Dynamic Dispersion of HIV-1 Subtype C Toward Brazilian Northeastern Region

Detalhes bibliográficos
Autor(a) principal: Oliveira, Rodrigo Cunha
Data de Publicação: 2021
Outros Autores: Graf, Tiago, Rego, Filipe Ferreira de Almeida, Silva, Gabriela Porto Santos Almeida, Giovanetti, Marta, Cunha, Joana Paixão Monteiro
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/50067
Resumo: Fundação de Amparo a` Pesquisa do Estado da Bahia (FAPESB) for the masters scholarship. M.G. thanks Fundação de Amparo a` Pesquisa do Estado do Rio de Janeiro (FAPERJ).
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spelling Oliveira, Rodrigo CunhaGraf, TiagoRego, Filipe Ferreira de AlmeidaSilva, Gabriela Porto Santos AlmeidaGiovanetti, MartaCunha, Joana Paixão Monteiro2021-11-25T18:45:41Z2021-11-25T18:45:41Z2021OLIVEIRA, Rodrigo Cunha et al. Dispersion of HIV-1 Subtype C Toward Brazilian Northeastern Region. AIDS Research and Human Retroviruses, 2021.0889-2229https://www.arca.fiocruz.br/handle/icict/5006710.1089/aid.2020.0308Fundação de Amparo a` Pesquisa do Estado da Bahia (FAPESB) for the masters scholarship. M.G. thanks Fundação de Amparo a` Pesquisa do Estado do Rio de Janeiro (FAPERJ).Universidade Federal da Bahia. Núcleo de Bioinformática, Departamento de Bioquímica e Biofísica. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Bahia, Brasil.Universidade Católica do Salvador. Salvador, BA, Brasil.Universidade Federal da Bahia. Núcleo de Bioinformática, Departamento de Bioquímia e Biofísica. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil / Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Laboratório de Genética Celular e Molecular. Minas Gerais, BH, Brasil.Universidade Federal da Bahia. Núcleo de Bioinformática, Departamento de Bioquímica e Biofísica. Salvador, BA, Brasil.The subtype C accounts for >50% of HIV type 1 (HIV-1) infections worldwide and it is currently the predominant viral form in South Brazil. Subtype C has been reported in all Brazilian regions; however, the phylogenetic relationship among strains circulating in those regions still remains unclear. This study aimed to investigate the origin and dynamic dispersion of HIV-1 subtype C toward Northeast Brazil. Our phylogenetic analysis suggests that most subtype C strains circulating in Brazil (99%) are descendant from the main lineage whose entrance in the country was previously described in the 1970s. According to the literature, additional introductions of subtype C were reported in the country through the Southeast region and in this study we identified another entry event that occurred most likely through the North region. Furthermore, our analysis suggests that the spread of subtype C to Brazilian Northeastern states occurred through multiple independent introductions of the main lineage that originated in South Brazil between mid-1980s and late 1990s. Despite the observation of eventual new HIV-1 subtype C introductions, our results highlight the predominance of a single lineage of this subtype in Brazil and the importance of South region in its dissemination throughout the country.engMary Ann LiebertHIV-1InfecçõesBrasilNordesteHIV-1Subtype CBrazilNortheastDynamic Dispersion of HIV-1 Subtype C Toward Brazilian Northeastern Regioninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83097https://www.arca.fiocruz.br/bitstream/icict/50067/1/license.txt36b51ef91c52b5338d9d29ba0cc807bcMD51ORIGINALOliveira, Rodrigo Cunha Dynamic....pdfOliveira, Rodrigo Cunha Dynamic....pdfapplication/pdf469971https://www.arca.fiocruz.br/bitstream/icict/50067/2/Oliveira%2c%20Rodrigo%20Cunha%20Dynamic....pdf6014a611662171136a18674afbf92cecMD52icict/500672023-03-15 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dc.title.pt_BR.fl_str_mv Dynamic Dispersion of HIV-1 Subtype C Toward Brazilian Northeastern Region
title Dynamic Dispersion of HIV-1 Subtype C Toward Brazilian Northeastern Region
spellingShingle Dynamic Dispersion of HIV-1 Subtype C Toward Brazilian Northeastern Region
Oliveira, Rodrigo Cunha
HIV-1
Infecções
Brasil
Nordeste
HIV-1
Subtype C
Brazil
Northeast
title_short Dynamic Dispersion of HIV-1 Subtype C Toward Brazilian Northeastern Region
title_full Dynamic Dispersion of HIV-1 Subtype C Toward Brazilian Northeastern Region
title_fullStr Dynamic Dispersion of HIV-1 Subtype C Toward Brazilian Northeastern Region
title_full_unstemmed Dynamic Dispersion of HIV-1 Subtype C Toward Brazilian Northeastern Region
title_sort Dynamic Dispersion of HIV-1 Subtype C Toward Brazilian Northeastern Region
author Oliveira, Rodrigo Cunha
author_facet Oliveira, Rodrigo Cunha
Graf, Tiago
Rego, Filipe Ferreira de Almeida
Silva, Gabriela Porto Santos Almeida
Giovanetti, Marta
Cunha, Joana Paixão Monteiro
author_role author
author2 Graf, Tiago
Rego, Filipe Ferreira de Almeida
Silva, Gabriela Porto Santos Almeida
Giovanetti, Marta
Cunha, Joana Paixão Monteiro
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Oliveira, Rodrigo Cunha
Graf, Tiago
Rego, Filipe Ferreira de Almeida
Silva, Gabriela Porto Santos Almeida
Giovanetti, Marta
Cunha, Joana Paixão Monteiro
dc.subject.other.pt_BR.fl_str_mv HIV-1
Infecções
Brasil
Nordeste
topic HIV-1
Infecções
Brasil
Nordeste
HIV-1
Subtype C
Brazil
Northeast
dc.subject.en.pt_BR.fl_str_mv HIV-1
Subtype C
Brazil
Northeast
description Fundação de Amparo a` Pesquisa do Estado da Bahia (FAPESB) for the masters scholarship. M.G. thanks Fundação de Amparo a` Pesquisa do Estado do Rio de Janeiro (FAPERJ).
publishDate 2021
dc.date.accessioned.fl_str_mv 2021-11-25T18:45:41Z
dc.date.available.fl_str_mv 2021-11-25T18:45:41Z
dc.date.issued.fl_str_mv 2021
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv OLIVEIRA, Rodrigo Cunha et al. Dispersion of HIV-1 Subtype C Toward Brazilian Northeastern Region. AIDS Research and Human Retroviruses, 2021.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/50067
dc.identifier.issn.pt_BR.fl_str_mv 0889-2229
dc.identifier.doi.none.fl_str_mv 10.1089/aid.2020.0308
identifier_str_mv OLIVEIRA, Rodrigo Cunha et al. Dispersion of HIV-1 Subtype C Toward Brazilian Northeastern Region. AIDS Research and Human Retroviruses, 2021.
0889-2229
10.1089/aid.2020.0308
url https://www.arca.fiocruz.br/handle/icict/50067
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Mary Ann Liebert
publisher.none.fl_str_mv Mary Ann Liebert
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/50067/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/50067/2/Oliveira%2c%20Rodrigo%20Cunha%20Dynamic....pdf
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repository.name.fl_str_mv Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)
repository.mail.fl_str_mv repositorio.arca@fiocruz.br
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