C-Reactive Protein and B-Type Natriuretic Peptide Yield Either a Non-Significant or a Modest Incremental Value to Traditional Risk Factors in Predicting Long-Term Overall Mortality in Older Adults
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Data de Publicação: | 2013 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
Texto Completo: | https://www.arca.fiocruz.br/handle/icict/59391 |
Resumo: | This work was supported by Financiadora de Estudos e Projetos, Rio de Janeiro, Brazil; Ministério da Saúde, Brasília, Brazil; Fundação de Amparo à Pesquisa do Estado de Minas Gerais, Belo Horizonte, Brazil. M.F. Lima-Costa and A.L. Ribeiro are fellows of Conselho Nacional de Desenvolvimento Científico e Tecnológico. A.M. Beleigoli was supported by the Programa de Doutorando com Estágio no Exterior do Conselho de Aperfeiçoamento de Pessoal Superior, Brazil. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. |
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Beleigoli, Alline MariaBoersma, EricDiniz, Maria de Fatima HaueisenVidigal, Pedro G.Costa, Maria Fernanda Furtado LimaRibeiro, Antonio Luiz Pinho2023-07-04T12:45:30Z2023-07-04T12:45:30Z2013BELEIGOLI, Alline Maria et al. C-reactive protein and B-type natriuretic peptide yield either a non-significant or a modest incremental value to traditional risk factors in predicting long-term overall mortality in older adults. PLoS One, v. 8, n. 9, p. 1-10, e75809, 2013.1932-6203https://www.arca.fiocruz.br/handle/icict/5939110.1371/journal.pone.0075809This work was supported by Financiadora de Estudos e Projetos, Rio de Janeiro, Brazil; Ministério da Saúde, Brasília, Brazil; Fundação de Amparo à Pesquisa do Estado de Minas Gerais, Belo Horizonte, Brazil. M.F. Lima-Costa and A.L. Ribeiro are fellows of Conselho Nacional de Desenvolvimento Científico e Tecnológico. A.M. Beleigoli was supported by the Programa de Doutorando com Estágio no Exterior do Conselho de Aperfeiçoamento de Pessoal Superior, Brazil. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.Universidade Federal de Minas Gerais. Faculty of Medicine. Department of Internal Medicine. Belo Horizonte, MG, Brazil / Universidade Federal de Minas Gerais. Faculty of Medicine. Post-Graduation Department. Belo Horizonte, MG, Brazil.Department of Cardiology. Erasmus Medical Center. Rotterdam, The Netherlands.Universidade Federal de Minas Gerais. Faculty of Medicine. Department of Internal Medicine. Belo Horizonte, MG, Brazil / Universidade Federal de Minas Gerais. Faculty of Medicine. Post-Graduation Department. Belo Horizonte, MG, Brazil.Universidade Federal de Minas Gerais. Faculty of Medicine. Department of Diagnostic Medicine. Belo Horizonte, MG, Brazil.Universidade Federal de Minas Gerais. Faculty of Medicine. Department of Internal Medicine. Belo Horizonte, MG, Brazil / Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Belo Horizonte, MG, Brazil.Universidade Federal de Minas Gerais. Faculty of Medicine. Department of Internal Medicine. Belo Horizonte, MG, Brazil / Universidade Federal de Minas Gerais. Faculty of Medicine. Post-Graduation Department. Belo Horizonte, MG, Brazil / Universidade Federal de Minas Gerais. Faculty of Medicine. Hospital das Clínicas. Belo Horizonte, MG, Brazil.Background: New biomarkers may aid in preventive and end-of-life decisions in older adults if they enhance the prognostic ability of traditional risk factors. We investigated whether C-reactive protein (CRP) and/or B-type natriuretic peptide (BNP) improve the ability to predict overall mortality among the elderly of the Bambu, Brazil Study of Aging when added to traditional risk factors. Methods: From 1997 to 2007, 1,470 community-dwelling individuals (>= 60 years) were followed-up. Death was ascertained by continuous verification of death certificates. We calculated hazard ratios per 1 standard deviation change (HR) of death for traditional risk factors only (old model), and traditional risk factors plus CRP and/or BNP (new models) and assessed calibration of the models. Subsequently, we compared c-statistic of each of the new models to the old one, and calculated integrated discriminative improvement (IDI) and net reclassification improvement (NRI). Results: 544 (37.0%) participants died in a mean follow-up time of 9.0 years. CRP (HR 1.28, 95% CI 1.17-1.40), BNP (HR 1.31 95% CI 1.19-1.45), and CRP plus BNP (HR 1.26, 95% CI 1.15-1.38, and HR 1.29, 95% CI 1.16-1.42, respectively) were independent determinants of mortality. All models were well-calibrated. Discrimination was similar among the old (c-statistic 0.78 [0.78-0.81]) and new models (p=0.43 for CRP; p=0.57 for BNP; and p=0.31 for CRP plus BNP). Compared to the old model, CRP, BNP, and CRP plus BNP models led to an IDI of 0.009 (p<0.001), -0.005 (p<0.001) and -0.003 (p=0.84), and a NRI of 0.04 (p=0.24), 0.07 (p=0.08) and 0.06 (p=0.10), respectively. Conclusions: Despite being independent predictors of long-term risk of death, compared to traditional risk factors CRP and/or BNP led to either a modest or non-significant improvement in the ability of predicting all-cause mortality in older adults.engPublic Library of ScienceC-Reactive Protein and B-Type Natriuretic Peptide Yield Either a Non-Significant or a Modest Incremental Value to Traditional Risk Factors in Predicting Long-Term Overall Mortality in Older Adultsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleC-Reactive Protein (CRP)B-type natriuretic peptide (BNP)BiomarkersTraditional risk factorsMortality in older Adultsinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALpone.0075809.pdfpone.0075809.pdfapplication/pdf1049554https://www.arca.fiocruz.br/bitstream/icict/59391/2/pone.0075809.pdf95a23081d30cc56f0740b34f3cf13867MD52LICENSElicense.txttext/plain1748https://www.arca.fiocruz.br/bitstream/icict/59391/1/license.txt8a4605be74aa9ea9d79846c1fba20a33MD51icict/593912023-07-04 12:05:55.24oai:www.arca.fiocruz.br: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Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-07-04T15:05:55Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false |
dc.title.en_US.fl_str_mv |
C-Reactive Protein and B-Type Natriuretic Peptide Yield Either a Non-Significant or a Modest Incremental Value to Traditional Risk Factors in Predicting Long-Term Overall Mortality in Older Adults |
title |
C-Reactive Protein and B-Type Natriuretic Peptide Yield Either a Non-Significant or a Modest Incremental Value to Traditional Risk Factors in Predicting Long-Term Overall Mortality in Older Adults |
spellingShingle |
C-Reactive Protein and B-Type Natriuretic Peptide Yield Either a Non-Significant or a Modest Incremental Value to Traditional Risk Factors in Predicting Long-Term Overall Mortality in Older Adults Beleigoli, Alline Maria C-Reactive Protein (CRP) B-type natriuretic peptide (BNP) Biomarkers Traditional risk factors Mortality in older Adults |
title_short |
C-Reactive Protein and B-Type Natriuretic Peptide Yield Either a Non-Significant or a Modest Incremental Value to Traditional Risk Factors in Predicting Long-Term Overall Mortality in Older Adults |
title_full |
C-Reactive Protein and B-Type Natriuretic Peptide Yield Either a Non-Significant or a Modest Incremental Value to Traditional Risk Factors in Predicting Long-Term Overall Mortality in Older Adults |
title_fullStr |
C-Reactive Protein and B-Type Natriuretic Peptide Yield Either a Non-Significant or a Modest Incremental Value to Traditional Risk Factors in Predicting Long-Term Overall Mortality in Older Adults |
title_full_unstemmed |
C-Reactive Protein and B-Type Natriuretic Peptide Yield Either a Non-Significant or a Modest Incremental Value to Traditional Risk Factors in Predicting Long-Term Overall Mortality in Older Adults |
title_sort |
C-Reactive Protein and B-Type Natriuretic Peptide Yield Either a Non-Significant or a Modest Incremental Value to Traditional Risk Factors in Predicting Long-Term Overall Mortality in Older Adults |
author |
Beleigoli, Alline Maria |
author_facet |
Beleigoli, Alline Maria Boersma, Eric Diniz, Maria de Fatima Haueisen Vidigal, Pedro G. Costa, Maria Fernanda Furtado Lima Ribeiro, Antonio Luiz Pinho |
author_role |
author |
author2 |
Boersma, Eric Diniz, Maria de Fatima Haueisen Vidigal, Pedro G. Costa, Maria Fernanda Furtado Lima Ribeiro, Antonio Luiz Pinho |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Beleigoli, Alline Maria Boersma, Eric Diniz, Maria de Fatima Haueisen Vidigal, Pedro G. Costa, Maria Fernanda Furtado Lima Ribeiro, Antonio Luiz Pinho |
dc.subject.en.none.fl_str_mv |
C-Reactive Protein (CRP) B-type natriuretic peptide (BNP) Biomarkers Traditional risk factors Mortality in older Adults |
topic |
C-Reactive Protein (CRP) B-type natriuretic peptide (BNP) Biomarkers Traditional risk factors Mortality in older Adults |
description |
This work was supported by Financiadora de Estudos e Projetos, Rio de Janeiro, Brazil; Ministério da Saúde, Brasília, Brazil; Fundação de Amparo à Pesquisa do Estado de Minas Gerais, Belo Horizonte, Brazil. M.F. Lima-Costa and A.L. Ribeiro are fellows of Conselho Nacional de Desenvolvimento Científico e Tecnológico. A.M. Beleigoli was supported by the Programa de Doutorando com Estágio no Exterior do Conselho de Aperfeiçoamento de Pessoal Superior, Brazil. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. |
publishDate |
2013 |
dc.date.issued.fl_str_mv |
2013 |
dc.date.accessioned.fl_str_mv |
2023-07-04T12:45:30Z |
dc.date.available.fl_str_mv |
2023-07-04T12:45:30Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
BELEIGOLI, Alline Maria et al. C-reactive protein and B-type natriuretic peptide yield either a non-significant or a modest incremental value to traditional risk factors in predicting long-term overall mortality in older adults. PLoS One, v. 8, n. 9, p. 1-10, e75809, 2013. |
dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/59391 |
dc.identifier.issn.en_US.fl_str_mv |
1932-6203 |
dc.identifier.doi.none.fl_str_mv |
10.1371/journal.pone.0075809 |
identifier_str_mv |
BELEIGOLI, Alline Maria et al. C-reactive protein and B-type natriuretic peptide yield either a non-significant or a modest incremental value to traditional risk factors in predicting long-term overall mortality in older adults. PLoS One, v. 8, n. 9, p. 1-10, e75809, 2013. 1932-6203 10.1371/journal.pone.0075809 |
url |
https://www.arca.fiocruz.br/handle/icict/59391 |
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eng |
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eng |
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Public Library of Science |
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Public Library of Science |
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reponame:Repositório Institucional da FIOCRUZ (ARCA) instname:Fundação Oswaldo Cruz (FIOCRUZ) instacron:FIOCRUZ |
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