Leishmania amazonensis infection induces behavioral alterations and modulates cytokine and neurotrophin production in the murine cerebral cortex

Detalhes bibliográficos
Autor(a) principal: Portes, Alex
Data de Publicação: 2016
Outros Autores: Giestal-de-Araujo, Elizabeth, Fagundes, Aline, Pandolfo, Pablo, Geraldo, Arnaldo de Sá, Lira, Marie Luce Flores, Amaral, Veronica Figueiredo, Lagrota-Candido, Jussara
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/32475
Resumo: 2020-04-12
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spelling Portes, AlexGiestal-de-Araujo, ElizabethFagundes, AlinePandolfo, PabloGeraldo, Arnaldo de SáLira, Marie Luce FloresAmaral, Veronica FigueiredoLagrota-Candido, Jussara2019-04-12T14:22:33Z2019-04-12T14:22:33Z2016PORTES, Alex et al. Leishmania amazonensis infection induces behavioral alterations and modulates cytokine and neurotrophin production in the murine cerebral cortex. Journal of Neuroimmunology, v. 301, p. 65-73, 2016.0165-5728https://www.arca.fiocruz.br/handle/icict/3247510.1016/j.jneuroim.2016.11.003engElsevierLeishmania amazonensis infection induces behavioral alterations and modulates cytokine and neurotrophin production in the murine cerebral cortexinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article2020-04-12Universidade Federal Fluminense. Departamento de Imunobiologia. Laboratório de Imunopatologia. Niterói, RJ, Brasil.Universidade Federal Fluminense. Departamento de Neurobiologia. Laboratório de Cultura de Tecidos Hertha Meyer. Niterói, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Vigilância em Leishmanioses. Rio de Janeiro, RJ, Brasil.Universidade Federal Fluminense. Departamento de Neurobiologia. Laboratório de Neurobiologia do Comportamento Animal. Niterói, RJ, Brasil.Universidade Federal Fluminense. Departamento de Neurobiologia. Laboratório de Neurobiologia do Comportamento Animal. Niterói, RJ, Brasil.Universidade Federal Fluminense. Departamento de Imunobiologia. Laboratório de Imunopatologia. Niterói, RJ, Brasil.Universidade Federal Fluminense. Departamento de Imunobiologia. Laboratório de Imunopatologia. Niterói, RJ, Brasil.Universidade Federal Fluminense. Departamento de Imunobiologia. Laboratório de Imunopatologia. Niterói, RJ, Brasil.Neurological symptoms have been associated with Leishmania infection, however little is known about how the nervous system is affected in leishmaniasis. This work aimed to analyze parasitic load, production of cytokines/neurotrophins in the prefrontal cortex and behavioral changes in BALB/c mice infected with Leishmania amazonensis. At 2 and 4months post-infection, infected mice showed a decrease in IFN-γ, IL-1, IL-6, IL-4, IL-10 cytokines and BDNF and NGF neurotrophins in prefrontal cortex associated with increased anxiety behavior. Parasite DNA was found in brain of all animals at 4months post-infection, when the levels of IBA-1 (activated macrophage/microglia marker) and TNF-α was increased in the prefrontal cortex. However TNF-α returned to normal levels at 6months post-infection suggesting a neuroprotective mechanism.Leishmania amazonensisCentral nervous systemCytokinesAnxietyNeurotrophic factorsinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83104https://www.arca.fiocruz.br/bitstream/icict/32475/1/license.txt79178e5f2a0eb066867a274556814938MD51ORIGINALve_Portes_Alex_etal_INI_2016.pdfve_Portes_Alex_etal_INI_2016.pdfapplication/pdf1033641https://www.arca.fiocruz.br/bitstream/icict/32475/2/ve_Portes_Alex_etal_INI_2016.pdf9e686ad6a7635a40658c0e862efd9837MD52TEXTve_Portes_Alex_etal_INI_2016.pdf.txtve_Portes_Alex_etal_INI_2016.pdf.txtExtracted texttext/plain48403https://www.arca.fiocruz.br/bitstream/icict/32475/3/ve_Portes_Alex_etal_INI_2016.pdf.txt22e0108857abcfd29ee706c324e23dd8MD53icict/324752021-03-24 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dc.title.pt_BR.fl_str_mv Leishmania amazonensis infection induces behavioral alterations and modulates cytokine and neurotrophin production in the murine cerebral cortex
title Leishmania amazonensis infection induces behavioral alterations and modulates cytokine and neurotrophin production in the murine cerebral cortex
spellingShingle Leishmania amazonensis infection induces behavioral alterations and modulates cytokine and neurotrophin production in the murine cerebral cortex
Portes, Alex
Leishmania amazonensis
Central nervous system
Cytokines
Anxiety
Neurotrophic factors
title_short Leishmania amazonensis infection induces behavioral alterations and modulates cytokine and neurotrophin production in the murine cerebral cortex
title_full Leishmania amazonensis infection induces behavioral alterations and modulates cytokine and neurotrophin production in the murine cerebral cortex
title_fullStr Leishmania amazonensis infection induces behavioral alterations and modulates cytokine and neurotrophin production in the murine cerebral cortex
title_full_unstemmed Leishmania amazonensis infection induces behavioral alterations and modulates cytokine and neurotrophin production in the murine cerebral cortex
title_sort Leishmania amazonensis infection induces behavioral alterations and modulates cytokine and neurotrophin production in the murine cerebral cortex
author Portes, Alex
author_facet Portes, Alex
Giestal-de-Araujo, Elizabeth
Fagundes, Aline
Pandolfo, Pablo
Geraldo, Arnaldo de Sá
Lira, Marie Luce Flores
Amaral, Veronica Figueiredo
Lagrota-Candido, Jussara
author_role author
author2 Giestal-de-Araujo, Elizabeth
Fagundes, Aline
Pandolfo, Pablo
Geraldo, Arnaldo de Sá
Lira, Marie Luce Flores
Amaral, Veronica Figueiredo
Lagrota-Candido, Jussara
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Portes, Alex
Giestal-de-Araujo, Elizabeth
Fagundes, Aline
Pandolfo, Pablo
Geraldo, Arnaldo de Sá
Lira, Marie Luce Flores
Amaral, Veronica Figueiredo
Lagrota-Candido, Jussara
dc.subject.en.pt_BR.fl_str_mv Leishmania amazonensis
Central nervous system
Cytokines
Anxiety
Neurotrophic factors
topic Leishmania amazonensis
Central nervous system
Cytokines
Anxiety
Neurotrophic factors
description 2020-04-12
publishDate 2016
dc.date.issued.fl_str_mv 2016
dc.date.accessioned.fl_str_mv 2019-04-12T14:22:33Z
dc.date.available.fl_str_mv 2019-04-12T14:22:33Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv PORTES, Alex et al. Leishmania amazonensis infection induces behavioral alterations and modulates cytokine and neurotrophin production in the murine cerebral cortex. Journal of Neuroimmunology, v. 301, p. 65-73, 2016.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/32475
dc.identifier.issn.pt_BR.fl_str_mv 0165-5728
dc.identifier.doi.none.fl_str_mv 10.1016/j.jneuroim.2016.11.003
identifier_str_mv PORTES, Alex et al. Leishmania amazonensis infection induces behavioral alterations and modulates cytokine and neurotrophin production in the murine cerebral cortex. Journal of Neuroimmunology, v. 301, p. 65-73, 2016.
0165-5728
10.1016/j.jneuroim.2016.11.003
url https://www.arca.fiocruz.br/handle/icict/32475
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/32475/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/32475/2/ve_Portes_Alex_etal_INI_2016.pdf
https://www.arca.fiocruz.br/bitstream/icict/32475/3/ve_Portes_Alex_etal_INI_2016.pdf.txt
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repository.name.fl_str_mv Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)
repository.mail.fl_str_mv repositorio.arca@fiocruz.br
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