Overview of paratransgenesis as a strategy to control pathogen transmission by insect vectors

Detalhes bibliográficos
Autor(a) principal: Ratcliffe, Norman A.
Data de Publicação: 2022
Outros Autores: Pacheco, João P. Furtado, Dyson, Paul, Castro, Helena Carla, Gonzalez, Marcelo S., Azambuja, Patricia, Mello, Cícero B.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
DOI: 10.1186/s13071-021-05132-3
Texto Completo: https://www.arca.fiocruz.br/handle/icict/54085
Resumo: Universidade Federal Fluminense. Instituto de Biologia. Programa de Pós‑Graduação em Ciências e Biotecnologia. Niterói, RJ, Brasil / Department of Biosciences, Swansea University, Singleton Park, Swansea, UK
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spelling Ratcliffe, Norman A.Pacheco, João P. FurtadoDyson, PaulCastro, Helena CarlaGonzalez, Marcelo S.Azambuja, PatriciaMello, Cícero B.2022-07-30T15:31:39Z2022-07-30T15:31:39Z2022RATCLIFFE, Norman A. et al. Overview of paratransgenesis as a strategy to control pathogen transmission by insect vectors. Parasites & Vectors, v. 15, n. 112, p. 1 - 31, 2022.1756-3305https://www.arca.fiocruz.br/handle/icict/5408510.1186/s13071-021-05132-3engBMCParatrangêneseMicrobiomaVetores de insetosMosquitosTriatomíneosMoscas tsé-tséFlebotomíneosSegurança ambientalControle de pragasParatrangenesisMicrobiomeInsect vectorsMosquitoesTriatominesTsetse fliesSandfliesEnvironmental safetyPest controlOverview of paratransgenesis as a strategy to control pathogen transmission by insect vectorsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal Fluminense. Instituto de Biologia. Programa de Pós‑Graduação em Ciências e Biotecnologia. Niterói, RJ, Brasil / Department of Biosciences, Swansea University, Singleton Park, Swansea, UKUniversidade Federal Fluminense. Instituto de Biologia. Programa de Pós‑Graduação em Ciências e Biotecnologia. Niterói, RJ, Brasil / Universidade Federal Fluminense. Instituto de Biologia. Laboratório de Biologia de Insetos. Niterói, RJ, Brasil.Institute of Life Science, Medical School, Swansea University. Singleton Park, Swansea, UK.Universidade Federal Fluminense. Instituto de Biologia. Programa de Pós‑Graduação em Ciências e Biotecnologia. Niterói, RJ, Brasil.Universidade Federal Fluminense. Instituto de Biologia. Programa de Pós‑Graduação em Ciências e Biotecnologia. Niterói, RJ, Brasil.Universidade Federal Fluminense. Instituto de Biologia. Programa de Pós‑Graduação em Ciências e Biotecnologia. Niterói, RJ, Brasil.Universidade Federal Fluminense. Instituto de Biologia. Programa de Pós‑Graduação em Ciências e Biotecnologia. Niterói, RJ, Brasil.This article presents an overview of paratransgenesis as a strategy to control pathogen transmission by insect vectors. It first briefly summarises some of the disease-causing pathogens vectored by insects and emphasises the need for innovative control methods to counter the threat of resistance by both the vector insect to pesticides and the pathogens to therapeutic drugs. Subsequently, the state of art of paratransgenesis is described, which is a particularly ingenious method currently under development in many important vector insects that could provide an additional powerful tool for use in integrated pest control programmes. The requirements and recent advances of the paratransgenesis technique are detailed and an overview is given of the microorganisms selected for genetic modification, the effector molecules to be expressed and the environmental spread of the transgenic bacteria into wild insect populations. The results of experimental models of paratransgenesis developed with triatomines, mosquitoes, sandflies and tsetse flies are analysed. Finally, the regulatory and safety rules to be satisfied for the successful environmental release of the genetically engineered organisms produced in paratransgenesis are considered.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/54085/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALPatriciaAzambuja_etal_IOC_2022.pdfPatriciaAzambuja_etal_IOC_2022.pdfapplication/pdf2555838https://www.arca.fiocruz.br/bitstream/icict/54085/2/PatriciaAzambuja_etal_IOC_2022.pdf24323b1daf5651c10eed769500fcececMD52icict/540852022-07-30 12:31:39.434oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352022-07-30T15:31:39Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Overview of paratransgenesis as a strategy to control pathogen transmission by insect vectors
title Overview of paratransgenesis as a strategy to control pathogen transmission by insect vectors
spellingShingle Overview of paratransgenesis as a strategy to control pathogen transmission by insect vectors
Ratcliffe, Norman A.
Paratrangênese
Microbioma
Vetores de insetos
Mosquitos
Triatomíneos
Moscas tsé-tsé
Flebotomíneos
Segurança ambiental
Controle de pragas
Paratrangenesis
Microbiome
Insect vectors
Mosquitoes
Triatomines
Tsetse flies
Sandflies
Environmental safety
Pest control
title_short Overview of paratransgenesis as a strategy to control pathogen transmission by insect vectors
title_full Overview of paratransgenesis as a strategy to control pathogen transmission by insect vectors
title_fullStr Overview of paratransgenesis as a strategy to control pathogen transmission by insect vectors
title_full_unstemmed Overview of paratransgenesis as a strategy to control pathogen transmission by insect vectors
title_sort Overview of paratransgenesis as a strategy to control pathogen transmission by insect vectors
author Ratcliffe, Norman A.
author_facet Ratcliffe, Norman A.
Pacheco, João P. Furtado
Dyson, Paul
Castro, Helena Carla
Gonzalez, Marcelo S.
Azambuja, Patricia
Mello, Cícero B.
author_role author
author2 Pacheco, João P. Furtado
Dyson, Paul
Castro, Helena Carla
Gonzalez, Marcelo S.
Azambuja, Patricia
Mello, Cícero B.
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Ratcliffe, Norman A.
Pacheco, João P. Furtado
Dyson, Paul
Castro, Helena Carla
Gonzalez, Marcelo S.
Azambuja, Patricia
Mello, Cícero B.
dc.subject.other.pt_BR.fl_str_mv Paratrangênese
Microbioma
Vetores de insetos
Mosquitos
Triatomíneos
Moscas tsé-tsé
Flebotomíneos
Segurança ambiental
Controle de pragas
topic Paratrangênese
Microbioma
Vetores de insetos
Mosquitos
Triatomíneos
Moscas tsé-tsé
Flebotomíneos
Segurança ambiental
Controle de pragas
Paratrangenesis
Microbiome
Insect vectors
Mosquitoes
Triatomines
Tsetse flies
Sandflies
Environmental safety
Pest control
dc.subject.en.pt_BR.fl_str_mv Paratrangenesis
Microbiome
Insect vectors
Mosquitoes
Triatomines
Tsetse flies
Sandflies
Environmental safety
Pest control
description Universidade Federal Fluminense. Instituto de Biologia. Programa de Pós‑Graduação em Ciências e Biotecnologia. Niterói, RJ, Brasil / Department of Biosciences, Swansea University, Singleton Park, Swansea, UK
publishDate 2022
dc.date.accessioned.fl_str_mv 2022-07-30T15:31:39Z
dc.date.available.fl_str_mv 2022-07-30T15:31:39Z
dc.date.issued.fl_str_mv 2022
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv RATCLIFFE, Norman A. et al. Overview of paratransgenesis as a strategy to control pathogen transmission by insect vectors. Parasites & Vectors, v. 15, n. 112, p. 1 - 31, 2022.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/54085
dc.identifier.issn.pt_BR.fl_str_mv 1756-3305
dc.identifier.doi.none.fl_str_mv 10.1186/s13071-021-05132-3
identifier_str_mv RATCLIFFE, Norman A. et al. Overview of paratransgenesis as a strategy to control pathogen transmission by insect vectors. Parasites & Vectors, v. 15, n. 112, p. 1 - 31, 2022.
1756-3305
10.1186/s13071-021-05132-3
url https://www.arca.fiocruz.br/handle/icict/54085
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
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publisher.none.fl_str_mv BMC
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instname:Fundação Oswaldo Cruz (FIOCRUZ)
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instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/54085/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/54085/2/PatriciaAzambuja_etal_IOC_2022.pdf
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