Merozoite surface protein 2 allelic variation influences the specific antibody response during acute malaria in individuals from a Brazilian endemic area
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2007 |
| Outros Autores: | , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/37390 |
Resumo: | Universidade Federal do Rio de Janeiro. Hospital Universitário Clementino Fraga Filho. Departamento de Medicina Preventiva. Rio de Janeiro, RJ, Brasil. |
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Sallenave-Sales, SelmaFaria, Clarissa PerezZalis, Mariano GustavoRibeiro, Cláudio Tadeu DanielCruz, Maria de Fátima Ferreira da2019-11-26T15:01:56Z2019-11-26T15:01:56Z2007SALLENAVE-SALES, Selma et al. Merozoite surface protein 2 allelic variation influences the specific antibody response during acute malaria in individuals from a Brazilian endemic area. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 102, n. 3, p. 421-424, June 2007.0074-0206https://www.arca.fiocruz.br/handle/icict/3739010.1590/S0074-027620070050000481678-8060engFundação Oswaldo Cruz. Instituto Oswaldo CruzPlasmodium falciparumMaláriaProteína-2 da superfície do merozoitoResposta de anticorposPolimorfismo antigênicoPlasmodium falciparumMerozoite surface protein-2Antibody responseAntigenic polymorphismMalariaMerozoite surface protein 2 allelic variation influences the specific antibody response during acute malaria in individuals from a Brazilian endemic areainfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal do Rio de Janeiro. Hospital Universitário Clementino Fraga Filho. Departamento de Medicina Preventiva. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Hospital Universitário Clementino Fraga Filho. Departamento de Medicina Preventiva. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Imunologia. Centro Colaborador WHO para . Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Centro Colaborador da WHO para Pesquisa e Treinamento em Imunologia de Doenças Parasitárias. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Centro Colaborador da WHO para Pesquisa e Treinamento em Imunologia de Doenças Parasitárias. Rio de Janeiro, RJ, Brasil.The antibody response to Plasmodium falciparum parasites of naturally infected population is critical to elucidate the role of polymorphic alleles in malaria. Thus, we evaluated the impact of antigenic diversity of repetitive and family dimorphic domains of the merozoite surface protein 2 (MSP-2) on immune response of 96 individuals living in Peixoto de Azevedo (MT-Brazil), by ELISA using recombinant MSP-2 proteins. The majority of these individuals were carrying FC27-type infections. IgG antibody responses were predominantly directed to FC27 parasites and were correlated to the extension of polymorphism presented by each MSP-2 region. This finding demonstrated the impact of the genetic polymorphism on antibody response and therefore, its importance on malaria vaccine efficacy.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/37390/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALClaudioTDRibeiro_SelaSales_etal_IOC_2007.pdfClaudioTDRibeiro_SelaSales_etal_IOC_2007.pdfapplication/pdf185749https://www.arca.fiocruz.br/bitstream/icict/37390/2/ClaudioTDRibeiro_SelaSales_etal_IOC_2007.pdf3b0167c5c8bdf5b6afc923f319cea058MD52TEXTClaudioTDRibeiro_SelaSales_etal_IOC_2007.pdf.txtClaudioTDRibeiro_SelaSales_etal_IOC_2007.pdf.txtExtracted texttext/plain15276https://www.arca.fiocruz.br/bitstream/icict/37390/3/ClaudioTDRibeiro_SelaSales_etal_IOC_2007.pdf.txt94b98218bed660ed9edfe04827655a5fMD53icict/373902020-04-14 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| dc.title.pt_BR.fl_str_mv |
Merozoite surface protein 2 allelic variation influences the specific antibody response during acute malaria in individuals from a Brazilian endemic area |
| title |
Merozoite surface protein 2 allelic variation influences the specific antibody response during acute malaria in individuals from a Brazilian endemic area |
| spellingShingle |
Merozoite surface protein 2 allelic variation influences the specific antibody response during acute malaria in individuals from a Brazilian endemic area Sallenave-Sales, Selma Plasmodium falciparum Malária Proteína-2 da superfície do merozoito Resposta de anticorpos Polimorfismo antigênico Plasmodium falciparum Merozoite surface protein-2 Antibody response Antigenic polymorphism Malaria |
| title_short |
Merozoite surface protein 2 allelic variation influences the specific antibody response during acute malaria in individuals from a Brazilian endemic area |
| title_full |
Merozoite surface protein 2 allelic variation influences the specific antibody response during acute malaria in individuals from a Brazilian endemic area |
| title_fullStr |
Merozoite surface protein 2 allelic variation influences the specific antibody response during acute malaria in individuals from a Brazilian endemic area |
| title_full_unstemmed |
Merozoite surface protein 2 allelic variation influences the specific antibody response during acute malaria in individuals from a Brazilian endemic area |
| title_sort |
Merozoite surface protein 2 allelic variation influences the specific antibody response during acute malaria in individuals from a Brazilian endemic area |
| author |
Sallenave-Sales, Selma |
| author_facet |
Sallenave-Sales, Selma Faria, Clarissa Perez Zalis, Mariano Gustavo Ribeiro, Cláudio Tadeu Daniel Cruz, Maria de Fátima Ferreira da |
| author_role |
author |
| author2 |
Faria, Clarissa Perez Zalis, Mariano Gustavo Ribeiro, Cláudio Tadeu Daniel Cruz, Maria de Fátima Ferreira da |
| author2_role |
author author author author |
| dc.contributor.author.fl_str_mv |
Sallenave-Sales, Selma Faria, Clarissa Perez Zalis, Mariano Gustavo Ribeiro, Cláudio Tadeu Daniel Cruz, Maria de Fátima Ferreira da |
| dc.subject.other.pt_BR.fl_str_mv |
Plasmodium falciparum Malária Proteína-2 da superfície do merozoito Resposta de anticorpos Polimorfismo antigênico |
| topic |
Plasmodium falciparum Malária Proteína-2 da superfície do merozoito Resposta de anticorpos Polimorfismo antigênico Plasmodium falciparum Merozoite surface protein-2 Antibody response Antigenic polymorphism Malaria |
| dc.subject.en.pt_BR.fl_str_mv |
Plasmodium falciparum Merozoite surface protein-2 Antibody response Antigenic polymorphism Malaria |
| description |
Universidade Federal do Rio de Janeiro. Hospital Universitário Clementino Fraga Filho. Departamento de Medicina Preventiva. Rio de Janeiro, RJ, Brasil. |
| publishDate |
2007 |
| dc.date.issued.fl_str_mv |
2007 |
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2019-11-26T15:01:56Z |
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2019-11-26T15:01:56Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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SALLENAVE-SALES, Selma et al. Merozoite surface protein 2 allelic variation influences the specific antibody response during acute malaria in individuals from a Brazilian endemic area. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 102, n. 3, p. 421-424, June 2007. |
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https://www.arca.fiocruz.br/handle/icict/37390 |
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0074-0206 |
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10.1590/S0074-02762007005000048 |
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1678-8060 |
| identifier_str_mv |
SALLENAVE-SALES, Selma et al. Merozoite surface protein 2 allelic variation influences the specific antibody response during acute malaria in individuals from a Brazilian endemic area. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 102, n. 3, p. 421-424, June 2007. 0074-0206 10.1590/S0074-02762007005000048 1678-8060 |
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Fundação Oswaldo Cruz. Instituto Oswaldo Cruz |
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Fundação Oswaldo Cruz. Instituto Oswaldo Cruz |
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