Specific and nonhomologous isofunctional enzymes of the genetic information processing pathways as potential therapeutical targets for tritryps

Detalhes bibliográficos
Autor(a) principal: Gomes, Monete Rajão
Data de Publicação: 2011
Outros Autores: Guimarães, Ana Carolina Ramos, Miranda, Antonio Basílio de
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/15980
Resumo: Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Computacional e Sistemas. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Genômica Funcional e Bioinformática. Rio de Janeiro, RJ, Brasil.
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spelling Gomes, Monete RajãoGuimarães, Ana Carolina RamosMiranda, Antonio Basílio de2016-09-28T12:25:19Z2016-09-28T12:25:19Z2011GOMES, Monete Rajão; GUIMARÃES, Ana Carolina Ramos; MIRANDA, Antonio Basílio de. Specific and Nonhomologous Isofunctional Enzymes of the Genetic Information Processing Pathways as Potential Therapeutical Targets for Tritryps. Enzyme Research, v.2011, Article ID 543912, 8p, 2011.2090-0406https://www.arca.fiocruz.br/handle/icict/1598010.4061/2011/5439122090-0414engHindawi Publishing CorporationLeishmanioseEnzimasTerapêuticaDoença de ChagasTritrypsTherapeuticEnzymesLeishmaniasisGenetic Information Processing Pathways (GIPPs)Nonhomologous isofunctional enzymes (NISEs)Specific and nonhomologous isofunctional enzymes of the genetic information processing pathways as potential therapeutical targets for tritrypsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Computacional e Sistemas. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Genômica Funcional e Bioinformática. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Genômica Funcional e Bioinformática. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Computacional e Sistemas. Rio de Janeiro, RJ, Brasil .Leishmania major, Trypanosoma brucei, and Trypanosoma cruzi (Tritryps) are unicellular protozoa that cause leishmaniasis, sleeping sickness and Chagas' disease, respectively. Most drugs against them were discovered through the screening of large numbers of compounds against whole parasites. Nonhomologous isofunctional enzymes (NISEs) may present good opportunities for the identification of new putative drug targets because, though sharing the same enzymatic activity, they possess different three-dimensional structures thus allowing the development of molecules against one or other isoform. From public data of the Tritryps' genomes, we reconstructed the Genetic Information Processing Pathways (GIPPs). We then used AnEnPi to look for the presence of these enzymes between Homo sapiens and Tritryps, as well as specific enzymes of the parasites. We identified three candidates (ECs 3.1.11.2 and 6.1.1.-) in these pathways that may be further studied as new therapeutic targets for drug development against these parasites.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/15980/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALmonete_gomes_etal_IOC_2011.pdfmonete_gomes_etal_IOC_2011.pdfapplication/pdf621764https://www.arca.fiocruz.br/bitstream/icict/15980/2/monete_gomes_etal_IOC_2011.pdf11450f68745afaf395c05f8b3c50d103MD52TEXTmonete_gomes_etal_IOC_2011.pdf.txtmonete_gomes_etal_IOC_2011.pdf.txtExtracted texttext/plain41441https://www.arca.fiocruz.br/bitstream/icict/15980/3/monete_gomes_etal_IOC_2011.pdf.txt874a05c6201d4e45e5dc99e677f120daMD53icict/159802018-04-02 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dc.title.pt_BR.fl_str_mv Specific and nonhomologous isofunctional enzymes of the genetic information processing pathways as potential therapeutical targets for tritryps
title Specific and nonhomologous isofunctional enzymes of the genetic information processing pathways as potential therapeutical targets for tritryps
spellingShingle Specific and nonhomologous isofunctional enzymes of the genetic information processing pathways as potential therapeutical targets for tritryps
Gomes, Monete Rajão
Leishmaniose
Enzimas
Terapêutica
Doença de Chagas
Tritryps
Therapeutic
Enzymes
Leishmaniasis
Genetic Information Processing Pathways (GIPPs)
Nonhomologous isofunctional enzymes (NISEs)
title_short Specific and nonhomologous isofunctional enzymes of the genetic information processing pathways as potential therapeutical targets for tritryps
title_full Specific and nonhomologous isofunctional enzymes of the genetic information processing pathways as potential therapeutical targets for tritryps
title_fullStr Specific and nonhomologous isofunctional enzymes of the genetic information processing pathways as potential therapeutical targets for tritryps
title_full_unstemmed Specific and nonhomologous isofunctional enzymes of the genetic information processing pathways as potential therapeutical targets for tritryps
title_sort Specific and nonhomologous isofunctional enzymes of the genetic information processing pathways as potential therapeutical targets for tritryps
author Gomes, Monete Rajão
author_facet Gomes, Monete Rajão
Guimarães, Ana Carolina Ramos
Miranda, Antonio Basílio de
author_role author
author2 Guimarães, Ana Carolina Ramos
Miranda, Antonio Basílio de
author2_role author
author
dc.contributor.author.fl_str_mv Gomes, Monete Rajão
Guimarães, Ana Carolina Ramos
Miranda, Antonio Basílio de
dc.subject.other.pt_BR.fl_str_mv Leishmaniose
Enzimas
Terapêutica
Doença de Chagas
topic Leishmaniose
Enzimas
Terapêutica
Doença de Chagas
Tritryps
Therapeutic
Enzymes
Leishmaniasis
Genetic Information Processing Pathways (GIPPs)
Nonhomologous isofunctional enzymes (NISEs)
dc.subject.en.pt_BR.fl_str_mv Tritryps
Therapeutic
Enzymes
Leishmaniasis
Genetic Information Processing Pathways (GIPPs)
Nonhomologous isofunctional enzymes (NISEs)
description Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Computacional e Sistemas. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Genômica Funcional e Bioinformática. Rio de Janeiro, RJ, Brasil.
publishDate 2011
dc.date.issued.fl_str_mv 2011
dc.date.accessioned.fl_str_mv 2016-09-28T12:25:19Z
dc.date.available.fl_str_mv 2016-09-28T12:25:19Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv GOMES, Monete Rajão; GUIMARÃES, Ana Carolina Ramos; MIRANDA, Antonio Basílio de. Specific and Nonhomologous Isofunctional Enzymes of the Genetic Information Processing Pathways as Potential Therapeutical Targets for Tritryps. Enzyme Research, v.2011, Article ID 543912, 8p, 2011.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/15980
dc.identifier.issn.pt_BR.fl_str_mv 2090-0406
dc.identifier.doi.none.fl_str_mv 10.4061/2011/543912
dc.identifier.eissn.none.fl_str_mv 2090-0414
identifier_str_mv GOMES, Monete Rajão; GUIMARÃES, Ana Carolina Ramos; MIRANDA, Antonio Basílio de. Specific and Nonhomologous Isofunctional Enzymes of the Genetic Information Processing Pathways as Potential Therapeutical Targets for Tritryps. Enzyme Research, v.2011, Article ID 543912, 8p, 2011.
2090-0406
10.4061/2011/543912
2090-0414
url https://www.arca.fiocruz.br/handle/icict/15980
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Hindawi Publishing Corporation
publisher.none.fl_str_mv Hindawi Publishing Corporation
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/15980/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/15980/2/monete_gomes_etal_IOC_2011.pdf
https://www.arca.fiocruz.br/bitstream/icict/15980/3/monete_gomes_etal_IOC_2011.pdf.txt
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