andreza S. Oliveira, Walker N. Guimarães, Luiz Henrique Brodskyn, Claúdia Ida Carvalho, Edgar Marcelino de Bacellar, Olıvia |
| author2_role |
author author author author author author |
| dc.contributor.author.fl_str_mv |
Carneiro, Pedro Paulo Dórea, Andreza S. Oliveira, Walker N. Guimarães, Luiz Henrique Brodskyn, Claúdia Ida Carvalho, Edgar Marcelino de Bacellar, Olıvia |
| dc.subject.other.pt_BR.fl_str_mv |
Imunidade inata Citocinas Leishmaniose cutânea Leishmania braziliensis Receptores toll-like |
| topic |
Imunidade inata Citocinas Leishmaniose cutânea Leishmania braziliensis Receptores toll-like innate immunity Cytokines Cutaneous leishmaniasis Leishmania braziliensis Toll-like receptors |
| dc.subject.en.pt_BR.fl_str_mv |
innate immunity Cytokines Cutaneous leishmaniasis Leishmania braziliensis Toll-like receptors |
| description |
National Institutes of Health (AI 136032 to EC). EC and OB are senior researchers at the Brazilian Council for Scientific and Technological Development (Conselho Nacional de Desenvolvimento Cientı́fico e Tecnológico (CNPq). |
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2021 |
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2021-12-09T12:56:28Z |
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2021-12-09T12:56:28Z |
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2021 |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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CARNEIRO, Pedro Paulo et al. Blockade of TLR2 and TLR4 Attenuates Inflammatory Response and Parasite Load in Cutaneous Leishmaniasis. Frontiers in Immunology, 2021. |
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https://www.arca.fiocruz.br/handle/icict/50231 |
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1664-3224 |
| dc.identifier.doi.none.fl_str_mv |
10.3389/fimmu.2021.706510 |
| identifier_str_mv |
CARNEIRO, Pedro Paulo et al. Blockade of TLR2 and TLR4 Attenuates Inflammatory Response and Parasite Load in Cutaneous Leishmaniasis. Frontiers in Immunology, 2021. 1664-3224 10.3389/fimmu.2021.706510 |
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