Stress induced phosphoprotein 1 overexpression controls proliferation, migration and invasion and is associated with poor survival in oral squamous cell carcinoma

Dourado, Mauricio Rocha; Elseragy, Amr; Costa, Bruno Cesar da; Téo, Fábio Haach; Guimarães, Gustavo Narvaes; Machado, Renato Assis; Risteli, Maija; Wahbi, Wafa; Rocha, Clarissa Araujo Gurgel; Paranaíba, Lívia Máris Ribeiro; Arriagada, Wilfredo Alejandro González; Silva, Sabrina Daniela da; Rangel, Ana Lucia Carrinho Ayroza; Marques, Marcelo Rocha; Rossa Junior, Carlos; Salo, Tuula; Coletta, Ricardo D.

Stress induced phosphoprotein 1 overexpression controls proliferation, migration and invasion and is associated with poor survival in oral squamous cell carcinoma

Detalhes bibliográficos
Autor(a) principal:	Dourado, Mauricio Rocha
Data de Publicação:	2023
Outros Autores:	Elseragy, Amr, Costa, Bruno Cesar da, Téo, Fábio Haach, Guimarães, Gustavo Narvaes, Machado, Renato Assis, Risteli, Maija, Wahbi, Wafa, Rocha, Clarissa Araujo Gurgel, Paranaíba, Lívia Máris Ribeiro, Arriagada, Wilfredo Alejandro González, Silva, Sabrina Daniela da, Rangel, Ana Lucia Carrinho Ayroza, Marques, Marcelo Rocha, Rossa Junior, Carlos, Salo, Tuula, Coletta, Ricardo D.
Tipo de documento:	Artigo
Idioma:	eng
Título da fonte:	Repositório Institucional da FIOCRUZ (ARCA)
DOI:	10.3389/fonc.2022.1085917
Texto Completo:	https://www.arca.fiocruz.br/handle/icict/59004
Resumo:	Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP). Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq). Universities of Oulu and Helsinki. Juselius Foundation, and Oulu and Helsinki University Hospital.

Metadados do item

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oai_identifier_str	oai:www.arca.fiocruz.br:icict/59004
network_acronym_str	CRUZ
network_name_str	Repositório Institucional da FIOCRUZ (ARCA)
repository_id_str	2135
spelling	Dourado, Mauricio RochaElseragy, AmrCosta, Bruno Cesar daTéo, Fábio HaachGuimarães, Gustavo NarvaesMachado, Renato AssisRisteli, MaijaWahbi, WafaRocha, Clarissa Araujo GurgelParanaíba, Lívia Máris RibeiroArriagada, Wilfredo Alejandro GonzálezSilva, Sabrina Daniela daRangel, Ana Lucia Carrinho AyrozaMarques, Marcelo RochaRossa Junior, CarlosSalo, TuulaColetta, Ricardo D.2023-06-13T17:16:57Z2023-06-13T17:16:57Z2023DOURADO, Mauricio Rocha et al. Stress induced phosphoprotein 1 overexpression controls proliferation, migration and invasion and is associated with poor survival in oral squamous cell carcinoma. Frontiers in Oncology, v. 12, p. 1-15, 2023.2234-943Xhttps://www.arca.fiocruz.br/handle/icict/5900410.3389/fonc.2022.1085917Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP). Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq). Universities of Oulu and Helsinki. Juselius Foundation, and Oulu and Helsinki University Hospital.Universidade de Campinas. Faculdade de Odontologia de Piracicaba. Departamento de Diagnóstico Oral. Programa de Pós-Graduação em Biologia Oral. Piracicaba, SP, Brasil.Cancer and Translational Medicine Research Unit. Faculty of Medicine and Medical Research Center. Oulu University Hospital. University of Oulu. Oulu, Finland.Universidade de Campinas. Faculdade de Odontologia de Piracicaba. Departamento de Diagnóstico Oral. Programa de Pós-Graduação em Biologia Oral. Piracicaba, SP, Brasil.Universidade de Campinas. Faculdade de Odontologia de Piracicaba. Departamento de Diagnóstico Oral. Programa de Pós-Graduação em Biologia Oral. Piracicaba, SP, Brasil.Universidade de Campinas. Faculdade de Odontologia de Piracicaba. Departamento de Biociências. Programa de Pós-Graduação em Biologia Oral. Piracicaba, SP, Brasil.Universidade de Campinas. Faculdade de Odontologia de Piracicaba. Departamento de Diagnóstico Oral. Programa de Pós-Graduação em Biologia Oral. Piracicaba, SP, Brasil / Universidade de São Paulo. Hospital de Reabilitação de Anomalias Craniofaciais. Bauru, SP, Brasil.Cancer and Translational Medicine Research Unit. Faculty of Medicine and Medical Research Center. Oulu University Hospital. University of Oulu. Oulu, Finland.Department of Oral and Maxillofacial Diseases. Helsinki University Central Hospital and Translational Immunology Research Program. University of Helsinki. Helsinki, Finland.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Salvador, BA, Brasil / Instituto D'Or de Pesquisa e Ensino. Centro de Biotecnologia e Terapia Celular. Salvador, BA, Brasil.Universidade Federal de Alfenas. Instituto de Ciências Biomédicas. m Departamento de Patologia e Parasitologia. Alfenas, MG, Brasil.Universidad de los Andes. Facultad de Odontología, and Centro de Investigación e Innovación Biomédica. Santiago, Chile.Lady Davis Institute for Medical Research and Segal Cancer Center. Jewish General Hospital. Department of Otolaryngology-Head and Neck Surgery. McGill University. Montreal, QC, Canada.Departamento de Patologia Oral e Medicina Oral. Escola dental. Universidade Estadual do Oeste do Paraná. Cascavel, PR, Brasil.Universidade de Campinas. Faculdade de Odontologia de Piracicaba. Departamento de Biociências. Programa de Pós-Graduação em Biologia Oral. Piracicaba, SP, Brasil.Universidade Estadual Paulista. Faculdade de Odontologia de Araraquara. Departamento de Diagnóstico e Cirurgia. Araraquara, SP, Brasil.Cancer and Translational Medicine Research Unit. Faculty of Medicine and Medical Research Center. Oulu University Hospital. University of Oulu. Oulu, Finland / Department of Oral and Maxillofacial Diseases. Helsinki University Central Hospital and Translational Immunology Research Program. University of Helsinki. Helsinki, Finland / HUSLAB. Department of Pathology. Helsinki University Central Hospital. University of Helsinki. Helsinki, Finland.Universidade de Campinas. Faculdade de Odontologia de Piracicaba. Departamento de Diagnóstico Oral. Programa de Pós-Graduação em Biologia Oral. Piracicaba, SP, Brasil.Objective: Although there have been remarkable achievements in the molecular landscape of oral squamous cell carcinoma (OSCC) in recent years, bringing advances in the understanding of its pathogenesis, development and progression, little has been applied in the prognosis and choosing the optimal treatment. In this study, we explored the influence of the stress induced phosphoprotein 1 (STIP1), which is frequently reported to be highly expressed in many cancers, in OSCCs. Methods: STIP1 expression was assessed in the TCGA database and in two independent cohorts by immunohistochemistry. Knockdown strategy was applied in OSCC cell lines to determine the impact of STIP1 on viability, proliferation, migration and invasion. The zebrafish model was applied for studying tumor formation and metastasis in vivo. The association of STIP1 and miR-218-5p was explored by bioinformatics and mimics transfection. Results: STIP1 was highly expressed in OSCCs and significantly associated with shortened survival and higher risk of recurrence. STIP1 down-regulation decreased proliferation, migration and invasion of tumor cells, and reduced the number of metastases in the Zebrafish model. STIP1 and miR-218-5p were inversely expressed, and the transfection of miR-218-5p mimics into OSCC cells decreased STIP1 levels as well as proliferation, migration and invasion. Conclusion: Our findings show that STIP1 overexpression, which is inversely associated with miR-218-5p levels, contributes to OSCC aggressiveness by controlling proliferation, migration and invasion and is a determinant of poor prognosis.engFrontiers MediaMIR-218-5pSTIP1InvasãoCâncer bucalPrognósticoProliferaçãoMIR-218-5pSTIP1InvasionOral cancerPrognosisProliferationNeoplasias bucaisPrognósticoStress induced phosphoprotein 1 overexpression controls proliferation, migration and invasion and is associated with poor survival in oral squamous cell carcinomainfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/59004/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALDourado, M. R. Stress induced phosphoprotein 1 overexpression....pdfDourado, M. R. Stress induced phosphoprotein 1 overexpression....pdfapplication/pdf4792276https://www.arca.fiocruz.br/bitstream/icict/59004/2/Dourado%2c%20M.%20R.%20Stress%20induced%20phosphoprotein%201%20overexpression....pdffb0676388f0b1ccc763202498f215bc2MD52icict/590042023-06-13 14:16:59.009oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-06-13T17:16:59Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.en_US.fl_str_mv	Stress induced phosphoprotein 1 overexpression controls proliferation, migration and invasion and is associated with poor survival in oral squamous cell carcinoma
title	Stress induced phosphoprotein 1 overexpression controls proliferation, migration and invasion and is associated with poor survival in oral squamous cell carcinoma
spellingShingle	Stress induced phosphoprotein 1 overexpression controls proliferation, migration and invasion and is associated with poor survival in oral squamous cell carcinoma Dourado, Mauricio Rocha MIR-218-5p STIP1 Invasão Câncer bucal Prognóstico Proliferação MIR-218-5p STIP1 Invasion Oral cancer Prognosis Proliferation Neoplasias bucais Prognóstico
title_short	Stress induced phosphoprotein 1 overexpression controls proliferation, migration and invasion and is associated with poor survival in oral squamous cell carcinoma
title_full	Stress induced phosphoprotein 1 overexpression controls proliferation, migration and invasion and is associated with poor survival in oral squamous cell carcinoma
title_fullStr	Stress induced phosphoprotein 1 overexpression controls proliferation, migration and invasion and is associated with poor survival in oral squamous cell carcinoma
title_full_unstemmed	Stress induced phosphoprotein 1 overexpression controls proliferation, migration and invasion and is associated with poor survival in oral squamous cell carcinoma
title_sort	Stress induced phosphoprotein 1 overexpression controls proliferation, migration and invasion and is associated with poor survival in oral squamous cell carcinoma
author	Dourado, Mauricio Rocha
author_facet	Dourado, Mauricio Rocha Elseragy, Amr Costa, Bruno Cesar da Téo, Fábio Haach Guimarães, Gustavo Narvaes Machado, Renato Assis Risteli, Maija Wahbi, Wafa Rocha, Clarissa Araujo Gurgel Paranaíba, Lívia Máris Ribeiro Arriagada, Wilfredo Alejandro González Silva, Sabrina Daniela da Rangel, Ana Lucia Carrinho Ayroza Marques, Marcelo Rocha Rossa Junior, Carlos Salo, Tuula Coletta, Ricardo D.
author_role	author
author2	Elseragy, Amr Costa, Bruno Cesar da Téo, Fábio Haach Guimarães, Gustavo Narvaes Machado, Renato Assis Risteli, Maija Wahbi, Wafa Rocha, Clarissa Araujo Gurgel Paranaíba, Lívia Máris Ribeiro Arriagada, Wilfredo Alejandro González Silva, Sabrina Daniela da Rangel, Ana Lucia Carrinho Ayroza Marques, Marcelo Rocha Rossa Junior, Carlos Salo, Tuula Coletta, Ricardo D.
author2_role	author author author author author author author author author author author author author author author author
dc.contributor.author.fl_str_mv	Dourado, Mauricio Rocha Elseragy, Amr Costa, Bruno Cesar da Téo, Fábio Haach Guimarães, Gustavo Narvaes Machado, Renato Assis Risteli, Maija Wahbi, Wafa Rocha, Clarissa Araujo Gurgel Paranaíba, Lívia Máris Ribeiro Arriagada, Wilfredo Alejandro González Silva, Sabrina Daniela da Rangel, Ana Lucia Carrinho Ayroza Marques, Marcelo Rocha Rossa Junior, Carlos Salo, Tuula Coletta, Ricardo D.
dc.subject.other.en_US.fl_str_mv	MIR-218-5p STIP1 Invasão Câncer bucal Prognóstico Proliferação
topic	MIR-218-5p STIP1 Invasão Câncer bucal Prognóstico Proliferação MIR-218-5p STIP1 Invasion Oral cancer Prognosis Proliferation Neoplasias bucais Prognóstico
dc.subject.en.en_US.fl_str_mv	MIR-218-5p STIP1 Invasion Oral cancer Prognosis Proliferation
dc.subject.decs.en_US.fl_str_mv	Neoplasias bucais Prognóstico
description	Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP). Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq). Universities of Oulu and Helsinki. Juselius Foundation, and Oulu and Helsinki University Hospital.
publishDate	2023
dc.date.accessioned.fl_str_mv	2023-06-13T17:16:57Z
dc.date.available.fl_str_mv	2023-06-13T17:16:57Z
dc.date.issued.fl_str_mv	2023
dc.type.status.fl_str_mv	info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv	info:eu-repo/semantics/article
format	article
status_str	publishedVersion
dc.identifier.citation.fl_str_mv	DOURADO, Mauricio Rocha et al. Stress induced phosphoprotein 1 overexpression controls proliferation, migration and invasion and is associated with poor survival in oral squamous cell carcinoma. Frontiers in Oncology, v. 12, p. 1-15, 2023.
dc.identifier.uri.fl_str_mv	https://www.arca.fiocruz.br/handle/icict/59004
dc.identifier.issn.en_US.fl_str_mv	2234-943X
dc.identifier.doi.none.fl_str_mv	10.3389/fonc.2022.1085917
identifier_str_mv	DOURADO, Mauricio Rocha et al. Stress induced phosphoprotein 1 overexpression controls proliferation, migration and invasion and is associated with poor survival in oral squamous cell carcinoma. Frontiers in Oncology, v. 12, p. 1-15, 2023. 2234-943X 10.3389/fonc.2022.1085917
url	https://www.arca.fiocruz.br/handle/icict/59004
dc.language.iso.fl_str_mv	eng
language	eng
dc.rights.driver.fl_str_mv	info:eu-repo/semantics/openAccess
eu_rights_str_mv	openAccess
dc.publisher.none.fl_str_mv	Frontiers Media
publisher.none.fl_str_mv	Frontiers Media
dc.source.none.fl_str_mv	reponame:Repositório Institucional da FIOCRUZ (ARCA) instname:Fundação Oswaldo Cruz (FIOCRUZ) instacron:FIOCRUZ
instname_str	Fundação Oswaldo Cruz (FIOCRUZ)
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reponame_str	Repositório Institucional da FIOCRUZ (ARCA)
collection	Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv	https://www.arca.fiocruz.br/bitstream/icict/59004/1/license.txt https://www.arca.fiocruz.br/bitstream/icict/59004/2/Dourado%2c%20M.%20R.%20Stress%20induced%20phosphoprotein%201%20overexpression....pdf
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repository.name.fl_str_mv	Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)
repository.mail.fl_str_mv	repositorio.arca@fiocruz.br
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Stress induced phosphoprotein 1 overexpression controls proliferation, migration and invasion and is associated with poor survival in oral squamous cell carcinoma

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