Leishmania exposure in dogs from two endemic countries from new and old worlds (Brazil and Portugal): evaluation of three serological tests using bayesian latent class models
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2022 |
| Outros Autores: | , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/54908 |
Resumo: | Fundação para a Ciência e a Tecnologia. |
| id |
CRUZ_687e73ad18145a17aa88b233dd237991 |
|---|---|
| oai_identifier_str |
oai:www.arca.fiocruz.br:icict/54908 |
| network_acronym_str |
CRUZ |
| network_name_str |
Repositório Institucional da FIOCRUZ (ARCA) |
| repository_id_str |
2135 |
| spelling |
Maia, CarlaFraga, Deborah Bittencourt MothéCristóvão, JoséBorja, Lairton SouzaSolcà, Manuela da SilvaCampino, LeneaVeras, Patrícia Sampaio TavaresGonçalves, Luzia2022-09-27T19:51:53Z2022-09-27T19:51:53Z2022MAIA, Carla et al. Leishmania exposure in dogs from two endemic countries from New and Old Worlds (Brazil and Portugal): evaluation of three serological tests using Bayesian Latent Class Models. Parasites & Vectors, v. 15, n. 202, p. 1-8, 2022.1756-3305https://www.arca.fiocruz.br/handle/icict/5490810.1186/s13071-022-05328-1Fundação para a Ciência e a Tecnologia.Universidade NOVA de Lisboa. Instituto de Higiene e Medicina Tropical. Global Health and Tropical Medicine. Lisbon, Portugal / Medical Parasitology Unit, IHMT-UNL. Lisbon, Portugal.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Interação Parasito‑Hospedeiro e Epidemiologia. Salvador, BA, Brasil / Universidade Federal da Bahia. Escola de Medicina Veterinária e Zootecnia. Departamento de Medicina Veterinária Preventiva e Produção Animal. Salvador, BA, Brasil / Instituto de Ciência e Tecnologia de Doenças Tropicais, INCT-DT, BA, Brasil.Universidade NOVA de Lisboa. Instituto de Higiene e Medicina Tropical. Global Health and Tropical Medicine. Lisbon, Portugal / Medical Parasitology Unit, IHMT-UNL. Lisbon, Portugal.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Interação Parasito‑Hospedeiro e Epidemiologia. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Interação Parasito‑Hospedeiro e Epidemiologia. Salvador, BA, Brasil / Universidade Federal da Bahia. Escola de Medicina Veterinária e Zootecnia. Departamento de Medicina Veterinária Preventiva e Produção Animal. Salvador, BA, Brasil.Medical Parasitology Unit, IHMT-UNL. Lisbon, Portugal.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Interação Parasito‑Hospedeiro e Epidemiologia. Salvador, BA, Brasil / Instituto de Ciência e Tecnologia de Doenças Tropicais, INCT-DT, BA, Brasil.Universidade NOVA de Lisboa. Instituto de Higiene e Medicina Tropical. Global Health and Tropical Medicine. Lisbon, Portugal / International Public Health and Biostatistics Unit, IHMT-UNL. Lisbon, Portugal / Universidade de Lisboa. Centro de Estatística e Aplicações. Lisbon, Portugal.Background: Zoonotic leishmaniosis caused by Leishmania infantum is endemic in several countries of the Mediterranean Basin, Latin America, and Asia. Dogs are the main hosts and reservoirs of human infection. Thus, from a One Health perspective, early diagnosis of Leishmania infection in dogs is essential to control the dissemination of the parasite among other dogs and to humans. The aim of this study was to estimate the diagnosis accuracy of three serological tests to detect antibodies to Leishmania in dogs from two endemic settings using Bayesian latent class models (BLCM). Methods: A total of 378 dogs from two Portuguese and Brazilian endemic areas of leishmaniosis (194 animals from Portugal and 184 from Brazil) were screened. Detection of anti-Leishmania antibodies was performed using two commercial ELISA (L. infantum IgG-ELISA® and EIE-LVC®) and a rapid immunochromatographic test (DPP-LVC®). Bayesian latent class models were used to estimate Leishmania infection prevalence, together with sensitivities and specificities of the three diagnostic tests, in the two dog populations simultaneously. Predictive values were also calculated. Credibility intervals (CI) were obtained, considering different types of prior information. Results: A posterior median Leishmania seroprevalence of 13.4% (95% CI 9.0–18.7) and of 21.6% (15.0–28.3) was estimated to the Portuguese and Brazilian dog subpopulations, respectively. The Bayesian analysis indicated that all tests were highly specific (specificity above 90%), and that the DPP-LVC® was more sensitive (96.6%; 83.1–99.9) than both ELISAs in the Portuguese subpopulation, while in the Brazilian subpopulation, EIE-LVC® and L. infantum IgG-ELISA®, had the highest sensitivity (88.2%; 73.7–97.0) and specificity (98.7%; 95.1–99.9), respectively. Conclusions: In general, the levels of diagnosis accuracy of the three serological tests to detect Leishmania antibodies assessed by BLCM indicate their utility in canine epidemiological studies. The same approach should be used to assess the performance of these techniques in the clinical management of infected and sick dogs using representative samples from the wide spectrum of clinical situations, namely from subclinical infection to manifest disease. The low positive predictive value of the serological tests used in the current protocol of the Brazilian Ministry of Health suggests that they should not be used individually and may not be sufficient to target reservoir-based control interventions.engBMCLeishmania infantumDogsPrevalenceSensitivity and SpecificitySerologyModelos Bayesianos de Classes LatentesPrecisão do diagnósticoCãoLeishmania infantumPrevalênciaSensibilidadeSorologiaEspecificidadeBayesian latent class modelsDiagnosis accuracyDogLeishmania infantumPrevalenceSensitivitySerologySpecificityLeishmania infantumPrevalênciaSorologiaSensibilidade e EspecificidadeLeishmania exposure in dogs from two endemic countries from new and old worlds (Brazil and Portugal): evaluation of three serological tests using bayesian latent class modelsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALMaia, Carla - Leishmania_exposure_in_dogs.pdfMaia, Carla - Leishmania_exposure_in_dogs.pdfapplication/pdf913316https://www.arca.fiocruz.br/bitstream/icict/54908/2/Maia%2c%20Carla%20-%20Leishmania_exposure_in_dogs.pdfc5c22b1e448c90eb63f07a7dd467e4f1MD52LICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/54908/1/license.txt5a560609d32a3863062d77ff32785d58MD51icict/549082023-03-15 14:32:52.781oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:32:52Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false |
| dc.title.en_US.fl_str_mv |
Leishmania exposure in dogs from two endemic countries from new and old worlds (Brazil and Portugal): evaluation of three serological tests using bayesian latent class models |
| title |
Leishmania exposure in dogs from two endemic countries from new and old worlds (Brazil and Portugal): evaluation of three serological tests using bayesian latent class models |
| spellingShingle |
Leishmania exposure in dogs from two endemic countries from new and old worlds (Brazil and Portugal): evaluation of three serological tests using bayesian latent class models Maia, Carla Leishmania infantum Dogs Prevalence Sensitivity and Specificity Serology Modelos Bayesianos de Classes Latentes Precisão do diagnóstico Cão Leishmania infantum Prevalência Sensibilidade Sorologia Especificidade Bayesian latent class models Diagnosis accuracy Dog Leishmania infantum Prevalence Sensitivity Serology Specificity Leishmania infantum Prevalência Sorologia Sensibilidade e Especificidade |
| title_short |
Leishmania exposure in dogs from two endemic countries from new and old worlds (Brazil and Portugal): evaluation of three serological tests using bayesian latent class models |
| title_full |
Leishmania exposure in dogs from two endemic countries from new and old worlds (Brazil and Portugal): evaluation of three serological tests using bayesian latent class models |
| title_fullStr |
Leishmania exposure in dogs from two endemic countries from new and old worlds (Brazil and Portugal): evaluation of three serological tests using bayesian latent class models |
| title_full_unstemmed |
Leishmania exposure in dogs from two endemic countries from new and old worlds (Brazil and Portugal): evaluation of three serological tests using bayesian latent class models |
| title_sort |
Leishmania exposure in dogs from two endemic countries from new and old worlds (Brazil and Portugal): evaluation of three serological tests using bayesian latent class models |
| author |
Maia, Carla |
| author_facet |
Maia, Carla Fraga, Deborah Bittencourt Mothé Cristóvão, José Borja, Lairton Souza Solcà, Manuela da Silva Campino, Lenea Veras, Patrícia Sampaio Tavares Gonçalves, Luzia |
| author_role |
author |
| author2 |
Fraga, Deborah Bittencourt Mothé Cristóvão, José Borja, Lairton Souza Solcà, Manuela da Silva Campino, Lenea Veras, Patrícia Sampaio Tavares Gonçalves, Luzia |
| author2_role |
author author author author author author author |
| dc.contributor.author.fl_str_mv |
Maia, Carla Fraga, Deborah Bittencourt Mothé Cristóvão, José Borja, Lairton Souza Solcà, Manuela da Silva Campino, Lenea Veras, Patrícia Sampaio Tavares Gonçalves, Luzia |
| dc.subject.mesh.en_US.fl_str_mv |
Leishmania infantum Dogs Prevalence Sensitivity and Specificity Serology |
| topic |
Leishmania infantum Dogs Prevalence Sensitivity and Specificity Serology Modelos Bayesianos de Classes Latentes Precisão do diagnóstico Cão Leishmania infantum Prevalência Sensibilidade Sorologia Especificidade Bayesian latent class models Diagnosis accuracy Dog Leishmania infantum Prevalence Sensitivity Serology Specificity Leishmania infantum Prevalência Sorologia Sensibilidade e Especificidade |
| dc.subject.other.en_US.fl_str_mv |
Modelos Bayesianos de Classes Latentes Precisão do diagnóstico Cão Leishmania infantum Prevalência Sensibilidade Sorologia Especificidade |
| dc.subject.en.en_US.fl_str_mv |
Bayesian latent class models Diagnosis accuracy Dog Leishmania infantum Prevalence Sensitivity Serology Specificity |
| dc.subject.decs.en_US.fl_str_mv |
Leishmania infantum Prevalência Sorologia Sensibilidade e Especificidade |
| description |
Fundação para a Ciência e a Tecnologia. |
| publishDate |
2022 |
| dc.date.accessioned.fl_str_mv |
2022-09-27T19:51:53Z |
| dc.date.available.fl_str_mv |
2022-09-27T19:51:53Z |
| dc.date.issued.fl_str_mv |
2022 |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
| dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.citation.fl_str_mv |
MAIA, Carla et al. Leishmania exposure in dogs from two endemic countries from New and Old Worlds (Brazil and Portugal): evaluation of three serological tests using Bayesian Latent Class Models. Parasites & Vectors, v. 15, n. 202, p. 1-8, 2022. |
| dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/54908 |
| dc.identifier.issn.en_US.fl_str_mv |
1756-3305 |
| dc.identifier.doi.none.fl_str_mv |
10.1186/s13071-022-05328-1 |
| identifier_str_mv |
MAIA, Carla et al. Leishmania exposure in dogs from two endemic countries from New and Old Worlds (Brazil and Portugal): evaluation of three serological tests using Bayesian Latent Class Models. Parasites & Vectors, v. 15, n. 202, p. 1-8, 2022. 1756-3305 10.1186/s13071-022-05328-1 |
| url |
https://www.arca.fiocruz.br/handle/icict/54908 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
| eu_rights_str_mv |
openAccess |
| dc.publisher.none.fl_str_mv |
BMC |
| publisher.none.fl_str_mv |
BMC |
| dc.source.none.fl_str_mv |
reponame:Repositório Institucional da FIOCRUZ (ARCA) instname:Fundação Oswaldo Cruz (FIOCRUZ) instacron:FIOCRUZ |
| instname_str |
Fundação Oswaldo Cruz (FIOCRUZ) |
| instacron_str |
FIOCRUZ |
| institution |
FIOCRUZ |
| reponame_str |
Repositório Institucional da FIOCRUZ (ARCA) |
| collection |
Repositório Institucional da FIOCRUZ (ARCA) |
| bitstream.url.fl_str_mv |
https://www.arca.fiocruz.br/bitstream/icict/54908/2/Maia%2c%20Carla%20-%20Leishmania_exposure_in_dogs.pdf https://www.arca.fiocruz.br/bitstream/icict/54908/1/license.txt |
| bitstream.checksum.fl_str_mv |
c5c22b1e448c90eb63f07a7dd467e4f1 5a560609d32a3863062d77ff32785d58 |
| bitstream.checksumAlgorithm.fl_str_mv |
MD5 MD5 |
| repository.name.fl_str_mv |
Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ) |
| repository.mail.fl_str_mv |
repositorio.arca@fiocruz.br |
| _version_ |
1813008844304941056 |