New biomarkers of human papillomavirus infection in epidermodysplasia verruciformis

Detalhes bibliográficos
Autor(a) principal: Nuovo, Gerard
Data de Publicação: 2019
Outros Autores: Nicol, Alcina, Andrade, Cecilia Vianna de, Magro, Cynthia
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/33319
Resumo: 2020-06-03
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spelling Nuovo, GerardNicol, AlcinaAndrade, Cecilia Vianna deMagro, Cynthia2019-06-03T13:35:57Z2019-06-03T13:35:57Z2019NUOVO, Gerard et al. New biomarkers of human papillomavirus infection in epidermodysplasia verruciformis. Annals of Diagnostic Pathology, v. 40, p. 81-87, 2019.1092-9134https://www.arca.fiocruz.br/handle/icict/3331910.1016/j.anndiagpath.2019.04.0101532-8198engElsevierNew biomarkers of human papillomavirus infection in epidermodysplasia verruciformisinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article2020-06-03The Ohio State University Comprehensive Cancer Center. Columbus, OH, USA / Phylogeny Medical Laboratory. Powell, OH, USA.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Nacional de Saúde da Mulher, da Criança e do Adolescente Fernandes Figueira. Rio de Janeiro, RJ, Brasil.Cornell Medical Center. New York, NY, USA.The cause of epidermodysplasia verruciformis is infection by human papillomavirus, usually types 5 or 8, and it exhibits a high potential for malignant transformation. The diagnostic histologic features of epidermodysplasia verruciformis are not always present and can be mimicked by non-viral diseases. The purpose of this study was to interrogate such lesions for new potential biomarkers to aid in the diagnostic accuracy. HPV DNA was high copy and localized to the upper half of the lesion in cells with cytologic features that included perinuclear halos, blue-grey cytoplasm, and hyper/parakeratosis. Serial section analyses demonstrated that there was increased expression of importin-β, exportin-5, Mcl1, p16, Ki67 and PDL1 in 13/13 epidermodysplasia verruciformis lesions. Each of these proteins localized primarily to the less differentiated cells in the parabasal aspect of the lesion. Only Ki67 and exportin-5 were expressed in the normal epithelia, though much less so, in 13/13 aged matched controls. It is concluded that the host response to HPV 5/8 infection in epidermodysplasia verruciformis includes the up regulation of several proteins including p16, Ki67, importin-β, exportin-5, Mcl1, and PDL1. Thus, these proteins may serve as new biomarkers of this disease that can aid in cases that are equivocal for epidermodysplasia verruciformis on histologic examination.Mcl1PDL1ImportinExportinHPVEDVinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83104https://www.arca.fiocruz.br/bitstream/icict/33319/1/license.txt79178e5f2a0eb066867a274556814938MD51ORIGINALve_Nuovo_Gerard_etal_INI_2019.pdfve_Nuovo_Gerard_etal_INI_2019.pdfapplication/pdf4148409https://www.arca.fiocruz.br/bitstream/icict/33319/2/ve_Nuovo_Gerard_etal_INI_2019.pdfa28af880ea8eb29d6f97c0435654b712MD52TEXTve_Nuovo_Gerard_etal_INI_2019.pdf.txtve_Nuovo_Gerard_etal_INI_2019.pdf.txtExtracted texttext/plain32967https://www.arca.fiocruz.br/bitstream/icict/33319/3/ve_Nuovo_Gerard_etal_INI_2019.pdf.txt0ed3d4b8ba20e435f376376237d7acc1MD53icict/333192021-03-24 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dc.title.pt_BR.fl_str_mv New biomarkers of human papillomavirus infection in epidermodysplasia verruciformis
title New biomarkers of human papillomavirus infection in epidermodysplasia verruciformis
spellingShingle New biomarkers of human papillomavirus infection in epidermodysplasia verruciformis
Nuovo, Gerard
Mcl1
PDL1
Importin
Exportin
HPV
EDV
title_short New biomarkers of human papillomavirus infection in epidermodysplasia verruciformis
title_full New biomarkers of human papillomavirus infection in epidermodysplasia verruciformis
title_fullStr New biomarkers of human papillomavirus infection in epidermodysplasia verruciformis
title_full_unstemmed New biomarkers of human papillomavirus infection in epidermodysplasia verruciformis
title_sort New biomarkers of human papillomavirus infection in epidermodysplasia verruciformis
author Nuovo, Gerard
author_facet Nuovo, Gerard
Nicol, Alcina
Andrade, Cecilia Vianna de
Magro, Cynthia
author_role author
author2 Nicol, Alcina
Andrade, Cecilia Vianna de
Magro, Cynthia
author2_role author
author
author
dc.contributor.author.fl_str_mv Nuovo, Gerard
Nicol, Alcina
Andrade, Cecilia Vianna de
Magro, Cynthia
dc.subject.en.pt_BR.fl_str_mv Mcl1
PDL1
Importin
Exportin
HPV
EDV
topic Mcl1
PDL1
Importin
Exportin
HPV
EDV
description 2020-06-03
publishDate 2019
dc.date.accessioned.fl_str_mv 2019-06-03T13:35:57Z
dc.date.available.fl_str_mv 2019-06-03T13:35:57Z
dc.date.issued.fl_str_mv 2019
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv NUOVO, Gerard et al. New biomarkers of human papillomavirus infection in epidermodysplasia verruciformis. Annals of Diagnostic Pathology, v. 40, p. 81-87, 2019.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/33319
dc.identifier.issn.pt_BR.fl_str_mv 1092-9134
dc.identifier.doi.none.fl_str_mv 10.1016/j.anndiagpath.2019.04.010
dc.identifier.eissn.none.fl_str_mv 1532-8198
identifier_str_mv NUOVO, Gerard et al. New biomarkers of human papillomavirus infection in epidermodysplasia verruciformis. Annals of Diagnostic Pathology, v. 40, p. 81-87, 2019.
1092-9134
10.1016/j.anndiagpath.2019.04.010
1532-8198
url https://www.arca.fiocruz.br/handle/icict/33319
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/33319/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/33319/2/ve_Nuovo_Gerard_etal_INI_2019.pdf
https://www.arca.fiocruz.br/bitstream/icict/33319/3/ve_Nuovo_Gerard_etal_INI_2019.pdf.txt
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