IFN-alpha as a time-sensitive biomarker during Oropouche virus infection in early and late seroconverters

Detalhes bibliográficos
Autor(a) principal: Oliveira, Euzébio de
Data de Publicação: 2019
Outros Autores: Azevedo, Raimunda do Socorro Silva, Reis, Jordana Grazziela Coelho Dos, Antonelli, Lis Ribeiro do Valle, Ferreira, Milene Silveira, Azevedo, Ana Carolina Campi, Silva, Matheus Fernandes Costa, Martins, Lívia Carício, Chiang, Jannifer Oliveira, Carvalho, Andréa Teixeira de, Martins Filho, Olindo Assis, Vasconcelos, Pedro Fernando Costa
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/57518
https://doi.org/10.1038/s41598-019-54223-w
Resumo: Instituto Evandro Chagas. Ananindeua, PA, Brazil.
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spelling Oliveira, Euzébio deAzevedo, Raimunda do Socorro SilvaReis, Jordana Grazziela Coelho DosAntonelli, Lis Ribeiro do ValleFerreira, Milene SilveiraAzevedo, Ana Carolina CampiSilva, Matheus Fernandes CostaMartins, Lívia CarícioChiang, Jannifer OliveiraCarvalho, Andréa Teixeira deMartins Filho, Olindo AssisVasconcelos, Pedro Fernando Costa2023-03-23T13:33:57Z2023-03-23T13:33:57Z2019OLIVEIRA, Euzébio de et al. IFN-α as a time-sensitive biomarker during Oropouche virus infection in early and late seroconverters. Sci Rep., v. 9, n. 1, p. 17924, 2019. doi: 10.1038/s41598-019-54223-w.2045-2322https://www.arca.fiocruz.br/handle/icict/57518https://doi.org/10.1038/s41598-019-54223-wengNature Publishing GroupIFN-alpha as a time-sensitive biomarker during Oropouche virus infection in early and late seroconvertersinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleInstituto Evandro Chagas. Ananindeua, PA, Brazil.Instituto Evandro Chagas. Ananindeua, PA, Brazil.Universidade Federal de Minas Gerais. Belo Horizonte, MG, Brazil/ Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brazil.Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brazil.Instituto Evandro Chagas. Ananindeua, PA, Brazil.Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brazil.Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brazil.Instituto Evandro Chagas. Ananindeua, PA, Brazil.Instituto Evandro Chagas. Ananindeua, PA, Brazil.Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brazil.Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brazil.Instituto Evandro Chagas. Ananindeua, PA, Brazil.In the present study, patients with acute OROV fever were classified as early seroconverters (IgM/IgG positive at baseline) or late seroconverters (IgM/IgG negative at baseline) and the timeline kinetics of the production of chemokines and cytokines were assessed at 1-3, 4-7, 8-10 and ≥11 days after patients have reported the first symptoms. Regardless immunoglobulin profile, all OROV fever patients presented higher levels of CXCL8, and IFN-α and lower levels of TNF and IL-10 at baseline as compared to healthy donors (HD). Lower levels of CCL2, CXCL10, and IFN-γ and higher levels of CCL2, CXCL10, IL-6, and IL-17A were detected in early and late seroconverters, respectively, as compared to HD. While early seroconverters presented the increasing levels of CCL2 along the timeline, late seroconverters displayed decreasing levels of CCL2, CXCL10, and IL-6 following days of disease onset. Noteworthy was that IFN-α was revealed as universal biomarker of human OROV fever, while CXCL8 & IL-5 and CXCL10 & IL-17 were consistently observed in early and late seroconverters, respectively. Thus, our results suggest that the production of IFN-α, CXCL10, and IL-17 precede the seroconversion bringing novel insights on the immunological events triggered by the OROV disease.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALIFN-α as a time-sensitive biomarker during.pdfIFN-α as a time-sensitive biomarker during.pdfapplication/pdf3070393https://www.arca.fiocruz.br/bitstream/icict/57518/2/IFN-%ce%b1%20as%20a%20time-sensitive%20biomarker%20during.pdf736f683e0fef491ac906638609a4d9bbMD52LICENSElicense.txttext/plain1748https://www.arca.fiocruz.br/bitstream/icict/57518/1/license.txt8a4605be74aa9ea9d79846c1fba20a33MD51icict/575182023-03-23 10:33:58.607oai:www.arca.fiocruz.br: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Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-23T13:33:58Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.en_US.fl_str_mv IFN-alpha as a time-sensitive biomarker during Oropouche virus infection in early and late seroconverters
title IFN-alpha as a time-sensitive biomarker during Oropouche virus infection in early and late seroconverters
spellingShingle IFN-alpha as a time-sensitive biomarker during Oropouche virus infection in early and late seroconverters
Oliveira, Euzébio de
title_short IFN-alpha as a time-sensitive biomarker during Oropouche virus infection in early and late seroconverters
title_full IFN-alpha as a time-sensitive biomarker during Oropouche virus infection in early and late seroconverters
title_fullStr IFN-alpha as a time-sensitive biomarker during Oropouche virus infection in early and late seroconverters
title_full_unstemmed IFN-alpha as a time-sensitive biomarker during Oropouche virus infection in early and late seroconverters
title_sort IFN-alpha as a time-sensitive biomarker during Oropouche virus infection in early and late seroconverters
author Oliveira, Euzébio de
author_facet Oliveira, Euzébio de
Azevedo, Raimunda do Socorro Silva
Reis, Jordana Grazziela Coelho Dos
Antonelli, Lis Ribeiro do Valle
Ferreira, Milene Silveira
Azevedo, Ana Carolina Campi
Silva, Matheus Fernandes Costa
Martins, Lívia Carício
Chiang, Jannifer Oliveira
Carvalho, Andréa Teixeira de
Martins Filho, Olindo Assis
Vasconcelos, Pedro Fernando Costa
author_role author
author2 Azevedo, Raimunda do Socorro Silva
Reis, Jordana Grazziela Coelho Dos
Antonelli, Lis Ribeiro do Valle
Ferreira, Milene Silveira
Azevedo, Ana Carolina Campi
Silva, Matheus Fernandes Costa
Martins, Lívia Carício
Chiang, Jannifer Oliveira
Carvalho, Andréa Teixeira de
Martins Filho, Olindo Assis
Vasconcelos, Pedro Fernando Costa
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Oliveira, Euzébio de
Azevedo, Raimunda do Socorro Silva
Reis, Jordana Grazziela Coelho Dos
Antonelli, Lis Ribeiro do Valle
Ferreira, Milene Silveira
Azevedo, Ana Carolina Campi
Silva, Matheus Fernandes Costa
Martins, Lívia Carício
Chiang, Jannifer Oliveira
Carvalho, Andréa Teixeira de
Martins Filho, Olindo Assis
Vasconcelos, Pedro Fernando Costa
description Instituto Evandro Chagas. Ananindeua, PA, Brazil.
publishDate 2019
dc.date.issued.fl_str_mv 2019
dc.date.accessioned.fl_str_mv 2023-03-23T13:33:57Z
dc.date.available.fl_str_mv 2023-03-23T13:33:57Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv OLIVEIRA, Euzébio de et al. IFN-α as a time-sensitive biomarker during Oropouche virus infection in early and late seroconverters. Sci Rep., v. 9, n. 1, p. 17924, 2019. doi: 10.1038/s41598-019-54223-w.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/57518
dc.identifier.issn.en_US.fl_str_mv 2045-2322
dc.identifier.doi.none.fl_str_mv https://doi.org/10.1038/s41598-019-54223-w
identifier_str_mv OLIVEIRA, Euzébio de et al. IFN-α as a time-sensitive biomarker during Oropouche virus infection in early and late seroconverters. Sci Rep., v. 9, n. 1, p. 17924, 2019. doi: 10.1038/s41598-019-54223-w.
2045-2322
url https://www.arca.fiocruz.br/handle/icict/57518
https://doi.org/10.1038/s41598-019-54223-w
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