Interaction of stromal and microvascular components in keratocystic odontogenic tumors

Detalhes bibliográficos
Autor(a) principal: Sousa Neto, Ernesto Santos
Data de Publicação: 2016
Outros Autores: Cangussu, Maria Cristina Teixeira, Gurgel, Clarissa Araújo, Guimarães, Vanessa Sousa Nazaré, Ramos, Eduardo Antônio Gonçalves, Xavier, Flávia Caló Aquino, Cury, Patrícia Ramos, Carneiro Júnior, Braúlio, Leonardi, Rosalia, Santos, Jean Nunes Dos
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/18093
Resumo: Federal University of Bahia. School of Dentistry. Dentistry and Health Postgraduate Program. Salvador, BA, Brazil
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spelling Sousa Neto, Ernesto SantosCangussu, Maria Cristina TeixeiraGurgel, Clarissa AraújoGuimarães, Vanessa Sousa NazaréRamos, Eduardo Antônio GonçalvesXavier, Flávia Caló AquinoCury, Patrícia RamosCarneiro Júnior, BraúlioLeonardi, RosaliaSantos, Jean Nunes Dos2017-03-21T13:08:08Z2017-03-21T13:08:08Z2016SOUZA NETO, E. S. et al. Interaction of stromal and microvascular components in keratocystic odontogenic tumors. Journal of Oral Pathology & Medicine, v. 45, p. 557–564, 2016.0904-2512https://www.arca.fiocruz.br/handle/icict/1809310.1111/jop.12400engWileyAngiogeneseCélulasQueratocistoLinfangiogeneseMacrófagosMiofibroblastosAngiogenesisCellsKeratocystLymphangiogenesisMacrophagesMyofibroblastsInteraction of stromal and microvascular components in keratocystic odontogenic tumorsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFederal University of Bahia. School of Dentistry. Dentistry and Health Postgraduate Program. Salvador, BA, BrazilFederal University of Bahia. School of Dentistry. Dentistry and Health Postgraduate Program. Salvador, BA, Brazil / Federal University of Bahia. School of Dentistry. Department Dental Public Health. Salvador, BA, BrazilFederal University of Bahia. School of Dentistry. Dentistry and Health Postgraduate Program. Salvador, BA, Brazil / Fiocruz. Oswaldo Cruz Foundation. Human Pathology Postgraduate Program. Salvador, BA, Brazil / Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Patologia e Biologia Molecular. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Patologia e Biologia Molecular. Salvador, BA, BrasilFiocruz. Oswaldo Cruz Foundation. Human Pathology Postgraduate Program. Salvador, BA, BrazilFederal University of Bahia. School of Dentistry. Dentistry and Health Postgraduate Program. Salvador, BA, Brazil / Federal University of Bahia. School of Dentistry. Laboratory of Oral Surgical Pathology. Salvador, BA, BrazilFederal University of Bahia. School of Dentistry. Dentistry and Health Postgraduate Program. Salvador, BA, Brazil / Federal University of Bahia. School of Dentistry. Division of Periodontics. Salvador, BA, BrazilFederal University of Bahia. School of Dentistry. Dentistry and Health Postgraduate Program. Salvador, BA, Brazil / Federal University of Bahia. School of Dentistry. Department of Oral and Maxillofacial Surgery. Salvador, BA, BrazilUniversity of Catania. Department of Medical and Surgical Sciences. Catania, ItalyFederal University of Bahia. School of Dentistry. Dentistry and Health Postgraduate Program. Salvador, BA, Brazil / Fiocruz. Oswaldo Cruz Foundation. Human Pathology Postgraduate Program. Salvador, BA, Brazil / Federal University of Bahia. School of Dentistry. Laboratory of Oral Surgical Pathology. Salvador, BA, Brazil /Little is known about the interaction of stromal components in odontogenic tumors. Thus, the aim of this study was to investigate mast cells (MCs), myofibroblasts, macrophages, and their possible association with angiogenesis and lymphangiogenesis in keratocystic odontogenic tumors (KCOTs). MATERIAL AND METHODS: Thirty cases of KCOTs were included and analyzed by immunohistochemistry for mast cell tryptase, a-SMA, CD34, CD163, and D240. For comparative purpose, 15 radicular cysts (CRs) and 7 pericoronal follicles (PFs) were included. RESULTS: There was an increase in MCs for RCs and this difference was significant when they were compared to KCOTS and PFs. A significant increase in the density of MFs was observed for KCOTs when compared to RCs and PFs (P = 0.00). No significant difference in CD163- positive macrophages (P = 0.084) and CD34-positive vessels (P = 0.244) densities was observed between KCOTs, RCs, and PFs, although KCOTs showed a higher density of all proteins. Significant difference in lymphatic vessel density was observed for KCOTs when compared to RCs and PFs (P = 0.00). Positive correlation was observed between mast cell tryptase and CD34 in KCOTs (P = 0.025). CONCLUSIONS: A significant interaction between the MC population and CD34-positive vessels in KCOTs supported the hypothesis that MCs and blood vessels contribute to the stromal scaffold of KCOTinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/18093/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALSousa Neto ES Interaction of....pdfSousa Neto ES Interaction of....pdfapplication/pdf1105446https://www.arca.fiocruz.br/bitstream/icict/18093/2/Sousa%20Neto%20ES%20Interaction%20of....pdf8a693c108a6bfd7f88997105886da938MD52TEXTSousa Neto ES Interaction of....pdf.txtSousa Neto ES Interaction of....pdf.txtExtracted texttext/plain38889https://www.arca.fiocruz.br/bitstream/icict/18093/3/Sousa%20Neto%20ES%20Interaction%20of....pdf.txt697e89848b12193853dd049b0d1c5bd8MD53icict/180932023-03-15 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dc.title.pt_BR.fl_str_mv Interaction of stromal and microvascular components in keratocystic odontogenic tumors
title Interaction of stromal and microvascular components in keratocystic odontogenic tumors
spellingShingle Interaction of stromal and microvascular components in keratocystic odontogenic tumors
Sousa Neto, Ernesto Santos
Angiogenese
Células
Queratocisto
Linfangiogenese
Macrófagos
Miofibroblastos
Angiogenesis
Cells
Keratocyst
Lymphangiogenesis
Macrophages
Myofibroblasts
title_short Interaction of stromal and microvascular components in keratocystic odontogenic tumors
title_full Interaction of stromal and microvascular components in keratocystic odontogenic tumors
title_fullStr Interaction of stromal and microvascular components in keratocystic odontogenic tumors
title_full_unstemmed Interaction of stromal and microvascular components in keratocystic odontogenic tumors
title_sort Interaction of stromal and microvascular components in keratocystic odontogenic tumors
author Sousa Neto, Ernesto Santos
author_facet Sousa Neto, Ernesto Santos
Cangussu, Maria Cristina Teixeira
Gurgel, Clarissa Araújo
Guimarães, Vanessa Sousa Nazaré
Ramos, Eduardo Antônio Gonçalves
Xavier, Flávia Caló Aquino
Cury, Patrícia Ramos
Carneiro Júnior, Braúlio
Leonardi, Rosalia
Santos, Jean Nunes Dos
author_role author
author2 Cangussu, Maria Cristina Teixeira
Gurgel, Clarissa Araújo
Guimarães, Vanessa Sousa Nazaré
Ramos, Eduardo Antônio Gonçalves
Xavier, Flávia Caló Aquino
Cury, Patrícia Ramos
Carneiro Júnior, Braúlio
Leonardi, Rosalia
Santos, Jean Nunes Dos
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Sousa Neto, Ernesto Santos
Cangussu, Maria Cristina Teixeira
Gurgel, Clarissa Araújo
Guimarães, Vanessa Sousa Nazaré
Ramos, Eduardo Antônio Gonçalves
Xavier, Flávia Caló Aquino
Cury, Patrícia Ramos
Carneiro Júnior, Braúlio
Leonardi, Rosalia
Santos, Jean Nunes Dos
dc.subject.other.pt_BR.fl_str_mv Angiogenese
Células
Queratocisto
Linfangiogenese
Macrófagos
Miofibroblastos
topic Angiogenese
Células
Queratocisto
Linfangiogenese
Macrófagos
Miofibroblastos
Angiogenesis
Cells
Keratocyst
Lymphangiogenesis
Macrophages
Myofibroblasts
dc.subject.en.pt_BR.fl_str_mv Angiogenesis
Cells
Keratocyst
Lymphangiogenesis
Macrophages
Myofibroblasts
description Federal University of Bahia. School of Dentistry. Dentistry and Health Postgraduate Program. Salvador, BA, Brazil
publishDate 2016
dc.date.issued.fl_str_mv 2016
dc.date.accessioned.fl_str_mv 2017-03-21T13:08:08Z
dc.date.available.fl_str_mv 2017-03-21T13:08:08Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv SOUZA NETO, E. S. et al. Interaction of stromal and microvascular components in keratocystic odontogenic tumors. Journal of Oral Pathology & Medicine, v. 45, p. 557–564, 2016.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/18093
dc.identifier.issn.pt_BR.fl_str_mv 0904-2512
dc.identifier.doi.none.fl_str_mv 10.1111/jop.12400
identifier_str_mv SOUZA NETO, E. S. et al. Interaction of stromal and microvascular components in keratocystic odontogenic tumors. Journal of Oral Pathology & Medicine, v. 45, p. 557–564, 2016.
0904-2512
10.1111/jop.12400
url https://www.arca.fiocruz.br/handle/icict/18093
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Wiley
publisher.none.fl_str_mv Wiley
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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