Maternal Th17 profile after Zika virus infection is involved in congenital Zika syndrome development in children

Detalhes bibliográficos
Autor(a) principal: Fialho, Eder M. S.
Data de Publicação: 2023
Outros Autores: Veras, Emanoel M., Jesus, Caroline M. de, Gomes, Líllian N., Khouri, Ricardo, Sousa, Patrícia S., Ribeiro, Marizélia R. C., Batista, Rosângela F. L., Costa, Luciana C., Nascimento, Flávia R. F., Silva, Antônio A. M., Pereira, Paulo V. Soeiro
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/60826
Resumo: Coordenação de Aperfeiçoamento de Pessoal do Ensino Superior - Brasil (CAPES). Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq). Fundação de Amparo Pesquisa do Maranhão (FAPEMA).
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spelling Fialho, Eder M. S.Veras, Emanoel M.Jesus, Caroline M. deGomes, Líllian N.Khouri, RicardoSousa, Patrícia S.Ribeiro, Marizélia R. C.Batista, Rosângela F. L.Costa, Luciana C.Nascimento, Flávia R. F.Silva, Antônio A. M.Pereira, Paulo V. Soeiro2023-10-18T12:42:16Z2023-10-18T12:42:16Z2023FIALHO, Eder M. S. et al. Maternal Th17 profile after Zika virus infection is involved in congenital Zika syndrome development in children. Viruses, v. 15, n. 1320, p. 1-16, 2023.1999-4915https://www.arca.fiocruz.br/handle/icict/6082610.3390/v15061320Coordenação de Aperfeiçoamento de Pessoal do Ensino Superior - Brasil (CAPES). Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq). Fundação de Amparo Pesquisa do Maranhão (FAPEMA).Universidade Federal do Maranhão. Centro de Ciências Biológicas e da Saúde. Programa de Pós-Graduação em Ciências da Saúde. São Luís, MA, Brasil.Universidade Federal do Maranhão. Escola de medicina. São Luís, MA, Brasil.Universidade Federal do Maranhão. Centro de Ciências Biológicas e da Saúde Programa de Pós-Graduação em Saúde e Tecnologia. Centro. São Luís, MA, Brasil.Universidade de São Paulo. Departamento de Imunologia. São Paulo, SP, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.Secretaria de Estado de Saúde do Estado do Maranhão. Centro de Referência em Neurodesenvolvimento. Assistência e Reabilitação de Crianças/NINAR. São Luís, MA, Brasil.Universidade Federal do Maranhão. Departamento de Medicina III. São Luís, MA, Brasil.Universidade Federal do Maranhão. Departamento de Saúde Pública. São Luís, MA, Brasil.Universidade Federal do Maranhão. Departamento de Saúde Pública. São Luís, MA, Brasil.Universidade Federal do Maranhão. Centro de Ciências Biológicas e da Saúde. Programa de Pós-Graduação em Ciências da Saúde. São Luís, MA, Brasil / Universidade Federal do Maranhão. Departamento de Patologia. São Luís, MA, Brasil.Universidade Federal do Maranhão. Departamento de Saúde Pública. São Luís, MA, Brasil.Universidade Federal do Maranhão. Centro de Ciências Biológicas e da Saúde. Programa de Pós-Graduação em Ciências da Saúde. São Luís, MA, Brasil / Universidade Federal do Maranhão. Departamento de Patologia. São Luís, MA, Brasil.Brazil is one of the countries that experienced an epidemic of microcephaly and other congenital manifestations related to maternal Zika virus infection which can result in Congenital Zika Syndrome (CZS). Since the Zika virus can modulate the immune system, studying mothers’ and children’s immune profiles become essential to better understanding CZS development. Therefore,we investigated the lymphocyte population profile of children who developed CZS and their mothers’ immune response in this study. The study groups were formed from the Plaque Reduction Neutralization Test (PRNT) (CZS+ group) result. To evaluate the lymphocyte population profile, we performed phenotyping of peripheral lymphocytes and quantification of serum cytokine levels. The immunophenotyping and cytokine profile was correlated between CSZ+ children and their mothers. Both groups exhibited increased interleukin-17 levels and a reduction in the subpopulation of CD4+ T lymphocytes. In contrast, the maternal group showed a reduction in the population of B lymphocytes. Thus, the development of CZS is related to the presence of an inflammatory immune profile in children and their mothers characterized by Th17 activation.engMDPITransmissão verticalMicrocefaliaInfecção por doençaInterleucina-17Vertical transmissionMicrocephalyDisease infectionInterleukin-17Transmissão Vertical de Doenças InfecciosasMicrocefaliaInterleucina-17Maternal Th17 profile after Zika virus infection is involved in congenital Zika syndrome development in childreninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/60826/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALFialho, Eder M. S. - Maternal Th17 Profile after Zika Virus Infection Is Involved in Congenital Zika Syndrome Development in Children.pdfFialho, Eder M. S. - Maternal Th17 Profile after Zika Virus Infection Is Involved in Congenital Zika Syndrome Development in Children.pdfapplication/pdf1795467https://www.arca.fiocruz.br/bitstream/icict/60826/2/Fialho%2c%20Eder%20M.%20S.%20-%20Maternal%20Th17%20Profile%20after%20Zika%20Virus%20Infection%20Is%20Involved%20in%20Congenital%20Zika%20Syndrome%20Development%20in%20Children.pdf12f8e493204f7b43171ae5f02c6f59f1MD52icict/608262023-10-18 09:42:17.564oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-10-18T12:42:17Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.en_US.fl_str_mv Maternal Th17 profile after Zika virus infection is involved in congenital Zika syndrome development in children
title Maternal Th17 profile after Zika virus infection is involved in congenital Zika syndrome development in children
spellingShingle Maternal Th17 profile after Zika virus infection is involved in congenital Zika syndrome development in children
Fialho, Eder M. S.
Transmissão vertical
Microcefalia
Infecção por doença
Interleucina-17
Vertical transmission
Microcephaly
Disease infection
Interleukin-17
Transmissão Vertical de Doenças Infecciosas
Microcefalia
Interleucina-17
title_short Maternal Th17 profile after Zika virus infection is involved in congenital Zika syndrome development in children
title_full Maternal Th17 profile after Zika virus infection is involved in congenital Zika syndrome development in children
title_fullStr Maternal Th17 profile after Zika virus infection is involved in congenital Zika syndrome development in children
title_full_unstemmed Maternal Th17 profile after Zika virus infection is involved in congenital Zika syndrome development in children
title_sort Maternal Th17 profile after Zika virus infection is involved in congenital Zika syndrome development in children
author Fialho, Eder M. S.
author_facet Fialho, Eder M. S.
Veras, Emanoel M.
Jesus, Caroline M. de
Gomes, Líllian N.
Khouri, Ricardo
Sousa, Patrícia S.
Ribeiro, Marizélia R. C.
Batista, Rosângela F. L.
Costa, Luciana C.
Nascimento, Flávia R. F.
Silva, Antônio A. M.
Pereira, Paulo V. Soeiro
author_role author
author2 Veras, Emanoel M.
Jesus, Caroline M. de
Gomes, Líllian N.
Khouri, Ricardo
Sousa, Patrícia S.
Ribeiro, Marizélia R. C.
Batista, Rosângela F. L.
Costa, Luciana C.
Nascimento, Flávia R. F.
Silva, Antônio A. M.
Pereira, Paulo V. Soeiro
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Fialho, Eder M. S.
Veras, Emanoel M.
Jesus, Caroline M. de
Gomes, Líllian N.
Khouri, Ricardo
Sousa, Patrícia S.
Ribeiro, Marizélia R. C.
Batista, Rosângela F. L.
Costa, Luciana C.
Nascimento, Flávia R. F.
Silva, Antônio A. M.
Pereira, Paulo V. Soeiro
dc.subject.other.en_US.fl_str_mv Transmissão vertical
Microcefalia
Infecção por doença
Interleucina-17
topic Transmissão vertical
Microcefalia
Infecção por doença
Interleucina-17
Vertical transmission
Microcephaly
Disease infection
Interleukin-17
Transmissão Vertical de Doenças Infecciosas
Microcefalia
Interleucina-17
dc.subject.en.en_US.fl_str_mv Vertical transmission
Microcephaly
Disease infection
Interleukin-17
dc.subject.decs.en_US.fl_str_mv Transmissão Vertical de Doenças Infecciosas
Microcefalia
Interleucina-17
description Coordenação de Aperfeiçoamento de Pessoal do Ensino Superior - Brasil (CAPES). Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq). Fundação de Amparo Pesquisa do Maranhão (FAPEMA).
publishDate 2023
dc.date.accessioned.fl_str_mv 2023-10-18T12:42:16Z
dc.date.available.fl_str_mv 2023-10-18T12:42:16Z
dc.date.issued.fl_str_mv 2023
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv FIALHO, Eder M. S. et al. Maternal Th17 profile after Zika virus infection is involved in congenital Zika syndrome development in children. Viruses, v. 15, n. 1320, p. 1-16, 2023.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/60826
dc.identifier.issn.en_US.fl_str_mv 1999-4915
dc.identifier.doi.none.fl_str_mv 10.3390/v15061320
identifier_str_mv FIALHO, Eder M. S. et al. Maternal Th17 profile after Zika virus infection is involved in congenital Zika syndrome development in children. Viruses, v. 15, n. 1320, p. 1-16, 2023.
1999-4915
10.3390/v15061320
url https://www.arca.fiocruz.br/handle/icict/60826
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
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collection Repositório Institucional da FIOCRUZ (ARCA)
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