Limitations of Probiotic Therapy in Acute, Severe Dehydrating Diarrhea

Detalhes bibliográficos
Autor(a) principal: Ribeiro, Hugo Costa
Data de Publicação: 2003
Outros Autores: Ribeiro, Tereza Cristina Medrado, Mattos, Angela Peixoto de, Valois, Sandra S, Neri, Daniela A, Almeida, Patricia, Cerqueira, Celina M, Ramos, Eduardo Antônio Gonçalves, Young, Rosemary J, Vanderhoof, Jon A
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/26417
Resumo: Ramos, Eduardo Antonio Gonçalves. “Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento”.
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spelling Ribeiro, Hugo CostaRibeiro, Tereza Cristina MedradoMattos, Angela Peixoto deValois, Sandra SNeri, Daniela AAlmeida, PatriciaCerqueira, Celina MRamos, Eduardo Antônio GonçalvesYoung, Rosemary JVanderhoof, Jon A2018-05-14T13:58:58Z2018-05-14T13:58:58Z2003RIBEIRO, H. C. et al. Limitations of Probiotic Therapy in Acute, Severe Dehydrating Diarrhea. Journal of Pediatric Gastroenterology and Nutrition, v. 36, p. 112–115, 2003.0277-2116https://www.arca.fiocruz.br/handle/icict/26417Ramos, Eduardo Antonio Gonçalves. “Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento”.Pronex/CNPq (661086/1998-4), BrazilFederal University of Bahia. School of Medicine. Department of Pediatrics. Salvador, BA, BrazilFederal University of Bahia. School of Medicine. Department of Pediatrics. Salvador, BA, BrazilFederal University of Bahia. School of Medicine. Department of Pediatrics. Salvador, BA, BrazilFederal University of Bahia. School of Medicine. Department of Pediatrics. Salvador, BA, BrazilFederal University of Bahia. School of Medicine. Department of Pediatrics. Salvador, BA, BrazilFederal University of Bahia. School of Medicine. Department of Pediatrics. Salvador, BA, BrazilFederal University of Bahia. School of Medicine. Department of Pediatrics. Salvador, BA, BrazilFederal University of Bahia. School of Medicine. Department of Pediatrics. Salvador, BA, BrazilUniversity of Nebraska Medical Center. Omaha, Nebraska, U.S.AUniversity of Nebraska Medical Center. Omaha, Nebraska, U.S.ABackground: Recent studies have shown that probiotics, most commonly Lactobacillus GG, may be useful in treating acute gastroenteritis. However, beneficial effects appear to be limited to a modest decrease in the duration of diarrhea. No studies have evaluated this therapy in moderate to severe dehydrating diarrhea in a metabolic facility. Methods: Male children less than 2 years of age were admitted to a metabolic unit of the Department of Pediatrics at the Federal University of Bahia, Brazil, with moderate dehydration and were randomized in a double-blind, placebo-controlled fashion. Oral rehydration solution (ORS) was administered per protocol and either placebo or Lactobacillus GG was given in combination with the ORS. Output of urine, stool, and vomitus was recorded along with stool weight, nude body weight, and standard laboratory assessments for hydration. Results: There was no significant reduction in diarrhea duration and stool output in the Lactobacillus GG group. However, Kaplan-Meier survival analysis demonstrated that, even in moderate to severe diarrhea, resolution of the illness occurred so rapidly, that statistically significant benefits of probiotic therapy could not be demonstrated. Conclusion: Our data implies that colonization must occur before benefits of probiotics can be realized. Probiotics are, therefore, likely to be of limited benefit in treating diarrheal illnesses of short duration such as viral enteritis. The beneficial effects of probiotics may be limited to prophylactic usage in high-risk populations.engLippincott, Williams & WilkinsDiarréiaProbióticosGastroenteriteDesidrataçãoLactobacillus GGHumanosDiarrheaProbioticsGastroenteritisDehydrationLactobacillus GGHumansLimitations of Probiotic Therapy in Acute, Severe Dehydrating Diarrheainfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/26417/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALRamos EA Limitations of Probiotic Therapy in Acute.....pdfRamos EA Limitations of Probiotic Therapy in 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dc.title.pt_BR.fl_str_mv Limitations of Probiotic Therapy in Acute, Severe Dehydrating Diarrhea
title Limitations of Probiotic Therapy in Acute, Severe Dehydrating Diarrhea
spellingShingle Limitations of Probiotic Therapy in Acute, Severe Dehydrating Diarrhea
Ribeiro, Hugo Costa
Diarréia
Probióticos
Gastroenterite
Desidratação
Lactobacillus GG
Humanos
Diarrhea
Probiotics
Gastroenteritis
Dehydration
Lactobacillus GG
Humans
title_short Limitations of Probiotic Therapy in Acute, Severe Dehydrating Diarrhea
title_full Limitations of Probiotic Therapy in Acute, Severe Dehydrating Diarrhea
title_fullStr Limitations of Probiotic Therapy in Acute, Severe Dehydrating Diarrhea
title_full_unstemmed Limitations of Probiotic Therapy in Acute, Severe Dehydrating Diarrhea
title_sort Limitations of Probiotic Therapy in Acute, Severe Dehydrating Diarrhea
author Ribeiro, Hugo Costa
author_facet Ribeiro, Hugo Costa
Ribeiro, Tereza Cristina Medrado
Mattos, Angela Peixoto de
Valois, Sandra S
Neri, Daniela A
Almeida, Patricia
Cerqueira, Celina M
Ramos, Eduardo Antônio Gonçalves
Young, Rosemary J
Vanderhoof, Jon A
author_role author
author2 Ribeiro, Tereza Cristina Medrado
Mattos, Angela Peixoto de
Valois, Sandra S
Neri, Daniela A
Almeida, Patricia
Cerqueira, Celina M
Ramos, Eduardo Antônio Gonçalves
Young, Rosemary J
Vanderhoof, Jon A
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Ribeiro, Hugo Costa
Ribeiro, Tereza Cristina Medrado
Mattos, Angela Peixoto de
Valois, Sandra S
Neri, Daniela A
Almeida, Patricia
Cerqueira, Celina M
Ramos, Eduardo Antônio Gonçalves
Young, Rosemary J
Vanderhoof, Jon A
dc.subject.other.pt_BR.fl_str_mv Diarréia
Probióticos
Gastroenterite
Desidratação
Lactobacillus GG
Humanos
topic Diarréia
Probióticos
Gastroenterite
Desidratação
Lactobacillus GG
Humanos
Diarrhea
Probiotics
Gastroenteritis
Dehydration
Lactobacillus GG
Humans
dc.subject.en.pt_BR.fl_str_mv Diarrhea
Probiotics
Gastroenteritis
Dehydration
Lactobacillus GG
Humans
description Ramos, Eduardo Antonio Gonçalves. “Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento”.
publishDate 2003
dc.date.issued.fl_str_mv 2003
dc.date.accessioned.fl_str_mv 2018-05-14T13:58:58Z
dc.date.available.fl_str_mv 2018-05-14T13:58:58Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv RIBEIRO, H. C. et al. Limitations of Probiotic Therapy in Acute, Severe Dehydrating Diarrhea. Journal of Pediatric Gastroenterology and Nutrition, v. 36, p. 112–115, 2003.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/26417
dc.identifier.issn.pt_BR.fl_str_mv 0277-2116
identifier_str_mv RIBEIRO, H. C. et al. Limitations of Probiotic Therapy in Acute, Severe Dehydrating Diarrhea. Journal of Pediatric Gastroenterology and Nutrition, v. 36, p. 112–115, 2003.
0277-2116
url https://www.arca.fiocruz.br/handle/icict/26417
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
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dc.publisher.none.fl_str_mv Lippincott, Williams & Wilkins
publisher.none.fl_str_mv Lippincott, Williams & Wilkins
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