Meningococcal Carriage among Adolescents after Mass Meningococcal C Conjugate Vaccination Campaigns in Salvador, Brazil

Detalhes bibliográficos
Autor(a) principal: Nunes, Amélia Maria Pithon Borges
Data de Publicação: 2016
Outros Autores: Ribeiro, Guilherme de Sousa, Ferreira, Ítalo Eustáquio, Moura, Ana Rafaela Silva Simões, Felzemburgh, Ridalva Dias Martins, Lemos, Ana Paula Silva de, Reis, Mitermayer Galvão dos, Moraes, José Cassio de, Campos, Leila Carvalho
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/18196
Resumo: Ministério da Saúde, Brazil, TC335/2013; Fundação de Amparo à Pesquisa do Estado da Bahia, SUS007/2014.
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spelling Nunes, Amélia Maria Pithon BorgesRibeiro, Guilherme de SousaFerreira, Ítalo EustáquioMoura, Ana Rafaela Silva SimõesFelzemburgh, Ridalva Dias MartinsLemos, Ana Paula Silva deReis, Mitermayer Galvão dosMoraes, José Cassio deCampos, Leila Carvalho2017-03-29T16:45:08Z2017-03-29T16:45:08Z2016NUNES, A. M. P. B. et al. Meningococcal Carriage among Adolescents after Mass Meningococcal C Conjugate Vaccination Campaigns in Salvador, Brazil. Plos One, v. 11, n. 11, p. e0166475, 2016.1932-6203https://www.arca.fiocruz.br/handle/icict/1819610.1371/journal.pone.0166475Ministério da Saúde, Brazil, TC335/2013; Fundação de Amparo à Pesquisa do Estado da Bahia, SUS007/2014.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Instituto de Saúde Coletiva. Salvador, BA, BrasilFundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, BrasilUniversidadeUniversidade Federal da Bahia. Escola de Enfermagem. Salvador, BA, BrasilInstituto Adolfo Lutz. Centro de Bacteriologia. Salvador, BA, BrasilFundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, BrasilFaculdade de Ciências Médicas da Santa Casa de São Paulo. São Paulo, SP, BrasilFundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, BrasilNeisseria meningitidis is a commensal bacterium of the human nasopharynx. In rare cases, it penetrates the mucosa, entering the blood stream and causing various forms of disease. Meningococcal conjugate vaccines can prevent invasive disease not only by direct effect in vaccinated individuals but also by herd protection, preventing acquisition of carriage, which interrupts transmission and leads to protection of unvaccinated persons. In 2010 in Salvador, Brazil, an outbreak of group C meningococcal disease led to a mass meningococcal serogroup C conjugate vaccination drive, targeting those <5 and 10-24 years of age. The present study aimed to estimate the prevalence of and identify factors associated with N. meningitidis carriage among adolescents from Salvador, Brazil, in the post-vaccination period. In spring 2014, we performed a cross-sectional study involving 1,200 public school students aged 11-19 years old. Oropharyngeal swabs were collected to identify N. meningitidis. Of the 59 colonized participants, 36 (61.0%) carried non-groupable N. meningitidis, while genogroup B (11.9%), Y (8.5%), E (6.8%), Z (5.1%), C (3.4%), and W (3.4%) were also detected. The overall prevalence of N. meningitidis carriage was 4.9% (95% confidence interval [CI], 3.6-6.1%); the prevalence of N. meningitidis genogroup C was 0.17% (95% CI, 0.0-0.40%). There was no difference by age. Factors associated with carriage were having only one, shared, bedroom in the household (PR, 2.02; 95% CI, 0.99-4.12, p = 0.05); the mother being the only smoker in the home (PR, 2.48; 95% CI, 1.16-5.29; p = 0.01); and going to pubs/parties more than 5 times/month (PR, 2.61; 95% CI, 1.38-4.92; p = 0.02). Our findings show that the N. meningitidis carriage rate in adolescents from Salvador, Bahia, is low and is potentially influenced by the low prevalence of N. meningitidis genogroup C. However, continued surveillance is important to identify changes in the dynamics of N. meningitidis, including the emergence of diseases due to a non-C serogroup.engPublic Library of ScienceMeningite meningococicaNeisseria meningitidis Sorogrupo CCampanhas de vacinaçãoVacinaçãoHumanosAdolescenteBrasilMeningitis, MeningococcalNeisseria meningitidis, Serogroup CVaccination CampaignsVaccinationHumansAdolescentsBrazilMeningococcal Carriage among Adolescents after Mass Meningococcal C Conjugate Vaccination Campaigns in Salvador, Brazilinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/18196/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALNunes AMPB Meningococcal carriage....pdfNunes AMPB Meningococcal 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dc.title.pt_BR.fl_str_mv Meningococcal Carriage among Adolescents after Mass Meningococcal C Conjugate Vaccination Campaigns in Salvador, Brazil
title Meningococcal Carriage among Adolescents after Mass Meningococcal C Conjugate Vaccination Campaigns in Salvador, Brazil
spellingShingle Meningococcal Carriage among Adolescents after Mass Meningococcal C Conjugate Vaccination Campaigns in Salvador, Brazil
Nunes, Amélia Maria Pithon Borges
Meningite meningococica
Neisseria meningitidis Sorogrupo C
Campanhas de vacinação
Vacinação
Humanos
Adolescente
Brasil
Meningitis, Meningococcal
Neisseria meningitidis, Serogroup C
Vaccination Campaigns
Vaccination
Humans
Adolescents
Brazil
title_short Meningococcal Carriage among Adolescents after Mass Meningococcal C Conjugate Vaccination Campaigns in Salvador, Brazil
title_full Meningococcal Carriage among Adolescents after Mass Meningococcal C Conjugate Vaccination Campaigns in Salvador, Brazil
title_fullStr Meningococcal Carriage among Adolescents after Mass Meningococcal C Conjugate Vaccination Campaigns in Salvador, Brazil
title_full_unstemmed Meningococcal Carriage among Adolescents after Mass Meningococcal C Conjugate Vaccination Campaigns in Salvador, Brazil
title_sort Meningococcal Carriage among Adolescents after Mass Meningococcal C Conjugate Vaccination Campaigns in Salvador, Brazil
author Nunes, Amélia Maria Pithon Borges
author_facet Nunes, Amélia Maria Pithon Borges
Ribeiro, Guilherme de Sousa
Ferreira, Ítalo Eustáquio
Moura, Ana Rafaela Silva Simões
Felzemburgh, Ridalva Dias Martins
Lemos, Ana Paula Silva de
Reis, Mitermayer Galvão dos
Moraes, José Cassio de
Campos, Leila Carvalho
author_role author
author2 Ribeiro, Guilherme de Sousa
Ferreira, Ítalo Eustáquio
Moura, Ana Rafaela Silva Simões
Felzemburgh, Ridalva Dias Martins
Lemos, Ana Paula Silva de
Reis, Mitermayer Galvão dos
Moraes, José Cassio de
Campos, Leila Carvalho
author2_role author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Nunes, Amélia Maria Pithon Borges
Ribeiro, Guilherme de Sousa
Ferreira, Ítalo Eustáquio
Moura, Ana Rafaela Silva Simões
Felzemburgh, Ridalva Dias Martins
Lemos, Ana Paula Silva de
Reis, Mitermayer Galvão dos
Moraes, José Cassio de
Campos, Leila Carvalho
dc.subject.other.pt_BR.fl_str_mv Meningite meningococica
Neisseria meningitidis Sorogrupo C
Campanhas de vacinação
Vacinação
Humanos
Adolescente
Brasil
topic Meningite meningococica
Neisseria meningitidis Sorogrupo C
Campanhas de vacinação
Vacinação
Humanos
Adolescente
Brasil
Meningitis, Meningococcal
Neisseria meningitidis, Serogroup C
Vaccination Campaigns
Vaccination
Humans
Adolescents
Brazil
dc.subject.en.pt_BR.fl_str_mv Meningitis, Meningococcal
Neisseria meningitidis, Serogroup C
Vaccination Campaigns
Vaccination
Humans
Adolescents
Brazil
description Ministério da Saúde, Brazil, TC335/2013; Fundação de Amparo à Pesquisa do Estado da Bahia, SUS007/2014.
publishDate 2016
dc.date.issued.fl_str_mv 2016
dc.date.accessioned.fl_str_mv 2017-03-29T16:45:08Z
dc.date.available.fl_str_mv 2017-03-29T16:45:08Z
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dc.identifier.citation.fl_str_mv NUNES, A. M. P. B. et al. Meningococcal Carriage among Adolescents after Mass Meningococcal C Conjugate Vaccination Campaigns in Salvador, Brazil. Plos One, v. 11, n. 11, p. e0166475, 2016.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/18196
dc.identifier.issn.pt_BR.fl_str_mv 1932-6203
dc.identifier.doi.none.fl_str_mv 10.1371/journal.pone.0166475
identifier_str_mv NUNES, A. M. P. B. et al. Meningococcal Carriage among Adolescents after Mass Meningococcal C Conjugate Vaccination Campaigns in Salvador, Brazil. Plos One, v. 11, n. 11, p. e0166475, 2016.
1932-6203
10.1371/journal.pone.0166475
url https://www.arca.fiocruz.br/handle/icict/18196
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