Proposal of a histopathological predictive rule for the differential diagnosis between American tegumentary leishmaniasis and sporotrichosis skin lesions

Detalhes bibliográficos
Autor(a) principal: Quintella, L. P.
Data de Publicação: 2012
Outros Autores: Passos, S. R. L., Miranda, L. H. M., Cuzzi, T., Barros, M. B. de L., Francesconi-do-Vale, A. C., Galhardo, M. C. G., Madeira, M. de F., Carvalho, M. H. Figueiredo de, Schubach, A. de O.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/33311
Resumo: 2020-05-31
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spelling Quintella, L. P.Passos, S. R. L.Miranda, L. H. M.Cuzzi, T.Barros, M. B. de L.Francesconi-do-Vale, A. C.Galhardo, M. C. G.Madeira, M. de F.Carvalho, M. H. Figueiredo deSchubach, A. de O.2019-05-31T13:40:36Z2019-05-31T13:40:36Z2012QUINTELLA, L. P. et al. Proposal of a histopathological predictive rule for the differential diagnosis between American tegumentary leishmaniasis and sporotrichosis skin lesions. British Journal of Dermatology, v. 167, p. 837-846, 2012.0007-0963https://www.arca.fiocruz.br/handle/icict/3331110.1111/j.1365-2133.2012.11012.x1365-2133engWileyProposal of a histopathological predictive rule for the differential diagnosis between American tegumentary leishmaniasis and sporotrichosis skin lesionsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article2020-05-31Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Serviço de Anatomia Patológica. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Serviço de Anatomia Patológica. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Serviço de Anatomia Patológica. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Serviço de Anatomia Patológica. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Serviço de Anatomia Patológica. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Serviço de Anatomia Patológica. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Serviço de Anatomia Patológica. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Serviço de Anatomia Patológica. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Serviço de Anatomia Patológica. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Serviço de Anatomia Patológica. Rio de Janeiro, RJ, Brasil.Background: American tegumentary leishmaniasis (ATL) and sporotrichosis exhibitsimilar histopathology and low frequencies of microorganism detection. Objectives: This study seeks to identify microscopic alterations that can distinguish between these diseases.Methods: Haematoxylin and eosin stained slides of 171 ATL and 97 sporotrichosis samples from active cutaneous lesions were examined for histopathological alterations. The lesions were diagnosed by isolating the agent (which was not visible) in culture. An intuitive diagnosis was assigned to each slide. The strength of the association between the histopathological findings and the diagnosis was estimated by an odds ratio, and each finding was graded according to a regression model. A score was assigned to each sample based on the histopathological findings. A study of the interobserver reliability was performed by calculating kappa coefficients of the histopathological findings and intuitive diagnoses. Results: The markers ‘macrophage concentration’, ‘tuberculoid granuloma’ and‘extracellular matrix degeneration’ were associated with ATL. ‘Suppurative granu-loma’, ‘stellate granuloma’, ‘different types of giant cells’, ‘granulomas in granu-lation tissue’ and ‘abscess outside the granuloma’ were associated with adiagnosis of sporotrichosis. ‘Macrophage concentration’ and ‘suppurative granuloma’ had the highest (substantial and almost perfect, respectively) reliability. The regression model score indicated 92Æ0% accuracy. The intuitive diagnosishad 82Æ5% diagnostic accuracy and substantial reliability. Conclusions: Taking into account the clinical and epidemiological context, some histopathological alterations might be useful for the differential diagnosis between ATL and sporotrichosis cutaneous lesions in cases in which the aetiological agent is not visible.American tegumentary leishmaniasisSporotrichosisSkin lesionsinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txttext/plain1748https://www.arca.fiocruz.br/bitstream/icict/33311/1/license.txt8a4605be74aa9ea9d79846c1fba20a33MD51ORIGINALve_Quintella_L_etal_INI_2012.pdfve_Quintella_L_etal_INI_2012.pdfapplication/pdf478215https://www.arca.fiocruz.br/bitstream/icict/33311/2/ve_Quintella_L_etal_INI_2012.pdfc8f0306de3ed36fe946f31b462138afdMD52TEXTve_Quintella_L_etal_INI_2012.pdf.txtve_Quintella_L_etal_INI_2012.pdf.txtExtracted texttext/plain45653https://www.arca.fiocruz.br/bitstream/icict/33311/3/ve_Quintella_L_etal_INI_2012.pdf.txt38c3a6ccc82ae3679d86ef0650ad6175MD53icict/333112021-03-24 16:32:32.61oai:www.arca.fiocruz.br:icict/33311Tk9URTogUExBQ0UgWU9VUiBPV04gTElDRU5TRSBIRVJFClRoaXMgc2FtcGxlIGxpY2Vuc2UgaXMgcHJvdmlkZWQgZm9yIGluZm9ybWF0aW9uYWwgcHVycG9zZXMgb25seS4KCk5PTi1FWENMVVNJVkUgRElTVFJJQlVUSU9OIExJQ0VOU0UKCkJ5IHNpZ25pbmcgYW5kIHN1Ym1pdHRpbmcgdGhpcyBsaWNlbnNlLCB5b3UgKHRoZSBhdXRob3Iocykgb3IgY29weXJpZ2h0Cm93bmVyKSBncmFudHMgdG8gRFNwYWNlIFVuaXZlcnNpdHkgKERTVSkgdGhlIG5vbi1leGNsdXNpdmUgcmlnaHQgdG8gcmVwcm9kdWNlLAp0cmFuc2xhdGUgKGFzIGRlZmluZWQgYmVsb3cpLCBhbmQvb3IgZGlzdHJpYnV0ZSB5b3VyIHN1Ym1pc3Npb24gKGluY2x1ZGluZwp0aGUgYWJzdHJhY3QpIHdvcmxkd2lkZSBpbiBwcmludCBhbmQgZWxlY3Ryb25pYyBmb3JtYXQgYW5kIGluIGFueSBtZWRpdW0sCmluY2x1ZGluZyBidXQgbm90IGxpbWl0ZWQgdG8gYXVkaW8gb3IgdmlkZW8uCgpZb3UgYWdyZWUgdGhhdCBEU1UgbWF5LCB3aXRob3V0IGNoYW5naW5nIHRoZSBjb250ZW50LCB0cmFuc2xhdGUgdGhlCnN1Ym1pc3Npb24gdG8gYW55IG1lZGl1bSBvciBmb3JtYXQgZm9yIHRoZSBwdXJwb3NlIG9mIHByZXNlcnZhdGlvbi4KCllvdSBhbHNvIGFncmVlIHRoYXQgRFNVIG1heSBrZWVwIG1vcmUgdGhhbiBvbmUgY29weSBvZiB0aGlzIHN1Ym1pc3Npb24gZm9yCnB1cnBvc2VzIG9mIHNlY3VyaXR5LCBiYWNrLXVwIGFuZCBwcmVzZXJ2YXRpb24uCgpZb3UgcmVwcmVzZW50IHRoYXQgdGhlIHN1Ym1pc3Npb24gaXMgeW91ciBvcmlnaW5hbCB3b3JrLCBhbmQgdGhhdCB5b3UgaGF2ZQp0aGUgcmlnaHQgdG8gZ3JhbnQgdGhlIHJpZ2h0cyBjb250YWluZWQgaW4gdGhpcyBsaWNlbnNlLiBZb3UgYWxzbyByZXByZXNlbnQKdGhhdCB5b3VyIHN1Ym1pc3Npb24gZG9lcyBub3QsIHRvIHRoZSBiZXN0IG9mIHlvdXIga25vd2xlZGdlLCBpbmZyaW5nZSB1cG9uCmFueW9uZSdzIGNvcHlyaWdodC4KCklmIHRoZSBzdWJtaXNzaW9uIGNvbnRhaW5zIG1hdGVyaWFsIGZvciB3aGljaCB5b3UgZG8gbm90IGhvbGQgY29weXJpZ2h0LAp5b3UgcmVwcmVzZW50IHRoYXQgeW91IGhhdmUgb2J0YWluZWQgdGhlIHVucmVzdHJpY3RlZCBwZXJtaXNzaW9uIG9mIHRoZQpjb3B5cmlnaHQgb3duZXIgdG8gZ3JhbnQgRFNVIHRoZSByaWdodHMgcmVxdWlyZWQgYnkgdGhpcyBsaWNlbnNlLCBhbmQgdGhhdApzdWNoIHRoaXJkLXBhcnR5IG93bmVkIG1hdGVyaWFsIGlzIGNsZWFybHkgaWRlbnRpZmllZCBhbmQgYWNrbm93bGVkZ2VkCndpdGhpbiB0aGUgdGV4dCBvciBjb250ZW50IG9mIHRoZSBzdWJtaXNzaW9uLgoKSUYgVEhFIFNVQk1JU1NJT04gSVMgQkFTRUQgVVBPTiBXT1JLIFRIQVQgSEFTIEJFRU4gU1BPTlNPUkVEIE9SIFNVUFBPUlRFRApCWSBBTiBBR0VOQ1kgT1IgT1JHQU5JWkFUSU9OIE9USEVSIFRIQU4gRFNVLCBZT1UgUkVQUkVTRU5UIFRIQVQgWU9VIEhBVkUKRlVMRklMTEVEIEFOWSBSSUdIVCBPRiBSRVZJRVcgT1IgT1RIRVIgT0JMSUdBVElPTlMgUkVRVUlSRUQgQlkgU1VDSApDT05UUkFDVCBPUiBBR1JFRU1FTlQuCgpEU1Ugd2lsbCBjbGVhcmx5IGlkZW50aWZ5IHlvdXIgbmFtZShzKSBhcyB0aGUgYXV0aG9yKHMpIG9yIG93bmVyKHMpIG9mIHRoZQpzdWJtaXNzaW9uLCBhbmQgd2lsbCBub3QgbWFrZSBhbnkgYWx0ZXJhdGlvbiwgb3RoZXIgdGhhbiBhcyBhbGxvd2VkIGJ5IHRoaXMKbGljZW5zZSwgdG8geW91ciBzdWJtaXNzaW9uLgo=Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352021-03-24T19:32:32Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Proposal of a histopathological predictive rule for the differential diagnosis between American tegumentary leishmaniasis and sporotrichosis skin lesions
title Proposal of a histopathological predictive rule for the differential diagnosis between American tegumentary leishmaniasis and sporotrichosis skin lesions
spellingShingle Proposal of a histopathological predictive rule for the differential diagnosis between American tegumentary leishmaniasis and sporotrichosis skin lesions
Quintella, L. P.
American tegumentary leishmaniasis
Sporotrichosis
Skin lesions
title_short Proposal of a histopathological predictive rule for the differential diagnosis between American tegumentary leishmaniasis and sporotrichosis skin lesions
title_full Proposal of a histopathological predictive rule for the differential diagnosis between American tegumentary leishmaniasis and sporotrichosis skin lesions
title_fullStr Proposal of a histopathological predictive rule for the differential diagnosis between American tegumentary leishmaniasis and sporotrichosis skin lesions
title_full_unstemmed Proposal of a histopathological predictive rule for the differential diagnosis between American tegumentary leishmaniasis and sporotrichosis skin lesions
title_sort Proposal of a histopathological predictive rule for the differential diagnosis between American tegumentary leishmaniasis and sporotrichosis skin lesions
author Quintella, L. P.
author_facet Quintella, L. P.
Passos, S. R. L.
Miranda, L. H. M.
Cuzzi, T.
Barros, M. B. de L.
Francesconi-do-Vale, A. C.
Galhardo, M. C. G.
Madeira, M. de F.
Carvalho, M. H. Figueiredo de
Schubach, A. de O.
author_role author
author2 Passos, S. R. L.
Miranda, L. H. M.
Cuzzi, T.
Barros, M. B. de L.
Francesconi-do-Vale, A. C.
Galhardo, M. C. G.
Madeira, M. de F.
Carvalho, M. H. Figueiredo de
Schubach, A. de O.
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Quintella, L. P.
Passos, S. R. L.
Miranda, L. H. M.
Cuzzi, T.
Barros, M. B. de L.
Francesconi-do-Vale, A. C.
Galhardo, M. C. G.
Madeira, M. de F.
Carvalho, M. H. Figueiredo de
Schubach, A. de O.
dc.subject.en.pt_BR.fl_str_mv American tegumentary leishmaniasis
Sporotrichosis
Skin lesions
topic American tegumentary leishmaniasis
Sporotrichosis
Skin lesions
description 2020-05-31
publishDate 2012
dc.date.issued.fl_str_mv 2012
dc.date.accessioned.fl_str_mv 2019-05-31T13:40:36Z
dc.date.available.fl_str_mv 2019-05-31T13:40:36Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv QUINTELLA, L. P. et al. Proposal of a histopathological predictive rule for the differential diagnosis between American tegumentary leishmaniasis and sporotrichosis skin lesions. British Journal of Dermatology, v. 167, p. 837-846, 2012.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/33311
dc.identifier.issn.pt_BR.fl_str_mv 0007-0963
dc.identifier.doi.none.fl_str_mv 10.1111/j.1365-2133.2012.11012.x
dc.identifier.eissn.none.fl_str_mv 1365-2133
identifier_str_mv QUINTELLA, L. P. et al. Proposal of a histopathological predictive rule for the differential diagnosis between American tegumentary leishmaniasis and sporotrichosis skin lesions. British Journal of Dermatology, v. 167, p. 837-846, 2012.
0007-0963
10.1111/j.1365-2133.2012.11012.x
1365-2133
url https://www.arca.fiocruz.br/handle/icict/33311
dc.language.iso.fl_str_mv eng
language eng
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dc.publisher.none.fl_str_mv Wiley
publisher.none.fl_str_mv Wiley
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