Sex-associated differences in pre-antiretroviral therapy plasma HIV-1 RNA in diverse areas of the world vary by CD4(+) T-cell count

Detalhes bibliográficos
Autor(a) principal: Grinsztejn, Beatriz
Data de Publicação: 2011
Outros Autores: Smeaton, Laura, Barnett, Ronald, Klingman, Karin, Hakim, James, Flanigan, Timothy, Kumarasamy, N, Campbell, Thomas, Currier, Judith
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/30102
Resumo: Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em DST/AIDS. Rio de Janeiro, RJ, Brasil.
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spelling Grinsztejn, BeatrizSmeaton, LauraBarnett, RonaldKlingman, KarinHakim, JamesFlanigan, TimothyKumarasamy, NCampbell, ThomasCurrier, Judith2018-11-19T14:46:48Z2018-11-19T14:46:48Z2011GRINSZTEJN, Beatriz. et al. Sex-associated differences in pre-antiretroviral therapy plasma HIV-1 RNA in diverse areas of the world vary by CD4(+) T-cell count. Antiviral Therapy, v. 16, n. 7, p. 1057-62, 2011.1359-6535https://www.arca.fiocruz.br/handle/icict/3010210.3851/IMP1872engSex-associated differences in pre-antiretroviral therapy plasma HIV-1 RNA in diverse areas of the world vary by CD4(+) T-cell countinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em DST/AIDS. Rio de Janeiro, RJ, Brasil.Harvard School of Public Health. Statistical & Data Analysis Center. Boston, Massachusetts, USA.National Institutes of Health. Office of Biotechnology Activities. Bethesda, Maryland, USA.NIH. National Institute of Allergy and Infectious Diseases. Division of AIDS. HIV Research Branch. Bethesda, MD, USA.University of Zimbabwe College of Health Sciences. Harare, Zimbabwe.Brown Medical School. Providence, Rhode Island, USA.YRG Centre for AIDS Research & Education. Chennai, India.University of Colorado Health Sciences Center. Denver, Colorado, USA.University of California. Los Angeles, CA, USA.Background: Sex differences in the natural history of HIV infection may vary between resource-rich and resource-limited settings. Methods: Baseline characteristics from a randomized clinical trial of treatment-naive subjects conducted at sites in Africa, Asia, the Caribbean, and North and South America were analysed to determine if there were significant differences by sex. Results: Of the 1,571 participants, 740 (47.1%) were women. Women had higher mean screening CD4(+) T-cell counts (mean 15 cells higher; P<0.001), lower mean haemoglobin and creatinine clearance, a lower mean baseline HIV-1 viral load (4.85 log(10) versus 5.05 log₁₀ copies/ml; P<0.001) and were less likely to have a prior AIDS diagnosis than men. The sex difference in viral load was related to CD4(+) T-cell count; however, it was independent of country and persisted within the strata with CD4(+) T-cell count <200 cells/mm³. Conclusions: Women in resource-limited settings have lower levels of plasma HIV-1 RNA and appear to present for enrolment into clinical trials at an earlier stage of disease than men. The biological basis for lower viral load in women compared to men remains unexplained. It will be important to determine if the sex differences observed at baseline impact clinical outcomes once the PEARLS clinical trial is completed.Viral loadSexInternationalClinical trialCD4 cell countinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83099https://www.arca.fiocruz.br/bitstream/icict/30102/1/license.txt586c046dcfeef936e32f0323bb9a47c0MD51ORIGINALSex-associated Differences in Pre-Antiretroviral Therapy_Beatriz_Grinsztejn_INI_Lapclin-AIDS_2011.pdfSex-associated Differences in Pre-Antiretroviral Therapy_Beatriz_Grinsztejn_INI_Lapclin-AIDS_2011.pdfapplication/pdf437974https://www.arca.fiocruz.br/bitstream/icict/30102/2/Sex-associated%20Differences%20in%20Pre-Antiretroviral%20Therapy_Beatriz_Grinsztejn_INI_Lapclin-AIDS_2011.pdf76e808fe612017aa42893c15dc5fa5bbMD52TEXTSex-associated Differences in Pre-Antiretroviral 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dc.title.pt_BR.fl_str_mv Sex-associated differences in pre-antiretroviral therapy plasma HIV-1 RNA in diverse areas of the world vary by CD4(+) T-cell count
title Sex-associated differences in pre-antiretroviral therapy plasma HIV-1 RNA in diverse areas of the world vary by CD4(+) T-cell count
spellingShingle Sex-associated differences in pre-antiretroviral therapy plasma HIV-1 RNA in diverse areas of the world vary by CD4(+) T-cell count
Grinsztejn, Beatriz
Viral load
Sex
International
Clinical trial
CD4 cell count
title_short Sex-associated differences in pre-antiretroviral therapy plasma HIV-1 RNA in diverse areas of the world vary by CD4(+) T-cell count
title_full Sex-associated differences in pre-antiretroviral therapy plasma HIV-1 RNA in diverse areas of the world vary by CD4(+) T-cell count
title_fullStr Sex-associated differences in pre-antiretroviral therapy plasma HIV-1 RNA in diverse areas of the world vary by CD4(+) T-cell count
title_full_unstemmed Sex-associated differences in pre-antiretroviral therapy plasma HIV-1 RNA in diverse areas of the world vary by CD4(+) T-cell count
title_sort Sex-associated differences in pre-antiretroviral therapy plasma HIV-1 RNA in diverse areas of the world vary by CD4(+) T-cell count
author Grinsztejn, Beatriz
author_facet Grinsztejn, Beatriz
Smeaton, Laura
Barnett, Ronald
Klingman, Karin
Hakim, James
Flanigan, Timothy
Kumarasamy, N
Campbell, Thomas
Currier, Judith
author_role author
author2 Smeaton, Laura
Barnett, Ronald
Klingman, Karin
Hakim, James
Flanigan, Timothy
Kumarasamy, N
Campbell, Thomas
Currier, Judith
author2_role author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Grinsztejn, Beatriz
Smeaton, Laura
Barnett, Ronald
Klingman, Karin
Hakim, James
Flanigan, Timothy
Kumarasamy, N
Campbell, Thomas
Currier, Judith
dc.subject.en.pt_BR.fl_str_mv Viral load
Sex
International
Clinical trial
CD4 cell count
topic Viral load
Sex
International
Clinical trial
CD4 cell count
description Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em DST/AIDS. Rio de Janeiro, RJ, Brasil.
publishDate 2011
dc.date.issued.fl_str_mv 2011
dc.date.accessioned.fl_str_mv 2018-11-19T14:46:48Z
dc.date.available.fl_str_mv 2018-11-19T14:46:48Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv GRINSZTEJN, Beatriz. et al. Sex-associated differences in pre-antiretroviral therapy plasma HIV-1 RNA in diverse areas of the world vary by CD4(+) T-cell count. Antiviral Therapy, v. 16, n. 7, p. 1057-62, 2011.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/30102
dc.identifier.issn.pt_BR.fl_str_mv 1359-6535
dc.identifier.doi.none.fl_str_mv 10.3851/IMP1872
identifier_str_mv GRINSZTEJN, Beatriz. et al. Sex-associated differences in pre-antiretroviral therapy plasma HIV-1 RNA in diverse areas of the world vary by CD4(+) T-cell count. Antiviral Therapy, v. 16, n. 7, p. 1057-62, 2011.
1359-6535
10.3851/IMP1872
url https://www.arca.fiocruz.br/handle/icict/30102
dc.language.iso.fl_str_mv eng
language eng
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dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
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instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/30102/1/license.txt
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