Inflammatory markers and occurrence of falls: Bambuí Cohort Study of Aging
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2019 |
| Outros Autores: | , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| DOI: | 10.11606/s1518-8787.2019053000855 |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/36587 |
Resumo: | Fundação Oswaldo Cruz. Instituto René Rachou. Programa de Pós-Graduação em Saúde Coletiva. Belo Horizonte, MG, Brasil. |
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Amorim, Juleimar Soares Coelho deTorres, Karen Cecília LimaCarvalho, Andréa Teixeira deMartins Filho, Olindo AssisCosta, Maria Fernanda Furtado LimaPeixoto, Sérgio William Viana2019-10-18T19:04:45Z2019-10-18T19:04:45Z2019AMORIM, Juleimar Soares Coelho de et al. Inflammatory markers and occurrence of falls: Bambuí Cohort Study of Aging. Revista de Saúde Pública, v. 53, p. 1-11, 2019.0034-8910https://www.arca.fiocruz.br/handle/icict/3658710.11606/s1518-8787.2019053000855engFaculdade de Saúde Pública da Universidade de São PauloInflammatory markers and occurrence of falls: Bambuí Cohort Study of Aginginfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto René Rachou. Programa de Pós-Graduação em Saúde Coletiva. Belo Horizonte, MG, Brasil.Fundação Oswaldo Cruz. Instituto René Rachou. Grupo Integrado de Pesquisas em Biomarcadores. Belo Horizonte, MG, Brasil.Fundação Oswaldo Cruz. Instituto René Rachou. Grupo Integrado de Pesquisas em Biomarcadores. Belo Horizonte, MG, Brasil.Fundação Oswaldo Cruz. Instituto René Rachou. Grupo Integrado de Pesquisas em Biomarcadores. Belo Horizonte, MG, Brasil.Fundação Oswaldo Cruz. Instituto René Rachou. Núcleo de Estudos em Saúde Pública e Envelhecimento. Belo Horizonte, MG, Brasil.Fundação Oswaldo Cruz. Instituto René Rachou. Núcleo de Estudos em Saúde Pública e Envelhecimento. Belo Horizonte, MG, Brasil / Universidade Federal de Minas Gerais. Escola de Enfermagem. Departamento de Enfermagem Aplicada. Belo Horizonte, MG, Brasil.OBJECTIVE: Analyze whether inflammatory markers are associated with falls among older adults living in Bambuí. METHODS: Study that analyzed baseline data from a Bambuí Cohort Study of Aging, involving 1,250 participants. Data about falls were collected from previous 12 months, classified as single or multiple occurrence and severity (participant seeking health services). Information about sociodemographic characteristics, health behaviors and health condition was also collected and used as confounding factors. The exposures of interest included interleukins (IL-1β, IL-6, IL-8, IL-10, IL-12), tumor necrosis factor (TNF), ultra-sensitive C-reactive protein (us-CRP) and chemokines (CXCL9, CCL5, CCL10, MCP1). Data were processed through logistic regression, obtaining odds ratio and 95% confidence interval (95%CI). RESULTS: The prevalence of falls was 27.1%; 40.1% of the older adults reported multiple falls and 33.3% sought health services. After adjustments, the following elevated levels were associated with falls: us-CRP (OR = 1.46, 95%CI 1.04–2.03), CCL5 (OR = 1.38, 95%CI 1.01–1.90) and CXCL9 (OR = 1.43, 95%CI 1.02–2.02). An association was observed between the number of elevated markers and the occurrence of falls: two (OR = 1.47, 95%CI 1.02–2.12) and three (OR = 2.08, 95%CI 1.12–3.87) elevated biomarkers indicated fall probability of 32.0% and 39.4%, respectively. CONCLUSIONS: Elevated levels of us-CRP, CCL5 and CXCL9, which were associated with falls, may contribute to a proper understanding of the mechanism associated with the occurrence of falls among older people.AgedAgingAccidental FallsRisk FactorsBiomarkersInflammation Mediatorsinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83082https://www.arca.fiocruz.br/bitstream/icict/36587/1/license.txt9193a7c197bc67acd023525e72a03240MD51ORIGINALInflammatory markers and occurrence of falls.pdfInflammatory markers and occurrence of falls.pdfapplication/pdf10067810https://www.arca.fiocruz.br/bitstream/icict/36587/2/Inflammatory%20markers%20and%20occurrence%20of%20falls.pdf8390faf0bb3d8296cffd83cb7a12903dMD52TEXTInflammatory markers and occurrence of falls.pdf.txtInflammatory markers and occurrence of falls.pdf.txtExtracted 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| dc.title.pt_BR.fl_str_mv |
Inflammatory markers and occurrence of falls: Bambuí Cohort Study of Aging |
| title |
Inflammatory markers and occurrence of falls: Bambuí Cohort Study of Aging |
| spellingShingle |
Inflammatory markers and occurrence of falls: Bambuí Cohort Study of Aging Amorim, Juleimar Soares Coelho de Aged Aging Accidental Falls Risk Factors Biomarkers Inflammation Mediators |
| title_short |
Inflammatory markers and occurrence of falls: Bambuí Cohort Study of Aging |
| title_full |
Inflammatory markers and occurrence of falls: Bambuí Cohort Study of Aging |
| title_fullStr |
Inflammatory markers and occurrence of falls: Bambuí Cohort Study of Aging |
| title_full_unstemmed |
Inflammatory markers and occurrence of falls: Bambuí Cohort Study of Aging |
| title_sort |
Inflammatory markers and occurrence of falls: Bambuí Cohort Study of Aging |
| author |
Amorim, Juleimar Soares Coelho de |
| author_facet |
Amorim, Juleimar Soares Coelho de Torres, Karen Cecília Lima Carvalho, Andréa Teixeira de Martins Filho, Olindo Assis Costa, Maria Fernanda Furtado Lima Peixoto, Sérgio William Viana |
| author_role |
author |
| author2 |
Torres, Karen Cecília Lima Carvalho, Andréa Teixeira de Martins Filho, Olindo Assis Costa, Maria Fernanda Furtado Lima Peixoto, Sérgio William Viana |
| author2_role |
author author author author author |
| dc.contributor.author.fl_str_mv |
Amorim, Juleimar Soares Coelho de Torres, Karen Cecília Lima Carvalho, Andréa Teixeira de Martins Filho, Olindo Assis Costa, Maria Fernanda Furtado Lima Peixoto, Sérgio William Viana |
| dc.subject.en.pt_BR.fl_str_mv |
Aged Aging Accidental Falls Risk Factors Biomarkers Inflammation Mediators |
| topic |
Aged Aging Accidental Falls Risk Factors Biomarkers Inflammation Mediators |
| description |
Fundação Oswaldo Cruz. Instituto René Rachou. Programa de Pós-Graduação em Saúde Coletiva. Belo Horizonte, MG, Brasil. |
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2019 |
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2019-10-18T19:04:45Z |
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2019-10-18T19:04:45Z |
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2019 |
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AMORIM, Juleimar Soares Coelho de et al. Inflammatory markers and occurrence of falls: Bambuí Cohort Study of Aging. Revista de Saúde Pública, v. 53, p. 1-11, 2019. |
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https://www.arca.fiocruz.br/handle/icict/36587 |
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0034-8910 |
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10.11606/s1518-8787.2019053000855 |
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AMORIM, Juleimar Soares Coelho de et al. Inflammatory markers and occurrence of falls: Bambuí Cohort Study of Aging. Revista de Saúde Pública, v. 53, p. 1-11, 2019. 0034-8910 10.11606/s1518-8787.2019053000855 |
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Faculdade de Saúde Pública da Universidade de São Paulo |
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