Paracoccidioidomycosis in people living with HIV/AIDS: A historical retrospective cohort study in a national reference center for infectious diseases, Rio de Janeiro, Brazil

Detalhes bibliográficos
Autor(a) principal: Falcão, Eduardo Mastrangelo
Data de Publicação: 2022
Outros Autores: Macedo, Priscila Marques de, Freitas, Dayvison Francis Saraiva, Freitas, Andréa d'Avila, Grinsztejn, Beatriz, Veloso, Valdiléa G., Almeida-Paes, Rodrigo, Valle, Antonio Carlos Francesconi do
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/53958
Resumo: Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em Dermatologia Infecciosa. Rio de Janeiro, RJ, Brasil.
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spelling Falcão, Eduardo MastrangeloMacedo, Priscila Marques deFreitas, Dayvison Francis SaraivaFreitas, Andréa d'AvilaGrinsztejn, BeatrizVeloso, Valdiléa G.Almeida-Paes, RodrigoValle, Antonio Carlos Francesconi do2022-07-26T10:45:06Z2022-07-26T10:45:06Z2022FALCÃO, Eduardo Mastrangelo et al. Paracoccidioidomycosis in people living with HIV/AIDS: A historical retrospective cohort study in a national reference center for infectious diseases. PLoS Neglected Tropical Diseases, v. 16, n. 6, p. 1-13, June 2022.1935-2735https://www.arca.fiocruz.br/handle/icict/5395810.1371/journal.pntd.0010529engPublic Library of ScienceParacoccidioidomycosis in people living with HIV/AIDS: A historical retrospective cohort study in a national reference center for infectious diseases, Rio de Janeiro, Brazilinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em Dermatologia Infecciosa. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em Dermatologia Infecciosa. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em Dermatologia Infecciosa. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Departamento de Cuidados de Saúde de Internação. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em DST/AIDS. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em DST/AIDS. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Micologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em Dermatologia Infecciosa. Rio de Janeiro, RJ, Brasil.Paracoccidioidomycosis (PCM) is one of the main endemic systemic mycoses in Latin America, usually occurring in rural areas. When PCM occurs simultaneously with underlying immunosuppressive conditions, it can present as an opportunistic disease. Between 2000 and 2017, literature reported around 200 PCM cases in people living with HIV/AIDS (PLWHA). To address research gaps on this co-infection and to study its possible temporal changes in the last decade, we performed an active co-infection case search on the HIV/AIDS and PCM cohorts from a Brazilian reference center database from 1989 to 2019. We found 20 PLWHA among 684 PCM patients (2.92%), predominantly male (70.0%) and urban workers (80.0%). The median age of patients was higher in the 2010-2019 decade (p = 0.006). The occurrence of PCM in PLWHA was lower when compared with other fungal diseases. Although 50.0% of the patients had already been diagnosed with HIV infection and presented CD4+ T cell counts greater than 200/mm3 at the time of PCM diagnosis, the suspicion of immunosuppression in the context of atypical and more severe clinical forms of PCM revealed the diagnosis of HIV infection in 35.0% of the patients. Two (10.0%) patients had an evolution compatible with immune reconstitution inflammatory syndrome (IRIS) after starting antiretroviral therapy (ART).We highlight the importance of considering a PCM diagnosis in PLWHA to prevent a late-onset treatment and progression to severe manifestations and unfavorable outcomes. In addition, HIV investigation is recommended in PCM patients, especially those with atypical and more severe clinical presentations.ParacoccidioidomycosisHIVAIDSInfectious diseasesOpportunistic infectionsDrug therapyParacoccidioidesinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83099https://www.arca.fiocruz.br/bitstream/icict/53958/1/license.txt586c046dcfeef936e32f0323bb9a47c0MD51ORIGINALParacoccidioidomycosis_Eduardo_Falcao_etal_INI_2022.pdfParacoccidioidomycosis_Eduardo_Falcao_etal_INI_2022.pdfapplication/pdf1873296https://www.arca.fiocruz.br/bitstream/icict/53958/2/Paracoccidioidomycosis_Eduardo_Falcao_etal_INI_2022.pdf5bf3cb260d38d8c16787e9234c4b5283MD52icict/539582023-08-15 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dc.title.pt_BR.fl_str_mv Paracoccidioidomycosis in people living with HIV/AIDS: A historical retrospective cohort study in a national reference center for infectious diseases, Rio de Janeiro, Brazil
title Paracoccidioidomycosis in people living with HIV/AIDS: A historical retrospective cohort study in a national reference center for infectious diseases, Rio de Janeiro, Brazil
spellingShingle Paracoccidioidomycosis in people living with HIV/AIDS: A historical retrospective cohort study in a national reference center for infectious diseases, Rio de Janeiro, Brazil
Falcão, Eduardo Mastrangelo
Paracoccidioidomycosis
HIV
AIDS
Infectious diseases
Opportunistic infections
Drug therapy
Paracoccidioides
title_short Paracoccidioidomycosis in people living with HIV/AIDS: A historical retrospective cohort study in a national reference center for infectious diseases, Rio de Janeiro, Brazil
title_full Paracoccidioidomycosis in people living with HIV/AIDS: A historical retrospective cohort study in a national reference center for infectious diseases, Rio de Janeiro, Brazil
title_fullStr Paracoccidioidomycosis in people living with HIV/AIDS: A historical retrospective cohort study in a national reference center for infectious diseases, Rio de Janeiro, Brazil
title_full_unstemmed Paracoccidioidomycosis in people living with HIV/AIDS: A historical retrospective cohort study in a national reference center for infectious diseases, Rio de Janeiro, Brazil
title_sort Paracoccidioidomycosis in people living with HIV/AIDS: A historical retrospective cohort study in a national reference center for infectious diseases, Rio de Janeiro, Brazil
author Falcão, Eduardo Mastrangelo
author_facet Falcão, Eduardo Mastrangelo
Macedo, Priscila Marques de
Freitas, Dayvison Francis Saraiva
Freitas, Andréa d'Avila
Grinsztejn, Beatriz
Veloso, Valdiléa G.
Almeida-Paes, Rodrigo
Valle, Antonio Carlos Francesconi do
author_role author
author2 Macedo, Priscila Marques de
Freitas, Dayvison Francis Saraiva
Freitas, Andréa d'Avila
Grinsztejn, Beatriz
Veloso, Valdiléa G.
Almeida-Paes, Rodrigo
Valle, Antonio Carlos Francesconi do
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Falcão, Eduardo Mastrangelo
Macedo, Priscila Marques de
Freitas, Dayvison Francis Saraiva
Freitas, Andréa d'Avila
Grinsztejn, Beatriz
Veloso, Valdiléa G.
Almeida-Paes, Rodrigo
Valle, Antonio Carlos Francesconi do
dc.subject.en.pt_BR.fl_str_mv Paracoccidioidomycosis
HIV
AIDS
Infectious diseases
Opportunistic infections
Drug therapy
Paracoccidioides
topic Paracoccidioidomycosis
HIV
AIDS
Infectious diseases
Opportunistic infections
Drug therapy
Paracoccidioides
description Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em Dermatologia Infecciosa. Rio de Janeiro, RJ, Brasil.
publishDate 2022
dc.date.accessioned.fl_str_mv 2022-07-26T10:45:06Z
dc.date.available.fl_str_mv 2022-07-26T10:45:06Z
dc.date.issued.fl_str_mv 2022
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv FALCÃO, Eduardo Mastrangelo et al. Paracoccidioidomycosis in people living with HIV/AIDS: A historical retrospective cohort study in a national reference center for infectious diseases. PLoS Neglected Tropical Diseases, v. 16, n. 6, p. 1-13, June 2022.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/53958
dc.identifier.issn.pt_BR.fl_str_mv 1935-2735
dc.identifier.doi.none.fl_str_mv 10.1371/journal.pntd.0010529
identifier_str_mv FALCÃO, Eduardo Mastrangelo et al. Paracoccidioidomycosis in people living with HIV/AIDS: A historical retrospective cohort study in a national reference center for infectious diseases. PLoS Neglected Tropical Diseases, v. 16, n. 6, p. 1-13, June 2022.
1935-2735
10.1371/journal.pntd.0010529
url https://www.arca.fiocruz.br/handle/icict/53958
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Public Library of Science
publisher.none.fl_str_mv Public Library of Science
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/53958/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/53958/2/Paracoccidioidomycosis_Eduardo_Falcao_etal_INI_2022.pdf
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repository.name.fl_str_mv Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)
repository.mail.fl_str_mv repositorio.arca@fiocruz.br
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