The population impact of late presentation with advanced HIV disease and delayed antiretroviral therapy in adults receiving HIV care in Latin America
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2019 |
| Outros Autores: | , , , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/37904 |
Resumo: | Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán. Departamento de Infectología. Mexico City, Mexico. |
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Belaunzarán-Zamudio, Pablo F.Caro-Vega, Yanink N.Shepherd, Bryan E.Rebeiro, Peter F.Crabtree-Ramírez, Brenda E.Cortes, Claudia P.Grinsztejn, BeatrizGotuzzo, EduardoMejia, FernandoPadgett, DenisPape, Jean W.Rouzier, VanessaVeloso, Valdiléa G.Cardoso, Sandra WagnerMcGowan, Catherine C.Sierra-Madero, Juan G.2019-12-12T14:36:57Z2019-12-12T14:36:57Z2019BELAUNZARÁN-ZAMUDIO, Pablo F. et al. The population impact of late presentation with advanced HIV disease and delayed antiretroviral therapy in adults receiving HIV care in Latin America. American Journal of Epidemiology, p. 1-30, Oct. 2019.0002-9262https://www.arca.fiocruz.br/handle/icict/3790410.1093/aje/kwz2521476-6256engOxford University PressThe population impact of late presentation with advanced HIV disease and delayed antiretroviral therapy in adults receiving HIV care in Latin Americainfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleInstituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán. Departamento de Infectología. Mexico City, Mexico.Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán. Departamento de Infectología. Mexico City, Mexico.Vanderbilt University. Department of Biostatistics. Nashville, TN, USA.Vanderbilt University. Department of Medicine. Nashville, TN, USA.Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán. Departamento de Infectología. Mexico City, Mexico.Universidad de Chile. Fundación Arriarán. Santiago, Chile.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em DST/AIDS. Rio de Janeiro, RJ, Brasil.Instituto de Medicina Tropical Alexander von Humboldt. Lima, Peru.Instituto de Medicina Tropical Alexander von Humboldt. Lima, Peru.Instituto Hondureño de Seguridad Social. Tegucigalpa, Honduras / Hospital Escuela. Tegucigalpa, Honduras.Le Groupe Haitien d’Etude du Sarcome de Kaposi et des Infections Opportunistes. Port-au-Prince, Haiti.Le Groupe Haitien d’Etude du Sarcome de Kaposi et des Infections Opportunistes. Port-au-Prince, Haiti.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em DST/AIDS. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em DST/AIDS. Rio de Janeiro, RJ, Brasil.Vanderbilt University. Department of Medicine. Nashville, TN, USA.Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán. Departamento de Infectología. Mexico City, Mexico.Late presentation to care and antiretroviral therapy (ART) initiation with advanced HIV-disease are common in Latin America. We estimated the impact of these conditions on mortality in the region. We included adults enrolled during 2001-2014 at HIV-care clinics. We estimated the adjusted attributable risk (AR) and population attributable fraction (PAF) for all-cause mortality of presentation to care with advanced HIV-disease (advanced-LP), ART initiation with advanced HIV-disease, and not initiating ART. Advanced HIV-disease was defined as CD4<200 cells/μL or AIDS. AR and PAF were derived using marginal structural models. Of 9,229 patients, 56% presented with advanced HIV-disease. ARs of death for advanced-LP were 86%, 71%, and 58%, and PAFs were 78%, 58%, and 43% at 1, 5, and 10 years post-enrollment. Among people without advanced-LP, ARs of death for delaying ART were 39%, 32%, and 37% at 1, 5, and 10 years post-enrollment and PAFs were 20%, 14%, and 15%. Among people with advanced-LP, ART decreased the hazard of death by 63% in the first year post-enrollment, but 93% of these started ART; thus universal ART among them would only reduce mortality by 10%. Earlier presentation to care and earlier ART initiation would prevent most HIV-deaths in Latin America.AIDSEarly diagnosisHIV InfectionsLatin AmericaRetrospective studiesAdultsinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83104https://www.arca.fiocruz.br/bitstream/icict/37904/1/license.txt79178e5f2a0eb066867a274556814938MD51ORIGINALva_Belaunzarán-Zamudio_Pablo_etal_INI_2019.pdfva_Belaunzarán-Zamudio_Pablo_etal_INI_2019.pdfapplication/pdf922933https://www.arca.fiocruz.br/bitstream/icict/37904/2/va_Belaunzar%c3%a1n-Zamudio_Pablo_etal_INI_2019.pdf756f6343169af54dc237c93857a86abdMD52TEXTva_Belaunzarán-Zamudio_Pablo_etal_INI_2019.pdf.txtva_Belaunzarán-Zamudio_Pablo_etal_INI_2019.pdf.txtExtracted 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| dc.title.pt_BR.fl_str_mv |
The population impact of late presentation with advanced HIV disease and delayed antiretroviral therapy in adults receiving HIV care in Latin America |
| title |
The population impact of late presentation with advanced HIV disease and delayed antiretroviral therapy in adults receiving HIV care in Latin America |
| spellingShingle |
The population impact of late presentation with advanced HIV disease and delayed antiretroviral therapy in adults receiving HIV care in Latin America Belaunzarán-Zamudio, Pablo F. AIDS Early diagnosis HIV Infections Latin America Retrospective studies Adults |
| title_short |
The population impact of late presentation with advanced HIV disease and delayed antiretroviral therapy in adults receiving HIV care in Latin America |
| title_full |
The population impact of late presentation with advanced HIV disease and delayed antiretroviral therapy in adults receiving HIV care in Latin America |
| title_fullStr |
The population impact of late presentation with advanced HIV disease and delayed antiretroviral therapy in adults receiving HIV care in Latin America |
| title_full_unstemmed |
The population impact of late presentation with advanced HIV disease and delayed antiretroviral therapy in adults receiving HIV care in Latin America |
| title_sort |
The population impact of late presentation with advanced HIV disease and delayed antiretroviral therapy in adults receiving HIV care in Latin America |
| author |
Belaunzarán-Zamudio, Pablo F. |
| author_facet |
Belaunzarán-Zamudio, Pablo F. Caro-Vega, Yanink N. Shepherd, Bryan E. Rebeiro, Peter F. Crabtree-Ramírez, Brenda E. Cortes, Claudia P. Grinsztejn, Beatriz Gotuzzo, Eduardo Mejia, Fernando Padgett, Denis Pape, Jean W. Rouzier, Vanessa Veloso, Valdiléa G. Cardoso, Sandra Wagner McGowan, Catherine C. Sierra-Madero, Juan G. |
| author_role |
author |
| author2 |
Caro-Vega, Yanink N. Shepherd, Bryan E. Rebeiro, Peter F. Crabtree-Ramírez, Brenda E. Cortes, Claudia P. Grinsztejn, Beatriz Gotuzzo, Eduardo Mejia, Fernando Padgett, Denis Pape, Jean W. Rouzier, Vanessa Veloso, Valdiléa G. Cardoso, Sandra Wagner McGowan, Catherine C. Sierra-Madero, Juan G. |
| author2_role |
author author author author author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Belaunzarán-Zamudio, Pablo F. Caro-Vega, Yanink N. Shepherd, Bryan E. Rebeiro, Peter F. Crabtree-Ramírez, Brenda E. Cortes, Claudia P. Grinsztejn, Beatriz Gotuzzo, Eduardo Mejia, Fernando Padgett, Denis Pape, Jean W. Rouzier, Vanessa Veloso, Valdiléa G. Cardoso, Sandra Wagner McGowan, Catherine C. Sierra-Madero, Juan G. |
| dc.subject.en.pt_BR.fl_str_mv |
AIDS Early diagnosis HIV Infections Latin America Retrospective studies Adults |
| topic |
AIDS Early diagnosis HIV Infections Latin America Retrospective studies Adults |
| description |
Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán. Departamento de Infectología. Mexico City, Mexico. |
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2019 |
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2019-12-12T14:36:57Z |
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2019-12-12T14:36:57Z |
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2019 |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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BELAUNZARÁN-ZAMUDIO, Pablo F. et al. The population impact of late presentation with advanced HIV disease and delayed antiretroviral therapy in adults receiving HIV care in Latin America. American Journal of Epidemiology, p. 1-30, Oct. 2019. |
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https://www.arca.fiocruz.br/handle/icict/37904 |
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0002-9262 |
| dc.identifier.doi.none.fl_str_mv |
10.1093/aje/kwz252 |
| dc.identifier.eissn.none.fl_str_mv |
1476-6256 |
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BELAUNZARÁN-ZAMUDIO, Pablo F. et al. The population impact of late presentation with advanced HIV disease and delayed antiretroviral therapy in adults receiving HIV care in Latin America. American Journal of Epidemiology, p. 1-30, Oct. 2019. 0002-9262 10.1093/aje/kwz252 1476-6256 |
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Oxford University Press |
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Oxford University Press |
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