Newborns with Zika virus-associated microcephaly exhibit marked systemic inflammatory imbalance (Preprint)

Detalhes bibliográficos
Autor(a) principal: Vinhaes, Caian L.
Data de Publicação: 2020
Outros Autores: Arriaga Gutiérrez, María Belen, Almeida, Breno L. de, Oliveira, João V., Santos, Cleiton S., Calcagno, Juan I., Carvalho, Tereza X., Giovanetti, Marta, Alcantara, Luiz Carlos Junior, Siqueira, Isadora Cristina de, Andrade, Bruno de Bezerril
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/41347
Resumo: Fundação Oswaldo Cruz, Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq; award number: 443875/2018-9 and 425380/2016) and Fundação de Amparo à Pesquisa do Estado da Bahia (FAPESB; award number: PPSUS/BA-FAPESB003/2017/SESAB/CNPq/MS 5125/2017). LCJA, MG and BLA were supported by CNPq/Ministério da Ciência, Tecnologia e Inovação (MCTI), Departamento de Ciência e Tecnologia (DECIT) / Secretaria de Ciência, Tecnologia e Insumos Estratégicos (SCTIE) / Ministério da Saúde (440685/2016-8) and Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) (88887.130716/2016-00). LCJA and ICS were supported by the European Union’s Horizon 2020 Programme through ZIKAlliance (grant no. PRES-005- FEX-17-4-2-33). The work from BBA was supported by the National Institutes of Health (U01AI115940) and by CNPq (senior fellowship). MBA received a fellowship from the FAPESB. CLV is a scientific initiation fellow from CNPq.
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spelling Vinhaes, Caian L.Arriaga Gutiérrez, María BelenAlmeida, Breno L. deOliveira, João V.Santos, Cleiton S.Calcagno, Juan I.Carvalho, Tereza X.Giovanetti, MartaAlcantara, Luiz Carlos JuniorSiqueira, Isadora Cristina deAndrade, Bruno de Bezerril2020-05-21T17:34:27Z2020-05-21T17:34:27Z2020VINHAES, Caian L. et al. Newborns with Zika virus-associated microcephaly exhibit marked systemic inflammatory imbalance. Journal of Infectious Diseases, p. 1-25, Apr. 2020. Preprint.0022-1899https://www.arca.fiocruz.br/handle/icict/4134710.1093/infdis/jiaa197Fundação Oswaldo Cruz, Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq; award number: 443875/2018-9 and 425380/2016) and Fundação de Amparo à Pesquisa do Estado da Bahia (FAPESB; award number: PPSUS/BA-FAPESB003/2017/SESAB/CNPq/MS 5125/2017). LCJA, MG and BLA were supported by CNPq/Ministério da Ciência, Tecnologia e Inovação (MCTI), Departamento de Ciência e Tecnologia (DECIT) / Secretaria de Ciência, Tecnologia e Insumos Estratégicos (SCTIE) / Ministério da Saúde (440685/2016-8) and Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) (88887.130716/2016-00). LCJA and ICS were supported by the European Union’s Horizon 2020 Programme through ZIKAlliance (grant no. PRES-005- FEX-17-4-2-33). The work from BBA was supported by the National Institutes of Health (U01AI115940) and by CNPq (senior fellowship). MBA received a fellowship from the FAPESB. CLV is a scientific initiation fellow from CNPq.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Multinational Organization Network Sponsoring Translational and Epidemiological Research Initiative. Salvador, BA, Brazil / Faculdade de Tecnologia e Ciências. Curso de Medicina. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Multinational Organization Network Sponsoring Translational and Epidemiological Research Initiative. Salvador, BA, Brazil / Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.Secretaria de Saúde do Estado da Bahia. Maternidade de Referência Prof. José Maria de Magalhães Netto. Salvador, BA, Brasil.Secretaria de Saúde do Estado da Bahia. Maternidade de Referência Prof. José Maria de Magalhães Netto. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Flavivírus. Rio de Janeiro, RJ, Brasil / Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Laboratório de Genética Celular e Molecular. Belo Horizonte, MG, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Flavivírus. Rio de Janeiro, RJ, Brasil / Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Laboratório de Genética Celular e Molecular. Belo Horizonte, MG, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Multinational Organization Network Sponsoring Translational and Epidemiological Research Initiative. Salvador, BA, Brazil / Faculdade de Tecnologia e Ciências. Curso de Medicina. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brasil / Universidade Salvador. Laureate Universities, Salvador, BA, Brazil / University of Cape Town. Institute of Infectious Disease and Molecular Medicine. Wellcome Centre for Infectious Disease Research in Africa. Cape Town, South Africa / Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brasil.Zika Virus (ZIKV) is an emergent flavivirus initially considered a benign and self-limited exanthematic illness. In 2015, a new epidemic emerged in northeastern of Brazil with increased incidence of a previously rare clinical outcome, microcephaly, in newborns from mothers who were infected during pregnancy. Little is known about the immunopathogenesis of ZIKV-associated microcephaly. Understanding the inflammatory profile and degree of inflammation of persons affected with such condition is an important step towards development of innovative therapeutic strategies. Methods: A case-control study compared plasma levels of several inflammatory biomarkers from newborns with ZIKV-microcephaly, asymptomatic ZKV infection or uninfected controls. Plasma biomarkers were assessed using Luminex. A series of multidimensional analysis was performed to characterize the systemic immune activation profile of the clinical groups. Results: We identified an inflammatory signature associated with ZIKV-microcephaly that suggested an increased inflammation. Network analysis suggested that ZIKV-microcephaly is associated with imbalanced immune activation and inflammation. The cephalic perimeter was inversely proportional with the degree of inflammatory perturbation. Furthermore, a combination of plasma inflammatory biomarkers could discriminate ZIKV with microcephaly from those with ZIKV without microcephaly or uninfected neonates.engOxford University PressVírus zikaRecém-nascidosMicrocefaliaInflamaçãoZika VirusNewbornsMicrocephalyInflammationNewborns with Zika virus-associated microcephaly exhibit marked systemic inflammatory imbalance (Preprint)info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/41347/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALVinhaes Caian, Newborns....pdfVinhaes Caian, Newborns....pdfapplication/pdf1052365https://www.arca.fiocruz.br/bitstream/icict/41347/2/Vinhaes%20Caian%2c%20Newborns....pdf0a3c425b41d0215e08c35d8594a8c611MD52TEXTVinhaes Caian, 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dc.title.pt_BR.fl_str_mv Newborns with Zika virus-associated microcephaly exhibit marked systemic inflammatory imbalance (Preprint)
title Newborns with Zika virus-associated microcephaly exhibit marked systemic inflammatory imbalance (Preprint)
spellingShingle Newborns with Zika virus-associated microcephaly exhibit marked systemic inflammatory imbalance (Preprint)
Vinhaes, Caian L.
Vírus zika
Recém-nascidos
Microcefalia
Inflamação
Zika Virus
Newborns
Microcephaly
Inflammation
title_short Newborns with Zika virus-associated microcephaly exhibit marked systemic inflammatory imbalance (Preprint)
title_full Newborns with Zika virus-associated microcephaly exhibit marked systemic inflammatory imbalance (Preprint)
title_fullStr Newborns with Zika virus-associated microcephaly exhibit marked systemic inflammatory imbalance (Preprint)
title_full_unstemmed Newborns with Zika virus-associated microcephaly exhibit marked systemic inflammatory imbalance (Preprint)
title_sort Newborns with Zika virus-associated microcephaly exhibit marked systemic inflammatory imbalance (Preprint)
author Vinhaes, Caian L.
author_facet Vinhaes, Caian L.
Arriaga Gutiérrez, María Belen
Almeida, Breno L. de
Oliveira, João V.
Santos, Cleiton S.
Calcagno, Juan I.
Carvalho, Tereza X.
Giovanetti, Marta
Alcantara, Luiz Carlos Junior
Siqueira, Isadora Cristina de
Andrade, Bruno de Bezerril
author_role author
author2 Arriaga Gutiérrez, María Belen
Almeida, Breno L. de
Oliveira, João V.
Santos, Cleiton S.
Calcagno, Juan I.
Carvalho, Tereza X.
Giovanetti, Marta
Alcantara, Luiz Carlos Junior
Siqueira, Isadora Cristina de
Andrade, Bruno de Bezerril
author2_role author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Vinhaes, Caian L.
Arriaga Gutiérrez, María Belen
Almeida, Breno L. de
Oliveira, João V.
Santos, Cleiton S.
Calcagno, Juan I.
Carvalho, Tereza X.
Giovanetti, Marta
Alcantara, Luiz Carlos Junior
Siqueira, Isadora Cristina de
Andrade, Bruno de Bezerril
dc.subject.other.pt_BR.fl_str_mv Vírus zika
Recém-nascidos
Microcefalia
Inflamação
topic Vírus zika
Recém-nascidos
Microcefalia
Inflamação
Zika Virus
Newborns
Microcephaly
Inflammation
dc.subject.en.pt_BR.fl_str_mv Zika Virus
Newborns
Microcephaly
Inflammation
description Fundação Oswaldo Cruz, Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq; award number: 443875/2018-9 and 425380/2016) and Fundação de Amparo à Pesquisa do Estado da Bahia (FAPESB; award number: PPSUS/BA-FAPESB003/2017/SESAB/CNPq/MS 5125/2017). LCJA, MG and BLA were supported by CNPq/Ministério da Ciência, Tecnologia e Inovação (MCTI), Departamento de Ciência e Tecnologia (DECIT) / Secretaria de Ciência, Tecnologia e Insumos Estratégicos (SCTIE) / Ministério da Saúde (440685/2016-8) and Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) (88887.130716/2016-00). LCJA and ICS were supported by the European Union’s Horizon 2020 Programme through ZIKAlliance (grant no. PRES-005- FEX-17-4-2-33). The work from BBA was supported by the National Institutes of Health (U01AI115940) and by CNPq (senior fellowship). MBA received a fellowship from the FAPESB. CLV is a scientific initiation fellow from CNPq.
publishDate 2020
dc.date.accessioned.fl_str_mv 2020-05-21T17:34:27Z
dc.date.available.fl_str_mv 2020-05-21T17:34:27Z
dc.date.issued.fl_str_mv 2020
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv VINHAES, Caian L. et al. Newborns with Zika virus-associated microcephaly exhibit marked systemic inflammatory imbalance. Journal of Infectious Diseases, p. 1-25, Apr. 2020. Preprint.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/41347
dc.identifier.issn.pt_BR.fl_str_mv 0022-1899
dc.identifier.doi.pt_BR.fl_str_mv 10.1093/infdis/jiaa197
identifier_str_mv VINHAES, Caian L. et al. Newborns with Zika virus-associated microcephaly exhibit marked systemic inflammatory imbalance. Journal of Infectious Diseases, p. 1-25, Apr. 2020. Preprint.
0022-1899
10.1093/infdis/jiaa197
url https://www.arca.fiocruz.br/handle/icict/41347
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
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dc.publisher.none.fl_str_mv Oxford University Press
publisher.none.fl_str_mv Oxford University Press
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
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