Trends in overall opportunistic illnesses, Pneumocystis carinii pneumonia, cerebral toxoplasmosis and Mycobacterium avium complex incidence rates over the 30 years of the HIV epidemic: a systematic review

Detalhes bibliográficos
Autor(a) principal: Coelho, Lara
Data de Publicação: 2014
Outros Autores: Veloso, Valdiléa G., Grinsztejn, Beatriz, Luz, Paula Mendes
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/32104
Resumo: Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Rio de Janeiro, RJ, Brasil.
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spelling Coelho, LaraVeloso, Valdiléa G.Grinsztejn, BeatrizLuz, Paula Mendes2019-03-15T13:00:09Z2019-03-15T13:00:09Z2014COELHO, Lara et al. Trends in overall opportunistic illnesses, Pneumocystis carinii pneumonia, cerebral toxoplasmosis and Mycobacterium avium complex incidence rates over the 30 years of the HIV epidemic: a systematic review. Brazilian Journal of Infectious Diseases, v. 18, n. 2, p. 196-210, 2014.1413-8670https://www.arca.fiocruz.br/handle/icict/3210410.1016/j.bjid.2013.10.0031678-4391engElsevierTrends in overall opportunistic illnesses, Pneumocystis carinii pneumonia, cerebral toxoplasmosis and Mycobacterium avium complex incidence rates over the 30 years of the HIV epidemic: a systematic reviewinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Rio de Janeiro, RJ, Brasil.Background: The natural history of HIV infection has changed dramatically after the introduction of highly active antiretroviral therapy. Currently, opportunistic illnesses still represent a major cause of death and hospitalization in this population. In this study, we review the trends in opportunistic illnesses incidence rates and compare the results observed in high-income settings with that for low/middle-income settings, with special attention given to studies from Brazil. Methods: We systematically searched Pubmed, Web of Science, Lilacs and Google scholar for publications on HIV associated opportunistic illness. Studies reporting rates based on person-time for all opportunistic illnesses and/or the three opportunistic infections of interest, namely, Pneumocystis carinii pneumonia, cerebral toxoplasmosis, and Mycobacterium avium complex were included. Results: Significant reductions in the incidence rates were demonstrated for opportunistic illnesses overall and also for the specific opportunistic infections included in the present study, both in high and low/middle-income settings. Out of the 37 studies included in the present review, almost 70% were from high-income settings. All the studies conducted in low/middle-income settings were single center studies and four were from Brazil. We found no study from Brazil reporting annual incidence rates of opportunistic illnesses. Conclusions: Opportunistic illnesses remain an important public health problem. To better guide health policies in low/middle-income settings, multicenter cohort studies should be encouraged. Studies from Brazil are urgently needed to assess the current burden of opportunistic illnesses in our population and to support the planning of HIV/AIDS health care services organization.AIDS-related opportunistic infectionsOpportunistic infectionAcquired immunodeficiency syndromeIncidenceinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83104https://www.arca.fiocruz.br/bitstream/icict/32104/1/license.txt79178e5f2a0eb066867a274556814938MD51ORIGINALve_Coelho_Lara_etal_INI_2014.pdfve_Coelho_Lara_etal_INI_2014.pdfapplication/pdf952601https://www.arca.fiocruz.br/bitstream/icict/32104/2/ve_Coelho_Lara_etal_INI_2014.pdf0a767f2dbc37ef3d7b0fa6a7d83d4d96MD52TEXTve_Coelho_Lara_etal_INI_2014.pdf.txtve_Coelho_Lara_etal_INI_2014.pdf.txtExtracted 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dc.title.pt_BR.fl_str_mv Trends in overall opportunistic illnesses, Pneumocystis carinii pneumonia, cerebral toxoplasmosis and Mycobacterium avium complex incidence rates over the 30 years of the HIV epidemic: a systematic review
title Trends in overall opportunistic illnesses, Pneumocystis carinii pneumonia, cerebral toxoplasmosis and Mycobacterium avium complex incidence rates over the 30 years of the HIV epidemic: a systematic review
spellingShingle Trends in overall opportunistic illnesses, Pneumocystis carinii pneumonia, cerebral toxoplasmosis and Mycobacterium avium complex incidence rates over the 30 years of the HIV epidemic: a systematic review
Coelho, Lara
AIDS-related opportunistic infections
Opportunistic infection
Acquired immunodeficiency syndrome
Incidence
title_short Trends in overall opportunistic illnesses, Pneumocystis carinii pneumonia, cerebral toxoplasmosis and Mycobacterium avium complex incidence rates over the 30 years of the HIV epidemic: a systematic review
title_full Trends in overall opportunistic illnesses, Pneumocystis carinii pneumonia, cerebral toxoplasmosis and Mycobacterium avium complex incidence rates over the 30 years of the HIV epidemic: a systematic review
title_fullStr Trends in overall opportunistic illnesses, Pneumocystis carinii pneumonia, cerebral toxoplasmosis and Mycobacterium avium complex incidence rates over the 30 years of the HIV epidemic: a systematic review
title_full_unstemmed Trends in overall opportunistic illnesses, Pneumocystis carinii pneumonia, cerebral toxoplasmosis and Mycobacterium avium complex incidence rates over the 30 years of the HIV epidemic: a systematic review
title_sort Trends in overall opportunistic illnesses, Pneumocystis carinii pneumonia, cerebral toxoplasmosis and Mycobacterium avium complex incidence rates over the 30 years of the HIV epidemic: a systematic review
author Coelho, Lara
author_facet Coelho, Lara
Veloso, Valdiléa G.
Grinsztejn, Beatriz
Luz, Paula Mendes
author_role author
author2 Veloso, Valdiléa G.
Grinsztejn, Beatriz
Luz, Paula Mendes
author2_role author
author
author
dc.contributor.author.fl_str_mv Coelho, Lara
Veloso, Valdiléa G.
Grinsztejn, Beatriz
Luz, Paula Mendes
dc.subject.en.pt_BR.fl_str_mv AIDS-related opportunistic infections
Opportunistic infection
Acquired immunodeficiency syndrome
Incidence
topic AIDS-related opportunistic infections
Opportunistic infection
Acquired immunodeficiency syndrome
Incidence
description Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Rio de Janeiro, RJ, Brasil.
publishDate 2014
dc.date.issued.fl_str_mv 2014
dc.date.accessioned.fl_str_mv 2019-03-15T13:00:09Z
dc.date.available.fl_str_mv 2019-03-15T13:00:09Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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status_str publishedVersion
dc.identifier.citation.fl_str_mv COELHO, Lara et al. Trends in overall opportunistic illnesses, Pneumocystis carinii pneumonia, cerebral toxoplasmosis and Mycobacterium avium complex incidence rates over the 30 years of the HIV epidemic: a systematic review. Brazilian Journal of Infectious Diseases, v. 18, n. 2, p. 196-210, 2014.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/32104
dc.identifier.issn.pt_BR.fl_str_mv 1413-8670
dc.identifier.doi.none.fl_str_mv 10.1016/j.bjid.2013.10.003
dc.identifier.eissn.none.fl_str_mv 1678-4391
identifier_str_mv COELHO, Lara et al. Trends in overall opportunistic illnesses, Pneumocystis carinii pneumonia, cerebral toxoplasmosis and Mycobacterium avium complex incidence rates over the 30 years of the HIV epidemic: a systematic review. Brazilian Journal of Infectious Diseases, v. 18, n. 2, p. 196-210, 2014.
1413-8670
10.1016/j.bjid.2013.10.003
1678-4391
url https://www.arca.fiocruz.br/handle/icict/32104
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
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dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
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instname_str Fundação Oswaldo Cruz (FIOCRUZ)
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