Meningococcal Carriage among Adolescents after Mass Meningococcal C Conjugate Vaccination Campaigns in Salvador, Brazil
Autor(a) principal: | |
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Data de Publicação: | 2016 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
Texto Completo: | https://www.arca.fiocruz.br/handle/icict/18196 |
Resumo: | Ministério da Saúde, Brazil, TC335/2013; Fundação de Amparo à Pesquisa do Estado da Bahia, SUS007/2014. |
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Nunes, Amélia Maria Pithon BorgesRibeiro, Guilherme de SousaFerreira, Ítalo EustáquioMoura, Ana Rafaela Silva SimõesFelzemburgh, Ridalva Dias MartinsLemos, Ana Paula Silva deReis, Mitermayer Galvão dosMoraes, José Cassio deCampos, Leila Carvalho2017-03-29T16:45:08Z2017-03-29T16:45:08Z2016NUNES, A. M. P. B. et al. Meningococcal Carriage among Adolescents after Mass Meningococcal C Conjugate Vaccination Campaigns in Salvador, Brazil. Plos One, v. 11, n. 11, p. e0166475, 2016.1932-6203https://www.arca.fiocruz.br/handle/icict/1819610.1371/journal.pone.0166475Ministério da Saúde, Brazil, TC335/2013; Fundação de Amparo à Pesquisa do Estado da Bahia, SUS007/2014.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Instituto de Saúde Coletiva. Salvador, BA, BrasilFundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, BrasilUniversidadeUniversidade Federal da Bahia. Escola de Enfermagem. Salvador, BA, BrasilInstituto Adolfo Lutz. Centro de Bacteriologia. Salvador, BA, BrasilFundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, BrasilFaculdade de Ciências Médicas da Santa Casa de São Paulo. São Paulo, SP, BrasilFundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, BrasilNeisseria meningitidis is a commensal bacterium of the human nasopharynx. In rare cases, it penetrates the mucosa, entering the blood stream and causing various forms of disease. Meningococcal conjugate vaccines can prevent invasive disease not only by direct effect in vaccinated individuals but also by herd protection, preventing acquisition of carriage, which interrupts transmission and leads to protection of unvaccinated persons. In 2010 in Salvador, Brazil, an outbreak of group C meningococcal disease led to a mass meningococcal serogroup C conjugate vaccination drive, targeting those <5 and 10-24 years of age. The present study aimed to estimate the prevalence of and identify factors associated with N. meningitidis carriage among adolescents from Salvador, Brazil, in the post-vaccination period. In spring 2014, we performed a cross-sectional study involving 1,200 public school students aged 11-19 years old. Oropharyngeal swabs were collected to identify N. meningitidis. Of the 59 colonized participants, 36 (61.0%) carried non-groupable N. meningitidis, while genogroup B (11.9%), Y (8.5%), E (6.8%), Z (5.1%), C (3.4%), and W (3.4%) were also detected. The overall prevalence of N. meningitidis carriage was 4.9% (95% confidence interval [CI], 3.6-6.1%); the prevalence of N. meningitidis genogroup C was 0.17% (95% CI, 0.0-0.40%). There was no difference by age. Factors associated with carriage were having only one, shared, bedroom in the household (PR, 2.02; 95% CI, 0.99-4.12, p = 0.05); the mother being the only smoker in the home (PR, 2.48; 95% CI, 1.16-5.29; p = 0.01); and going to pubs/parties more than 5 times/month (PR, 2.61; 95% CI, 1.38-4.92; p = 0.02). Our findings show that the N. meningitidis carriage rate in adolescents from Salvador, Bahia, is low and is potentially influenced by the low prevalence of N. meningitidis genogroup C. However, continued surveillance is important to identify changes in the dynamics of N. meningitidis, including the emergence of diseases due to a non-C serogroup.engPublic Library of ScienceMeningite meningococicaNeisseria meningitidis Sorogrupo CCampanhas de vacinaçãoVacinaçãoHumanosAdolescenteBrasilMeningitis, MeningococcalNeisseria meningitidis, Serogroup CVaccination CampaignsVaccinationHumansAdolescentsBrazilMeningococcal Carriage among Adolescents after Mass Meningococcal C Conjugate Vaccination Campaigns in Salvador, Brazilinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/18196/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALNunes AMPB Meningococcal carriage....pdfNunes AMPB Meningococcal 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dc.title.pt_BR.fl_str_mv |
Meningococcal Carriage among Adolescents after Mass Meningococcal C Conjugate Vaccination Campaigns in Salvador, Brazil |
title |
Meningococcal Carriage among Adolescents after Mass Meningococcal C Conjugate Vaccination Campaigns in Salvador, Brazil |
spellingShingle |
Meningococcal Carriage among Adolescents after Mass Meningococcal C Conjugate Vaccination Campaigns in Salvador, Brazil Nunes, Amélia Maria Pithon Borges Meningite meningococica Neisseria meningitidis Sorogrupo C Campanhas de vacinação Vacinação Humanos Adolescente Brasil Meningitis, Meningococcal Neisseria meningitidis, Serogroup C Vaccination Campaigns Vaccination Humans Adolescents Brazil |
title_short |
Meningococcal Carriage among Adolescents after Mass Meningococcal C Conjugate Vaccination Campaigns in Salvador, Brazil |
title_full |
Meningococcal Carriage among Adolescents after Mass Meningococcal C Conjugate Vaccination Campaigns in Salvador, Brazil |
title_fullStr |
Meningococcal Carriage among Adolescents after Mass Meningococcal C Conjugate Vaccination Campaigns in Salvador, Brazil |
title_full_unstemmed |
Meningococcal Carriage among Adolescents after Mass Meningococcal C Conjugate Vaccination Campaigns in Salvador, Brazil |
title_sort |
Meningococcal Carriage among Adolescents after Mass Meningococcal C Conjugate Vaccination Campaigns in Salvador, Brazil |
author |
Nunes, Amélia Maria Pithon Borges |
author_facet |
Nunes, Amélia Maria Pithon Borges Ribeiro, Guilherme de Sousa Ferreira, Ítalo Eustáquio Moura, Ana Rafaela Silva Simões Felzemburgh, Ridalva Dias Martins Lemos, Ana Paula Silva de Reis, Mitermayer Galvão dos Moraes, José Cassio de Campos, Leila Carvalho |
author_role |
author |
author2 |
Ribeiro, Guilherme de Sousa Ferreira, Ítalo Eustáquio Moura, Ana Rafaela Silva Simões Felzemburgh, Ridalva Dias Martins Lemos, Ana Paula Silva de Reis, Mitermayer Galvão dos Moraes, José Cassio de Campos, Leila Carvalho |
author2_role |
author author author author author author author author |
dc.contributor.author.fl_str_mv |
Nunes, Amélia Maria Pithon Borges Ribeiro, Guilherme de Sousa Ferreira, Ítalo Eustáquio Moura, Ana Rafaela Silva Simões Felzemburgh, Ridalva Dias Martins Lemos, Ana Paula Silva de Reis, Mitermayer Galvão dos Moraes, José Cassio de Campos, Leila Carvalho |
dc.subject.other.pt_BR.fl_str_mv |
Meningite meningococica Neisseria meningitidis Sorogrupo C Campanhas de vacinação Vacinação Humanos Adolescente Brasil |
topic |
Meningite meningococica Neisseria meningitidis Sorogrupo C Campanhas de vacinação Vacinação Humanos Adolescente Brasil Meningitis, Meningococcal Neisseria meningitidis, Serogroup C Vaccination Campaigns Vaccination Humans Adolescents Brazil |
dc.subject.en.pt_BR.fl_str_mv |
Meningitis, Meningococcal Neisseria meningitidis, Serogroup C Vaccination Campaigns Vaccination Humans Adolescents Brazil |
description |
Ministério da Saúde, Brazil, TC335/2013; Fundação de Amparo à Pesquisa do Estado da Bahia, SUS007/2014. |
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2016 |
dc.date.issued.fl_str_mv |
2016 |
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2017-03-29T16:45:08Z |
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2017-03-29T16:45:08Z |
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dc.identifier.citation.fl_str_mv |
NUNES, A. M. P. B. et al. Meningococcal Carriage among Adolescents after Mass Meningococcal C Conjugate Vaccination Campaigns in Salvador, Brazil. Plos One, v. 11, n. 11, p. e0166475, 2016. |
dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/18196 |
dc.identifier.issn.pt_BR.fl_str_mv |
1932-6203 |
dc.identifier.doi.none.fl_str_mv |
10.1371/journal.pone.0166475 |
identifier_str_mv |
NUNES, A. M. P. B. et al. Meningococcal Carriage among Adolescents after Mass Meningococcal C Conjugate Vaccination Campaigns in Salvador, Brazil. Plos One, v. 11, n. 11, p. e0166475, 2016. 1932-6203 10.1371/journal.pone.0166475 |
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https://www.arca.fiocruz.br/handle/icict/18196 |
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