Asymptomatic anorectal Chlamydia trachomatis and Neisseria gonorrhoeae infections are associated with systemic CD8+ T-cell activation
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2017 |
| Outros Autores: | , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/25478 |
Resumo: | 2018-09-30 |
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Vieira, Vinicius AAvelino-Silva, Vivian ICerqueira, Natalia BCosta, Dayane ACosta, Priscilla RVasconcelos, Ricardo PMadruga, José Valdez RamalhoMoreira, Ronaldo IHoagland, Brenda Regina de SiqueiraSantos, Valdiléa Gonçalves Veloso dosGrinsztejn, BeatrizKallas, Esper Georges2018-03-23T18:19:23Z2018-03-23T18:19:23Z2017VIEIRA, Vinicius A. et al. Asymptomatic anorectal Chlamydia trachomatis and Neisseria gonorrhoeae infections are associated with systemic CD8+ T cell activation. AIDS, v. 31, n.15, p.2069-2076, set. 2017.0269-9370https://www.arca.fiocruz.br/handle/icict/2547810.1097/QAD.0000000000001580engAsymptomatic anorectal Chlamydia trachomatis and Neisseria gonorrhoeae infections are associated with systemic CD8+ T-cell activationinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article2018-09-30University of São Paulo School of Medicine. Division of Clinical Immunology and Allergy, São Paulo, BrazilHospital Sírio-Libanês. Instituto de Ensino e Pesquisa, São Paulo, BrazilUniversity of São Paulo School of Medicine. Division of Clinical Immunology and Allergy, São Paulo, BrazilUniversity of São Paulo School of Medicine. Division of Clinical Immunology and Allergy, São Paulo, BrazilUniversity of São Paulo School of Medicine. Department of Infectious and Parasitic Diseases, São Paulo, BrazilCentro de Referência e Treinamento em DST/AIDS, São Paulo, BrazilFundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas, Rio de Janeiro, Rio de Janeiro, BrazilFundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas, Rio de Janeiro, Rio de Janeiro, BrazilFundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas, Rio de Janeiro, Rio de Janeiro, BrazilFundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas, Rio de Janeiro, Rio de Janeiro, BrazilUniversity of São Paulo School of Medicine. Division of Clinical Immunology and Allergy, São Paulo, Brazil / Hospital Sírio-Libanês. Instituto de Ensino e Pesquisa, São Paulo, BrazilBackground: Oral pre-exposure prophylaxis (PrEP) has been established as a pivotal strategy in HIV prevention. However, bacterial sexually transmitted infections (STIs), such as Chlamydia trachomatis (CT) and Neisseria gonorrhoeae (NG), are also highly prevalent. Although the presence of STI-related mucosal lesions is a known risk factor for HIV acquisition, the potential increase in risk associated with asymptomatic STIs is not completely understood. Recent data demonstrated higher T cell activation is a risk factor for sexually acquired HIV-1 infection. We examined the effect of asymptomatic CT and NG anorectal infection on systemic immune activation, potentially increasing the risk of HIV acquisition. Methods: We analyzed samples from participants of PrEP Brasil, a demonstration study of daily oral emtricitabine/tenofovir disoproxil fumarate HIV PrEP among healthy men who have sex with men, for T cell activation by flow cytometry. We included 34 asymptomatic participants with anorectal swab for CT and/or NG infectiion while negative for other STIs, and 35 controls. Results: We found a higher frequency of HLA-DR+CD38+ CD8+ T cells (1.5 vs. 0.9% p<0.005) and with memory phenotype in the group with asymptomatic CT and/or NG infection. Exhaustion and senescence markers were also significant higher in this group. No difference was observed in the soluble CD14 levels. Conclusion: Our findings suggest asymptomatic anorectal CT and/or NG increase systemic immune activation, potentially increasing the risk of HIV acquisition. Regular screening and treatment of asymptomatic STIs should be explored as adjuvant tools for HIV prevention.Cellular ImmunityImmune ActivationHIVNeisseria GonorrhoeaeChlamydia trachomatisPrEPT lymphocyteImunidade CelularHIVNeisseria gonorrhoeaeChlamydia trachomatisinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83099https://www.arca.fiocruz.br/bitstream/icict/25478/1/license.txt586c046dcfeef936e32f0323bb9a47c0MD51ORIGINALAsymptomatic anorectal Chlamydia trachomatis and Neisseria gonorrhoeae infections are associated with systemic CD8+ T cell activation.pdfAsymptomatic anorectal Chlamydia trachomatis and Neisseria gonorrhoeae infections are associated with systemic CD8+ T cell activation.pdfapplication/pdf523413https://www.arca.fiocruz.br/bitstream/icict/25478/2/Asymptomatic%20anorectal%20Chlamydia%20trachomatis%20and%20Neisseria%20gonorrhoeae%20infections%20are%20associated%20with%20systemic%20CD8%2b%20T%20cell%20activation.pdf2e204935f7d0d5b1621e263881a6507eMD52TEXTAsymptomatic anorectal Chlamydia trachomatis and Neisseria gonorrhoeae infections are associated with systemic CD8+ T cell activation.pdf.txtAsymptomatic anorectal Chlamydia trachomatis and Neisseria gonorrhoeae infections are associated with systemic CD8+ T cell activation.pdf.txtExtracted texttext/plain37626https://www.arca.fiocruz.br/bitstream/icict/25478/3/Asymptomatic%20anorectal%20Chlamydia%20trachomatis%20and%20Neisseria%20gonorrhoeae%20infections%20are%20associated%20with%20systemic%20CD8%2b%20T%20cell%20activation.pdf.txt7f3f03764d9612b6c8d3e6fafb673669MD53icict/254782023-06-15 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| dc.title.pt_BR.fl_str_mv |
Asymptomatic anorectal Chlamydia trachomatis and Neisseria gonorrhoeae infections are associated with systemic CD8+ T-cell activation |
| title |
Asymptomatic anorectal Chlamydia trachomatis and Neisseria gonorrhoeae infections are associated with systemic CD8+ T-cell activation |
| spellingShingle |
Asymptomatic anorectal Chlamydia trachomatis and Neisseria gonorrhoeae infections are associated with systemic CD8+ T-cell activation Vieira, Vinicius A Cellular Immunity Immune Activation HIV Neisseria Gonorrhoeae Chlamydia trachomatis PrEP T lymphocyte Imunidade Celular HIV Neisseria gonorrhoeae Chlamydia trachomatis |
| title_short |
Asymptomatic anorectal Chlamydia trachomatis and Neisseria gonorrhoeae infections are associated with systemic CD8+ T-cell activation |
| title_full |
Asymptomatic anorectal Chlamydia trachomatis and Neisseria gonorrhoeae infections are associated with systemic CD8+ T-cell activation |
| title_fullStr |
Asymptomatic anorectal Chlamydia trachomatis and Neisseria gonorrhoeae infections are associated with systemic CD8+ T-cell activation |
| title_full_unstemmed |
Asymptomatic anorectal Chlamydia trachomatis and Neisseria gonorrhoeae infections are associated with systemic CD8+ T-cell activation |
| title_sort |
Asymptomatic anorectal Chlamydia trachomatis and Neisseria gonorrhoeae infections are associated with systemic CD8+ T-cell activation |
| author |
Vieira, Vinicius A |
| author_facet |
Vieira, Vinicius A Avelino-Silva, Vivian I Cerqueira, Natalia B Costa, Dayane A Costa, Priscilla R Vasconcelos, Ricardo P Madruga, José Valdez Ramalho Moreira, Ronaldo I Hoagland, Brenda Regina de Siqueira Santos, Valdiléa Gonçalves Veloso dos Grinsztejn, Beatriz Kallas, Esper Georges |
| author_role |
author |
| author2 |
Avelino-Silva, Vivian I Cerqueira, Natalia B Costa, Dayane A Costa, Priscilla R Vasconcelos, Ricardo P Madruga, José Valdez Ramalho Moreira, Ronaldo I Hoagland, Brenda Regina de Siqueira Santos, Valdiléa Gonçalves Veloso dos Grinsztejn, Beatriz Kallas, Esper Georges |
| author2_role |
author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Vieira, Vinicius A Avelino-Silva, Vivian I Cerqueira, Natalia B Costa, Dayane A Costa, Priscilla R Vasconcelos, Ricardo P Madruga, José Valdez Ramalho Moreira, Ronaldo I Hoagland, Brenda Regina de Siqueira Santos, Valdiléa Gonçalves Veloso dos Grinsztejn, Beatriz Kallas, Esper Georges |
| dc.subject.en.pt_BR.fl_str_mv |
Cellular Immunity Immune Activation HIV Neisseria Gonorrhoeae Chlamydia trachomatis PrEP T lymphocyte |
| topic |
Cellular Immunity Immune Activation HIV Neisseria Gonorrhoeae Chlamydia trachomatis PrEP T lymphocyte Imunidade Celular HIV Neisseria gonorrhoeae Chlamydia trachomatis |
| dc.subject.decs.pt_BR.fl_str_mv |
Imunidade Celular HIV Neisseria gonorrhoeae Chlamydia trachomatis |
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2018-09-30 |
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2017 |
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2017 |
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2018-03-23T18:19:23Z |
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2018-03-23T18:19:23Z |
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VIEIRA, Vinicius A. et al. Asymptomatic anorectal Chlamydia trachomatis and Neisseria gonorrhoeae infections are associated with systemic CD8+ T cell activation. AIDS, v. 31, n.15, p.2069-2076, set. 2017. |
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https://www.arca.fiocruz.br/handle/icict/25478 |
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0269-9370 |
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10.1097/QAD.0000000000001580 |
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VIEIRA, Vinicius A. et al. Asymptomatic anorectal Chlamydia trachomatis and Neisseria gonorrhoeae infections are associated with systemic CD8+ T cell activation. AIDS, v. 31, n.15, p.2069-2076, set. 2017. 0269-9370 10.1097/QAD.0000000000001580 |
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