A 9-valent HPV vaccine against infection and intraepithelial neoplasia in women
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2015 |
| Outros Autores: | , , , , , , , , , , , , , , , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/13256 |
Resumo: | The Medical University of Vienna. Comprehensive Cancer Center. Vienna. |
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Joura, E. A.Giuliano, Anna R.Iversen, O. E.Bouchard, C.Mao, C.Mehlsen, J.Moreira Júnior, Edson DuarteNgan, Y.Petersen, L. K.Lazcano‑Ponce, E.Pitisuttithum, P.Restrepo, J. A.Stuart, G.Woelber, L.Yang, Y. C.Cuzick, J.Garland, S. M.Huh, W.Kjaer, S. K.Bautista, Oliver M.Chan, I. S. F.Chen, J.Gesser, R.Moeller, E.Ritter, M.Vuocolo, S.Luxembourg, A.Broad Spectrum HPV Vaccine Study2016-03-23T18:18:32Z2016-03-23T18:18:32Z2015JOURA, E. A. et al. A 9-valent HPV vaccine against infection and intraepithelial neoplasia in women. New England Journal of Medicine, v. 372, n. 8, p. 711-723, 2015.1533-4406https://www.arca.fiocruz.br/handle/icict/1325610.1056/NEJMoa1405044engMassachusetts Medical SocietyA 9-valent HPV vaccine against infection and intraepithelial neoplasia in womeninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleThe Medical University of Vienna. Comprehensive Cancer Center. Vienna.Moffitt Cancer Center. Tampa, Florida, USA.University of Bergen–Haukeland University Hospital. Department of Clinical Medicine. Bergen, Norway.Université Laval. Québec, Canadá.University of Washington. Seattle, USA.University of Copenhagen. Coordinating Research Center. Frederiksberg Hospital. Copenhagen.Associação Obras Sociais Irmã Dulce. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil.University of Hong Kong. Hong Kong.Aarhus University Hospital. Department of Obstetrics and Gynecology. Aarhus, Denmark.Instituto Nacional de Salud Pública. Cuernavaca, Morelos, Mexico.Mahidol University. Faculty of Tropical Medicine. Nakhon Pathom, Thailand.Investigación Clínica. Medellín, Colombia.University of British Columbia. Vancouver, Canada.University Medical Center Hamburg–Eppendorf. Department of Gynecology. Hamburg, Germany.Mackay Memorial Hospital. Taipei, Taiwan.Wolfson Institute of Preventive Medicine. London.Royal Women’s Hospital. University of Melbourne and Murdoch Childrens Research Institute. Parkville, VIC, Australia.University of Alabama. Division of Gynecologic Oncology. Birmingham.Danish Cancer Society Research Center and Department of Gynecology. Rigshospitalet, Copenhagen.University of Alabama. Division of Gynecologic Oncology. Birmingham / Merck, Whitehouse Station, NJ, USA.University of Alabama. Division of Gynecologic Oncology. Birmingham / Merck, Whitehouse Station, NJ, USA.University of Alabama. Division of Gynecologic Oncology. Birmingham / Merck, Whitehouse Station, NJ, USA.University of Alabama. Division of Gynecologic Oncology. Birmingham / Merck, Whitehouse Station, NJ, USA.University of Alabama. Division of Gynecologic Oncology. Birmingham / Merck, Whitehouse Station, NJ, USA.University of Alabama. Division of Gynecologic Oncology. Birmingham / Merck, Whitehouse Station, NJ, USA.University of Alabama. Division of Gynecologic Oncology. Birmingham / Merck, Whitehouse Station, NJUniversity of Alabama. Division of Gynecologic Oncology. Birmingham / Merck, Whitehouse Station, NJ, USA.Broad Spectrum HPV Vaccine Study.BACKGROUND: The investigational 9-valent viruslike particle vaccine against human papillomavirus (HPV) includes the HPV types in the quadrivalent HPV (qHPV) vaccine (6, 11, 16, and 18) and five additional oncogenic types (31, 33, 45, 52, and 58). Here we present the results of a study of the efficacy and immunogenicity of the 9vHPV vaccine in women 16 to 26 years of age. METHODS: We performed a randomized, international, double-blind, phase 2b-3 study of the 9vHPV vaccine in 14,215 women. Participants received the 9vHPV vaccine or the qHPV vaccine in a series of three intramuscular injections on day 1 and at months 2 and 6. Serum was collected for analysis of antibody responses. Swabs of labial, vulvar, perineal, perianal, endocervical, and ectocervical tissue were obtained and used for HPV DNA testing, and liquid-based cytologic testing (Papanicolaou testing) was performed regularly. Tissue obtained by means of biopsy or as part of definitive therapy (including a loop electrosurgical excision procedure and conization) was tested for HPV. RESULTS: The rate of high-grade cervical, vulvar, or vaginal disease irrespective of HPV type (i.e., disease caused by HPV types included in the 9vHPV vaccine and those not included) in the modified intention-to-treat population (which included participants with and those without prevalent infection or disease) was 14.0 per 1000 person-years in both vaccine groups. The rate of high-grade cervical, vulvar, or vaginal disease related to HPV-31, 33, 45, 52, and 58 in a prespecified per-protocol efficacy population (susceptible population) was 0.1 per 1000 person-years in the 9vHPV group and 1.6 per 1000 person-years in the qHPV group (efficacy of the 9vHPV vaccine, 96.7%; 95% confidence interval, 80.9 to 99.8). Antibody responses to HPV-6, 11, 16, and 18 were noninferior to those generated by the qHPV vaccine. Adverse events related to injection site were more common in the 9vHPV group than in the qHPV group. CONCLUSIONS: The 9vHPV vaccine prevented infection and disease related to HPV-31, 33, 45, 52, and 58 in a susceptible population and generated an antibody response to HPV-6, 11, 16, and 18 that was noninferior to that generated by the qHPV vaccine. The 9vHPV vaccine did not prevent infection and disease related to HPV types beyond the nine types covered by the vaccine.9-Valent HPV VaccineInfection NeoplasiaIntraepithelial NeoplasiaWomenAlphapapillomavirusNeoplasia Intraepitelial Cervical/prevenção & controleInfecções por Papillomavirus/prevenção & controleVacinas contra PapillomavirusNeoplasias do Colo do Útero/prevenção & controleAdolescenteAdultoAnticorpos Antivirais/sangueNeoplasia Intraepitelial Cervical/virologiaMétodo Duplo-CegoFemininoDoenças dos Genitais Femininos/epidemiologiaHumanosIncidênciaAnálise de Intenção de TratamentoInfecções por Papillomavirus/epidemiologiaVacinas contra Papillomavirus/administração & dosagemNeoplasias do Colo do Útero/virologiainfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; 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| dc.title.pt_BR.fl_str_mv |
A 9-valent HPV vaccine against infection and intraepithelial neoplasia in women |
| title |
A 9-valent HPV vaccine against infection and intraepithelial neoplasia in women |
| spellingShingle |
A 9-valent HPV vaccine against infection and intraepithelial neoplasia in women Joura, E. A. 9-Valent HPV Vaccine Infection Neoplasia Intraepithelial Neoplasia Women Alphapapillomavirus Neoplasia Intraepitelial Cervical/prevenção & controle Infecções por Papillomavirus/prevenção & controle Vacinas contra Papillomavirus Neoplasias do Colo do Útero/prevenção & controle Adolescente Adulto Anticorpos Antivirais/sangue Neoplasia Intraepitelial Cervical/virologia Método Duplo-Cego Feminino Doenças dos Genitais Femininos/epidemiologia Humanos Incidência Análise de Intenção de Tratamento Infecções por Papillomavirus/epidemiologia Vacinas contra Papillomavirus/administração & dosagem Neoplasias do Colo do Útero/virologia |
| title_short |
A 9-valent HPV vaccine against infection and intraepithelial neoplasia in women |
| title_full |
A 9-valent HPV vaccine against infection and intraepithelial neoplasia in women |
| title_fullStr |
A 9-valent HPV vaccine against infection and intraepithelial neoplasia in women |
| title_full_unstemmed |
A 9-valent HPV vaccine against infection and intraepithelial neoplasia in women |
| title_sort |
A 9-valent HPV vaccine against infection and intraepithelial neoplasia in women |
| author |
Joura, E. A. |
| author_facet |
Joura, E. A. Giuliano, Anna R. Iversen, O. E. Bouchard, C. Mao, C. Mehlsen, J. Moreira Júnior, Edson Duarte Ngan, Y. Petersen, L. K. Lazcano‑Ponce, E. Pitisuttithum, P. Restrepo, J. A. Stuart, G. Woelber, L. Yang, Y. C. Cuzick, J. Garland, S. M. Huh, W. Kjaer, S. K. Bautista, Oliver M. Chan, I. S. F. Chen, J. Gesser, R. Moeller, E. Ritter, M. Vuocolo, S. Luxembourg, A. Broad Spectrum HPV Vaccine Study |
| author_role |
author |
| author2 |
Giuliano, Anna R. Iversen, O. E. Bouchard, C. Mao, C. Mehlsen, J. Moreira Júnior, Edson Duarte Ngan, Y. Petersen, L. K. Lazcano‑Ponce, E. Pitisuttithum, P. Restrepo, J. A. Stuart, G. Woelber, L. Yang, Y. C. Cuzick, J. Garland, S. M. Huh, W. Kjaer, S. K. Bautista, Oliver M. Chan, I. S. F. Chen, J. Gesser, R. Moeller, E. Ritter, M. Vuocolo, S. Luxembourg, A. Broad Spectrum HPV Vaccine Study |
| author2_role |
author author author author author author author author author author author author author author author author author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Joura, E. A. Giuliano, Anna R. Iversen, O. E. Bouchard, C. Mao, C. Mehlsen, J. Moreira Júnior, Edson Duarte Ngan, Y. Petersen, L. K. Lazcano‑Ponce, E. Pitisuttithum, P. Restrepo, J. A. Stuart, G. Woelber, L. Yang, Y. C. Cuzick, J. Garland, S. M. Huh, W. Kjaer, S. K. Bautista, Oliver M. Chan, I. S. F. Chen, J. Gesser, R. Moeller, E. Ritter, M. Vuocolo, S. Luxembourg, A. Broad Spectrum HPV Vaccine Study |
| dc.subject.en.pt_BR.fl_str_mv |
9-Valent HPV Vaccine Infection Neoplasia Intraepithelial Neoplasia Women |
| topic |
9-Valent HPV Vaccine Infection Neoplasia Intraepithelial Neoplasia Women Alphapapillomavirus Neoplasia Intraepitelial Cervical/prevenção & controle Infecções por Papillomavirus/prevenção & controle Vacinas contra Papillomavirus Neoplasias do Colo do Útero/prevenção & controle Adolescente Adulto Anticorpos Antivirais/sangue Neoplasia Intraepitelial Cervical/virologia Método Duplo-Cego Feminino Doenças dos Genitais Femininos/epidemiologia Humanos Incidência Análise de Intenção de Tratamento Infecções por Papillomavirus/epidemiologia Vacinas contra Papillomavirus/administração & dosagem Neoplasias do Colo do Útero/virologia |
| dc.subject.decs.pt_BR.fl_str_mv |
Alphapapillomavirus Neoplasia Intraepitelial Cervical/prevenção & controle Infecções por Papillomavirus/prevenção & controle Vacinas contra Papillomavirus Neoplasias do Colo do Útero/prevenção & controle Adolescente Adulto Anticorpos Antivirais/sangue Neoplasia Intraepitelial Cervical/virologia Método Duplo-Cego Feminino Doenças dos Genitais Femininos/epidemiologia Humanos Incidência Análise de Intenção de Tratamento Infecções por Papillomavirus/epidemiologia Vacinas contra Papillomavirus/administração & dosagem Neoplasias do Colo do Útero/virologia |
| description |
The Medical University of Vienna. Comprehensive Cancer Center. Vienna. |
| publishDate |
2015 |
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2015 |
| dc.date.accessioned.fl_str_mv |
2016-03-23T18:18:32Z |
| dc.date.available.fl_str_mv |
2016-03-23T18:18:32Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
| dc.identifier.citation.fl_str_mv |
JOURA, E. A. et al. A 9-valent HPV vaccine against infection and intraepithelial neoplasia in women. New England Journal of Medicine, v. 372, n. 8, p. 711-723, 2015. |
| dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/13256 |
| dc.identifier.issn.none.fl_str_mv |
1533-4406 |
| dc.identifier.doi.pt_BR.fl_str_mv |
10.1056/NEJMoa1405044 |
| identifier_str_mv |
JOURA, E. A. et al. A 9-valent HPV vaccine against infection and intraepithelial neoplasia in women. New England Journal of Medicine, v. 372, n. 8, p. 711-723, 2015. 1533-4406 10.1056/NEJMoa1405044 |
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https://www.arca.fiocruz.br/handle/icict/13256 |
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eng |
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eng |
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info:eu-repo/semantics/openAccess |
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openAccess |
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Massachusetts Medical Society |
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Massachusetts Medical Society |
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