Kinetic Study of Yellow Fever 17DD Viral Infection in Gallus gallus domesticus Embryos

Detalhes bibliográficos
Autor(a) principal: Manso, Pedro Paulo de Abreu
Data de Publicação: 2016
Outros Autores: Oliveira, Bárbara Cristina E. P. Dias de, Sequeira, Patrícia Carvalho de, Souza, Yuli Rodrigues Maia de, Ferro, Jessica Maria dos Santos, Silva, Igor José da, Caputo, Luzia Fátima Gonçalves, Guedes, Priscila Tavares, Santos, Alexandre Araujo Cunha dos, Freire, Marcos da Silva, Bonaldo, Myrna Cristina, Machado, Marcelo Pelajo
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/14648
Resumo: Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Patologia. Rio de Janeiro, RJ, Brasil.
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spelling Manso, Pedro Paulo de AbreuOliveira, Bárbara Cristina E. P. Dias deSequeira, Patrícia Carvalho deSouza, Yuli Rodrigues Maia deFerro, Jessica Maria dos SantosSilva, Igor José daCaputo, Luzia Fátima GonçalvesGuedes, Priscila TavaresSantos, Alexandre Araujo Cunha dosFreire, Marcos da SilvaBonaldo, Myrna CristinaMachado, Marcelo Pelajo2016-06-23T19:27:36Z2016-07-07T12:00:32Z2016-06-23T19:27:36Z2016-07-07T12:00:32Z2016MANSO, Pedro Paulo de Abreu; et al. Kinetic Study of Yellow Fever 17DD Viral Infection in Gallus gallus domesticus Embryos. Plos One, v.11, n.5, e0155041, 16p, May 2016.1932-6203https://www.arca.fiocruz.br/handle/icict/1464810.1371/journal.pone.0155041engPublic Library of ScienceFebre amarelaGalinhasInfecção viralYellow Fever 17DDViral InfectionGallus gallus domesticusKinetic Study of Yellow Fever 17DD Viral Infection in Gallus gallus domesticus Embryosinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Patologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Patologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Molecular de Flavivírus. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Patologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Patologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Patologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Patologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Patologia. Rio de Janeiro, RJ, Brasil / Universidade Federal do Estado do Rio de Janeiro. UNIRIO. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Molecular de Flavivírus. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Instituto de Tecnologia em Imunobiológicos. Laboratório de Tecnologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Molecular de Flavivírus. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Patologia. Rio de Janeiro, RJ, Brasil.Yellow fever continues to be an important epidemiological problem in Africa and South America even though the disease can be controlled by vaccination. The vaccine has been produced since 1937 and is based on YFV 17DD chicken embryo infection. However, little is known about the histopathological background of virus infection and replication in this model. Here we show by morphological and molecular methods (brightfield and confocal microscopies, immunofluorescence, nested-PCR and sequencing) the kinetics of YFV 17DD infection in chicken embryos with 9 days of development, encompassing 24 to 96 hours post infection. Our principal findings indicate that the main cells involved in virus production are myoblasts with a mesenchymal shape, which also are the first cells to express virus proteins in Gallus gallus embryos at 48 hours after infection. At 72 hours post infection, we observed an increase of infected cells in embryos. Many sites are thus affected in the infection sequence, especially the skeletal muscle. We were also able to confirm an increase of nervous system infection at 96 hours post infection. Our data contribute to the comprehension of the pathogenesis of YF 17DD virus infection in Gallus gallus embryos.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZTEXTpedropaulo_manso_etal_IOC_2016.PDF.txtpedropaulo_manso_etal_IOC_2016.PDF.txtExtracted texttext/plain41790https://www.arca.fiocruz.br/bitstream/icict/14648/4/pedropaulo_manso_etal_IOC_2016.PDF.txt34550c22d039d8923094561748811b01MD54ORIGINALpedropaulo_manso_etal_IOC_2016.PDFapplication/pdf3837298https://www.arca.fiocruz.br/bitstream/icict/14648/2/pedropaulo_manso_etal_IOC_2016.PDF6c380180580b1760d8c32cb01f332b2cMD52LICENSElicense.txttext/plain2991https://www.arca.fiocruz.br/bitstream/icict/14648/3/license.txt5a560609d32a3863062d77ff32785d58MD53icict/146482022-06-24 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dc.title.pt_BR.fl_str_mv Kinetic Study of Yellow Fever 17DD Viral Infection in Gallus gallus domesticus Embryos
title Kinetic Study of Yellow Fever 17DD Viral Infection in Gallus gallus domesticus Embryos
spellingShingle Kinetic Study of Yellow Fever 17DD Viral Infection in Gallus gallus domesticus Embryos
Manso, Pedro Paulo de Abreu
Febre amarela
Galinhas
Infecção viral
Yellow Fever 17DD
Viral Infection
Gallus gallus domesticus
title_short Kinetic Study of Yellow Fever 17DD Viral Infection in Gallus gallus domesticus Embryos
title_full Kinetic Study of Yellow Fever 17DD Viral Infection in Gallus gallus domesticus Embryos
title_fullStr Kinetic Study of Yellow Fever 17DD Viral Infection in Gallus gallus domesticus Embryos
title_full_unstemmed Kinetic Study of Yellow Fever 17DD Viral Infection in Gallus gallus domesticus Embryos
title_sort Kinetic Study of Yellow Fever 17DD Viral Infection in Gallus gallus domesticus Embryos
author Manso, Pedro Paulo de Abreu
author_facet Manso, Pedro Paulo de Abreu
Oliveira, Bárbara Cristina E. P. Dias de
Sequeira, Patrícia Carvalho de
Souza, Yuli Rodrigues Maia de
Ferro, Jessica Maria dos Santos
Silva, Igor José da
Caputo, Luzia Fátima Gonçalves
Guedes, Priscila Tavares
Santos, Alexandre Araujo Cunha dos
Freire, Marcos da Silva
Bonaldo, Myrna Cristina
Machado, Marcelo Pelajo
author_role author
author2 Oliveira, Bárbara Cristina E. P. Dias de
Sequeira, Patrícia Carvalho de
Souza, Yuli Rodrigues Maia de
Ferro, Jessica Maria dos Santos
Silva, Igor José da
Caputo, Luzia Fátima Gonçalves
Guedes, Priscila Tavares
Santos, Alexandre Araujo Cunha dos
Freire, Marcos da Silva
Bonaldo, Myrna Cristina
Machado, Marcelo Pelajo
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Manso, Pedro Paulo de Abreu
Oliveira, Bárbara Cristina E. P. Dias de
Sequeira, Patrícia Carvalho de
Souza, Yuli Rodrigues Maia de
Ferro, Jessica Maria dos Santos
Silva, Igor José da
Caputo, Luzia Fátima Gonçalves
Guedes, Priscila Tavares
Santos, Alexandre Araujo Cunha dos
Freire, Marcos da Silva
Bonaldo, Myrna Cristina
Machado, Marcelo Pelajo
dc.subject.other.pt_BR.fl_str_mv Febre amarela
Galinhas
Infecção viral
topic Febre amarela
Galinhas
Infecção viral
Yellow Fever 17DD
Viral Infection
Gallus gallus domesticus
dc.subject.en.pt_BR.fl_str_mv Yellow Fever 17DD
Viral Infection
Gallus gallus domesticus
description Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Patologia. Rio de Janeiro, RJ, Brasil.
publishDate 2016
dc.date.accessioned.fl_str_mv 2016-06-23T19:27:36Z
2016-07-07T12:00:32Z
dc.date.available.fl_str_mv 2016-06-23T19:27:36Z
2016-07-07T12:00:32Z
dc.date.issued.fl_str_mv 2016
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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status_str publishedVersion
dc.identifier.citation.fl_str_mv MANSO, Pedro Paulo de Abreu; et al. Kinetic Study of Yellow Fever 17DD Viral Infection in Gallus gallus domesticus Embryos. Plos One, v.11, n.5, e0155041, 16p, May 2016.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/14648
dc.identifier.issn.pt_BR.fl_str_mv 1932-6203
dc.identifier.doi.pt_BR.fl_str_mv 10.1371/journal.pone.0155041
identifier_str_mv MANSO, Pedro Paulo de Abreu; et al. Kinetic Study of Yellow Fever 17DD Viral Infection in Gallus gallus domesticus Embryos. Plos One, v.11, n.5, e0155041, 16p, May 2016.
1932-6203
10.1371/journal.pone.0155041
url https://www.arca.fiocruz.br/handle/icict/14648
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Public Library of Science
publisher.none.fl_str_mv Public Library of Science
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
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