Integrin-directed antibody-based immunotherapy: focus on VLA-4

Detalhes bibliográficos
Autor(a) principal: Savino, Wilson
Data de Publicação: 2021
Outros Autores: Chaves, Beatriz, Bonomo, Adriana Cesar, Almeida, Vinicius Cotta de
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/49039
Resumo: Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa sobre o Timo. Rio de Janeiro, RJ, Brasil / Instituto Nacional de Ciência e Tecnologia em Neuroimunomodulação. Rio de Janeiro, RJ, Brasil / Rede de Pesquisa em Neuroinflamação do Rio de Janeiro. Rio de Janeiro, RJ, Brasil.
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spelling Savino, WilsonChaves, BeatrizBonomo, Adriana CesarAlmeida, Vinicius Cotta de2021-09-08T11:12:36Z2021-09-08T11:12:36Z2021SAVINO, Wilson et al. Integrin-directed antibody-based immunotherapy: focus on VLA-4. Immunotherapy Advances, v. 1, n. 1, p. 1 -11, Feb. 2021.1432-0851https://www.arca.fiocruz.br/handle/icict/4903910.1093/immadv/ltab002engOxford University PressTráfego de célulasImunoterapiaNeuroimunologiaCélulas TCell traffickingImmunotherapyNeuroimmunologyT cellsIntegrin-directed antibody-based immunotherapy: focus on VLA-4info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa sobre o Timo. Rio de Janeiro, RJ, Brasil / Instituto Nacional de Ciência e Tecnologia em Neuroimunomodulação. Rio de Janeiro, RJ, Brasil / Rede de Pesquisa em Neuroinflamação do Rio de Janeiro. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa sobre o Timo. Rio de Janeiro, RJ, Brasil / Instituto Nacional de Ciência e Tecnologia em Neuroimunomodulação. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Grupo de Modelagem Computacional. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa sobre o Timo. Rio de Janeiro, RJ, Brasil / Instituto Nacional de Ciência e Tecnologia em Neuroimunomodulação. Rio de Janeiro, RJ, Brasil / Rede de Pesquisa em Neuroinflamação do Rio de Janeiro. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa sobre o Timo. Rio de Janeiro, RJ, Brasil / Instituto Nacional de Ciência e Tecnologia em Neuroimunomodulação. Rio de Janeiro, RJ, Brasil / Rede de Pesquisa em Neuroinflamação do Rio de Janeiro. Rio de Janeiro, RJ, Brasil.One major finding of chronic inflammatory diseases of various origins is the establishment of inflamma tory infiltrates, bearing different leukocyte subpopulations, including activated T lymphocytes. Integrins are among the large series of molecular interactions that have been implicated as players in both triggering and maintenance of leukocyte influx from the blood into a given organ parenchyme. Accordingly, blocking the interaction between VLA-6 integrin and laminin, experimentally abrogates heart graft rejection. Many reports have shown that VLA-4 is used by T cells to cross endothelial barriers, as well as to migrate within target tissues. In this respect, a humanized IgG4 anti-VLA-4 monoclonal antibody (specific to the α4-integrin chain of VLA-4) has been successfully applied to treat multiple sclerosis as well as inflammatory bowel disease. Anti-VLA-4 monoclonal antibody has also been applied to block transendothelial passage in other autoimmune diseases, such as rheumatoid arthritis. On this same vein is the action of such a reagent in impairing in vitro transendothial and fibronectin-driven migration of CD4+ and CD8+ T cells expressing high densities of VLA-4 from Duchenne muscular dystrophy patients, thus potentially enlarging the use of this strategy to other diseases. Yet, in a small number of patients, the use of Natalizumab has been correl ated with the progressive multifocal leukoencephalopathy, a serious brain infection caused by the John Cunningham virus. This issue restricted the use of the reagent. In this respect, the development of smaller and more specific antibody reagents should be envisioned as a next-generation promising strategy.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/49039/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALWilsonSavino_ViniciusCAlmeida_etal_IOC_2021.pdfWilsonSavino_ViniciusCAlmeida_etal_IOC_2021.pdfapplication/pdf507306https://www.arca.fiocruz.br/bitstream/icict/49039/2/WilsonSavino_ViniciusCAlmeida_etal_IOC_2021.pdfd32a7193b31c8435ac00f436e63f3793MD52TEXTWilsonSavino_ViniciusCAlmeida_etal_IOC_2021.pdf.txtWilsonSavino_ViniciusCAlmeida_etal_IOC_2021.pdf.txtExtracted texttext/plain52363https://www.arca.fiocruz.br/bitstream/icict/49039/3/WilsonSavino_ViniciusCAlmeida_etal_IOC_2021.pdf.txtcfba9b40b70259c6cc3e205fb6e32363MD53icict/490392021-09-09 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dc.title.pt_BR.fl_str_mv Integrin-directed antibody-based immunotherapy: focus on VLA-4
title Integrin-directed antibody-based immunotherapy: focus on VLA-4
spellingShingle Integrin-directed antibody-based immunotherapy: focus on VLA-4
Savino, Wilson
Tráfego de células
Imunoterapia
Neuroimunologia
Células T
Cell trafficking
Immunotherapy
Neuroimmunology
T cells
title_short Integrin-directed antibody-based immunotherapy: focus on VLA-4
title_full Integrin-directed antibody-based immunotherapy: focus on VLA-4
title_fullStr Integrin-directed antibody-based immunotherapy: focus on VLA-4
title_full_unstemmed Integrin-directed antibody-based immunotherapy: focus on VLA-4
title_sort Integrin-directed antibody-based immunotherapy: focus on VLA-4
author Savino, Wilson
author_facet Savino, Wilson
Chaves, Beatriz
Bonomo, Adriana Cesar
Almeida, Vinicius Cotta de
author_role author
author2 Chaves, Beatriz
Bonomo, Adriana Cesar
Almeida, Vinicius Cotta de
author2_role author
author
author
dc.contributor.author.fl_str_mv Savino, Wilson
Chaves, Beatriz
Bonomo, Adriana Cesar
Almeida, Vinicius Cotta de
dc.subject.other.pt_BR.fl_str_mv Tráfego de células
Imunoterapia
Neuroimunologia
Células T
topic Tráfego de células
Imunoterapia
Neuroimunologia
Células T
Cell trafficking
Immunotherapy
Neuroimmunology
T cells
dc.subject.en.pt_BR.fl_str_mv Cell trafficking
Immunotherapy
Neuroimmunology
T cells
description Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa sobre o Timo. Rio de Janeiro, RJ, Brasil / Instituto Nacional de Ciência e Tecnologia em Neuroimunomodulação. Rio de Janeiro, RJ, Brasil / Rede de Pesquisa em Neuroinflamação do Rio de Janeiro. Rio de Janeiro, RJ, Brasil.
publishDate 2021
dc.date.accessioned.fl_str_mv 2021-09-08T11:12:36Z
dc.date.available.fl_str_mv 2021-09-08T11:12:36Z
dc.date.issued.fl_str_mv 2021
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv SAVINO, Wilson et al. Integrin-directed antibody-based immunotherapy: focus on VLA-4. Immunotherapy Advances, v. 1, n. 1, p. 1 -11, Feb. 2021.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/49039
dc.identifier.issn.pt_BR.fl_str_mv 1432-0851
dc.identifier.doi.none.fl_str_mv 10.1093/immadv/ltab002
identifier_str_mv SAVINO, Wilson et al. Integrin-directed antibody-based immunotherapy: focus on VLA-4. Immunotherapy Advances, v. 1, n. 1, p. 1 -11, Feb. 2021.
1432-0851
10.1093/immadv/ltab002
url https://www.arca.fiocruz.br/handle/icict/49039
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Oxford University Press
publisher.none.fl_str_mv Oxford University Press
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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https://www.arca.fiocruz.br/bitstream/icict/49039/3/WilsonSavino_ViniciusCAlmeida_etal_IOC_2021.pdf.txt
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