Effect of acetaminophen use during pregnancy on adverse pregnancy outcomes: a systematic review and meta-analysis

Detalhes bibliográficos
Autor(a) principal: Castro, Caroline T.
Data de Publicação: 2022
Outros Autores: Gama, Romana S., Pereira, Marcos, Oliveira, Marcio G., Pizzol, Tatiane S. Dal, Barreto, Mauricio L., Santos, Djanilson B.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/51104
Resumo: Fundação de Amparo à Pesquisa do Estado da Bahia (FAPESB).
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spelling Castro, Caroline T.Gama, Romana S.Pereira, MarcosOliveira, Marcio G.Pizzol, Tatiane S. DalBarreto, Mauricio L.Santos, Djanilson B.2022-02-08T19:36:59Z2022-02-08T19:36:59Z2022Castro, Caroline T. et al. Effect of acetaminophen use during pregnancy on adverse pregnancy outcomes: a systematic review and meta-analysis. Expert Opinion on Drug Safety. v. 21, n. 2, p. 241–251, 2022.1474-0338https://www.arca.fiocruz.br/handle/icict/51104doi.org/10.1080/14740338.2022.2020246Fundação de Amparo à Pesquisa do Estado da Bahia (FAPESB).Universidade Federal da Bahia. Instituto Multidisciplinar de Saúde. Programa de Pós-Graduação em Saúde Coletiva. Vitória da Conquista, BA, Brasil.Universidade Federal da Bahia. Programa de Pós-Graduação em Medicina e Saúde. Salvador, BA, Brasil.Universidade Federal da Bahia. Instituto de Saúde Coletiva. Programa de Pós-Graduação em Saúde Coletiva. Salvador, BA, Brasil.Universidade Federal da Bahia. Instituto Multidisciplinar de Saúde. Programa de Pós-Graduação em Saúde Coletiva. Vitória da Conquista, BA, Brasil.Universidade Federal do Rio Grande do Sul. Programa de Pós-Graduação em Epidemiologia. Porto Alegre, RS, Brasil.Universidade Federal da Bahia. Instituto de Saúde Coletiva. Programa de Pós-Graduação em Saúde Coletiva. Salvador, BA, Brasil. / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.Universidade Federal da Bahia. Instituto Multidisciplinar de Saúde. Programa de Pós-Graduação em Saúde Coletiva. Vitória da Conquista, BA, Brasil / Universidade Federal do Recôncavo da Bahia. Centro de Ciências da Saúde. Santo Antônio de Jesus, BA, Brasil.Introduction: A high number of women are exposed to acetaminophen during pregnancy worldwide. This drug safety during pregnancy regarding preterm birth, birth weight, and fetal development has not been well escribed. This study investigated the effect of acetaminophen use during pregnancy on selected adverse pregnancy outcomes. Areas covered: Databases were searched to identify studies reporting the effects of acetaminophen use during pregnancy on preterm birth, low birth weight, and small for gestational age. The studies’ quality was assessed by the Newcastle-Ottawa Scale and the Methodological Index for Non- Randomized Studies. Risk ratios with 95% confidence intervals were estimated using a fixed or random-effects model. Six studies were included for final review, four cohort and two case-control studies. We found no increased risk of preterm birth (RR 0.97; 95% CI 0.59–1.58), and decreased risks of low birth weight (RR 0.65; 95% CI 0.59–0.72) and small for gestational age (RR 0.69; 95% CI 0.50–0.97). Acetaminophen exposure during the third trimester revealed non-significantly in the outcomes. Expert opinion: Exposure to cetaminophen during pregnancy appears to not increase the risk of the outcomes analyzed. However, there is a lack of information regarding the exposure dose and frequency of acetaminophen use.engTaylor and FrancisAcetaminofenNascimento prematuroMetanáliseRevisão sistemáticaAcetaminophenPremature BirthMeta-analysisSystematic reviewEffect of acetaminophen use during pregnancy on adverse pregnancy outcomes: a systematic review and meta-analysisinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/51104/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALCastro, T. C. Effect of Acetaminophen ....pdfCastro, T. C. 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dc.title.pt_BR.fl_str_mv Effect of acetaminophen use during pregnancy on adverse pregnancy outcomes: a systematic review and meta-analysis
title Effect of acetaminophen use during pregnancy on adverse pregnancy outcomes: a systematic review and meta-analysis
spellingShingle Effect of acetaminophen use during pregnancy on adverse pregnancy outcomes: a systematic review and meta-analysis
Castro, Caroline T.
Acetaminofen
Nascimento prematuro
Metanálise
Revisão sistemática
Acetaminophen
Premature Birth
Meta-analysis
Systematic review
title_short Effect of acetaminophen use during pregnancy on adverse pregnancy outcomes: a systematic review and meta-analysis
title_full Effect of acetaminophen use during pregnancy on adverse pregnancy outcomes: a systematic review and meta-analysis
title_fullStr Effect of acetaminophen use during pregnancy on adverse pregnancy outcomes: a systematic review and meta-analysis
title_full_unstemmed Effect of acetaminophen use during pregnancy on adverse pregnancy outcomes: a systematic review and meta-analysis
title_sort Effect of acetaminophen use during pregnancy on adverse pregnancy outcomes: a systematic review and meta-analysis
author Castro, Caroline T.
author_facet Castro, Caroline T.
Gama, Romana S.
Pereira, Marcos
Oliveira, Marcio G.
Pizzol, Tatiane S. Dal
Barreto, Mauricio L.
Santos, Djanilson B.
author_role author
author2 Gama, Romana S.
Pereira, Marcos
Oliveira, Marcio G.
Pizzol, Tatiane S. Dal
Barreto, Mauricio L.
Santos, Djanilson B.
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Castro, Caroline T.
Gama, Romana S.
Pereira, Marcos
Oliveira, Marcio G.
Pizzol, Tatiane S. Dal
Barreto, Mauricio L.
Santos, Djanilson B.
dc.subject.other.pt_BR.fl_str_mv Acetaminofen
Nascimento prematuro
Metanálise
Revisão sistemática
topic Acetaminofen
Nascimento prematuro
Metanálise
Revisão sistemática
Acetaminophen
Premature Birth
Meta-analysis
Systematic review
dc.subject.en.pt_BR.fl_str_mv Acetaminophen
Premature Birth
Meta-analysis
Systematic review
description Fundação de Amparo à Pesquisa do Estado da Bahia (FAPESB).
publishDate 2022
dc.date.accessioned.fl_str_mv 2022-02-08T19:36:59Z
dc.date.available.fl_str_mv 2022-02-08T19:36:59Z
dc.date.issued.fl_str_mv 2022
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv Castro, Caroline T. et al. Effect of acetaminophen use during pregnancy on adverse pregnancy outcomes: a systematic review and meta-analysis. Expert Opinion on Drug Safety. v. 21, n. 2, p. 241–251, 2022.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/51104
dc.identifier.issn.pt_BR.fl_str_mv 1474-0338
dc.identifier.doi.none.fl_str_mv doi.org/10.1080/14740338.2022.2020246
identifier_str_mv Castro, Caroline T. et al. Effect of acetaminophen use during pregnancy on adverse pregnancy outcomes: a systematic review and meta-analysis. Expert Opinion on Drug Safety. v. 21, n. 2, p. 241–251, 2022.
1474-0338
doi.org/10.1080/14740338.2022.2020246
url https://www.arca.fiocruz.br/handle/icict/51104
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Taylor and Francis
publisher.none.fl_str_mv Taylor and Francis
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/51104/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/51104/2/Castro%2c%20T.%20C.%20Effect%20of%20Acetaminophen%20....pdf
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