Update on neurological manifestations of HTLV-1 infection

Detalhes bibliográficos
Autor(a) principal: Araujo, Abelardo Q-C.
Data de Publicação: 2015
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/34853
Resumo: 2020-08-16
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spelling Araujo, Abelardo Q-C.2019-08-16T14:03:38Z2019-08-16T14:03:38Z2015ARAUJO, Abelardo Q-C. Update on neurological manifestations of HTLV-1 infection. Current Infectious Disease Reports, v. 17, p. 1-7, 2015.1523-3847https://www.arca.fiocruz.br/handle/icict/3485310.1007/s11908-014-0459-01523-3847engSpringerUpdate on neurological manifestations of HTLV-1 infectioninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article2020-08-16Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em Neuroinfecções. Rio de Janeiro, RJ, Brasil / Federal University of Rio de Janeiro. Deolindo Couto Institute of Neurology. Rio de Janeiro, RJ, Brasil.The human T cell lymphotropic virus type 1 (HTLV-1) is a retrovirus that infects 10–20 million persons around the world. Initially associated with the hematological malignancy adult T cell leukemia/lymphoma (ATLL), HTLV-1 is also the cause of a chronic progressive myelopathy named “HTLV-1-associated myelopathy/tropical spastic paraparesis” (HAM/TSP). HAM/TSP arises as the tip of the iceberg of an assortment of neurological syndromes triggered by the virus such as inflammatory myopathies, polyneuropathies, amyotrophic lateral sclerosis (ALS)-like syndromes, dysautonomia, and cognitive impairment. HAM/TSP typifies a chronic progressive spastic paraparesis with neurogenic bladder and minimal sensory signs. The neuropathology of HAM/TSP is concentrated in the thoracic spinal cord and is typically biphasic. Initially, there is a perivascular lymphocytic cuffing and mild parenchymal mononuclear infiltrates. Subsequently, this is replaced by gliosis and scarring. The neuropathogenesis of HTLV-1 is still partially understood. At present, the therapy of HAM/TSP remains basically symptomatic.HTLV-1-associated myelopathy/tropical spastic paraparesisHTLV-1MyelopathyMyelitisPolymyositisPolyneuropathyinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txttext/plain1748https://www.arca.fiocruz.br/bitstream/icict/34853/1/license.txt8a4605be74aa9ea9d79846c1fba20a33MD51ORIGINALve_Araujo_Abelardo_etal_INI_2015.pdfve_Araujo_Abelardo_etal_INI_2015.pdfapplication/pdf269090https://www.arca.fiocruz.br/bitstream/icict/34853/2/ve_Araujo_Abelardo_etal_INI_2015.pdf8d2838d2193098e9b94872273b3c1f8cMD52TEXTve_Araujo_Abelardo_etal_INI_2015.pdf.txtve_Araujo_Abelardo_etal_INI_2015.pdf.txtExtracted texttext/plain35199https://www.arca.fiocruz.br/bitstream/icict/34853/3/ve_Araujo_Abelardo_etal_INI_2015.pdf.txt9a1ba2f434ebe6d6af89e5df2219f94eMD53icict/348532021-03-24 16:32:35.41oai:www.arca.fiocruz.br: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Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352021-03-24T19:32:35Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Update on neurological manifestations of HTLV-1 infection
title Update on neurological manifestations of HTLV-1 infection
spellingShingle Update on neurological manifestations of HTLV-1 infection
Araujo, Abelardo Q-C.
HTLV-1-associated myelopathy/tropical spastic paraparesis
HTLV-1
Myelopathy
Myelitis
Polymyositis
Polyneuropathy
title_short Update on neurological manifestations of HTLV-1 infection
title_full Update on neurological manifestations of HTLV-1 infection
title_fullStr Update on neurological manifestations of HTLV-1 infection
title_full_unstemmed Update on neurological manifestations of HTLV-1 infection
title_sort Update on neurological manifestations of HTLV-1 infection
author Araujo, Abelardo Q-C.
author_facet Araujo, Abelardo Q-C.
author_role author
dc.contributor.author.fl_str_mv Araujo, Abelardo Q-C.
dc.subject.en.pt_BR.fl_str_mv HTLV-1-associated myelopathy/tropical spastic paraparesis
HTLV-1
Myelopathy
Myelitis
Polymyositis
Polyneuropathy
topic HTLV-1-associated myelopathy/tropical spastic paraparesis
HTLV-1
Myelopathy
Myelitis
Polymyositis
Polyneuropathy
description 2020-08-16
publishDate 2015
dc.date.issued.fl_str_mv 2015
dc.date.accessioned.fl_str_mv 2019-08-16T14:03:38Z
dc.date.available.fl_str_mv 2019-08-16T14:03:38Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv ARAUJO, Abelardo Q-C. Update on neurological manifestations of HTLV-1 infection. Current Infectious Disease Reports, v. 17, p. 1-7, 2015.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/34853
dc.identifier.issn.pt_BR.fl_str_mv 1523-3847
dc.identifier.doi.none.fl_str_mv 10.1007/s11908-014-0459-0
dc.identifier.eissn.none.fl_str_mv 1523-3847
identifier_str_mv ARAUJO, Abelardo Q-C. Update on neurological manifestations of HTLV-1 infection. Current Infectious Disease Reports, v. 17, p. 1-7, 2015.
1523-3847
10.1007/s11908-014-0459-0
url https://www.arca.fiocruz.br/handle/icict/34853
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
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dc.publisher.none.fl_str_mv Springer
publisher.none.fl_str_mv Springer
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
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