Strongyloidiasis and infective dermatitis alter human T lymphotropic virus-1 clonality in vivo.

Detalhes bibliográficos
Autor(a) principal: Gillet, Nicolas A
Data de Publicação: 2013
Outros Autores: Cook, Lucy, Laydon, Daniel J, Hlela, Carol, Verdonck, Kristien, Alvarez, Carolina, Gotuzzo, Eduardo, Clark, Daniel, Vallve, Maria de Lourdes Farre, Bittencourt, Achilea Candida Lisboa, Asquith, Becca, Taylor, Graham P, Bangham, Charles R. M
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/8766
Resumo: Wright-Fleming Institute. Imperial College London. London, United Kingdom / University of Liège (ULg). Molecular and Cellular Epigenetics. Interdisciplinary Cluster for Applied Genoproteomics (GIGA). Liège, Belgium
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spelling Gillet, Nicolas ACook, LucyLaydon, Daniel JHlela, CarolVerdonck, KristienAlvarez, CarolinaGotuzzo, EduardoClark, DanielVallve, Maria de Lourdes FarreBittencourt, Achilea Candida LisboaAsquith, BeccaTaylor, Graham PBangham, Charles R. M2014-11-07T17:18:41Z2014-11-07T17:18:41Z2013GILLET, N. A. et al. Strongyloidiasis and infective dermatitis alter human T lymphotropic virus-1 clonality in vivo. PLoS Pathogens, v. 9, n. 4, p. e1003263, 2013.1553-7374https://www.arca.fiocruz.br/handle/icict/876610.1371/journal.ppat.1003263engPublic Library of ScienceStrongyloidiasis and infective dermatitis alter human T lymphotropic virus-1 clonality in vivo.info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleWright-Fleming Institute. Imperial College London. London, United Kingdom / University of Liège (ULg). Molecular and Cellular Epigenetics. Interdisciplinary Cluster for Applied Genoproteomics (GIGA). Liège, BelgiumWright-Fleming Institute. Imperial College London. London, United KingdomWright-Fleming Institute. Imperial College London. London, United KingdomWright-Fleming Institute. Imperial College London. London, United KingdomUniversidad Peruana Cayetano Heredia. Instituto de Medicina Tropical Alexander von Humboldt. Lima, Peru / Hospital Nacional Cayetano Heredia. Lima, Peru / Institute of Tropical Medicine. Antwerp, BelgiumUniversidad Peruana Cayetano Heredia. Instituto de Medicina Tropical Alexander von Humboldt. Lima, Peru / Hospital Nacional Cayetano Heredia. Lima, PeruUniversidad Peruana Cayetano Heredia. Instituto de Medicina Tropical Alexander von Humboldt. Lima, Peru / Hospital Nacional Cayetano Heredia. Lima, PeruUniversidad Peruana Cayetano Heredia. Instituto de Medicina Tropical Alexander von Humboldt. Lima, Peru / Hospital Nacional Cayetano Heredia. Lima, PeruFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Patologia Experimental. Salvador, BA, BrasilFederal University of Bahia. Complexo Hospitalar Universitário Prof. Edgard Santos. Department of Pathology. Salvador, BA, BrasilWright-Fleming Institute. Imperial College London. London, United KingdomWright-Fleming Institute. Section of Infectious Diseases. Imperial College London. London, United KingdomWright-Fleming Institute. Imperial College London. London, United KingdomHuman T-lymphotropic Virus-1 (HTLV-1) is a retrovirus that persists lifelong by driving clonal proliferation of infected T-cells. HTLV-1 causes a neuroinflammatory disease and adult T-cell leukemia/lymphoma. Strongyloidiasis, a gastrointestinal infection by the helminth Strongyloides stercoralis, and Infective Dermatitis associated with HTLV-1 (IDH), appear to be risk factors for the development of HTLV-1 related diseases. We used high-throughput sequencing to map and quantify the insertion sites of the provirus in order to monitor the clonality of the HTLV-1-infected T-cell population (i.e. the number of distinct clones and abundance of each clone). A newly developed biodiversity estimator called "DivE" was used to estimate the total number of clones in the blood. We found that the major determinant of proviral load in all subjects without leukemia/lymphoma was the total number of HTLV-1-infected clones. Nevertheless, the significantly higher proviral load in patients with strongyloidiasis or IDH was due to an increase in the mean clone abundance, not to an increase in the number of infected clones. These patients appear to be less capable of restricting clone abundance than those with HTLV-1 alone. In patients co-infected with Strongyloides there was an increased degree of oligoclonal expansion and a higher rate of turnover (i.e. appearance and disappearance) of HTLV-1-infected clones. In Strongyloides co-infected patients and those with IDH, proliferation of the most abundant HTLV-1â º T-cell clones is independent of the genomic environment of the provirus, in sharp contrast to patients with HTLV-1 infection alone. This implies that new selection forces are driving oligoclonal proliferation in Strongyloides co-infection and IDH. We conclude that strongyloidiasis and IDH increase the risk of development of HTLV-1-associated diseases by increasing the rate of infection of new clones and the abundance of existing HTLV-1â º clones.Dermatite/complicaçõesInfecções por HTLV-I/complicaçõesVírus 1 Linfotrópico T Humano/fisiologiaStrongyloides stercoralisEstrongiloidíase/complicaçõesLinfócitos T/virologiaCarga ViralAdultoAnimaisCoinfecçãoInfecções por HTLV-I/virologiaVírus 1 Linfotrópico T Humano/genéticaHumanosLeucemia-Linfoma de Células T do Adulto/virologiaMeia-IdadeProvirus/fisiologiaFatores de RiscoEstrongiloidíase/parasitologiainfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALGillet, NA Strongyloidiasis....pdfGillet, NA Strongyloidiasis....pdfapplication/pdf1059336https://www.arca.fiocruz.br/bitstream/icict/8766/2/Gillet%2c%20NA%20Strongyloidiasis....pdf232799195c15409c16eb6fad2b1d9470MD52LICENSElicense.txtlicense.txttext/plain; charset=utf-81914https://www.arca.fiocruz.br/bitstream/icict/8766/3/license.txt7d48279ffeed55da8dfe2f8e81f3b81fMD53TEXTGillet, NA Strongyloidiasis....pdf.txtGillet, NA Strongyloidiasis....pdf.txtExtracted texttext/plain59827https://www.arca.fiocruz.br/bitstream/icict/8766/4/Gillet%2c%20NA%20Strongyloidiasis....pdf.txt84c2f6dc97b464f35ea4cf0d25aa7cc0MD54icict/87662023-03-15 14:33:06.645oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:33:06Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Strongyloidiasis and infective dermatitis alter human T lymphotropic virus-1 clonality in vivo.
title Strongyloidiasis and infective dermatitis alter human T lymphotropic virus-1 clonality in vivo.
spellingShingle Strongyloidiasis and infective dermatitis alter human T lymphotropic virus-1 clonality in vivo.
Gillet, Nicolas A
Dermatite/complicações
Infecções por HTLV-I/complicações
Vírus 1 Linfotrópico T Humano/fisiologia
Strongyloides stercoralis
Estrongiloidíase/complicações
Linfócitos T/virologia
Carga Viral
Adulto
Animais
Coinfecção
Infecções por HTLV-I/virologia
Vírus 1 Linfotrópico T Humano/genética
Humanos
Leucemia-Linfoma de Células T do Adulto/virologia
Meia-Idade
Provirus/fisiologia
Fatores de Risco
Estrongiloidíase/parasitologia
title_short Strongyloidiasis and infective dermatitis alter human T lymphotropic virus-1 clonality in vivo.
title_full Strongyloidiasis and infective dermatitis alter human T lymphotropic virus-1 clonality in vivo.
title_fullStr Strongyloidiasis and infective dermatitis alter human T lymphotropic virus-1 clonality in vivo.
title_full_unstemmed Strongyloidiasis and infective dermatitis alter human T lymphotropic virus-1 clonality in vivo.
title_sort Strongyloidiasis and infective dermatitis alter human T lymphotropic virus-1 clonality in vivo.
author Gillet, Nicolas A
author_facet Gillet, Nicolas A
Cook, Lucy
Laydon, Daniel J
Hlela, Carol
Verdonck, Kristien
Alvarez, Carolina
Gotuzzo, Eduardo
Clark, Daniel
Vallve, Maria de Lourdes Farre
Bittencourt, Achilea Candida Lisboa
Asquith, Becca
Taylor, Graham P
Bangham, Charles R. M
author_role author
author2 Cook, Lucy
Laydon, Daniel J
Hlela, Carol
Verdonck, Kristien
Alvarez, Carolina
Gotuzzo, Eduardo
Clark, Daniel
Vallve, Maria de Lourdes Farre
Bittencourt, Achilea Candida Lisboa
Asquith, Becca
Taylor, Graham P
Bangham, Charles R. M
author2_role author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Gillet, Nicolas A
Cook, Lucy
Laydon, Daniel J
Hlela, Carol
Verdonck, Kristien
Alvarez, Carolina
Gotuzzo, Eduardo
Clark, Daniel
Vallve, Maria de Lourdes Farre
Bittencourt, Achilea Candida Lisboa
Asquith, Becca
Taylor, Graham P
Bangham, Charles R. M
dc.subject.decs.pt_BR.fl_str_mv Dermatite/complicações
Infecções por HTLV-I/complicações
Vírus 1 Linfotrópico T Humano/fisiologia
Strongyloides stercoralis
Estrongiloidíase/complicações
Linfócitos T/virologia
Carga Viral
Adulto
Animais
Coinfecção
Infecções por HTLV-I/virologia
Vírus 1 Linfotrópico T Humano/genética
Humanos
Leucemia-Linfoma de Células T do Adulto/virologia
Meia-Idade
Provirus/fisiologia
Fatores de Risco
Estrongiloidíase/parasitologia
topic Dermatite/complicações
Infecções por HTLV-I/complicações
Vírus 1 Linfotrópico T Humano/fisiologia
Strongyloides stercoralis
Estrongiloidíase/complicações
Linfócitos T/virologia
Carga Viral
Adulto
Animais
Coinfecção
Infecções por HTLV-I/virologia
Vírus 1 Linfotrópico T Humano/genética
Humanos
Leucemia-Linfoma de Células T do Adulto/virologia
Meia-Idade
Provirus/fisiologia
Fatores de Risco
Estrongiloidíase/parasitologia
description Wright-Fleming Institute. Imperial College London. London, United Kingdom / University of Liège (ULg). Molecular and Cellular Epigenetics. Interdisciplinary Cluster for Applied Genoproteomics (GIGA). Liège, Belgium
publishDate 2013
dc.date.issued.fl_str_mv 2013
dc.date.accessioned.fl_str_mv 2014-11-07T17:18:41Z
dc.date.available.fl_str_mv 2014-11-07T17:18:41Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv GILLET, N. A. et al. Strongyloidiasis and infective dermatitis alter human T lymphotropic virus-1 clonality in vivo. PLoS Pathogens, v. 9, n. 4, p. e1003263, 2013.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/8766
dc.identifier.issn.none.fl_str_mv 1553-7374
dc.identifier.doi.none.fl_str_mv 10.1371/journal.ppat.1003263
identifier_str_mv GILLET, N. A. et al. Strongyloidiasis and infective dermatitis alter human T lymphotropic virus-1 clonality in vivo. PLoS Pathogens, v. 9, n. 4, p. e1003263, 2013.
1553-7374
10.1371/journal.ppat.1003263
url https://www.arca.fiocruz.br/handle/icict/8766
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Public Library of Science
publisher.none.fl_str_mv Public Library of Science
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
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