Kinetic Study of Yellow Fever 17DD Viral Infection in Gallus gallus domesticus Embryos
Autor(a) principal: | |
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Data de Publicação: | 2016 |
Outros Autores: | , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
Texto Completo: | https://www.arca.fiocruz.br/handle/icict/14648 |
Resumo: | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Patologia. Rio de Janeiro, RJ, Brasil. |
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Manso, Pedro Paulo de AbreuOliveira, Bárbara Cristina E. P. Dias deSequeira, Patrícia Carvalho deSouza, Yuli Rodrigues Maia deFerro, Jessica Maria dos SantosSilva, Igor José daCaputo, Luzia Fátima GonçalvesGuedes, Priscila TavaresSantos, Alexandre Araujo Cunha dosFreire, Marcos da SilvaBonaldo, Myrna CristinaMachado, Marcelo Pelajo2016-06-23T19:27:36Z2016-07-07T12:00:32Z2016-06-23T19:27:36Z2016-07-07T12:00:32Z2016MANSO, Pedro Paulo de Abreu; et al. Kinetic Study of Yellow Fever 17DD Viral Infection in Gallus gallus domesticus Embryos. Plos One, v.11, n.5, e0155041, 16p, May 2016.1932-6203https://www.arca.fiocruz.br/handle/icict/1464810.1371/journal.pone.0155041engPublic Library of ScienceFebre amarelaGalinhasInfecção viralYellow Fever 17DDViral InfectionGallus gallus domesticusKinetic Study of Yellow Fever 17DD Viral Infection in Gallus gallus domesticus Embryosinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Patologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Patologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Molecular de Flavivírus. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Patologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Patologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Patologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Patologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Patologia. Rio de Janeiro, RJ, Brasil / Universidade Federal do Estado do Rio de Janeiro. UNIRIO. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Molecular de Flavivírus. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Instituto de Tecnologia em Imunobiológicos. Laboratório de Tecnologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Molecular de Flavivírus. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Patologia. Rio de Janeiro, RJ, Brasil.Yellow fever continues to be an important epidemiological problem in Africa and South America even though the disease can be controlled by vaccination. The vaccine has been produced since 1937 and is based on YFV 17DD chicken embryo infection. However, little is known about the histopathological background of virus infection and replication in this model. Here we show by morphological and molecular methods (brightfield and confocal microscopies, immunofluorescence, nested-PCR and sequencing) the kinetics of YFV 17DD infection in chicken embryos with 9 days of development, encompassing 24 to 96 hours post infection. Our principal findings indicate that the main cells involved in virus production are myoblasts with a mesenchymal shape, which also are the first cells to express virus proteins in Gallus gallus embryos at 48 hours after infection. At 72 hours post infection, we observed an increase of infected cells in embryos. Many sites are thus affected in the infection sequence, especially the skeletal muscle. We were also able to confirm an increase of nervous system infection at 96 hours post infection. Our data contribute to the comprehension of the pathogenesis of YF 17DD virus infection in Gallus gallus embryos.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZTEXTpedropaulo_manso_etal_IOC_2016.PDF.txtpedropaulo_manso_etal_IOC_2016.PDF.txtExtracted texttext/plain41790https://www.arca.fiocruz.br/bitstream/icict/14648/4/pedropaulo_manso_etal_IOC_2016.PDF.txt34550c22d039d8923094561748811b01MD54ORIGINALpedropaulo_manso_etal_IOC_2016.PDFapplication/pdf3837298https://www.arca.fiocruz.br/bitstream/icict/14648/2/pedropaulo_manso_etal_IOC_2016.PDF6c380180580b1760d8c32cb01f332b2cMD52LICENSElicense.txttext/plain2991https://www.arca.fiocruz.br/bitstream/icict/14648/3/license.txt5a560609d32a3863062d77ff32785d58MD53icict/146482022-06-24 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dc.title.pt_BR.fl_str_mv |
Kinetic Study of Yellow Fever 17DD Viral Infection in Gallus gallus domesticus Embryos |
title |
Kinetic Study of Yellow Fever 17DD Viral Infection in Gallus gallus domesticus Embryos |
spellingShingle |
Kinetic Study of Yellow Fever 17DD Viral Infection in Gallus gallus domesticus Embryos Manso, Pedro Paulo de Abreu Febre amarela Galinhas Infecção viral Yellow Fever 17DD Viral Infection Gallus gallus domesticus |
title_short |
Kinetic Study of Yellow Fever 17DD Viral Infection in Gallus gallus domesticus Embryos |
title_full |
Kinetic Study of Yellow Fever 17DD Viral Infection in Gallus gallus domesticus Embryos |
title_fullStr |
Kinetic Study of Yellow Fever 17DD Viral Infection in Gallus gallus domesticus Embryos |
title_full_unstemmed |
Kinetic Study of Yellow Fever 17DD Viral Infection in Gallus gallus domesticus Embryos |
title_sort |
Kinetic Study of Yellow Fever 17DD Viral Infection in Gallus gallus domesticus Embryos |
author |
Manso, Pedro Paulo de Abreu |
author_facet |
Manso, Pedro Paulo de Abreu Oliveira, Bárbara Cristina E. P. Dias de Sequeira, Patrícia Carvalho de Souza, Yuli Rodrigues Maia de Ferro, Jessica Maria dos Santos Silva, Igor José da Caputo, Luzia Fátima Gonçalves Guedes, Priscila Tavares Santos, Alexandre Araujo Cunha dos Freire, Marcos da Silva Bonaldo, Myrna Cristina Machado, Marcelo Pelajo |
author_role |
author |
author2 |
Oliveira, Bárbara Cristina E. P. Dias de Sequeira, Patrícia Carvalho de Souza, Yuli Rodrigues Maia de Ferro, Jessica Maria dos Santos Silva, Igor José da Caputo, Luzia Fátima Gonçalves Guedes, Priscila Tavares Santos, Alexandre Araujo Cunha dos Freire, Marcos da Silva Bonaldo, Myrna Cristina Machado, Marcelo Pelajo |
author2_role |
author author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Manso, Pedro Paulo de Abreu Oliveira, Bárbara Cristina E. P. Dias de Sequeira, Patrícia Carvalho de Souza, Yuli Rodrigues Maia de Ferro, Jessica Maria dos Santos Silva, Igor José da Caputo, Luzia Fátima Gonçalves Guedes, Priscila Tavares Santos, Alexandre Araujo Cunha dos Freire, Marcos da Silva Bonaldo, Myrna Cristina Machado, Marcelo Pelajo |
dc.subject.other.pt_BR.fl_str_mv |
Febre amarela Galinhas Infecção viral |
topic |
Febre amarela Galinhas Infecção viral Yellow Fever 17DD Viral Infection Gallus gallus domesticus |
dc.subject.en.pt_BR.fl_str_mv |
Yellow Fever 17DD Viral Infection Gallus gallus domesticus |
description |
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Patologia. Rio de Janeiro, RJ, Brasil. |
publishDate |
2016 |
dc.date.accessioned.fl_str_mv |
2016-06-23T19:27:36Z 2016-07-07T12:00:32Z |
dc.date.available.fl_str_mv |
2016-06-23T19:27:36Z 2016-07-07T12:00:32Z |
dc.date.issued.fl_str_mv |
2016 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
MANSO, Pedro Paulo de Abreu; et al. Kinetic Study of Yellow Fever 17DD Viral Infection in Gallus gallus domesticus Embryos. Plos One, v.11, n.5, e0155041, 16p, May 2016. |
dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/14648 |
dc.identifier.issn.pt_BR.fl_str_mv |
1932-6203 |
dc.identifier.doi.pt_BR.fl_str_mv |
10.1371/journal.pone.0155041 |
identifier_str_mv |
MANSO, Pedro Paulo de Abreu; et al. Kinetic Study of Yellow Fever 17DD Viral Infection in Gallus gallus domesticus Embryos. Plos One, v.11, n.5, e0155041, 16p, May 2016. 1932-6203 10.1371/journal.pone.0155041 |
url |
https://www.arca.fiocruz.br/handle/icict/14648 |
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eng |
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eng |
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info:eu-repo/semantics/openAccess |
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openAccess |
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Public Library of Science |
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Public Library of Science |
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