Klotho: its various functions and association with sickle cell disease subphenotypes.

Detalhes bibliográficos
Autor(a) principal: Pacheco, Ana Paula Almeida de Souza
Data de Publicação: 2014
Outros Autores: Gonçalves, Marilda de Souza
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/9675
Resumo: Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
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spelling Pacheco, Ana Paula Almeida de SouzaGonçalves, Marilda de Souza2015-03-11T17:50:18Z2015-03-11T17:50:18Z2014PACHECO, A. P. A. S.; GONÇALVES, M. S. Klotho: its various functions and association with sickle cell disease subphenotypes. Revista Brasileira de Hematologia e Hemoterapia, v. 36, n. 6, p. 430-436, 20141516-8484https://www.arca.fiocruz.br/handle/icict/9675dx.doi.org/10.1016/j.bjhh.2014.07.022engSociedade Brasileira de Hematologia e HemoterapiaKlotho: its various functions and association with sickle cell disease subphenotypes.info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Salvador, BA, BrasiltThe Klotho protein, whose gene has predominant renal expression, acts in the control ofserum phosphorus and 1,25-dihydroxyvitamin D3 and regulates the function of ion chan-nels. It also participates in the mechanism of protection against oxidative stress and acts onthe vascular endothelium by inducing the production of nitric oxide. Mutations that reflectdefects in the Klotho gene expression may be implicated in the onset of osteonecrosis, pri-apism, and leg ulcers in patients with sickle cell disease, as a result of oxidative stress andendothelial impairment, important factors in the development and severity of this disease.Previous reports regarding the association of Klotho single nucleotide polymorphisms withsickle cell disease subphenotypes have found that these polymorphisms are important toidentify genetic markers of risk in these individuals and allow early and more effectivetherapeutic intervention.Vitamin DOxidative stressSickle cell diseaseEndotheliumGene polymorphismainfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-81914https://www.arca.fiocruz.br/bitstream/icict/9675/1/license.txt7d48279ffeed55da8dfe2f8e81f3b81fMD51ORIGINALPacheco APA Klotho....pdfPacheco APA Klotho....pdfapplication/pdf1764319https://www.arca.fiocruz.br/bitstream/icict/9675/2/Pacheco%20APA%20Klotho....pdfc892355a6a69cdaf263eb1c5c62b0d34MD52TEXTPacheco APA Klotho....pdf.txtPacheco APA Klotho....pdf.txtExtracted texttext/plain29225https://www.arca.fiocruz.br/bitstream/icict/9675/3/Pacheco%20APA%20Klotho....pdf.txt7d1baf2d43c1261771389fd947630e6eMD53icict/96752023-03-15 14:33:04.036oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:33:04Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Klotho: its various functions and association with sickle cell disease subphenotypes.
title Klotho: its various functions and association with sickle cell disease subphenotypes.
spellingShingle Klotho: its various functions and association with sickle cell disease subphenotypes.
Pacheco, Ana Paula Almeida de Souza
Vitamin D
Oxidative stress
Sickle cell disease
Endothelium
Gene polymorphisma
title_short Klotho: its various functions and association with sickle cell disease subphenotypes.
title_full Klotho: its various functions and association with sickle cell disease subphenotypes.
title_fullStr Klotho: its various functions and association with sickle cell disease subphenotypes.
title_full_unstemmed Klotho: its various functions and association with sickle cell disease subphenotypes.
title_sort Klotho: its various functions and association with sickle cell disease subphenotypes.
author Pacheco, Ana Paula Almeida de Souza
author_facet Pacheco, Ana Paula Almeida de Souza
Gonçalves, Marilda de Souza
author_role author
author2 Gonçalves, Marilda de Souza
author2_role author
dc.contributor.author.fl_str_mv Pacheco, Ana Paula Almeida de Souza
Gonçalves, Marilda de Souza
dc.subject.en.pt_BR.fl_str_mv Vitamin D
Oxidative stress
Sickle cell disease
Endothelium
Gene polymorphisma
topic Vitamin D
Oxidative stress
Sickle cell disease
Endothelium
Gene polymorphisma
description Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
publishDate 2014
dc.date.issued.fl_str_mv 2014
dc.date.accessioned.fl_str_mv 2015-03-11T17:50:18Z
dc.date.available.fl_str_mv 2015-03-11T17:50:18Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv PACHECO, A. P. A. S.; GONÇALVES, M. S. Klotho: its various functions and association with sickle cell disease subphenotypes. Revista Brasileira de Hematologia e Hemoterapia, v. 36, n. 6, p. 430-436, 2014
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/9675
dc.identifier.issn.none.fl_str_mv 1516-8484
dc.identifier.doi.none.fl_str_mv dx.doi.org/10.1016/j.bjhh.2014.07.022
identifier_str_mv PACHECO, A. P. A. S.; GONÇALVES, M. S. Klotho: its various functions and association with sickle cell disease subphenotypes. Revista Brasileira de Hematologia e Hemoterapia, v. 36, n. 6, p. 430-436, 2014
1516-8484
dx.doi.org/10.1016/j.bjhh.2014.07.022
url https://www.arca.fiocruz.br/handle/icict/9675
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Sociedade Brasileira de Hematologia e Hemoterapia
publisher.none.fl_str_mv Sociedade Brasileira de Hematologia e Hemoterapia
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
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