Heme Oxygenase-1 promotes the persistence of Leishmania chagasi infection
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2012 |
| Outros Autores: | , , , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/7275 |
Resumo: | Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Salvador, BA, Brasil |
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Luz, Nívea FariasAndrade, Bruno de BezerrilFeijó, Daniel FSantos, Théo de AraújoCarvalho, Graziele Quintela deAndrade, DanielaAbánades, Daniel RuizMelo, Enaldo VSilva, Angela MBrodskyn, Claudia IdaBarral Netto, ManoelBarral, Aldina Maria PradoSoares, Rodrigo PedroAlmeida, Roque Pacheco deBozza, Marcelo TorresBorges, Valeria de Matos2013-12-04T15:54:24Z2013-12-04T15:54:24Z2012LUZ, N. F. et al. Heme Oxygenase-1 promotes the persistence of Leishmania chagasi infection. Journal of Immunology, v.188, n. 9, p. 4460-4467, 2012.0022-1767https://www.arca.fiocruz.br/handle/icict/727510.4049/jimmunol.1103072engThe American Association of Immunologists, Inc.,Heme Oxygenase-1 promotes the persistence of Leishmania chagasi infectioninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Salvador, BA, BrasilNational Institute of Allergy and Infectious Diseases. National Institutes of Health. Laboratory of Parasitic Diseases. Bethesda, MDUniversidade Federal do Rio de Janeiro. Instituto de Microbiologia. Departamento de Imunologia. Rio de Janeiro, RJ, BrasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Salvador, BA, BrasilUniversidade Federal de Sergipe. University Hospital. Department of Medicine. Aracaju, SE, BrasilUniversidade Federal de Sergipe. University Hospital. Department of Medicine. Aracaju, SE, BrasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Salvador, BA, Brasil / Instituto Nacional de Ciência e Tecnologia de Investigação em Imunologia. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Salvador, BA, Brasil / Instituto Nacional de Ciência e Tecnologia de Investigação em Imunologia. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Salvador, BA, Brasil / Universidade Federal de Sergipe. University Hospital. Department of Medicine. Aracaju, SE, BrasilFundação OSwaldo Cruz. Centro de Pesquisas René Rachou. Belo Horizonte, MG, BrasilUniversidade Federal de Sergipe. University Hospital. Department of Medicine. Aracaju, SE, Brasil / Universidade Federal de Sergipe. University Hospital. Department of Medicine. Aracaju, SE, BrasilUniversidade Federal do Rio de Janeiro. Instituto de Microbiologia. Departamento de Imunologia. Rio de Janeiro, RJ, BrasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Salvador, BA, Brasil / Instituto Nacional de Ciência e Tecnologia de Investigação em Imunologia. Salvador, BA, BrasilVisceral leishmaniasis (VL) remains a major public health problem worldwide. This disease is highly associated with chronic inflammation and a lack of the cellular immune responses against Leishmania. It is important to identify major factors driving the successful establishment of the Leishmania infection to develop better tools for the disease control. Heme oxygenase-1 (HO-1) is a key enzyme triggered by cellular stress, and its role in VL has not been investigated. In this study, we evaluated the role of HO-1 in the infection by Leishmania infantum chagasi, the causative agent of VL cases in Brazil. We found that L. chagasi infection or lipophosphoglycan isolated from promastigotes triggered HO-1 production by murine macrophages. Interestingly, cobalt protoporphyrin IX, an HO-1 inductor, increased the parasite burden in both mouse and human-derived macrophages. Upon L. chagasi infection, macrophages from Hmox1 knockout mice presented significantly lower parasite loads when compared with those from wild-type mice. Furthermore, upregulation of HO-1 by cobalt protoporphyrin IX diminished the production of TNF-a and reactive oxygen species by infected murine macrophages and increased Cu/Zn superoxide dismutase expression in human monocytes. Finally, patients with VL presented higher systemic concentrations of HO-1 than healthy individuals, and this increase of HO-1 was reduced after antileishmanial treatment, suggesting that HO-1 is associated with disease susceptibility. Our data argue that HO-1 has a critical role in the L. chagasi infection and is strongly associated with the inflammatory imbalance during VL. Manipulation of HO-1 pathways during VL could serve as an adjunctive therapeutic approachLeishmaniaLeishmaniose VisceralLeishmania infantumInfecçãoCamundongosinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALLuz NF Heme oxygenase....pdfLuz NF Heme oxygenase....pdfapplication/pdf1705190https://www.arca.fiocruz.br/bitstream/icict/7275/1/Luz%20NF%20Heme%20oxygenase....pdf76f434e3aa969061fbd046cfd76ea407MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81914https://www.arca.fiocruz.br/bitstream/icict/7275/2/license.txt7d48279ffeed55da8dfe2f8e81f3b81fMD52TEXTLuz NF Heme oxygenase....pdf.txtLuz NF Heme oxygenase....pdf.txtExtracted texttext/plain62206https://www.arca.fiocruz.br/bitstream/icict/7275/5/Luz%20NF%20Heme%20oxygenase....pdf.txt3c0c36d8290ebca01af2768d952b9145MD55THUMBNAILLuz NF Heme oxygenase....pdf.jpgLuz NF Heme oxygenase....pdf.jpgGenerated Thumbnailimage/jpeg2075https://www.arca.fiocruz.br/bitstream/icict/7275/4/Luz%20NF%20Heme%20oxygenase....pdf.jpg96ec781eb1ee998970b4243257c42fdeMD54icict/72752023-03-15 14:32:54.161oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:32:54Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false |
| dc.title.pt_BR.fl_str_mv |
Heme Oxygenase-1 promotes the persistence of Leishmania chagasi infection |
| title |
Heme Oxygenase-1 promotes the persistence of Leishmania chagasi infection |
| spellingShingle |
Heme Oxygenase-1 promotes the persistence of Leishmania chagasi infection Luz, Nívea Farias Leishmania Leishmaniose Visceral Leishmania infantum Infecção Camundongos |
| title_short |
Heme Oxygenase-1 promotes the persistence of Leishmania chagasi infection |
| title_full |
Heme Oxygenase-1 promotes the persistence of Leishmania chagasi infection |
| title_fullStr |
Heme Oxygenase-1 promotes the persistence of Leishmania chagasi infection |
| title_full_unstemmed |
Heme Oxygenase-1 promotes the persistence of Leishmania chagasi infection |
| title_sort |
Heme Oxygenase-1 promotes the persistence of Leishmania chagasi infection |
| author |
Luz, Nívea Farias |
| author_facet |
Luz, Nívea Farias Andrade, Bruno de Bezerril Feijó, Daniel F Santos, Théo de Araújo Carvalho, Graziele Quintela de Andrade, Daniela Abánades, Daniel Ruiz Melo, Enaldo V Silva, Angela M Brodskyn, Claudia Ida Barral Netto, Manoel Barral, Aldina Maria Prado Soares, Rodrigo Pedro Almeida, Roque Pacheco de Bozza, Marcelo Torres Borges, Valeria de Matos |
| author_role |
author |
| author2 |
Andrade, Bruno de Bezerril Feijó, Daniel F Santos, Théo de Araújo Carvalho, Graziele Quintela de Andrade, Daniela Abánades, Daniel Ruiz Melo, Enaldo V Silva, Angela M Brodskyn, Claudia Ida Barral Netto, Manoel Barral, Aldina Maria Prado Soares, Rodrigo Pedro Almeida, Roque Pacheco de Bozza, Marcelo Torres Borges, Valeria de Matos |
| author2_role |
author author author author author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Luz, Nívea Farias Andrade, Bruno de Bezerril Feijó, Daniel F Santos, Théo de Araújo Carvalho, Graziele Quintela de Andrade, Daniela Abánades, Daniel Ruiz Melo, Enaldo V Silva, Angela M Brodskyn, Claudia Ida Barral Netto, Manoel Barral, Aldina Maria Prado Soares, Rodrigo Pedro Almeida, Roque Pacheco de Bozza, Marcelo Torres Borges, Valeria de Matos |
| dc.subject.decs.pt_BR.fl_str_mv |
Leishmania Leishmaniose Visceral Leishmania infantum Infecção Camundongos |
| topic |
Leishmania Leishmaniose Visceral Leishmania infantum Infecção Camundongos |
| description |
Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Salvador, BA, Brasil |
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2012 |
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2012 |
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2013-12-04T15:54:24Z |
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2013-12-04T15:54:24Z |
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info:eu-repo/semantics/article |
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LUZ, N. F. et al. Heme Oxygenase-1 promotes the persistence of Leishmania chagasi infection. Journal of Immunology, v.188, n. 9, p. 4460-4467, 2012. |
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https://www.arca.fiocruz.br/handle/icict/7275 |
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0022-1767 |
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10.4049/jimmunol.1103072 |
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LUZ, N. F. et al. Heme Oxygenase-1 promotes the persistence of Leishmania chagasi infection. Journal of Immunology, v.188, n. 9, p. 4460-4467, 2012. 0022-1767 10.4049/jimmunol.1103072 |
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The American Association of Immunologists, Inc., |
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The American Association of Immunologists, Inc., |
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