Liver histological alterations in patients with chronic hepatitis C and normal ALT levels in the city of Salvador, Northeast-Brazil

Detalhes bibliográficos
Autor(a) principal: Santana, Nelma Pereira de
Data de Publicação: 2005
Outros Autores: Freitas, Luiz Antonio Rodrigues de, Lyra, André de Castro, Paraná, Raymundo, Santana, Genoile, Trépo, Christian, Lyra, Luiz Guilherme Costa
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/6215
Resumo: Federal University of Bahia. Gastro-Hepatology Service Hospital Prof. Edgard Santos. / Hospital São Rafael. Gastro-hepatology Service. Salvador, Bahia, Brasil
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spelling Santana, Nelma Pereira deFreitas, Luiz Antonio Rodrigues deLyra, André de CastroParaná, RaymundoSantana, GenoileTrépo, ChristianLyra, Luiz Guilherme Costa2013-01-18T19:42:20Z2013-01-18T19:42:20Z2005SANTANA, N. P. de et al. Liver histological alterations in patients with chronic hepatitis C and normal ALT levels in the city of Salvador, Northeast-Brazil. Brazilian Journal of Infectious Diseases, v. 9, n. 2, p. 134-141, apr. 2005.1413-8670https://www.arca.fiocruz.br/handle/icict/6215engLiver histological alterations in patients with chronic hepatitis C and normal ALT levels in the city of Salvador, Northeast-Brazilinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFederal University of Bahia. Gastro-Hepatology Service Hospital Prof. Edgard Santos. / Hospital São Rafael. Gastro-hepatology Service. Salvador, Bahia, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, Bahia, Brasil / Federal University of Bahia. Pathology Department. Salvador, Bahia, BrasilFederal University of Bahia. Gastro-Hepatology Service Hospital Prof. Edgard Santos. / Hospital São Rafael. Gastro-hepatology Service. Salvador, Bahia, BrasilUniversity of Bahia. Post-graduate course in Medicine and Health Federal. Salvador, Bahia, BrasilFederal University of Bahia. Gastro-Hepatology Service Hospital Prof. Edgard Santos. / Hospital São Rafael. Gastro-hepatology Service. Salvador, Bahia, BrasilINSERM. Viral Hepatitis LAaoratory. Lyon, FranceFederal University of Bahia. Gastro-Hepatology Service Hospital Prof. Edgard Santos. / Hospital São Rafael. Gastro-hepatology Service. Salvador, Bahia, BrasilPatients with chronic hepatitis C can have variable clinical progression. Hepatic histological alterations appear to be milder in asymptomatic subjects who have persistently normal ALT levels. Aims: To evaluate the severity of histological liver alterations in blood donors with normal and elevated ALT levels. Methods: We evaluated volunteer blood donors from the main blood bank of the city of Salvador-Brazil. Those who were anti-HCV positive were invited to participate in the study. Serum ALT and AST levels were measured at two time points, two months apart. Donors were divided into two groups: group I, individuals with ALT ≥ 1.5 times the upper limit of normal in at least one time point and group II, individuals with normal or near normal ALT, at both time points. Results: We evaluated 30,232 blood donors and 528 (1.7%) of them were anti-HCV positive. Eighty-two attended our service and HCV infection was confirmed in 66 individuals. Male gender predominated in both groups; the mean age was 36 for group I, and 33 for group II. Tattoos and intravenous illicit drug use were frequently-encountered risk factors. Liver biopsy was done in 43 subjects. Among donors with elevated ALT, two (10%) had minimum alterations, while in group II normal liver or minimum alterations were observed in six (26%) subjects. Chronic hepatitis or cirrhosis was encountered in 35 (81%) individuals: three (15%) and five (21%) subjects had chronic hepatitis without inflammatory activity, 10 (50%) and 11 (48%) had minimum to moderate activity and five (25%) and one (4.3%) had cirrhosis, in groups I and II, respectively (P was not significant). Conclusions: The prevalence of anti-HCV among this population of volunteer blood donors was 1.7%, and these subjects had few liver histological alterations or chronic hepatitis and cirrhosis. Liver injury severity was significant in patients with elevated ALT, however subjects with normal levels may also present chronic hepatitis and cirrhosis.ALT levelsLiver alterationsHCVNortheast-BrazilAlanina Transaminase/sangueAspartato Aminotransferases/sangueHepacivirus/imunologiaHepatite C Crônica/patologiaFígado/patologiaDoadores de SangueBrasil/epidemiologiaEnsaio de Imunoadsorção EnzimáticaAnticorpos Anti-Hepatite C/sangueHepatite C Crônica/enzimologiaHepatite C Crônica/epidemiologiaFatores de RiscoÍndice de Gravidade de DoençaFemininoHumanosMasculinoinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALSantana, Nelma Pereira de et al. Liver histological alterations.pdfSantana, Nelma Pereira de et al. 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dc.title.pt_BR.fl_str_mv Liver histological alterations in patients with chronic hepatitis C and normal ALT levels in the city of Salvador, Northeast-Brazil
title Liver histological alterations in patients with chronic hepatitis C and normal ALT levels in the city of Salvador, Northeast-Brazil
spellingShingle Liver histological alterations in patients with chronic hepatitis C and normal ALT levels in the city of Salvador, Northeast-Brazil
Santana, Nelma Pereira de
ALT levels
Liver alterations
HCV
Northeast-Brazil
Alanina Transaminase/sangue
Aspartato Aminotransferases/sangue
Hepacivirus/imunologia
Hepatite C Crônica/patologia
Fígado/patologia
Doadores de Sangue
Brasil/epidemiologia
Ensaio de Imunoadsorção Enzimática
Anticorpos Anti-Hepatite C/sangue
Hepatite C Crônica/enzimologia
Hepatite C Crônica/epidemiologia
Fatores de Risco
Índice de Gravidade de Doença
Feminino
Humanos
Masculino
title_short Liver histological alterations in patients with chronic hepatitis C and normal ALT levels in the city of Salvador, Northeast-Brazil
title_full Liver histological alterations in patients with chronic hepatitis C and normal ALT levels in the city of Salvador, Northeast-Brazil
title_fullStr Liver histological alterations in patients with chronic hepatitis C and normal ALT levels in the city of Salvador, Northeast-Brazil
title_full_unstemmed Liver histological alterations in patients with chronic hepatitis C and normal ALT levels in the city of Salvador, Northeast-Brazil
title_sort Liver histological alterations in patients with chronic hepatitis C and normal ALT levels in the city of Salvador, Northeast-Brazil
author Santana, Nelma Pereira de
author_facet Santana, Nelma Pereira de
Freitas, Luiz Antonio Rodrigues de
Lyra, André de Castro
Paraná, Raymundo
Santana, Genoile
Trépo, Christian
Lyra, Luiz Guilherme Costa
author_role author
author2 Freitas, Luiz Antonio Rodrigues de
Lyra, André de Castro
Paraná, Raymundo
Santana, Genoile
Trépo, Christian
Lyra, Luiz Guilherme Costa
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Santana, Nelma Pereira de
Freitas, Luiz Antonio Rodrigues de
Lyra, André de Castro
Paraná, Raymundo
Santana, Genoile
Trépo, Christian
Lyra, Luiz Guilherme Costa
dc.subject.en.pt_BR.fl_str_mv ALT levels
Liver alterations
HCV
Northeast-Brazil
topic ALT levels
Liver alterations
HCV
Northeast-Brazil
Alanina Transaminase/sangue
Aspartato Aminotransferases/sangue
Hepacivirus/imunologia
Hepatite C Crônica/patologia
Fígado/patologia
Doadores de Sangue
Brasil/epidemiologia
Ensaio de Imunoadsorção Enzimática
Anticorpos Anti-Hepatite C/sangue
Hepatite C Crônica/enzimologia
Hepatite C Crônica/epidemiologia
Fatores de Risco
Índice de Gravidade de Doença
Feminino
Humanos
Masculino
dc.subject.decs.pt_BR.fl_str_mv Alanina Transaminase/sangue
Aspartato Aminotransferases/sangue
Hepacivirus/imunologia
Hepatite C Crônica/patologia
Fígado/patologia
Doadores de Sangue
Brasil/epidemiologia
Ensaio de Imunoadsorção Enzimática
Anticorpos Anti-Hepatite C/sangue
Hepatite C Crônica/enzimologia
Hepatite C Crônica/epidemiologia
Fatores de Risco
Índice de Gravidade de Doença
Feminino
Humanos
Masculino
description Federal University of Bahia. Gastro-Hepatology Service Hospital Prof. Edgard Santos. / Hospital São Rafael. Gastro-hepatology Service. Salvador, Bahia, Brasil
publishDate 2005
dc.date.issued.fl_str_mv 2005
dc.date.accessioned.fl_str_mv 2013-01-18T19:42:20Z
dc.date.available.fl_str_mv 2013-01-18T19:42:20Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv SANTANA, N. P. de et al. Liver histological alterations in patients with chronic hepatitis C and normal ALT levels in the city of Salvador, Northeast-Brazil. Brazilian Journal of Infectious Diseases, v. 9, n. 2, p. 134-141, apr. 2005.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/6215
dc.identifier.issn.none.fl_str_mv 1413-8670
identifier_str_mv SANTANA, N. P. de et al. Liver histological alterations in patients with chronic hepatitis C and normal ALT levels in the city of Salvador, Northeast-Brazil. Brazilian Journal of Infectious Diseases, v. 9, n. 2, p. 134-141, apr. 2005.
1413-8670
url https://www.arca.fiocruz.br/handle/icict/6215
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
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instacron_str FIOCRUZ
institution FIOCRUZ
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