HTLV-1 in pregnant women from the Southern Bahia, Brazil: a neglected condition despite the high prevalence.
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2014 |
| Outros Autores: | , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| DOI: | 10.1186/1743-422X-11-28 |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/8054 |
Resumo: | Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório Avançado de Saúde Púbica. Salvador, BA, Brasil / Faculdade de Ilhéus. Ilhéus, BA, Brasil |
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Mello, Marco Antônio GomesConceição, Aline Ferreira daSousa, Sandra Mara BispoAlcantara, Luiz Carlos JúniorMarin, Lauro JulianoRaio, Mônica Regina da SilvaBoa-Sorte, Ney Cristian AmaralSantos, Lucas Pereira de SouzaAlmeida, Maria da Conceição Chagas deGalvão, Tâmara CoutinhoBastos, Raquel GoisLázaro, NoilsonCastro Filho, Bernardo GalvãoGadelha, Sandra Rocha2014-07-22T16:06:33Z2014-07-22T16:06:33Z2014MELLO, M. A. G. et al. HTLV-1 in pregnant women from the Southern Bahia, Brazil: a neglected condition despite the high prevalence. Virology Journal, v. 11, p. 28, 2014.1743-422Xhttps://www.arca.fiocruz.br/handle/icict/805410.1186/1743-422X-11-28engBioMed CentralHTLV-1 in pregnant women from the Southern Bahia, Brazil: a neglected condition despite the high prevalence.info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório Avançado de Saúde Púbica. Salvador, BA, Brasil / Faculdade de Ilhéus. Ilhéus, BA, BrasilUniversidade Estadual de Santa Cruz. Ilhéus, BA, BrasilUniversidade Estadual do Sudoeste da Bahia. Vitória da Conquista, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório de Laboratório de Hematologia, Genética e Biologia Computacional. Salvador, BA, BrasilUniversidade Estadual de Santa Cruz. Ilhéus, BA, BrasilUniversidade Estadual de Santa Cruz. Ilhéus, BA, BrasilEscola Bahiana de Medicina e Saúde Pública. Salvador, BA, BrasilUniversidade Estadual de Santa Cruz. Ilhéus, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório de Epidemiologia Molecular e Bioestatística. Salvador, BA, BrasilUniversidade Estadual de Santa Cruz. Ilhéus, BA, BrasilUniversidade Estadual de Santa Cruz. Ilhéus, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório Avançado de Saúde Púbica. Salvador, BA, Brasil / Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório Avançado de Saúde Púbica. Salvador, BA, Brasil / Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, BrasilUniversidade Estadual de Santa Cruz. Ilhéus, BA, BrasilBACKGROUND: As the most frequent pathway of vertical transmission of HTLV-1 is breast-feeding, and considering the higher prevalence in women, it is very important to perform screening examinations for anti-HTLV-1 antibodies as part of routine prenatal care. So far, no studies of HTLV-1 seroprevalence in pregnant women in the Southern region of Bahia, Brazil, have been described. METHODS: Pregnant women were selected at the two regional reference centers for health care from Southern Bahia. A total of 2766 pregnant women attending the antenatal unit between November 2008 and May 2010 have been analyzed. An extra blood sample was drawn during their routine antenatal testing. A standardized questionnaire was applied and all positive plasma samples were tested by ELISA and were confirmed by Western Blot and PCR. Besides that, positive women were contacted and visited. The family members that were present during the visit were asked to be serologically screened to the virus. A prospective study was also carried out and newborns were followed up to two years for evaluation of vertical transmission. RESULTS: HTLV prevalence was 1.05% (CI 95%: 0.70-1.50). There was no association of HTLV-1 infection with age, education, income and ethnic differences. The association with marital status was borderline (OR = 7.99; 95% CI 1.07-59.3; p = 0.042). In addition, 43 family members of the HTLV-1 seropositive women have been analyzed and specific reactivity was observed in 32.56%, including two children from previous pregnancy.Conclusion: It is very important to emphasize that the lack of HTLV-1 screening in pregnant women can promote HTLV transmission especially in endemic areas. HTLV screening in this vulnerable population and the promotion of bottle-feeding for children of seropositive mothers could be important cost-effective methods to limit the vertical transmission. Besides that, our data reinforce the need to establish strategies of active surveillance in household and family contacts as important epidemiological surveillance actions for the early detection of virus infection and the prevention of transmission by sexual or and parenteral contact.HTLVBahia-BrazilVertical transmissionPregnantPrenatal careinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALMello MA HTLV-1 in pregnant....pdfMello MA HTLV-1 in pregnant....pdfapplication/pdf282662https://www.arca.fiocruz.br/bitstream/icict/8054/1/Mello%20MA%20HTLV-1%20in%20pregnant....pdfb8aeee59c3495253c134ba4f12367c6fMD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81914https://www.arca.fiocruz.br/bitstream/icict/8054/2/license.txt7d48279ffeed55da8dfe2f8e81f3b81fMD52TEXTMello MA HTLV-1 in pregnant....pdf.txtMello MA HTLV-1 in pregnant....pdf.txtExtracted texttext/plain33786https://www.arca.fiocruz.br/bitstream/icict/8054/3/Mello%20MA%20HTLV-1%20in%20pregnant....pdf.txt75720b46d33eb67b7576e33fe322cd3bMD53icict/80542023-03-15 14:32:53.577oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:32:53Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false |
| dc.title.pt_BR.fl_str_mv |
HTLV-1 in pregnant women from the Southern Bahia, Brazil: a neglected condition despite the high prevalence. |
| title |
HTLV-1 in pregnant women from the Southern Bahia, Brazil: a neglected condition despite the high prevalence. |
| spellingShingle |
HTLV-1 in pregnant women from the Southern Bahia, Brazil: a neglected condition despite the high prevalence. Mello, Marco Antônio Gomes HTLV Bahia-Brazil Vertical transmission Pregnant Prenatal care |
| title_short |
HTLV-1 in pregnant women from the Southern Bahia, Brazil: a neglected condition despite the high prevalence. |
| title_full |
HTLV-1 in pregnant women from the Southern Bahia, Brazil: a neglected condition despite the high prevalence. |
| title_fullStr |
HTLV-1 in pregnant women from the Southern Bahia, Brazil: a neglected condition despite the high prevalence. |
| title_full_unstemmed |
HTLV-1 in pregnant women from the Southern Bahia, Brazil: a neglected condition despite the high prevalence. |
| title_sort |
HTLV-1 in pregnant women from the Southern Bahia, Brazil: a neglected condition despite the high prevalence. |
| author |
Mello, Marco Antônio Gomes |
| author_facet |
Mello, Marco Antônio Gomes Conceição, Aline Ferreira da Sousa, Sandra Mara Bispo Alcantara, Luiz Carlos Júnior Marin, Lauro Juliano Raio, Mônica Regina da Silva Boa-Sorte, Ney Cristian Amaral Santos, Lucas Pereira de Souza Almeida, Maria da Conceição Chagas de Galvão, Tâmara Coutinho Bastos, Raquel Gois Lázaro, Noilson Castro Filho, Bernardo Galvão Gadelha, Sandra Rocha |
| author_role |
author |
| author2 |
Conceição, Aline Ferreira da Sousa, Sandra Mara Bispo Alcantara, Luiz Carlos Júnior Marin, Lauro Juliano Raio, Mônica Regina da Silva Boa-Sorte, Ney Cristian Amaral Santos, Lucas Pereira de Souza Almeida, Maria da Conceição Chagas de Galvão, Tâmara Coutinho Bastos, Raquel Gois Lázaro, Noilson Castro Filho, Bernardo Galvão Gadelha, Sandra Rocha |
| author2_role |
author author author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Mello, Marco Antônio Gomes Conceição, Aline Ferreira da Sousa, Sandra Mara Bispo Alcantara, Luiz Carlos Júnior Marin, Lauro Juliano Raio, Mônica Regina da Silva Boa-Sorte, Ney Cristian Amaral Santos, Lucas Pereira de Souza Almeida, Maria da Conceição Chagas de Galvão, Tâmara Coutinho Bastos, Raquel Gois Lázaro, Noilson Castro Filho, Bernardo Galvão Gadelha, Sandra Rocha |
| dc.subject.en.pt_BR.fl_str_mv |
HTLV Bahia-Brazil Vertical transmission Pregnant Prenatal care |
| topic |
HTLV Bahia-Brazil Vertical transmission Pregnant Prenatal care |
| description |
Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório Avançado de Saúde Púbica. Salvador, BA, Brasil / Faculdade de Ilhéus. Ilhéus, BA, Brasil |
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2014 |
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2014-07-22T16:06:33Z |
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2014-07-22T16:06:33Z |
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2014 |
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info:eu-repo/semantics/article |
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MELLO, M. A. G. et al. HTLV-1 in pregnant women from the Southern Bahia, Brazil: a neglected condition despite the high prevalence. Virology Journal, v. 11, p. 28, 2014. |
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https://www.arca.fiocruz.br/handle/icict/8054 |
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1743-422X |
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10.1186/1743-422X-11-28 |
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MELLO, M. A. G. et al. HTLV-1 in pregnant women from the Southern Bahia, Brazil: a neglected condition despite the high prevalence. Virology Journal, v. 11, p. 28, 2014. 1743-422X 10.1186/1743-422X-11-28 |
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