Phenylpropanoids from Croton velutinus with cytotoxic, trypanocidal and anti-inflammatory activities

Detalhes bibliográficos
Autor(a) principal: Abreu, Lucas Silva
Data de Publicação: 2020
Outros Autores: Nascimento, Yuri Mangueira do, Espirito-Santo, Renan Fernandes do, Meira, Cassio Santana, Santos, Ivanilson Pimenta, Brandao, Railda Batista, Souto, Augusto Lopes, Guedes, Maria Lenise Silva, Soares, Milena Botelho Pereira, Villarreal, Cristiane Flora, Veloz, Marcelo Sobral da Eudes da Silva, Tavares, Josean Fechine
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/43822
Resumo: Coordenação de Aperfeiçoamento de Pessoal de Nivel Superior - Brasil (CAPES) (Finance Code 001) and Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq) for financial support and fellowships. We are also thankful for Rede Norte-Nordeste de Fitoterapicos (INCT-RENNOFITO) collaborations.
id CRUZ_6c51f4a7c0f3805d5b797dfd4b26477a
oai_identifier_str oai:www.arca.fiocruz.br:icict/43822
network_acronym_str CRUZ
network_name_str Repositório Institucional da FIOCRUZ (ARCA)
repository_id_str 2135
spelling Abreu, Lucas SilvaNascimento, Yuri Mangueira doEspirito-Santo, Renan Fernandes doMeira, Cassio SantanaSantos, Ivanilson PimentaBrandao, Railda BatistaSouto, Augusto LopesGuedes, Maria Lenise SilvaSoares, Milena Botelho PereiraVillarreal, Cristiane FloraVeloz, Marcelo Sobral da Eudes da SilvaTavares, Josean Fechine2020-10-06T11:45:00Z2020-10-06T11:45:00Z2020ABREU, Lucas Silva et al. Phenylpropanoids from Croton velutinus with cytotoxic, trypanocidal and anti-inflammatory activities. Fitoterapia, 2020.0367-326Xhttps://www.arca.fiocruz.br/handle/icict/43822Coordenação de Aperfeiçoamento de Pessoal de Nivel Superior - Brasil (CAPES) (Finance Code 001) and Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq) for financial support and fellowships. We are also thankful for Rede Norte-Nordeste de Fitoterapicos (INCT-RENNOFITO) collaborations.Universidade Federal da Paraiba. Instituto de Pesquisa em Fármacos e Medicamentos. Joao Pessoa, PB, Brasil.Universidade Federal da Paraiba. Instituto de Pesquisa em Fármacos e Medicamentos. Joao Pessoa, PB, Brasil.Fundação Oswaldo Cruz. instituto Gonçalo Moniz. Salvador, BA, Brasil.Fundação Oswaldo Cruz. instituto Gonçalo Moniz. Salvador, BA, Brasil.Fundação Oswaldo Cruz. instituto Gonçalo Moniz. Salvador, BA, Brasil.Universidade Federal da Bahia. Faculdade de Farmácia. Salvador, BA, Brasil.Universidade Federal da Paraiba. Instituto de Pesquisa em Fármacos e Medicamentos. Joao Pessoa, PB, Brasil., Universidade Federal da Bahia. Instituto de Biologia. Salvador, BA, Brasil.Fundação Oswaldo Cruz. instituto Gonçalo Moniz. Salvador, BA, Brasil.Universidade Federal da Bahia. Faculdade de Farmácia. Salvador, BA, Brasil.Universidade Federal da Paraiba. Instituto de Pesquisa em Fármacos e Medicamentos. Joao Pessoa, PB, Brasil.Universidade Federal da Bahia. Faculdade de Farmácia. Salvador, BA, Brasil.Universidade Federal da Paraiba. Instituto de Pesquisa em Fármacos e Medicamentos. Joao Pessoa, PB, Brasil.This current study presents the phytochemical analysis of Croton velutinus, describing phenylpropanoids obtained from this species. The fractionation of the roots hexane extract led to the isolation of four new phenylpropanoids derivatives, velutines A—D (1-4) and three known (5-7). Their structures were established based on spectro- scopic (1D-2D NAM; HRMS and IR) analysis. Cytotoxic, trypanocidal and anti-inflammatory activities of com- pounds 1-7 were evaluated. Only compounds 2 and 5 showed cytotoxic activity against cancer cell lines (016F10, HL-60, HCT116, MCF-7 and HepG2), with IC50 values ranging from 6.8 to 18.3 pM and 11.1 to 18.3 pM, respectively. Compounds 2 and 5 also showed trypanocidal activity against bloodstream trypomasti- gotes with ECse values of 9.0 and 9.58 pM, respectively. Finally, the anti-inflammatory potential of these compounds was evaluated on cultures of activated macrophages. All compounds exhibited concentration-de- pendent suppressive activity on the production of nitrite and IL-1[i by macrophages stimulated with LPS and IFN- y. These results indicate phenylpropanoids esters (2 and 5) from C. velutinus as promising cytotoxic, trypanocidal and anti-inflammatory candidates that warrants further studies.engElsevierCrotonCitotóxicosTripanocidasAnti-inflamatórioCroton velutinusPhenylpropanoidsCytotoxicTrypanocidalAnti-inflammatoryPhenylpropanoids from Croton velutinus with cytotoxic, trypanocidal and anti-inflammatory activitiesinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/43822/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALAbreu, Lucas Silva Phenylpropanoids....pdfAbreu, Lucas Silva Phenylpropanoids....pdfapplication/pdf3402897https://www.arca.fiocruz.br/bitstream/icict/43822/2/Abreu%2c%20Lucas%20Silva%20Phenylpropanoids....pdf05e2e5b16576eb25150a15989e54fcf1MD52TEXTAbreu, Lucas Silva Phenylpropanoids....pdf.txtAbreu, Lucas Silva Phenylpropanoids....pdf.txtExtracted texttext/plain6https://www.arca.fiocruz.br/bitstream/icict/43822/3/Abreu%2c%20Lucas%20Silva%20Phenylpropanoids....pdf.txt6d93d3216dc4a7f5df47d4876fbec4d3MD53icict/438222023-03-15 14:34:23.66oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:34:23Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Phenylpropanoids from Croton velutinus with cytotoxic, trypanocidal and anti-inflammatory activities
title Phenylpropanoids from Croton velutinus with cytotoxic, trypanocidal and anti-inflammatory activities
spellingShingle Phenylpropanoids from Croton velutinus with cytotoxic, trypanocidal and anti-inflammatory activities
Abreu, Lucas Silva
Croton
Citotóxicos
Tripanocidas
Anti-inflamatório
Croton velutinus
Phenylpropanoids
Cytotoxic
Trypanocidal
Anti-inflammatory
title_short Phenylpropanoids from Croton velutinus with cytotoxic, trypanocidal and anti-inflammatory activities
title_full Phenylpropanoids from Croton velutinus with cytotoxic, trypanocidal and anti-inflammatory activities
title_fullStr Phenylpropanoids from Croton velutinus with cytotoxic, trypanocidal and anti-inflammatory activities
title_full_unstemmed Phenylpropanoids from Croton velutinus with cytotoxic, trypanocidal and anti-inflammatory activities
title_sort Phenylpropanoids from Croton velutinus with cytotoxic, trypanocidal and anti-inflammatory activities
author Abreu, Lucas Silva
author_facet Abreu, Lucas Silva
Nascimento, Yuri Mangueira do
Espirito-Santo, Renan Fernandes do
Meira, Cassio Santana
Santos, Ivanilson Pimenta
Brandao, Railda Batista
Souto, Augusto Lopes
Guedes, Maria Lenise Silva
Soares, Milena Botelho Pereira
Villarreal, Cristiane Flora
Veloz, Marcelo Sobral da Eudes da Silva
Tavares, Josean Fechine
author_role author
author2 Nascimento, Yuri Mangueira do
Espirito-Santo, Renan Fernandes do
Meira, Cassio Santana
Santos, Ivanilson Pimenta
Brandao, Railda Batista
Souto, Augusto Lopes
Guedes, Maria Lenise Silva
Soares, Milena Botelho Pereira
Villarreal, Cristiane Flora
Veloz, Marcelo Sobral da Eudes da Silva
Tavares, Josean Fechine
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Abreu, Lucas Silva
Nascimento, Yuri Mangueira do
Espirito-Santo, Renan Fernandes do
Meira, Cassio Santana
Santos, Ivanilson Pimenta
Brandao, Railda Batista
Souto, Augusto Lopes
Guedes, Maria Lenise Silva
Soares, Milena Botelho Pereira
Villarreal, Cristiane Flora
Veloz, Marcelo Sobral da Eudes da Silva
Tavares, Josean Fechine
dc.subject.other.pt_BR.fl_str_mv Croton
Citotóxicos
Tripanocidas
Anti-inflamatório
topic Croton
Citotóxicos
Tripanocidas
Anti-inflamatório
Croton velutinus
Phenylpropanoids
Cytotoxic
Trypanocidal
Anti-inflammatory
dc.subject.en.pt_BR.fl_str_mv Croton velutinus
Phenylpropanoids
Cytotoxic
Trypanocidal
Anti-inflammatory
description Coordenação de Aperfeiçoamento de Pessoal de Nivel Superior - Brasil (CAPES) (Finance Code 001) and Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq) for financial support and fellowships. We are also thankful for Rede Norte-Nordeste de Fitoterapicos (INCT-RENNOFITO) collaborations.
publishDate 2020
dc.date.accessioned.fl_str_mv 2020-10-06T11:45:00Z
dc.date.available.fl_str_mv 2020-10-06T11:45:00Z
dc.date.issued.fl_str_mv 2020
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv ABREU, Lucas Silva et al. Phenylpropanoids from Croton velutinus with cytotoxic, trypanocidal and anti-inflammatory activities. Fitoterapia, 2020.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/43822
dc.identifier.issn.pt_BR.fl_str_mv 0367-326X
identifier_str_mv ABREU, Lucas Silva et al. Phenylpropanoids from Croton velutinus with cytotoxic, trypanocidal and anti-inflammatory activities. Fitoterapia, 2020.
0367-326X
url https://www.arca.fiocruz.br/handle/icict/43822
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/43822/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/43822/2/Abreu%2c%20Lucas%20Silva%20Phenylpropanoids....pdf
https://www.arca.fiocruz.br/bitstream/icict/43822/3/Abreu%2c%20Lucas%20Silva%20Phenylpropanoids....pdf.txt
bitstream.checksum.fl_str_mv 5a560609d32a3863062d77ff32785d58
05e2e5b16576eb25150a15989e54fcf1
6d93d3216dc4a7f5df47d4876fbec4d3
bitstream.checksumAlgorithm.fl_str_mv MD5
MD5
MD5
repository.name.fl_str_mv Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)
repository.mail.fl_str_mv repositorio.arca@fiocruz.br
_version_ 1798324647089930240

Registros relacionados