Distinct ability to accumulate eosinophils during the inflammatory cellular response to M. Bovis BCG in the mouse pleural cavity

Detalhes bibliográficos
Autor(a) principal: Werneck-Barroso, E.
Data de Publicação: 2000
Outros Autores: Moura, A. C. Novaes, Monteiro, M. Magalhães, Lima Júnior, O. Menezes de, Meirelles, M. de Nazareth Leal de, Henriques, M. das Graças Muller O.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/42521
Resumo: 2021-03-06
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spelling Werneck-Barroso, E.Moura, A. C. NovaesMonteiro, M. MagalhãesLima Júnior, O. Menezes deMeirelles, M. de Nazareth Leal deHenriques, M. das Graças Muller O.2020-08-03T21:23:57Z2020-08-03T21:23:57Z2000WERNECK-BARROSO, E. et al. Distinct ability to accumulate eosinophils during the inflammatory cellular response to M. bovis BCG in the mouse pleural cavity. Inflammation research, v. 49, n. 5, p. 206-213, 2000.1023-3830https://www.arca.fiocruz.br/handle/icict/4252110.1007/s000110050581engSpringerDistinct ability to accumulate eosinophils during the inflammatory cellular response to M. Bovis BCG in the mouse pleural cavityinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article2021-03-06Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil / Federal University of Rio de Janeiro. Institute of Thorax Diseases. Rio de Janeiro, RJ, Brazil.Universidade do Estado do Rio de Janeiro. Departamento de Biologia Celular e Genética. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Fisiologia e Farmacodinâmica. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto de Tecnologia em Fármacos. Laboratório de Farmacologia Aplicada. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Ultra-Estrutura e Biologia Celular. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto de Tecnologia em Fármacos. Laboratório de Farmacologia Aplicada. Rio de Janeiro, RJ, Brasil.Objective and design: The host response to Mycobacteria focuses on the development of cell-mediated immunity and granuloma formation. Here, we investigated the onset of cellular responses to mycobacteria in murine pleurisy. Material: Distinct mouse strains previously described as Bcg susceptible or resistant were inoculated intrathoracically with different doses of live M. bovis BCG. Methods: At various time intervals, cells harvested from the inflammatory site were identified and ultra-structurally analysed. Results: BCG-induced pleurisy had two peaks of cellular influx at 1 and 15 days after infection. At the first half hour, macrophages were found to be heavily infected. Neutrophil arrival started after 2 h of infection and peaked at 4 h. At this time, neutrophils were found ingesting mycobacteria exclusively with a high infecting dose. BCG was potently more eosinophilotactic in Bcg susceptible mice than in the resistant ones and to other well known eosinophilia inducers: IL-5, PAF-acether or LPS. Conclusions: Mycobacterial load and mouse susceptibility seem to determine the early granulocyte dynamics in the lesion.M. bovis BCGNeutrophilEosinophilInflammationinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txttext/plain1748https://www.arca.fiocruz.br/bitstream/icict/42521/1/license.txt8a4605be74aa9ea9d79846c1fba20a33MD51TEXTDistinct_Werneck-Barroso_etal_INI_2020.pdf.txtDistinct_Werneck-Barroso_etal_INI_2020.pdf.txtExtracted texttext/plain27445https://www.arca.fiocruz.br/bitstream/icict/42521/3/Distinct_Werneck-Barroso_etal_INI_2020.pdf.txt50bd11a82b92a425549e958c1c1063adMD53ORIGINALDistinct_Werneck-Barroso_etal_INI_2020.pdfDistinct_Werneck-Barroso_etal_INI_2020.pdfapplication/pdf382028https://www.arca.fiocruz.br/bitstream/icict/42521/4/Distinct_Werneck-Barroso_etal_INI_2020.pdf9f2aaaef08bae7cf273d6816357c3a69MD54icict/425212023-09-05 10:26:11.71oai:www.arca.fiocruz.br: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Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-09-05T13:26:11Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Distinct ability to accumulate eosinophils during the inflammatory cellular response to M. Bovis BCG in the mouse pleural cavity
title Distinct ability to accumulate eosinophils during the inflammatory cellular response to M. Bovis BCG in the mouse pleural cavity
spellingShingle Distinct ability to accumulate eosinophils during the inflammatory cellular response to M. Bovis BCG in the mouse pleural cavity
Werneck-Barroso, E.
M. bovis BCG
Neutrophil
Eosinophil
Inflammation
title_short Distinct ability to accumulate eosinophils during the inflammatory cellular response to M. Bovis BCG in the mouse pleural cavity
title_full Distinct ability to accumulate eosinophils during the inflammatory cellular response to M. Bovis BCG in the mouse pleural cavity
title_fullStr Distinct ability to accumulate eosinophils during the inflammatory cellular response to M. Bovis BCG in the mouse pleural cavity
title_full_unstemmed Distinct ability to accumulate eosinophils during the inflammatory cellular response to M. Bovis BCG in the mouse pleural cavity
title_sort Distinct ability to accumulate eosinophils during the inflammatory cellular response to M. Bovis BCG in the mouse pleural cavity
author Werneck-Barroso, E.
author_facet Werneck-Barroso, E.
Moura, A. C. Novaes
Monteiro, M. Magalhães
Lima Júnior, O. Menezes de
Meirelles, M. de Nazareth Leal de
Henriques, M. das Graças Muller O.
author_role author
author2 Moura, A. C. Novaes
Monteiro, M. Magalhães
Lima Júnior, O. Menezes de
Meirelles, M. de Nazareth Leal de
Henriques, M. das Graças Muller O.
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Werneck-Barroso, E.
Moura, A. C. Novaes
Monteiro, M. Magalhães
Lima Júnior, O. Menezes de
Meirelles, M. de Nazareth Leal de
Henriques, M. das Graças Muller O.
dc.subject.en.pt_BR.fl_str_mv M. bovis BCG
Neutrophil
Eosinophil
Inflammation
topic M. bovis BCG
Neutrophil
Eosinophil
Inflammation
description 2021-03-06
publishDate 2000
dc.date.issued.fl_str_mv 2000
dc.date.accessioned.fl_str_mv 2020-08-03T21:23:57Z
dc.date.available.fl_str_mv 2020-08-03T21:23:57Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv WERNECK-BARROSO, E. et al. Distinct ability to accumulate eosinophils during the inflammatory cellular response to M. bovis BCG in the mouse pleural cavity. Inflammation research, v. 49, n. 5, p. 206-213, 2000.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/42521
dc.identifier.issn.pt_BR.fl_str_mv 1023-3830
dc.identifier.doi.none.fl_str_mv 10.1007/s000110050581
identifier_str_mv WERNECK-BARROSO, E. et al. Distinct ability to accumulate eosinophils during the inflammatory cellular response to M. bovis BCG in the mouse pleural cavity. Inflammation research, v. 49, n. 5, p. 206-213, 2000.
1023-3830
10.1007/s000110050581
url https://www.arca.fiocruz.br/handle/icict/42521
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Springer
publisher.none.fl_str_mv Springer
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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https://www.arca.fiocruz.br/bitstream/icict/42521/3/Distinct_Werneck-Barroso_etal_INI_2020.pdf.txt
https://www.arca.fiocruz.br/bitstream/icict/42521/4/Distinct_Werneck-Barroso_etal_INI_2020.pdf
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